Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(143 products)
- CXCR(158 products)
- Cell wall(5 products)
- IL Receptor(110 products)
- IκB/IKK(57 products)
- LTR(3 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(2 products)
- NF-κB(386 products)
- NOD(25 products)
- NOS(61 products)
- Nrf2(81 products)
- PGE Synthase(31 products)
- ROS(70 products)
- TGF-beta/Smad(60 products)
- TLR(76 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
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Found 3435 products of "Immunology and Inflammation"
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NOS-IN-2
NOS-IN-2: potent, selective imidamide NOS inhibitor, IC50=20μM for iNOS, spares eNOS, low toxicity, useful in inflammation research.Formula:C18H20F3N3O2Color and Shape:SolidMolecular weight:367.37MALT1-IN-11
CAS:MALT1-IN-11: MALT1 inhibitor, IC50 <10-100 nM, reduces IL10, for cancer/autoimmune research.Formula:C20H16F4N8OColor and Shape:SolidMolecular weight:460.39trans-3-(3-Pyridyl)acrylic acid
CAS:Trans-3-(3-Pyridyl)acrylic acid (compound 15) is a trans-3-aryl acrylic acid demonstrating antiviral activity against tobacco mosaic virus (TMV) [1].Formula:C8H7NO2Color and Shape:SolidMolecular weight:149.15Fluopimomide
CAS:Fluopimomide (LH2010A), a powerful insecticide, is extensively utilized in the control of agricultural pests. It adversely affects the growth, locomotor behavior, reproduction, and lifespan of nematodes. Concurrently, it leads to increased production of reactive oxygen species (ROS), accumulation of lipids and lipofuscins, as well as a rise in malondialdehyde content. Additionally, Fluopimomide inhibits the antioxidant system of nematodes.Formula:C15H8ClF7N2O2Color and Shape:SolidMolecular weight:416.68ND-2158
CAS:ND-2158 is a potent and selective inhibitor of IRAK4.Formula:C22H30N4O4SPurity:98%Color and Shape:SolidMolecular weight:446.56Anti-osteoporosis agent-11
CAS:Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.Formula:C23H17NO2Se2Color and Shape:SolidMolecular weight:497.31YE6144
CAS:YE6144, IRF5 phosphorylation blocker. Affordable Excellence: Reliable Quality You Can TrustFormula:C21H27ClFN7OColor and Shape:SolidMolecular weight:447.94ZMC3
CAS:ZMC3 (NSC328784), a zinc chelator, exhibits properties as a zinc metallochaperone. It shows enhanced sensitivity in cells with the p53-R175H mutation and increases the cellular levels of ROS (reactive oxygen species).Formula:C17H20N6SeColor and Shape:SolidMolecular weight:387.34AhR agonist 2
AhR agonist 2 is aryl hydrocarbon receptor (AhR) agonist,oral, inducing rapid nuclear enrichment of the AhR and facilitating skin barrier repair,psoriasis.Formula:C12H7Br2N3Color and Shape:SolidMolecular weight:353.01MG-T-19
CAS:MG-T-19, a TIM-3 inhibitor, inhibit the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs.Formula:C18H8Br2ClF3N4O2SPurity:99.14%Color and Shape:SolidMolecular weight:596.6CD73-IN-19
CAS:CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.
Formula:C18H17N3O3SColor and Shape:SolidMolecular weight:355.411Cyclic-di-GMP sodium
c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.Formula:C20H24N10NaO14P2Color and Shape:SolidMolecular weight:713.08464AS2690168 (free base)
CAS:AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Formula:C17H13F3N4OColor and Shape:SolidMolecular weight:346.306FK-565
CAS:FK-565 is a ligand of nucleotide-binding oligomerization domain-1 (NOD1) that induces a mouse model of arteritis.Formula:C22H38N4O9Color and Shape:SolidMolecular weight:502.559mPGES1-IN-9
CAS:mPGES1-IN-9 (compound 1_8) is an mPGES1 inhibitor with an IC50 of 0.5 μM and is utilized in anti-inflammatory research.Formula:C25H18N4OSColor and Shape:SolidMolecular weight:422.502Amilo-5MER
CAS:Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.Formula:C23H40N6O9SColor and Shape:SolidMolecular weight:576.664Panaxcerol B
CAS:Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.Formula:C27H46O9Color and Shape:SolidMolecular weight:514.65cGAS-IN-4
CAS:cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.Formula:C19H18Cl2N4O3Color and Shape:SolidMolecular weight:421.277NLRP3-IN-7
NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.Formula:C18H15ClN2O4S3Color and Shape:SolidMolecular weight:454.97Galectin-3-IN-4
CAS:Galectin-3-IN-4 (compound 5), a carboxamide analog, effectively and selectively inhibits both human and mouse galectin-3. This compound demonstrates notable potency with IC50 values of 21 nM for hGal-3 and 167 nM for mGal-3. It is also orally bioavailable. For other galectins, Galectin-3-IN-4 shows IC50 values of 1580 nM for hGal-1 and 2750 nM for hGal-9, respectively [1].Formula:C24H22ClF2N5O5SColor and Shape:SolidMolecular weight:565.98Antioxidant agent-3
Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.Formula:C18H14O8Color and Shape:SolidMolecular weight:358.3YM-I-26
CAS:YM-I-26 is a selective inhibitor of the NLRP3 inflammasome. This compound enhances the phagocytic activity of β-amyloid in murine microglial BV2 cells and reduces the production of IL-1β and IL-10. YM-I-26 is useful for research into inflammation-related immunomodulatory activities.Formula:C28H33ClN2O5S2Color and Shape:SolidMolecular weight:577.16COX-2/PI3K-IN-1
COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).Formula:C19H14ClN5S2Color and Shape:SolidMolecular weight:411.93SARM1-IN-4
CAS:SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.Formula:C13H17F2N3O2Color and Shape:SolidMolecular weight:285.29FAPI-74
CAS:FAPI-74 is a PET (positron emission tomography) tracer involved in early FAPI-PET imaging.FAPI-74 can be used to study cancer tumors and degenerative diseases.
Formula:C36H49N9O8Color and Shape:SolidMolecular weight:735.83LHC-165
CAS:LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.Formula:C29H32F2N3O7PPurity:98%Color and Shape:SolidMolecular weight:603.55HEI3090
CAS:HEI3090 is an activator of the P2X7R receptor. This compound enhances the production of IL-18 by stimulating dendritic cells that express P2X7R, which in turn promotes the production of IFN-γ by natural killer cells and CD4T cells within tumors, triggering a sustained anti-tumor response. Additionally, HEI3090 can be used to improve the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC).Formula:C18H15Cl3N4O3Color and Shape:SolidMolecular weight:441.70WK692
CAS:Compound WK692 (compund WK692) is a BCL6 inhibitor that effectively suppresses the growth of diffuse large B-cell lymphoma cells without toxic side effects and acts synergistically with inhibitors of EZH2 and PRMT5.Formula:C26H28Br2N8O5Color and Shape:SolidMolecular weight:692.36AIM4
CAS:AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).Formula:C25H23Br2N5O4Color and Shape:SolidMolecular weight:617.289Nrf2 activator-6
CAS:Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).Formula:C31H37ClFN5O5Color and Shape:SolidMolecular weight:614.11DBMB
CAS:DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.Formula:C24H22N4OColor and Shape:SolidMolecular weight:382.458Galectin-8-IN-1
Galectin-8-IN-1 selectively binds galectin-8N with 48 μM affinity, 15x more than galectin-3.Formula:C16H18N2O6Color and Shape:SolidMolecular weight:334.32HG-12-6
CAS:HG-12-6 is a type II IRAK4 inhibitor, targeting its inactive form with an IC50 of 165 nM, and is used in autoimmunity and inflammation.Formula:C29H27F3N6O2SPurity:98%Color and Shape:SolidMolecular weight:580.624-Octylphenol
CAS:4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.Formula:C14H22OColor and Shape:SolidMolecular weight:206.32STING agonist-42
CAS:STINGagonist-42 (compound 8a) is a potent STING agonist. It activates STING in THP1 and RAW 264.7 cells, with EC50 values of 0.06 μM and 14.15 μM, respectively.Formula:C17H8F2LiN5O3Color and Shape:SolidMolecular weight:375.22ODN 2088
CAS:ODN 2088 is a potent inhibitor of TLR3, TLR7 and TLR9 that is non-cytotoxic and shows inhibition of the release of IFN-α and IL-6.Color and Shape:SolidCOX-2-IN-9
COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.Formula:C25H23N5O4S2Color and Shape:SolidMolecular weight:521.61Imipramine Blue chloride
Imipramine Blue chloride is an effective anti-invasive agent capable of inhibiting glioma invasion. It suppresses the production of reactive oxygen species (reactive oxygen species) mediated by NADPH oxidase.Formula:C40H51ClN4Color and Shape:SolidMolecular weight:623.31Anti-inflammatory agent 6
Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.Formula:C22H20O12Color and Shape:SolidMolecular weight:476.396-Alkyne-F-araNAD
CAS:6-Alkyne-F-araNAD is an irreversible CD38 inhibitor that aids in better visualization of intracellular CD38 localization when used alongside other fluorescent probes (such as SR101−F-araNMN).Formula:C24H28FN7O13P2Color and Shape:SolidMolecular weight:703.464IRAK4-IN-12
IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).Formula:C24H31FN8OColor and Shape:SolidMolecular weight:466.55iNOS/PGE2-IN-1
iNOS/PGE2-IN-1: iNOS/PGE2 inhibitor, reduces LPS-induced NO, low ulcer risk, anti-inflammatory.Formula:C26H22ClN3O4Color and Shape:SolidMolecular weight:475.92OP-5244 sodium
OP-5244 sodium: potent oral CD73 inhibitor (IC50: 0.25 nM), potential in cancer research by hindering adenosine, reversing immunosuppression.Formula:C19H28ClN5NaO9PColor and Shape:SolidMolecular weight:559.87COX-2-IN-10
COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.Formula:C31H32FN5O2SColor and Shape:SolidMolecular weight:557.68NIK-IN-2
CAS:NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Formula:C20H22N4O3Color and Shape:SolidMolecular weight:366.41Fexlamose
CAS:Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).Formula:C12H22O9S2Color and Shape:SolidMolecular weight:374.428Glutathione monoethyl ester
CAS:Glutathione monoethyl ester, a derivative of glutathione, can protect motor neuron cells (NSC-34) from TDP-43 pathology caused by mutations, which includes reducing aggregate formation, nuclear clearance, reactive oxygen species (ROS) production, and cell death.Formula:C12H21N3O6SColor and Shape:SolidMolecular weight:335.377Ac5GalNTGc
CAS:Ac5GalNTGc, an analog of hexosamine, inhibits mucin-type O-linked glycosylation biosynthesis [1].Formula:C18H25NO11SColor and Shape:SolidMolecular weight:463.46Anti-inflammatory agent 19
Anti-inflammatory agent 19: NO inhibitor (IC50: 36μM), blocks HMGB1, for late-stage inflammation, relevant for COVID-19, sepsis.Formula:C30H50O7Color and Shape:SolidMolecular weight:522.71IKZF1-degrader-1
CAS:IKZF1-degrader-1 (Compound 9-B) serves as a potent degrader of the IKZF1 protein, exhibiting a DC50 of 0.134 nM. It is applicable in the degradation of tumors [1].Formula:C35H29F2N5O3Color and Shape:SolidMolecular weight:605.63Yoda2
CAS:Yoda2 (KC289), the potassium salt of Yoda1, is an agonist of PIEZO1 with an EC50 of 150 nM. It induces Ca2+ elevation in HeLa cells and can cause concentration-dependent and NO-dependent relaxation in mouse portal vein (EC50= 1.2 μM). Additionally, Yoda2 is capable of stimulating NOS3 and promoting NO production.Formula:C16H9Cl2KN2O2S2Color and Shape:SolidMolecular weight:435.39SP4206
CAS:SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)Formula:C30H37Cl2N7O6Purity:98%Color and Shape:SolidMolecular weight:662.56RGT-068A
CAS:RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .Formula:C17H16ClN9O2Color and Shape:SolidMolecular weight:413.82K-14585
CAS:K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.Formula:C51H56Cl2N8O4Color and Shape:SolidMolecular weight:915.95RIPK2-IN-6
CAS:RIPK2-IN-6 (Compound 15a) is an inhibitor of RIPK that specifically targets the phosphorylation of RIPK2, thereby suppressing the NF-κB and MAPK signaling pathways. It has demonstrated anti-inflammatory and anti-fibrotic activities in a mouse model of colitis induced by Dextran sodium sulfate.Formula:C26H21NO3Color and Shape:SolidMolecular weight:395.45VISTA-IN-3
CAS:VISTA-IN-3 (Compound A4), a potent small molecule inhibitor of VISTA, exhibits a dissociation constant (K D) of 0.49 μM. This compound effectively induces the release of IFN-γ cytokines and demonstrates synergistic enhancement of anti-cancer activity when combined with PD-L1 antibody [1].Formula:C14H18N4O3Color and Shape:SolidMolecular weight:290.32AhR agonist 6
CAS:Compound 6, an AhR agonist, selectively activates the aryl hydrocarbon receptor (AhR) with an EC50 of 0.01 nM [1].Formula:C17H16F2O2Color and Shape:SolidMolecular weight:290.30AhR agonist 7
CAS:Compound 8, an AhR agonist 7, demonstrates potent activation of AhR with an EC50 of 13nM [1].Formula:C16H15ClFNO2Color and Shape:SolidMolecular weight:307.75ALR-6
CAS:ALR-6, an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP, possesses anti-inflammatory properties. It significantly inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without substantially affecting direct inhibition of 5-LOX [1].
Formula:C18H14O5Color and Shape:SolidMolecular weight:310.3MGD-4
CAS:MGD-4 is an orally active, Cereblon (CRBN)-dependent degrader of IKAROS proteins that demonstrates dose-dependent degradation of IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM). The compound effectively inhibits the growth of multiple myeloma.Formula:C14H16N4O3Color and Shape:SolidMolecular weight:288.3Galectin-3-IN-3
CAS:Galectin-3-IN-3 (Compound 4) serves as a selective and orally active inhibitor targeting Gal-3. It exhibits IC50 values of 11 nM for mGal-3 and 84 nM for hGal-3 [1].Formula:C25H22ClF2N7O4SColor and Shape:SolidMolecular weight:590.00NLRP3-IN-29
CAS:NLRP3-IN-29 (Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) with potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. It can be used for research on Alzheimer's disease [1].Formula:C21H22N2O3SColor and Shape:SolidMolecular weight:382.48PSMA ligand 1
CAS:PSMAligand 1 (Compound 1c) is a PSMA ligand with an IC50 of 26.74 nM. When labeled with [18F], PSMAligand 1 serves as a PSMAPET tracer for research related to the diagnosis of prostate cancer.Formula:C20H26FN3O9Color and Shape:SolidMolecular weight:471.43ASP-8731
CAS:ASP8731 is a selective inhibitor of BACH1 that prevents inflammation and vascular occlusion, and induces fetal hemoglobin in sickle cell disease.Formula:C20H21N5O4Color and Shape:SolidMolecular weight:395.41PVTX-405
CAS:PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a maximum degradation (Dmax) of 91%. It enhances degradation efficiency, significantly reduces off-target degradation, and minimizes hERG inhibition with an IC50 of 48 µM. PVTX-405 effectively inhibits MC38 tumor growth in Crbn391VC57BL/6 mouse xenograft models and shows superior synergistic anticancer effects when combined with immune checkpoint therapies (ICTs) such as anti-PD1 or anti-LAG3 antibodies.Formula:C30H31N5O4Color and Shape:SolidMolecular weight:525.60AM679
CAS:AM679 is a potent, selective FLAP inhibitor with strong leukotriene suppression in vivo, minimal CYP3A4 interaction, and excellent pharmacokinetics in rodent models.Formula:C40H44N4O5SPurity:99.45%Color and Shape:SolidMolecular weight:692.87PSB-0963
CAS:PSB-0963 is a selective competitive extracellular 5'-nucleotidase (eN/CD73) inhibitor with a Ki value of 150 nM for rat extracellular 5'-nucleotidase. It exhibits greater selectivity compared to other extracellular nucleotidases (NTPDases 1-3) and P2Y receptors. PSB-0963 is applicable in cancer research.Formula:C28H17N2NaO5SColor and Shape:SolidMolecular weight:516.50TMV-IN-8
CAS:TMV-IN-8 (compound 7d) is an anti-tobacco mosaic virus (TMV) agent with an antiviral EC50 of 157.6 μg/mL. TMV-IN-8 blocks the assembly of TMV by binding with coat protein (Kd = 0.7 μM) and suppresses TMV coat protein gene expression and biosynthesis process [1].Formula:C26H22N6O4Color and Shape:SolidMolecular weight:482.49C5aR-IN-3
CAS:C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.Formula:C36H40FN5O3Color and Shape:SolidMolecular weight:609.73DPP4-In hydrochloride
CAS:DPP4-In (hydrochloride) is an inhibitor of dipeptidyl peptidase 4 (DPP4) that effectively reduces the expression of DPP4.Formula:C14H21ClN4O2Color and Shape:SolidMolecular weight:312.8RuDiOBn
CAS:RuDiOBn exhibits low antioxidant activity by scavenging DPPH and ABTS free radicals with scavenging rates of 13.2% and 5.9% at a concentration of 100 μg/mL. It inhibits collagen glycation and reduces the formation of advanced glycation end-products (AGE) with an IC50 of 2.45 μg/mL. RuDiOBn also enhances fibroblast proliferation and migration, stimulates collagen synthesis, and aids in skin repair and regeneration while inhibiting collagenase.Formula:C29H22O7Color and Shape:SolidMolecular weight:482.481CD73-IN-12
CD73-IN-12, a compound from CN114437038A, shows strong anti-tumor activity by effectively inhibiting CD73 enzyme.Formula:C17H14F2N4O2Color and Shape:SolidMolecular weight:344.32NOTA-FAPI
CAS:NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.Formula:C36H47F2N9O8Purity:99.748%Color and Shape:SolidMolecular weight:771.81Ocipumaltib
CAS:Ocipumaltib (Example 2) is an inhibitor of mucosa-associated lymphoid tissue protein 1 (MALT1). It functions as an antineoplastic agent and is utilized in the study of cancer, infections, neurological disorders, and hematological diseases.Formula:C20H16ClF3N8O2Color and Shape:SolidMolecular weight:492.84TLR7/8 antagonist 1
Compound 16c, an imidazoquinoline, is a TLR7/8 agonist; IC50: 3.91 μM (TLR7), 2.19 μM (TLR8); targets TLR-2050 for disease treatment.Formula:C24H27N5O2Color and Shape:SolidMolecular weight:417.5Methoxyurea
CAS:Methoxyurea (Compound 3) is a potential modulator of nitric oxide (NO) donors, interacting with hemoglobin forms such as oxyhemoglobin (OxyHb) and methemoglobin (MetHb). It holds promise for use in research on sickle cell disease (SCD).Formula:C2H6N2O2Color and Shape:SolidMolecular weight:90.081Hetrombopag olamine
CAS:Hetrombopag olamine is a non-peptide thrombopoietin (TPO) receptor agonist with oral activity.Formula:C29H36N6O7Purity:98%Color and Shape:SolidMolecular weight:580.63STING agonist-20
CAS:STING agonist-20: potent, aids in XMT-2056 synthesis, used as a cancer vaccine adjuvant.Formula:C36H39N11O8Color and Shape:SolidMolecular weight:753.76STING agonist-21
CAS:STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].Formula:C17H11F6N5O2Color and Shape:SolidMolecular weight:431.29SMW139
CAS:SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.Formula:C19H21ClF3NO2Color and Shape:SolidMolecular weight:387.824Anti-inflammatory agent 23
Anti-inflammatory agent 23 blocks LPS-induced NO (IC50: 0.449 μM) and binds p65 well.Formula:C34H49NO6Color and Shape:SolidMolecular weight:567.76IRAK4-IN-15
CAS:IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.Formula:C25H29FN10Color and Shape:SolidMolecular weight:488.56α-Hydroxy alprazolam
CAS:α-Hydroxy alprazolam (U 40125), the primary metabolite of α-Hydroxy alprazolam, possesses pharmacological activity accounting for 60% of that of Alprazolam.Formula:C17H13ClN4OColor and Shape:SolidMolecular weight:324.76ALR-27
CAS:ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].Formula:C19H22O3Color and Shape:SolidMolecular weight:298.38ABZI
CAS:(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.Formula:C23H24N6O3Color and Shape:SolidMolecular weight:432.48Pelecopan
CAS:Pelecopan (BCX9930), an oral complement factor D inhibitor, prevents hemolysis in PNH (IC50=14.3 nM).Formula:C23H19FN2O4Color and Shape:SolidMolecular weight:406.41HTS05585
CAS:HTS05585 (Compound Hit-1) is a selective inhibitor of macrophage migration inhibitory factor (MIF) with a Kd value of 0.29 μM determined by microscale thermophoresis (MST) and confirmed through isothermal titration calorimetry (ITC) at 0.32 μM. It suppresses the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) in macrophages induced by LPS, making it a promising candidate for the study of inflammatory diseases such as sepsis.Formula:C18H15N3OColor and Shape:SolidMolecular weight:289.33ADU-S100 disodium salt
CAS:ADU-S100 (MIW815) disodium salt is an activator of stimulator of interferon genes (STING).Formula:C20H22N10Na2O10P2S2Purity:98%Color and Shape:SolidMolecular weight:734.51Creatine ethyl ester
CAS:Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.Formula:C6H13N3O2Color and Shape:SolidMolecular weight:159.186EGR-1-IN-3
CAS:EGR-1-IN-3 (Compound 36) is an inhibitor of early growth response 1 (EGR-1) binding to DNA. It effectively suppresses the binding of EGR-1 to DNA and the expression of inflammation-related genes (such as TSLP, IL-31, IL-6, and CCL2) induced by TNFα. This compound is applicable to the study of inflammatory diseases.Formula:C31H31N3O6SColor and Shape:SolidMolecular weight:573.659cGAS-IN-2
CAS:cGAS-IN-2 (compound 109) serves as a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), exhibiting an IC50 of 0.01512 μM against h-cGAS [1].Formula:C16H18Cl2N2O2Color and Shape:SolidMolecular weight:341.23Gardiquimod hydrochloride
CAS:Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.Formula:C17H24ClN5OColor and Shape:SolidMolecular weight:349.858Factor B-IN-3
CAS:Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.Formula:C24H29N3O4Color and Shape:SolidMolecular weight:423.5Evixapodlin
CAS:Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.Formula:C34H36Cl2N8O4Purity:97.02%Color and Shape:SolidMolecular weight:691.61Ref: TM-T36487
1mg111.00€5mg264.00€1mL*10mM (DMSO)405.00€10mg424.00€25mg747.00€50mg1,008.00€100mg1,359.00€200mg1,833.00€KI696
CAS:KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Formula:C28H30N4O6SPurity:99.74%Color and Shape:SolidMolecular weight:550.63Ref: TM-T11758L
1mg137.00€5mg281.00€1mL*10mM (DMSO)341.00€10mg423.00€25mg707.00€50mg1,018.00€100mg1,468.00€200mg1,963.00€AM103
CAS:AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).Formula:C36H38N3NaO4SPurity:99.75%Color and Shape:SolidMolecular weight:631.76Dazostinag disodium
CAS:Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist.Cost-effective and quality-assured.Formula:C21H20F2N8Na2O10P2S2Purity:98.84% - 99.96%Color and Shape:SolidMolecular weight:754.48UBS109
CAS:UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.Formula:C18H17N3OPurity:99.48%Color and Shape:SolidMolecular weight:291.35Ref: TM-T88314
2mg37.00€5mg54.00€1mL*10mM (DMSO)59.00€10mg87.00€25mg157.00€50mg241.00€100mg369.00€200mg536.00€Antiproliferative agent-22
CAS:Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.Formula:C17H13N3O3Purity:99.20% - 99.27%Color and Shape:SolidMolecular weight:307.3VVD-130037
CAS:VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Formula:C17H17ClN4O2Purity:99.01% - 99.92%Color and Shape:SolidMolecular weight:344.8Ref: TM-T88838
1mg72.00€5mg157.00€1mL*10mM (DMSO)171.00€10mg242.00€25mg387.00€50mg546.00€100mg1,429.00€
