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Immunology and Inflammation

Immunology and Inflammation

Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.

Subcategories of "Immunology and Inflammation"

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Found 3045 products of "Immunology and Inflammation"

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  • ABR-238901
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    ABR-238901

    CAS:
    <p>ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products</p>
    Formula:C11H9BrClN3O4S
    Purity:98.63% - 98.71%
    Color and Shape:Solid
    Molecular weight:394.63

    Ref: TM-T39115

  • RIPK1-IN-4
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    RIPK1-IN-4

    CAS:
    <p>RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s</p>
    Formula:C23H23N5O2
    Purity:99.94%
    Color and Shape:Solid
    Molecular weight:401.46

    Ref: TM-T12730

  • cGAS-IN-4
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    cGAS-IN-4

    CAS:
    <p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>
    Formula:C19H18Cl2N4O3
    Color and Shape:Solid
    Molecular weight:421.277

    Ref: TM-T204612

  • IRAK4-IN-15
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    IRAK4-IN-15

    CAS:
    <p>IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.</p>
    Formula:C25H29FN10
    Color and Shape:Solid
    Molecular weight:488.56

    Ref: TM-T63262

  • Creatine ethyl ester
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    Creatine ethyl ester

    CAS:
    <p>Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.</p>
    Formula:C6H13N3O2
    Color and Shape:Solid
    Molecular weight:159.186

    Ref: TM-T206807

  • DPP4-In hydrochloride
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    DPP4-In hydrochloride

    CAS:
    <p>DPP4-In (hydrochloride) is an inhibitor of dipeptidyl peptidase 4 (DPP4) that effectively reduces the expression of DPP4.</p>
    Formula:C14H21ClN4O2
    Color and Shape:Solid
    Molecular weight:312.8

    Ref: TM-T201441

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    Cyclic-di-GMP sodium

    <p>c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.</p>
    Formula:C20H24N10NaO14P2
    Color and Shape:Solid
    Molecular weight:713.08464

    Ref: TM-T64248

  • EGR-1-IN-3
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    EGR-1-IN-3

    CAS:
    <p>EGR-1-IN-3 (Compound 36) is an inhibitor of early growth response 1 (EGR-1) binding to DNA. It effectively suppresses the binding of EGR-1 to DNA and the expression of inflammation-related genes (such as TSLP, IL-31, IL-6, and CCL2) induced by TNFα. This compound is applicable to the study of inflammatory diseases.</p>
    Formula:C31H31N3O6S
    Color and Shape:Solid
    Molecular weight:573.659

    Ref: TM-T204527

  • FAPI-74
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    FAPI-74

    CAS:
    <p>FAPI-74 is a PET (positron emission tomography) tracer involved in early FAPI-PET imaging.FAPI-74 can be used to study cancer tumors and degenerative diseases.</p>
    Formula:C36H49N9O8
    Color and Shape:Solid
    Molecular weight:735.83

    Ref: TM-T78667

  • Amilo-5MER
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    Amilo-5MER

    CAS:
    <p>Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.</p>
    Formula:C23H40N6O9S
    Color and Shape:Solid
    Molecular weight:576.664

    Ref: TM-TP3229

  • Ocadusertib
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    Ocadusertib

    CAS:
    <p>Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).</p>
    Formula:C25H25N5O4
    Color and Shape:Solid
    Molecular weight:459.50

    Ref: TM-T201183

  • AhR agonist 8
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    AhR agonist 8

    CAS:
    <p>Compound 9, also known as AhR agonist 8, effectively activates the Aryl Hydrocarbon Receptor (AhR) with an EC50 of 0.154 nM. This compound is utilized in researching psoriasis and atopic dermatitis.</p>
    Formula:C17H15FN4O
    Color and Shape:Solid
    Molecular weight:310.33

    Ref: TM-T89981

  • TNFα activity modulator 3
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    TNFα activity modulator 3

    CAS:
    <p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>
    Formula:C27H24F2N6O2
    Color and Shape:Solid
    Molecular weight:502.52

    Ref: TM-T89932

  • NLRP3-IN-44
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    NLRP3-IN-44

    CAS:
    <p>NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.</p>
    Formula:C25H30N4O3
    Color and Shape:Solid
    Molecular weight:434.53

    Ref: TM-T89953

  • GTCpFE
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    GTCpFE

    CAS:
    GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.
    Formula:C22H20O8
    Color and Shape:Solid
    Molecular weight:412.39

    Ref: TM-T200141

  • Panaxcerol B
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    Panaxcerol B

    CAS:
    <p>Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.</p>
    Formula:C27H46O9
    Color and Shape:Solid
    Molecular weight:514.65

    Ref: TM-T89969

  • SBI-0640726
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    SBI-0640726

    CAS:
    <p>SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.</p>
    Formula:C23H15ClN2O2
    Color and Shape:Solid
    Molecular weight:386.83

    Ref: TM-T89836

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    LD03-DEX

    CAS:
    LD03-DEX is a precursor compound of dexamethasone, characterized by its immunosuppressive activity.
    Formula:C44H65FO8
    Molecular weight:740.98

    Ref: TM-T201519

  • Indeno[1,2,3-cd]pyrene
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    Indeno[1,2,3-cd]pyrene

    CAS:
    <p>Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon, exhibits moderate cytotoxicity to human alveolar epithelial cells (HPAEpiC). Additionally, it enhances allergic pulmonary inflammation responses through the activation of the aryl hydrocarbon receptor.</p>
    Formula:C22H12
    Color and Shape:Solid
    Molecular weight:276.33

    Ref: TM-T201817

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    UM-3006

    CAS:
    UM-3006 is a potent TLR7/8 agonist that enhances immune responses by activating the TLR signaling pathway. This compound holds significant research and application potential in the fields of vaccine adjuvants and immune diseases.
    Formula:C20H34N6O2
    Molecular weight:390.52

    Ref: TM-T201866