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Immunology and Inflammation

Immunology and Inflammation

Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.

Subcategories of "Immunology and Inflammation"

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Found 3045 products of "Immunology and Inflammation"

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  • YM-I-26
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    YM-I-26

    CAS:
    <p>YM-I-26 is a selective inhibitor of the NLRP3 inflammasome. This compound enhances the phagocytic activity of β-amyloid in murine microglial BV2 cells and reduces the production of IL-1β and IL-10. YM-I-26 is useful for research into inflammation-related immunomodulatory activities.</p>
    Formula:C28H33ClN2O5S2
    Color and Shape:Solid
    Molecular weight:577.16

    Ref: TM-T200649

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    Heme Oxygenase-1-IN-2

    <p>Heme Oxygenase-1-IN-2 is a novel inhibitor of heme oxygenase-1 (HO-1), displaying potent antiproliferative activity in vitro, with an IC50 value of 0.95 μM.</p>
    Formula:C19H18ClN3O
    Color and Shape:Solid
    Molecular weight:339.82

    Ref: TM-T61078

  • CD73-IN-19
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    CD73-IN-19

    CAS:
    <p>CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.</p>
    Formula:C18H17N3O3S
    Color and Shape:Solid
    Molecular weight:355.411

    Ref: TM-T204632

  • NLRP3-IN-53
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    NLRP3-IN-53

    CAS:
    <p>NLRP3-IN-53 (compound 1) is an NLRP3 inhibitor with an IC50 of 3.4nM.</p>
    Formula:C22H27N5O4
    Color and Shape:Solid
    Molecular weight:425.48

    Ref: TM-T200482

  • NOD1-IN-1
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    NOD1-IN-1

    CAS:
    <p>NOD1/2-IN-1 (Compound 2) is a potent inhibitor of RIPK2 with an IC50 value of 0.65 nM as determined by the ADP-Glo assay. It selectively inhibits the NOD1 pathway, with an IC50 of 33 nM, effectively blocking the production of pro-inflammatory cytokines and thereby reducing inflammatory responses. This compound has potential applications in the research of colitis.</p>
    Formula:C16H14ClN3O3
    Color and Shape:Solid
    Molecular weight:331.75

    Ref: TM-T200671

  • ODN 2088
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    ODN 2088

    CAS:
    <p>ODN 2088 is a potent inhibitor of TLR3, TLR7 and TLR9 that is non-cytotoxic and shows inhibition of the release of IFN-α and IL-6.</p>
    Color and Shape:Solid

    Ref: TM-T64278

  • Corannulene
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    Corannulene

    CAS:
    <p>Corannulene is an agonist of the aromatic hydrocarbon receptor (AhR). It induces a lower cytotoxic response in liver cancer cells compared to Benzo[a]pyrene and shows potential for use in cancer research.</p>
    Formula:C20H10
    Color and Shape:Solid
    Molecular weight:250.293

    Ref: TM-T204413

  • MAY0132
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    MAY0132

    CAS:
    <p>MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.</p>
    Formula:C16H15ClF3N
    Color and Shape:Solid
    Molecular weight:313.745

    Ref: TM-T204630

  • 2-Guanidinobezimidazole
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    2-Guanidinobezimidazole

    CAS:
    <p>2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB).</p>
    Formula:C8H9N5
    Color and Shape:Solid
    Molecular weight:175.191

    Ref: TM-T206771

  • VS-15
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    VS-15

    CAS:
    <p>VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.</p>
    Formula:C29H27N5O3
    Color and Shape:Solid
    Molecular weight:493.56

    Ref: TM-T200480

  • (R)-Ketoprofen
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    (R)-Ketoprofen

    CAS:
    <p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>
    Formula:C16H14O3
    Color and Shape:Solid
    Molecular weight:254.28

    Ref: TM-T200162

  • BMY-25551
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    BMY-25551

    CAS:
    BMY-25551, a Mitomycin A analog, exhibits cytotoxicity 8 to 20 times greater than Mitomycin C against both murine and human tumor cell lines. It is applicable in research pertaining to cancer and hematological disorders.
    Formula:C17H21N3O7
    Color and Shape:Solid
    Molecular weight:379.36

    Ref: TM-T201024

  • α-Gracinoic acid
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    α-Gracinoic acid

    CAS:
    <p>α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.</p>
    Formula:C29H42O4
    Color and Shape:Solid
    Molecular weight:454.64

    Ref: TM-T200464

  • SLC7A11-IN-2
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    SLC7A11-IN-2

    CAS:
    <p>SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.</p>
    Formula:C19H24N4O3
    Color and Shape:Solid
    Molecular weight:356.42

    Ref: TM-T200659

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    AMS-17

    <p>AMS-17, a strong NLRP3 inhibitor, quells microglia activation and cytokines like caspase-1, TNF-α, IL-1β, iNOS in studies.</p>
    Formula:C15H13F3N4O3S
    Color and Shape:Solid
    Molecular weight:386.35

    Ref: TM-T61709

  • LHC-165
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    LHC-165

    CAS:
    <p>LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.</p>
    Formula:C29H32F2N3O7P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.55

    Ref: TM-T15751

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    COX-2-IN-8

    <p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>
    Formula:C19H19N3O4S2
    Color and Shape:Solid
    Molecular weight:417.5

    Ref: TM-T62175

  • SP11
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    SP11

    CAS:
    <p>SP11 is a mitochondrial reactive oxygen species (ROS) inhibitor. It activates Fis1 with an IC50 of 9.4 µM by binding to Cys41 and enhances the translocation of Drp1 to mitochondria. SP11 is utilized for research into oxidative stress damage.</p>
    Formula:C18H19ClN2OS
    Color and Shape:Solid
    Molecular weight:346.87

    Ref: TM-T207379

  • SP4206
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    SP4206

    CAS:
    <p>SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)</p>
    Formula:C30H37Cl2N7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:662.56

    Ref: TM-T12982

  • RGT-068A
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    RGT-068A

    CAS:
    <p>RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .</p>
    Formula:C17H16ClN9O2
    Color and Shape:Solid
    Molecular weight:413.82

    Ref: TM-T73389