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Immunology and Inflammation

Immunology and Inflammation

Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.

Subcategories of "Immunology and Inflammation"

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Found 3045 products of "Immunology and Inflammation"

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  • Hypoxystat
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    Hypoxystat

    CAS:
    <p>Hypoxystat increases the affinity of hemoglobin for oxygen, thereby reducing the release of oxygen to tissues and inducing tissue hypoxia. [Hypoxystat] can alleviate mitochondrial disorder Leigh syndrome in Ndufs4 gene knockout mouse models. Hypoxystat is orally active.</p>
    Formula:C21H21NO5
    Color and Shape:Solid
    Molecular weight:367.395

    Ref: TM-T205665

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    OP-5244 sodium

    <p>OP-5244 sodium: potent oral CD73 inhibitor (IC50: 0.25 nM), potential in cancer research by hindering adenosine, reversing immunosuppression.</p>
    Formula:C19H28ClN5NaO9P
    Color and Shape:Solid
    Molecular weight:559.87

    Ref: TM-T63956

  • Keap1-Nrf2-IN-5
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    Keap1-Nrf2-IN-5

    CAS:
    <p>Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).</p>
    Formula:C23H30N4O6S
    Color and Shape:Solid
    Molecular weight:490.57

    Ref: TM-T63294

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    COX-2/NO-IN-1

    <p>COX-2/NO-IN-1: oral iNOS &amp; NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.</p>
    Formula:C15H15NO3
    Color and Shape:Solid
    Molecular weight:257.28

    Ref: TM-T60403

  • Methoxyurea
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    Methoxyurea

    CAS:
    <p>Methoxyurea (Compound 3) is a potential modulator of nitric oxide (NO) donors, interacting with hemoglobin forms such as oxyhemoglobin (OxyHb) and methemoglobin (MetHb). It holds promise for use in research on sickle cell disease (SCD).</p>
    Formula:C2H6N2O2
    Color and Shape:Solid
    Molecular weight:90.081

    Ref: TM-T206073

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    CD73-IN-12

    <p>CD73-IN-12, a compound from CN114437038A, shows strong anti-tumor activity by effectively inhibiting CD73 enzyme.</p>
    Formula:C17H14F2N4O2
    Color and Shape:Solid
    Molecular weight:344.32

    Ref: TM-T61118

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    Anti-inflammatory agent 6

    <p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>
    Formula:C22H20O12
    Color and Shape:Solid
    Molecular weight:476.39

    Ref: TM-T63107

  • Ocadusertib
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    Ocadusertib

    CAS:
    <p>Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).</p>
    Formula:C25H25N5O4
    Color and Shape:Solid
    Molecular weight:459.50

    Ref: TM-T201183

  • HG-12-6
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    HG-12-6

    CAS:
    <p>HG-12-6 is a type II IRAK4 inhibitor, targeting its inactive form with an IC50 of 165 nM, and is used in autoimmunity and inflammation.</p>
    Formula:C29H27F3N6O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:580.62

    Ref: TM-T11559

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    COX-2-IN-9

    <p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>
    Formula:C25H23N5O4S2
    Color and Shape:Solid
    Molecular weight:521.61

    Ref: TM-T63646

  • Nrf2 activator-6
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    Nrf2 activator-6

    CAS:
    <p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>
    Formula:C31H37ClFN5O5
    Color and Shape:Solid
    Molecular weight:614.11

    Ref: TM-T72697

  • STING-IN-11
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    STING-IN-11

    CAS:
    <p>STING-IN-11 (Compound 42) is an orally active STING inhibitor with an IC50 of 37.8 nM. It impedes palmitoylation of the STING protein and the downstream signaling of STING, thereby inhibiting STING-mediated inflammation. STING-IN-11 demonstrates good in vivo safety and can be utilized for research on STING-related inflammatory and autoimmune diseases.</p>
    Formula:C21H20ClF2N3O
    Color and Shape:Solid
    Molecular weight:403.853

    Ref: TM-T205702

  • AIM4
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    AIM4

    CAS:
    <p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>
    Formula:C25H23Br2N5O4
    Color and Shape:Solid
    Molecular weight:617.289

    Ref: TM-T206489

  • SARM1-IN-4
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    SARM1-IN-4

    CAS:
    <p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>
    Formula:C13H17F2N3O2
    Color and Shape:Solid
    Molecular weight:285.29

    Ref: TM-T206825

  • (S)-MALT1-IN-5
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    (S)-MALT1-IN-5

    CAS:
    <p>(S)-MALT1-IN-5: Potent MALT1 protease inhibitor, may help in abnormal T/B-cell signalling and MALT1-linked diseases.</p>
    Formula:C17H17ClF2N6O3
    Color and Shape:Solid
    Molecular weight:426.80

    Ref: TM-T62322

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    COX-2/PI3K-IN-1

    <p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>
    Formula:C19H14ClN5S2
    Color and Shape:Solid
    Molecular weight:411.93

    Ref: TM-T62103

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    Antioxidant agent-3

    <p>Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.</p>
    Formula:C18H14O8
    Color and Shape:Solid
    Molecular weight:358.3

    Ref: TM-T61312

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    NLRP3-IN-7

    <p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>
    Formula:C18H15ClN2O4S3
    Color and Shape:Solid
    Molecular weight:454.97

    Ref: TM-T62809

  • MG-T-19
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    MG-T-19

    CAS:
    <p>MG-T-19, a TIM-3 inhibitor, inhibit the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs.</p>
    Formula:C18H8Br2ClF3N4O2S
    Purity:99.14%
    Color and Shape:Solid
    Molecular weight:596.6

    Ref: TM-T201721

  • IRAK4-IN-30
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    IRAK4-IN-30

    CAS:
    <p>IRAK4-IN-30 (Compound I) is an inhibitor of IRAK4, with an IC50 of 0.6 nM.</p>
    Formula:C27H33N5O5
    Color and Shape:Solid
    Molecular weight:507.581

    Ref: TM-T205748