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Immunology and Inflammation

Immunology and Inflammation

Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.

Subcategories of "Immunology and Inflammation"

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Found 3035 products of "Immunology and Inflammation"

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  • Anti-inflammatory agent 102
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    Anti-inflammatory agent 102

    CAS:
    <p>Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).</p>
    Formula:C16H16ClN3O3
    Color and Shape:Solid
    Molecular weight:333.77

    Ref: TM-T207168

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    NLRP3-IN-7

    <p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>
    Formula:C18H15ClN2O4S3
    Color and Shape:Solid
    Molecular weight:454.97

    Ref: TM-T62809

  • cGAS-IN-4
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    cGAS-IN-4

    CAS:
    <p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>
    Formula:C19H18Cl2N4O3
    Color and Shape:Solid
    Molecular weight:421.277

    Ref: TM-T204612

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    Cyclic-di-GMP sodium

    <p>c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.</p>
    Formula:C20H24N10NaO14P2
    Color and Shape:Solid
    Molecular weight:713.08464

    Ref: TM-T64248

  • MALT1-IN-5
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    MALT1-IN-5

    CAS:
    <p>MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.</p>
    Formula:C17H17ClF2N6O3
    Color and Shape:Solid
    Molecular weight:426.80

    Ref: TM-T62323

  • A-9758
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    A-9758

    CAS:
    <p>A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.</p>
    Formula:C25H23Cl2F3N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:527.36

    Ref: TM-T10210

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    ABZI

    CAS:
    <p>(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.</p>
    Formula:C23H24N6O3
    Molecular weight:432.48

    Ref: TM-T207188

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    IRAK4-IN-12

    <p>IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).</p>
    Formula:C24H31FN8O
    Color and Shape:Solid
    Molecular weight:466.55

    Ref: TM-T62989

  • IRAK4-IN-15
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    IRAK4-IN-15

    CAS:
    <p>IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.</p>
    Formula:C25H29FN10
    Color and Shape:Solid
    Molecular weight:488.56

    Ref: TM-T63262

  • Nrf2-ARE/hMAO-B/QR2 modulator 1
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    Nrf2-ARE/hMAO-B/QR2 modulator 1

    CAS:
    <p>Nrf2-ARE/hMAO-B/QR2 modulator 1 a resveratrol derivative activated the NRF2-ARE inhibit hMAO-B and QR2, promote hippocampal neurogenesis Alzheimer's disease .</p>
    Formula:C14H12N2O3
    Purity:98.5%
    Color and Shape:Solid
    Molecular weight:256.26

    Ref: TM-T60395

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    COX-2-IN-10

    <p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>
    Formula:C31H32FN5O2S
    Color and Shape:Solid
    Molecular weight:557.68

    Ref: TM-T63943

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    COX-1/2-IN-2

    <p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM &amp; COX-2 at 4.6μM.</p>
    Formula:C15H10ClIN2O
    Color and Shape:Solid
    Molecular weight:396.61

    Ref: TM-T61865

  • FAPI-74
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    FAPI-74

    CAS:
    <p>FAPI-74 is a PET (positron emission tomography) tracer involved in early FAPI-PET imaging.FAPI-74 can be used to study cancer tumors and degenerative diseases.</p>
    Formula:C36H49N9O8
    Color and Shape:Solid
    Molecular weight:735.83

    Ref: TM-T78667

  • Creatine ethyl ester
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    Creatine ethyl ester

    CAS:
    <p>Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.</p>
    Formula:C6H13N3O2
    Color and Shape:Solid
    Molecular weight:159.186

    Ref: TM-T206807

  • EGR-1-IN-3
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    EGR-1-IN-3

    CAS:
    <p>EGR-1-IN-3 (Compound 36) is an inhibitor of early growth response 1 (EGR-1) binding to DNA. It effectively suppresses the binding of EGR-1 to DNA and the expression of inflammation-related genes (such as TSLP, IL-31, IL-6, and CCL2) induced by TNFα. This compound is applicable to the study of inflammatory diseases.</p>
    Formula:C31H31N3O6S
    Color and Shape:Solid
    Molecular weight:573.659

    Ref: TM-T204527

  • Gardiquimod hydrochloride
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    Gardiquimod hydrochloride

    CAS:
    <p>Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.</p>
    Formula:C17H24ClN5O
    Color and Shape:Solid
    Molecular weight:349.858

    Ref: TM-T204751

  • MSA-2 dimer
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    MSA-2 dimer

    CAS:
    <p>MSA-2 dimer: selective oral non-nucleotide STING agonist, Kd=145 μM, long-term antitumor effect, non-covalent, higher permeability.</p>
    Formula:C29H28O8S2
    Color and Shape:Solid
    Molecular weight:568.66

    Ref: TM-T36996

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    Anti-inflammatory agent 9

    <p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects &amp; is orally bioavailable.</p>
    Formula:C18H15N5O2S
    Color and Shape:Solid
    Molecular weight:365.41

    Ref: TM-T61400

  • WK692
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    WK692

    CAS:
    <p>Compound WK692 (compund WK692) is a BCL6 inhibitor that effectively suppresses the growth of diffuse large B-cell lymphoma cells without toxic side effects and acts synergistically with inhibitors of EZH2 and PRMT5.</p>
    Formula:C26H28Br2N8O5
    Color and Shape:Solid
    Molecular weight:692.36

    Ref: TM-T201068

  • AMC-04
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    AMC-04

    CAS:
    <p>AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].</p>
    Formula:C26H28N2O3
    Color and Shape:Solid
    Molecular weight:416.51

    Ref: TM-T85643