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Immunology and Inflammation

Immunology and Inflammation

Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.

Subcategories of "Immunology and Inflammation"

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Found 3035 products of "Immunology and Inflammation"

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  • CPDT
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    CPDT

    CAS:
    <p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>
    Formula:C6H6S3
    Color and Shape:Solid
    Molecular weight:174.307

    Ref: TM-T204763

  • IACS-8779 disodium
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    IACS-8779 disodium

    CAS:
    <p>IACS-8779 disodium: potent STING agonist, strong systemic anti-tumor effects, effective in melanoma model.</p>
    Formula:C21H23N9Na2O10P2S2
    Color and Shape:Solid
    Molecular weight:733.52

    Ref: TM-T72516

  • mPGES1-IN-5
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    mPGES1-IN-5

    CAS:
    <p>mPGES1-IN-5 (compound 18) is a multi-substituted pyrimidine compound that acts as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and demonstrates significant inhibitory activity in vivo against acute inflammation models.</p>
    Formula:C27H27N3O
    Color and Shape:Solid
    Molecular weight:409.52

    Ref: TM-T200592

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    NLRP3-IN-6

    <p>NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.</p>
    Formula:C18H15ClN2O4S3
    Color and Shape:Solid
    Molecular weight:454.97

    Ref: TM-T62808

  • RIPK1-IN-19
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    RIPK1-IN-19

    CAS:
    <p>RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.</p>
    Formula:C28H25FN6O2
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:496.54

    Ref: TM-T87334

  • NLRP3-IN-8
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    NLRP3-IN-8

    CAS:
    <p>NLRP3-IN-8, orally active inflammasome blocker, IC50 of 1.23μM, stable (t1/2 = 138.63min), non-toxic (IC50 &gt;100μM).</p>
    Formula:C23H20N2O6
    Color and Shape:Solid
    Molecular weight:420.41

    Ref: TM-T62221

  • IRAK1/4/pan-FLT3 Kinase-IN-2
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    IRAK1/4/pan-FLT3 Kinase-IN-2

    CAS:
    <p>IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and &lt; 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.</p>
    Formula:C20H22F3N5O
    Color and Shape:Solid
    Molecular weight:405.42

    Ref: TM-T207286

  • IRAK4-IN-31
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    IRAK4-IN-31

    CAS:
    <p>IRAK4-IN-31 is a crystalline inhibitor of IRAK4. It is applicable in research related to myelodysplastic syndromes (MDS).</p>
    Formula:C27H33N5O5
    Color and Shape:Solid
    Molecular weight:507.58

    Ref: TM-T207192

  • DEG-35
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    DEG-35

    CAS:
    <p>DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).</p>
    Formula:C25H21N3O5
    Color and Shape:Solid
    Molecular weight:443.45

    Ref: TM-T207249

  • AM679
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    AM679

    CAS:
    <p>AM679: potent, selective FLAP inhibitor; IC50s—2.2 nM (FLAP), 0.6 nM (hLA), 154 nM (hWB); blocks leukotrienes in vivo; no significant CYP3A4 interaction.</p>
    Formula:C40H44N4O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:692.87

    Ref: TM-T14205

  • IKZF2-degrader 1
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    IKZF2-degrader 1

    CAS:
    <p>IKZF2-degrader 1 (Compound 31) is a molecular glue-type degrader of IKZF2 with a DC50 of 0.5 nM. It exhibits relatively low degradation activity against CK1α, with a DC50 of 210 nM. This compound is applicable in research focused on IKZF2-dependent cancers.</p>
    Formula:C27H30FN7O3
    Color and Shape:Solid
    Molecular weight:519.57

    Ref: TM-T207476

  • CD73-IN-19
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    CD73-IN-19

    CAS:
    <p>CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.</p>
    Formula:C18H17N3O3S
    Color and Shape:Solid
    Molecular weight:355.411

    Ref: TM-T204632

  • AhR agonist 8
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    AhR agonist 8

    CAS:
    <p>Compound 9, also known as AhR agonist 8, effectively activates the Aryl Hydrocarbon Receptor (AhR) with an EC50 of 0.154 nM. This compound is utilized in researching psoriasis and atopic dermatitis.</p>
    Formula:C17H15FN4O
    Color and Shape:Solid
    Molecular weight:310.33

    Ref: TM-T89981

  • TNFα activity modulator 3
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    TNFα activity modulator 3

    CAS:
    <p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>
    Formula:C27H24F2N6O2
    Color and Shape:Solid
    Molecular weight:502.52

    Ref: TM-T89932

  • NLRP3-IN-44
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    NLRP3-IN-44

    CAS:
    <p>NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.</p>
    Formula:C25H30N4O3
    Color and Shape:Solid
    Molecular weight:434.53

    Ref: TM-T89953

  • GTCpFE
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    GTCpFE

    CAS:
    <p>GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.</p>
    Formula:C22H20O8
    Color and Shape:Solid
    Molecular weight:412.39

    Ref: TM-T200141

  • TBK1/IKKε-IN-1
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    TBK1/IKKε-IN-1

    CAS:
    <p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of &lt;100 nM).</p>
    Formula:C28H26N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.53

    Ref: TM-T13097

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    COX-2-IN-29

    <p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>
    Formula:C22H23FN2O6S2
    Color and Shape:Solid
    Molecular weight:494.56

    Ref: TM-T63336

  • Panaxcerol B
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    Panaxcerol B

    CAS:
    <p>Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.</p>
    Formula:C27H46O9
    Color and Shape:Solid
    Molecular weight:514.65

    Ref: TM-T89969

  • IL-17 modulator 1 disodium
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    IL-17 modulator 1 disodium

    CAS:
    <p>Potent, orally active IL-17 Modulator 1 (disodium) from patent WO 2020127685, used in psoriasis and arthritis research.</p>
    Formula:C28H37N6NaO6P
    Color and Shape:Solid
    Molecular weight:607.604

    Ref: TM-T36525