Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(140 products)
- CXCR(153 products)
- Cell wall(5 products)
- IL Receptor(109 products)
- IκB/IKK(59 products)
- LTR(3 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(446 products)
- NOD(17 products)
- NOS(62 products)
- Nrf2(82 products)
- PGE Synthase(31 products)
- ROS(70 products)
- TGF-beta/Smad(59 products)
- TLR(76 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
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Found 3304 products of "Immunology and Inflammation"
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BAA473
BAA473, a bile acid analog, activates the pyrin inflammasome, triggering IL-18 secretion in myeloid and intestinal cells.Formula:C36H62O5Purity:98%Color and Shape:SolidMolecular weight:574.87Anti-inflammatory agent 102
CAS:Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).Formula:C16H16ClN3O3Color and Shape:SolidMolecular weight:333.77Fexlamose
CAS:Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).Formula:C12H22O9S2Color and Shape:SolidMolecular weight:374.428Cryptopleurine
CAS:Cryptopleurine is an inhibitor of gene products associated with cell proliferation, survival, invasion and angiogenesis. It acts by targeting the NF-κB pathway.Formula:C24H27NO3Purity:98%Color and Shape:SolidMolecular weight:377.48IRAK4-IN-31
CAS:IRAK4-IN-31 is a crystalline inhibitor of IRAK4. It is applicable in research related to myelodysplastic syndromes (MDS).Formula:C27H33N5O5Color and Shape:SolidMolecular weight:507.58IACS-8779
CAS:<p>IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.</p>Formula:C21H25N9O10P2S2Purity:98%Color and Shape:SolidMolecular weight:689.55IL-17 modulator 1 disodium
CAS:Potent, orally active IL-17 Modulator 1 (disodium) from patent WO 2020127685, used in psoriasis and arthritis research.Formula:C28H37N6NaO6PColor and Shape:SolidMolecular weight:607.604NLRP3-IN-4
NLRP3-IN-4 is an effective, oral NLRP3 inflammasome inhibitor with potent anti-inflammatory effects on colitis.Formula:C22H22N2O5Color and Shape:SolidMolecular weight:394.42S-MTC acetate
CAS:S-MTC acetate (S-Methyl-L-thiocitrulline acetate) serves as a potent inhibitor of inducible nitric oxide synthases and is especially effective in inhibiting the constitutive (neuronal) type rather than the inducible (endothelial) type.Formula:C9H19N3O4SColor and Shape:SolidMolecular weight:265.33K-14585
CAS:<p>K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.</p>Formula:C51H56Cl2N8O4Color and Shape:SolidMolecular weight:915.95mPGES1-IN-4
CAS:<p>mPGES1-IN-4 (compound 32) is a multi-substituted pyrimidine compound acting as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and significantly suppresses acute inflammation models in vivo.</p>Formula:C27H25F2N3OColor and Shape:SolidMolecular weight:445.50NLRP3-IN-53
CAS:<p>NLRP3-IN-53 (compound 1) is an NLRP3 inhibitor with an IC50 of 3.4nM.</p>Formula:C22H27N5O4Color and Shape:SolidMolecular weight:425.48VS-15
CAS:<p>VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.</p>Formula:C29H27N5O3Color and Shape:SolidMolecular weight:493.56CD73-IN-13
CD73-IN-13, a potent CD73 inhibitor, may be developed for tumor-related disease treatment.Formula:C13H11F3N4O2Color and Shape:SolidMolecular weight:312.25HG-12-6
CAS:HG-12-6 is a type II IRAK4 inhibitor, targeting its inactive form with an IC50 of 165 nM, and is used in autoimmunity and inflammation.Formula:C29H27F3N6O2SPurity:98%Color and Shape:SolidMolecular weight:580.62COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Formula:C22H23FN2O6S2Color and Shape:SolidMolecular weight:494.56IRAK4-IN-14
CAS:IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.Formula:C25H28FN9OColor and Shape:SolidMolecular weight:489.55NLRP3-IN-57
<p>NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.</p>Formula:C44H60O7Color and Shape:SolidMolecular weight:700.94NLRP3-IN-78
CAS:NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.Formula:C12H5Cl2N3O4S2Color and Shape:SolidMolecular weight:390.222(R)-Ketoprofen
CAS:<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Formula:C16H14O3Color and Shape:SolidMolecular weight:254.28ROS inducer 9
CAS:<p>ROS inducer 9 (compound 4e) is an antibacterial agent with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against Escherichia coli. It eradicates bacteria by inhibiting GSH activity and increasing ROS levels. Additionally, ROS inducer 9 exhibits low toxicity toward red blood cells and RAW 264.7 cells.</p>Formula:C26H26BrF4N3O3Color and Shape:SolidMolecular weight:584.401CVN293
CAS:CVN293 is a inhibitor of the potassium channel KCNK13,BBB,It inhibits the production of the pro-inflammatory cytokine IL-1β induced by NLRP3 in microgliaFormula:C14H10FN7OPurity:99.50%Color and Shape:SolidMolecular weight:311.27Heme Oxygenase-1-IN-2
Heme Oxygenase-1-IN-2 is a novel inhibitor of heme oxygenase-1 (HO-1), displaying potent antiproliferative activity in vitro, with an IC50 value of 0.95 μM.Formula:C19H18ClN3OColor and Shape:SolidMolecular weight:339.82α-Gracinoic acid
CAS:<p>α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.</p>Formula:C29H42O4Color and Shape:SolidMolecular weight:454.64ODN 21158
CAS:<p>ODN 21158 is a potent, non-cytotoxic inhibitor of G-modified TLR3 and TLR9. ODN 21158 dose-dependently inhibits IFN-α secretion.</p>Color and Shape:SolidFactor B-IN-4
CAS:Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.Formula:C27H32N2O4Color and Shape:SolidMolecular weight:448.55STING-IN-11
CAS:STING-IN-11 is a potent, orally bioavailable STING inhibitor (IC₅₀ = 37.8 nM) that blocks STING protein palmitoylation and downstream signaling.Formula:C21H20ClF2N3OPurity:99.84%Color and Shape:SolidMolecular weight:403.85MAO-B-IN-7
MAO-B-IN-7 inhibits MAO-B/AChE, crossing the blood-brain barrier; IC50: 41/87 nM (h/eel AChE), 0.3 μM (MAO-B). Reduces oxidative stress and neuroinflammation.Formula:C25H31NO4Color and Shape:SolidMolecular weight:409.52FAPI-74
CAS:<p>FAPI-74 is a PET (positron emission tomography) tracer involved in early FAPI-PET imaging.FAPI-74 can be used to study cancer tumors and degenerative diseases.</p>Formula:C36H49N9O8Color and Shape:SolidMolecular weight:735.83NLRP3/AIM2-IN-1
<p>NLRP3/AIM2-IN-1 is an inhibitor of thermal sepsis (IC50 = 3.136 ± 0.7667 μM).</p>Formula:C15H16BNO4Color and Shape:SolidMolecular weight:285.1Anti-inflammatory agent 13
Pentacyclic triterpene, Anti-inflammatory 13 inhibits DAMP/PAMP inflammation models.Formula:C30H48O4Color and Shape:SolidMolecular weight:472.7COX-1/2-IN-2
COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.Formula:C15H10ClIN2OColor and Shape:SolidMolecular weight:396.61GB1490
CAS:GB1490 is an orally administered galectin inhibitor, demonstrating Kd values of 0.4 μM for galectin-1 and 2.7 μM for galectin-3 [1].Formula:C17H15Cl2FN4O4S2Color and Shape:SolidMolecular weight:493.36BIO-8169
CAS:BIO-8169, a selective interleukin receptor-associated kinase 4 (IRAK 4) inhibitor, demonstrates potent activity with an IC 50 value of 0.23 nM. Exhibiting strong pharmacokinetic properties, BIO-8169 effectively reduces pro-inflammatory cytokine production and mitigates autoimmune encephalomyelitis in the EAE mouse model. Additionally, it has notable blood-brain penetration, evidenced by a rat Kpu,u of 0.7.Formula:C24H27N5O4Color and Shape:SolidMolecular weight:449.50cGAS-IN-2
CAS:cGAS-IN-2 (compound 109) serves as a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), exhibiting an IC50 of 0.01512 μM against h-cGAS [1].Formula:C16H18Cl2N2O2Color and Shape:SolidMolecular weight:341.23MALT1-IN-11
CAS:<p>MALT1-IN-11: MALT1 inhibitor, IC50 <10-100 nM, reduces IL10, for cancer/autoimmune research.</p>Formula:C20H16F4N8OColor and Shape:SolidMolecular weight:460.39Polvitolimod
CAS:Polvitolimod is a TLR7 agonist used to treat infectious disease and cancer.Formula:C13H14FN5O4Color and Shape:SolidMolecular weight:323.28Galectin-3-IN-6
CAS:<p>Galectin-3-IN-6 (Compound 12) is an orally active galectin-3 (Gal-3) inhibitor, with an IC50 of 12 nM and a Kd of 13 nM for Gal-3. In a CCl4-induced mouse model of acute liver injury and fibrosis, Galectin-3-IN-6 significantly reduces fibrosis markers collagen-1 and α-smooth muscle actin (αSMA) by 64% and 71%, respectively, demonstrating notable anti-fibrotic activity. Galectin-3-IN-6 is applicable for research in fibrosis-related diseases, cancer, and cardiovascular disorders.</p>Formula:C28H29Cl2F3N4O6Color and Shape:SolidMolecular weight:645.454NLRP3-IN-29
CAS:<p>NLRP3-IN-29 (Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) with potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. It can be used for research on Alzheimer's disease [1].</p>Formula:C21H22N2O3SColor and Shape:SolidMolecular weight:382.48SDH-IN-25
CAS:<p>SDH-IN-25 is an SDH inhibitor with an IC50 of 4.82 mg/L, demonstrating broad-spectrum and potent antifungal activity. By binding to SDH amino acid residues (TRP173, TYR58, and ARG43), it mimics the action mode of the commercial fungicide flutolanil. SDH-IN-25 induces changes in hyphal morphology, disrupts respiratory metabolism by binding to complex II, generates reactive oxygen species (ROS), and affects mitochondrial membrane potential (MMP) in hyphae. This compound is utilized in agricultural disease control research.</p>Formula:C19H15BrCl2N2O4Color and Shape:SolidMolecular weight:486.143VISTA-IN-3
CAS:<p>VISTA-IN-3 (Compound A4), a potent small molecule inhibitor of VISTA, exhibits a dissociation constant (K D) of 0.49 μM. This compound effectively induces the release of IFN-γ cytokines and demonstrates synergistic enhancement of anti-cancer activity when combined with PD-L1 antibody [1].</p>Formula:C14H18N4O3Color and Shape:SolidMolecular weight:290.32IKZF1-degrader-1
CAS:IKZF1-degrader-1 (Compound 9-B) serves as a potent degrader of the IKZF1 protein, exhibiting a DC50 of 0.134 nM. It is applicable in the degradation of tumors [1].Formula:C35H29F2N5O3Color and Shape:SolidMolecular weight:605.63NOS-IN-2
NOS-IN-2: potent, selective imidamide NOS inhibitor, IC50=20μM for iNOS, spares eNOS, low toxicity, useful in inflammation research.Formula:C18H20F3N3O2Color and Shape:SolidMolecular weight:367.37Galectin-3-IN-4
CAS:Galectin-3-IN-4 (compound 5), a carboxamide analog, effectively and selectively inhibits both human and mouse galectin-3. This compound demonstrates notable potency with IC50 values of 21 nM for hGal-3 and 167 nM for mGal-3. It is also orally bioavailable. For other galectins, Galectin-3-IN-4 shows IC50 values of 1580 nM for hGal-1 and 2750 nM for hGal-9, respectively [1].Formula:C24H22ClF2N5O5SColor and Shape:SolidMolecular weight:565.98IRAK4-IN-9
CAS:IRAK4-IN-9 is a potent IRAK4 inhibitor with an IC50 of 1.5 nM, promising for inflammatory, autoimmune diseases, and cancer research.Formula:C22H25N7Color and Shape:SolidMolecular weight:387.48STING agonist-7
<p>STING agonist-7 is an agonist of non-nucleotide STING that binds selectively to mouse STING but not human STING [1].</p>Formula:C17H12N4O4Color and Shape:SolidMolecular weight:336.3RGT-068A
CAS:RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .Formula:C17H16ClN9O2Color and Shape:SolidMolecular weight:413.82Ac5GalNTGc
CAS:Ac5GalNTGc, an analog of hexosamine, inhibits mucin-type O-linked glycosylation biosynthesis [1].Formula:C18H25NO11SColor and Shape:SolidMolecular weight:463.46NP3-146 sodium
CAS:NP3-146 sodium is an inhibitor of the NLRP3 inflammasome.Formula:C20H26ClN2NaO5SColor and Shape:SolidMolecular weight:464.94MMG-11 quarterhydrate
<p>MMG-11 quarterhydrate, a potent hTLR2 antagonist, inhibits TLR2/1 and TLR2/6 with IC50s of 1.7μM and 5.7μM; low toxicity.</p>Formula:C15H16O8Color and Shape:SolidMolecular weight:310.78
