Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(140 products)
- CXCR(153 products)
- Cell wall(5 products)
- IL Receptor(109 products)
- IκB/IKK(59 products)
- LTR(3 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(446 products)
- NOD(17 products)
- NOS(62 products)
- Nrf2(82 products)
- PGE Synthase(31 products)
- ROS(70 products)
- TGF-beta/Smad(59 products)
- TLR(76 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
Show 11 more subcategories
Found 3304 products of "Immunology and Inflammation"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
NLRP3-IN-58
CAS:NLRP3-IN-58 (Compound DS15) acts as an inhibitor of NLRP3 inflammasome activation, with an IC50 value of 3.85 μM, and is capable of inhibiting 33% of IL-1β release at a concentration of 10 μM.Formula:C22H18ClN3O3SColor and Shape:SolidMolecular weight:439.92Ocadusertib
CAS:Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).Formula:C25H25N5O4Color and Shape:SolidMolecular weight:459.50NLRP3-IN-56
CAS:NLRP3-IN-56 (compound 062) is an inhibitor of NLRP3. It effectively suppresses the secretion of IL-1β in THP-1 cells, demonstrating an IC50 of 9.7 nM. NLRP3-IN-56 is useful for research into NLRP3-mediated symptoms and/or diseases.Formula:C20H18ClN3O3Color and Shape:SolidMolecular weight:383.83oxLig-1
CAS:OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).Formula:C36H58O5Color and Shape:SolidMolecular weight:570.84IRAK4-IN-12
IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).Formula:C24H31FN8OColor and Shape:SolidMolecular weight:466.55(Rel)-Factor B-IN-5
CAS:(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.Formula:C27H32N2O4Purity:>99.99%Color and Shape:SolidMolecular weight:448.55C-di-IMP
CAS:Cyclic-di-IMP (C-di-IMP), a STING agonist, serves as a research tool in tumor studies.Formula:C20H22N8O14P2Color and Shape:SolidMolecular weight:660.38SP4206
CAS:SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)Formula:C30H37Cl2N7O6Purity:98%Color and Shape:SolidMolecular weight:662.56LHC-165
CAS:LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.Formula:C29H32F2N3O7PPurity:98%Color and Shape:SolidMolecular weight:603.55Keap1-Nrf2-IN-5
CAS:Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Formula:C23H30N4O6SColor and Shape:SolidMolecular weight:490.57AhR agonist 7
CAS:Compound 8, an AhR agonist 7, demonstrates potent activation of AhR with an EC50 of 13nM [1].Formula:C16H15ClFNO2Color and Shape:SolidMolecular weight:307.75ALR-6
CAS:<p>ALR-6, an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP, possesses anti-inflammatory properties. It significantly inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without substantially affecting direct inhibition of 5-LOX [1].</p>Formula:C18H14O5Color and Shape:SolidMolecular weight:310.3Balsalazide disodium
CAS:<p>Balsalazide disodium is an aminosalicylate prodrug that releases mesalamine in the colon, providing diverse anti-inflammatory effects in regions affected by colitis. Additionally, it exhibits anticancer properties by modulating the IL-6/STAT3 pathway.</p>Formula:C17H13N3Na2O6Color and Shape:SolidMolecular weight:401.281Galectin-3-IN-3
CAS:Galectin-3-IN-3 (Compound 4) serves as a selective and orally active inhibitor targeting Gal-3. It exhibits IC50 values of 11 nM for mGal-3 and 84 nM for hGal-3 [1].Formula:C25H22ClF2N7O4SColor and Shape:SolidMolecular weight:590.00NLRP3-IN-80
CAS:<p>NLRP3-IN-80 (Compound 1) is an NLRP3 inhibitor useful for research into inflammatory aging.</p>Formula:C24H22F2N4O3Color and Shape:SolidMolecular weight:452.45IRAK4-IN-19
IRAK4-IN-19, an IRAK4 inhibitor (IC50: 4.3 nM), hampers IL23 synthesis and arthritis progression.Formula:C25H26F2N8OColor and Shape:SolidMolecular weight:492.52STING agonist-21
CAS:STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].Formula:C17H11F6N5O2Color and Shape:SolidMolecular weight:431.29Cyclic-di-GMP sodium
c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.Formula:C20H24N10NaO14P2Color and Shape:SolidMolecular weight:713.08464IKZF2-degrader 1
CAS:IKZF2-degrader 1 (Compound 31) is a molecular glue-type degrader of IKZF2 with a DC50 of 0.5 nM. It exhibits relatively low degradation activity against CK1α, with a DC50 of 210 nM. This compound is applicable in research focused on IKZF2-dependent cancers.Formula:C27H30FN7O3Color and Shape:SolidMolecular weight:519.57STING-IN-15
CAS:STING-IN-15 (compound 66) is a potent STING inhibitor, effectively suppressing human and mouse STING with IC50 values of 116 nM and 96.3 nM, respectively. In the REX1 D18N mouse model, STING-IN-15 significantly reduces tissue damage and inflammation.Formula:C20H14F2N4O3Color and Shape:SolidMolecular weight:396.35ALR-27
CAS:<p>ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].</p>Formula:C19H22O3Color and Shape:SolidMolecular weight:298.38Anti-inflammatory agent 12
Pentacyclic triterpene, anti-inflammatory agent 12, inhibits LPS inflammation (IC50: 2.22 μM). May benefit inflammatory disease studies.Formula:C30H50O4Color and Shape:SolidMolecular weight:474.72Hypoxystat
CAS:<p>Hypoxystat increases the affinity of hemoglobin for oxygen, thereby reducing the release of oxygen to tissues and inducing tissue hypoxia. [Hypoxystat] can alleviate mitochondrial disorder Leigh syndrome in Ndufs4 gene knockout mouse models. Hypoxystat is orally active.</p>Formula:C21H21NO5Color and Shape:SolidMolecular weight:367.395KBD4466
CAS:KBD4466 is a potent oral inhibitor of TLR7 and TLR8, with IC50 values of 0.9 nM and 2.8 nM, respectively. This compound effectively suppresses the inflammatory cytokines IL-6 and IFN-α. KBD4466 has shown to improve disease progression and increase survival rates in the BXSB/MpJ mouse model of systemic lupus erythematosus (SLE). It is suitable for research into autoimmune diseases.Formula:C24H23F3N6OColor and Shape:SolidMolecular weight:468.47PSMA-IN-4
CAS:PSMA-IN-4 (compound 9) functions as a potent PSMA inhibitor, exhibiting an IC 50 value of 1.2 μM [1].Formula:C5H10N2O6SMolecular weight:226.21MIF2-IN-1
MIF2-IN-1, potent inhibitor of MIF2 (IC50: 1μM), halts non-small cell lung cancer growth via MAPK pathway.Formula:C26H19F3N2O2SColor and Shape:SolidMolecular weight:480.5Nrf2-ARE/hMAO-B/QR2 modulator 1
CAS:Nrf2-ARE/hMAO-B/QR2 modulator 1 a resveratrol derivative activated the NRF2-ARE inhibit hMAO-B and QR2, promote hippocampal neurogenesis Alzheimer's disease .Formula:C14H12N2O3Purity:98.5%Color and Shape:SolidMolecular weight:256.26LD03-DEX
CAS:LD03-DEX is a precursor compound of dexamethasone, characterized by its immunosuppressive activity.Formula:C44H65FO8Molecular weight:740.98Factor B-IN-3
CAS:Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.Formula:C24H29N3O4Color and Shape:SolidMolecular weight:423.5cGAS-IN-4
CAS:<p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>Formula:C19H18Cl2N4O3Color and Shape:SolidMolecular weight:421.277NOTA-FAPI
CAS:<p>NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.</p>Formula:C36H47F2N9O8Purity:99.748%Color and Shape:SolidMolecular weight:771.81NDT-30805
NDT-30805, a triazolopyridine, blocks IL-1β in PBMC (IC50: 0.013μM) & NLRP3 inflammasome, for inflammation research.Formula:C23H22N6SColor and Shape:SolidMolecular weight:414.53Anti-inflammatory agent 9
Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.Formula:C18H15N5O2SColor and Shape:SolidMolecular weight:365.41TE-11
CAS:TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.Formula:C16H13NOColor and Shape:SolidMolecular weight:235.28UM-3006
CAS:UM-3006 is a potent TLR7/8 agonist that enhances immune responses by activating the TLR signaling pathway. This compound holds significant research and application potential in the fields of vaccine adjuvants and immune diseases.Formula:C20H34N6O2Molecular weight:390.52MSA-2 dimer
CAS:MSA-2 dimer: selective oral non-nucleotide STING agonist, Kd=145 μM, long-term antitumor effect, non-covalent, higher permeability.Formula:C29H28O8S2Color and Shape:SolidMolecular weight:568.66PZ-3022
CAS:PZ-3022 is an orally active, conformational PanK activator that counteracts C3-CoA inhibition. In a mouse model of propionic acidemia, it elevates hepatic CoASH and C2-CoA levels while reducing C3-CoA, making it useful for studying mitochondrial defects in propionic acidemia.Formula:C20H21N5OColor and Shape:SolidMolecular weight:347.41hDDAH-1-IN-2 sulfate
hDDAH-1-IN-2: selective oral hDDAH-1 inhibitor with low cell toxicity.Formula:C8H24N4O10S2Color and Shape:SolidMolecular weight:400.43Gardiquimod hydrochloride
CAS:Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.Formula:C17H24ClN5OColor and Shape:SolidMolecular weight:349.858SB24011
CAS:SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].Formula:C34H38N4O7Color and Shape:SolidMolecular weight:614.69IKZF1-degrader-2
CAS:IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].Formula:C33H30FN5O5Color and Shape:SolidMolecular weight:595.62IRAK4 modulator-1
CAS:IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].Formula:C19H13ClN4O2Color and Shape:SolidMolecular weight:364.79AM679
CAS:AM679 is a potent, selective FLAP inhibitor with strong leukotriene suppression in vivo, minimal CYP3A4 interaction, and excellent pharmacokinetics in rodent models.Formula:C40H44N4O5SPurity:98%Color and Shape:SolidMolecular weight:692.87TBK1/IKKε-IN-1
CAS:<p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).</p>Formula:C28H26N4O5Purity:98%Color and Shape:SolidMolecular weight:498.53RIPK1-IN-19
CAS:<p>RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.</p>Formula:C28H25FN6O2Purity:98.81%Color and Shape:SolidMolecular weight:496.54ROS151
ROS151 is an AChE inhibitor with IC50 values of 14 nM (hAChE), 1.68 μM (eqBChE), and 8.17 μM (hFAAH). Additionally, it acts as a chelating agent for Fe3+ and Cu2+. ROS151 is utilized in research related to Alzheimer's disease.Formula:C18H18FN3O6Color and Shape:SolidMolecular weight:391.35EGR-1-IN-3
CAS:<p>EGR-1-IN-3 (Compound 36) is an inhibitor of early growth response 1 (EGR-1) binding to DNA. It effectively suppresses the binding of EGR-1 to DNA and the expression of inflammation-related genes (such as TSLP, IL-31, IL-6, and CCL2) induced by TNFα. This compound is applicable to the study of inflammatory diseases.</p>Formula:C31H31N3O6SColor and Shape:SolidMolecular weight:573.659NLRP3-IN-7
<p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>Formula:C18H15ClN2O4S3Color and Shape:SolidMolecular weight:454.97NLRP3-IN-8
CAS:NLRP3-IN-8, orally active inflammasome blocker, IC50 of 1.23μM, stable (t1/2 = 138.63min), non-toxic (IC50 >100μM).Formula:C23H20N2O6Color and Shape:SolidMolecular weight:420.41Creatine ethyl ester
CAS:Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.Formula:C6H13N3O2Color and Shape:SolidMolecular weight:159.186
