Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(143 products)
- CXCR(158 products)
- Cell wall(5 products)
- IL Receptor(111 products)
- IκB/IKK(57 products)
- LTR(3 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(2 products)
- NF-κB(385 products)
- NOD(25 products)
- NOS(61 products)
- Nrf2(81 products)
- PGE Synthase(31 products)
- ROS(71 products)
- TGF-beta/Smad(60 products)
- TLR(76 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
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Found 3444 products of "Immunology and Inflammation"
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Cryptopleurine
CAS:Cryptopleurine is an inhibitor of gene products associated with cell proliferation, survival, invasion and angiogenesis. It acts by targeting the NF-κB pathway.Formula:C24H27NO3Purity:98%Color and Shape:SolidMolecular weight:377.48CD73-IN-13
CD73-IN-13, a potent CD73 inhibitor, may be developed for tumor-related disease treatment.Formula:C13H11F3N4O2Color and Shape:SolidMolecular weight:312.25MGD-28
CAS:MGD-28 is a Cullin-CRBN-dependent IKZF family protein degrader for IKZF1 (Ikaros), IKZF2 (Helios), IKZF3 (Aiolos) ,and CK1α, antiproliferative.Formula:C33H34FN7O3Purity:99.39%Color and Shape:SolidMolecular weight:595.67NIK-IN-2
CAS:NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Formula:C20H22N4O3Color and Shape:SolidMolecular weight:366.41CD73-IN-19
CAS:CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.
Formula:C18H17N3O3SColor and Shape:SolidMolecular weight:355.411LHC-165
CAS:LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.Formula:C29H32F2N3O7PPurity:98%Color and Shape:SolidMolecular weight:603.55RGT-068A
CAS:RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .Formula:C17H16ClN9O2Color and Shape:SolidMolecular weight:413.82Fexlamose
CAS:Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).Formula:C12H22O9S2Color and Shape:SolidMolecular weight:374.428RuDiOBn
CAS:RuDiOBn exhibits low antioxidant activity by scavenging DPPH and ABTS free radicals with scavenging rates of 13.2% and 5.9% at a concentration of 100 μg/mL. It inhibits collagen glycation and reduces the formation of advanced glycation end-products (AGE) with an IC50 of 2.45 μg/mL. RuDiOBn also enhances fibroblast proliferation and migration, stimulates collagen synthesis, and aids in skin repair and regeneration while inhibiting collagenase.Formula:C29H22O7Color and Shape:SolidMolecular weight:482.481Anti-inflammatory agent 102
CAS:Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).Formula:C16H16ClN3O3Color and Shape:SolidMolecular weight:333.77COX-2-IN-10
COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.Formula:C31H32FN5O2SColor and Shape:SolidMolecular weight:557.68Lobaric acid
CAS:Lobaric acid, from Stereocaulon lichen, has antioxidant and anticancer properties, inhibits PTP1B and 12(S)-LOX, and reduces TMV lesions in plants.Formula:C25H28O8Color and Shape:SolidMolecular weight:456.48AS2690168 (free base)
CAS:AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Formula:C17H13F3N4OColor and Shape:SolidMolecular weight:346.306DPP4-In hydrochloride
CAS:DPP4-In (hydrochloride) is an inhibitor of dipeptidyl peptidase 4 (DPP4) that effectively reduces the expression of DPP4.Formula:C14H21ClN4O2Color and Shape:SolidMolecular weight:312.8Anti-inflammatory agent 18
Anti-inflammatory agent 18: NO activity blocker (IC50: 15.94 μM), hampers HMGB1-induced inflammation, potential for COVID-19, sepsis study.Formula:C30H50O6Color and Shape:SolidMolecular weight:506.71HG-12-6
CAS:HG-12-6 is a type II IRAK4 inhibitor, targeting its inactive form with an IC50 of 165 nM, and is used in autoimmunity and inflammation.Formula:C29H27F3N6O2SPurity:98%Color and Shape:SolidMolecular weight:580.62Galectin-8-IN-1
Galectin-8-IN-1 selectively binds galectin-8N with 48 μM affinity, 15x more than galectin-3.Formula:C16H18N2O6Color and Shape:SolidMolecular weight:334.32MALT1-IN-5
CAS:MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.Formula:C17H17ClF2N6O3Color and Shape:SolidMolecular weight:426.80S-MTC acetate
CAS:S-MTC acetate (S-Methyl-L-thiocitrulline acetate) serves as a potent inhibitor of inducible nitric oxide synthases and is especially effective in inhibiting the constitutive (neuronal) type rather than the inducible (endothelial) type.Formula:C9H19N3O4SColor and Shape:SolidMolecular weight:265.33C5aR-IN-3
CAS:C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.Formula:C36H40FN5O3Color and Shape:SolidMolecular weight:609.73NLRP3-IN-44
CAS:NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.Formula:C25H30N4O3Color and Shape:SolidMolecular weight:434.53Glutathione monoethyl ester
CAS:Glutathione monoethyl ester, a derivative of glutathione, can protect motor neuron cells (NSC-34) from TDP-43 pathology caused by mutations, which includes reducing aggregate formation, nuclear clearance, reactive oxygen species (ROS) production, and cell death.Formula:C12H21N3O6SColor and Shape:SolidMolecular weight:335.377Itaconic acid prodrug-1
CAS:Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid that efficiently delivers Itaconic acid to skin tissues upon oral administration. It exhibits immunomodulatory effects, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 is useful for research into alopecia areata and other inflammatory skin conditions.Formula:C15H22O10Color and Shape:SolidMolecular weight:362.329NLRP3-IN-69
CAS:NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.Formula:C25H24O7Color and Shape:SolidMolecular weight:436.454Amilo-5MER
CAS:Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.Formula:C23H40N6O9SColor and Shape:SolidMolecular weight:576.664(R)-Ketoprofen
CAS:(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.Formula:C16H14O3Color and Shape:SolidMolecular weight:254.28TLR7/8 antagonist 1
Compound 16c, an imidazoquinoline, is a TLR7/8 agonist; IC50: 3.91 μM (TLR7), 2.19 μM (TLR8); targets TLR-2050 for disease treatment.Formula:C24H27N5O2Color and Shape:SolidMolecular weight:417.5SP4206
CAS:SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)Formula:C30H37Cl2N7O6Purity:98%Color and Shape:SolidMolecular weight:662.56STING agonist-20
CAS:STING agonist-20: potent, aids in XMT-2056 synthesis, used as a cancer vaccine adjuvant.Formula:C36H39N11O8Color and Shape:SolidMolecular weight:753.76Galectin-3-IN-2
Galectin-3-IN-2 inhibits galactose lectin-3 (Gal-3) with an 8.3 μM IC50, impacting cancer-related metabolism.Formula:C24H30FN3O10SColor and Shape:SolidMolecular weight:571.57SMW139
CAS:SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.Formula:C19H21ClF3NO2Color and Shape:SolidMolecular weight:387.824mPGES1-IN-5
CAS:mPGES1-IN-5 (compound 18) is a multi-substituted pyrimidine compound that acts as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and demonstrates significant inhibitory activity in vivo against acute inflammation models.Formula:C27H27N3OColor and Shape:SolidMolecular weight:409.52IRAK4-IN-15
CAS:IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.Formula:C25H29FN10Color and Shape:SolidMolecular weight:488.56WK692
CAS:Compound WK692 (compund WK692) is a BCL6 inhibitor that effectively suppresses the growth of diffuse large B-cell lymphoma cells without toxic side effects and acts synergistically with inhibitors of EZH2 and PRMT5.Formula:C26H28Br2N8O5Color and Shape:SolidMolecular weight:692.36E 5090
CAS:E5090 is a novel orally active inhibitor of IL-1 generation. It also has anti-inflammatory properties.Formula:C19H20O5Purity:98%Color and Shape:SolidMolecular weight:328.36ZM514
ZM514 inhibits CD73 (hCD73 IC50: 1.39 μM, mCD73 IC50: 14.65 μM) with low cytotoxicity, suitable for cancer research.Formula:C36H57NO4Color and Shape:SolidMolecular weight:567.84IRAK4-IN-18
IRAK4-IN-18: Potent IRAK4 inhibitor (IC50: 15 nM), reduces IL23 in cells, prevents rat arthritis.Formula:C24H25FN6O3Color and Shape:SolidMolecular weight:464.49TLR4/NF-κB/MAPK-IN-1
CAS:TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways.Formula:C19H25BrO6Color and Shape:SolidMolecular weight:429.3CD73-IN-2
CD73-IN-2 is a potent inhibitor of CD73 (IC50: 0.09 nM).Formula:C17H25ClN5O7PColor and Shape:SolidMolecular weight:477.84COX-2-IN-51
CAS:COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.Formula:C23H18F4O3SColor and Shape:SolidMolecular weight:450.446Pelecopan
CAS:Pelecopan (BCX9930), an oral complement factor D inhibitor, prevents hemolysis in PNH (IC50=14.3 nM).Formula:C23H19FN2O4Color and Shape:SolidMolecular weight:406.41Creatine ethyl ester
CAS:Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.Formula:C6H13N3O2Color and Shape:SolidMolecular weight:159.186EGR-1-IN-3
CAS:EGR-1-IN-3 (Compound 36) is an inhibitor of early growth response 1 (EGR-1) binding to DNA. It effectively suppresses the binding of EGR-1 to DNA and the expression of inflammation-related genes (such as TSLP, IL-31, IL-6, and CCL2) induced by TNFα. This compound is applicable to the study of inflammatory diseases.Formula:C31H31N3O6SColor and Shape:SolidMolecular weight:573.659Gardiquimod hydrochloride
CAS:Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.Formula:C17H24ClN5OColor and Shape:SolidMolecular weight:349.858Anti-osteoporosis agent-11
CAS:Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.Formula:C23H17NO2Se2Color and Shape:SolidMolecular weight:497.31MSA-2 dimer
CAS:MSA-2 dimer: selective oral non-nucleotide STING agonist, Kd=145 μM, long-term antitumor effect, non-covalent, higher permeability.Formula:C29H28O8S2Color and Shape:SolidMolecular weight:568.66Anti-inflammatory agent 9
Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.Formula:C18H15N5O2SColor and Shape:SolidMolecular weight:365.41Heme Oxygenase-2-IN-1
Heme Oxygenase-2-IN-1 is a selective HO-2 inhibitor with IC50s: 14.9 μM (HO-1), 0.9 μM (HO-2).Formula:C19H17N3O2Color and Shape:SolidMolecular weight:319.36BAA473
BAA473, a bile acid analog, activates the pyrin inflammasome, triggering IL-18 secretion in myeloid and intestinal cells.Formula:C36H62O5Purity:98%Color and Shape:SolidMolecular weight:574.87CYP1B1-IN-10
CAS:CYP1B1-IN-10 (Compound 15C) is a highly selective inhibitor of human cytochrome P450 1B1 (hCYP1B1) with an IC50 value of 0.11 μM. It shows promise for use in research focused on hormone-dependent tumors, including breast and ovarian cancers.Formula:C23H18N2Color and Shape:SolidMolecular weight:322.40
