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Immunology and Inflammation

Immunology and Inflammation

Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.

Subcategories of "Immunology and Inflammation"

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Found 3055 products of "Immunology and Inflammation"

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  • CymitQuimica logo
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    NLRP3-IN-7

    <p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>
    Formula:C18H15ClN2O4S3
    Color and Shape:Solid
    Molecular weight:454.97

    Ref: TM-T62809

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    Antioxidant agent-3

    <p>Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.</p>
    Formula:C18H14O8
    Color and Shape:Solid
    Molecular weight:358.3

    Ref: TM-T61312

  • IRAK4-IN-14
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    IRAK4-IN-14

    CAS:
    <p>IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.</p>
    Formula:C25H28FN9O
    Color and Shape:Solid
    Molecular weight:489.55

    Ref: TM-T63278

  • NLRP3-IN-80
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    NLRP3-IN-80

    CAS:
    <p>NLRP3-IN-80 (Compound 1) is an NLRP3 inhibitor useful for research into inflammatory aging.</p>
    Formula:C24H22F2N4O3
    Color and Shape:Solid
    Molecular weight:452.45

    Ref: TM-T207648

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    COX-2/PI3K-IN-1

    <p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>
    Formula:C19H14ClN5S2
    Color and Shape:Solid
    Molecular weight:411.93

    Ref: TM-T62103

  • SARM1-IN-4
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    SARM1-IN-4

    CAS:
    <p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>
    Formula:C13H17F2N3O2
    Color and Shape:Solid
    Molecular weight:285.29

    Ref: TM-T206825

  • AIM4
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    AIM4

    CAS:
    <p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>
    Formula:C25H23Br2N5O4
    Color and Shape:Solid
    Molecular weight:617.289

    Ref: TM-T206489

  • Nrf2 activator-6
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    Nrf2 activator-6

    CAS:
    <p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>
    Formula:C31H37ClFN5O5
    Color and Shape:Solid
    Molecular weight:614.11

    Ref: TM-T72697

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    COX-2-IN-9

    <p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>
    Formula:C25H23N5O4S2
    Color and Shape:Solid
    Molecular weight:521.61

    Ref: TM-T63646

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    Anti-inflammatory agent 6

    <p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>
    Formula:C22H20O12
    Color and Shape:Solid
    Molecular weight:476.39

    Ref: TM-T63107

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    OP-5244 sodium

    <p>OP-5244 sodium: potent oral CD73 inhibitor (IC50: 0.25 nM), potential in cancer research by hindering adenosine, reversing immunosuppression.</p>
    Formula:C19H28ClN5NaO9P
    Color and Shape:Solid
    Molecular weight:559.87

    Ref: TM-T63956

  • TLR7 agonist 28
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    TLR7 agonist 28

    CAS:
    <p>TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.</p>
    Formula:C26H25N9O7
    Color and Shape:Solid
    Molecular weight:575.533

    Ref: TM-T204940

  • ALR-6
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    ALR-6

    CAS:
    <p>ALR-6, an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP, possesses anti-inflammatory properties. It significantly inhibits 5-LOX product formation (&gt;80%) in pro-inflammatory M1-MDM without substantially affecting direct inhibition of 5-LOX [1].</p>
    Formula:C18H14O5
    Color and Shape:Solid
    Molecular weight:310.3

    Ref: TM-T85639

  • AhR agonist 7
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    AhR agonist 7

    CAS:
    Compound 8, an AhR agonist 7, demonstrates potent activation of AhR with an EC50 of 13nM [1].
    Formula:C16H15ClFNO2
    Color and Shape:Solid
    Molecular weight:307.75

    Ref: TM-T85606

  • Ac5GalNTGc
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    Ac5GalNTGc

    CAS:
    <p>Ac5GalNTGc, an analog of hexosamine, inhibits mucin-type O-linked glycosylation biosynthesis [1].</p>
    Formula:C18H25NO11S
    Color and Shape:Solid
    Molecular weight:463.46

    Ref: TM-T85546

  • Galectin-3-IN-4
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    Galectin-3-IN-4

    CAS:
    <p>Galectin-3-IN-4 (compound 5), a carboxamide analog, effectively and selectively inhibits both human and mouse galectin-3. This compound demonstrates notable potency with IC50 values of 21 nM for hGal-3 and 167 nM for mGal-3. It is also orally bioavailable. For other galectins, Galectin-3-IN-4 shows IC50 values of 1580 nM for hGal-1 and 2750 nM for hGal-9, respectively [1].</p>
    Formula:C24H22ClF2N5O5S
    Color and Shape:Solid
    Molecular weight:565.98

    Ref: TM-T86487

  • IKZF1-degrader-1
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    IKZF1-degrader-1

    CAS:
    IKZF1-degrader-1 (Compound 9-B) serves as a potent degrader of the IKZF1 protein, exhibiting a DC50 of 0.134 nM. It is applicable in the degradation of tumors [1].
    Formula:C35H29F2N5O3
    Color and Shape:Solid
    Molecular weight:605.63

    Ref: TM-T86707

  • VISTA-IN-3
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    VISTA-IN-3

    CAS:
    <p>VISTA-IN-3 (Compound A4), a potent small molecule inhibitor of VISTA, exhibits a dissociation constant (K D) of 0.49 μM. This compound effectively induces the release of IFN-γ cytokines and demonstrates synergistic enhancement of anti-cancer activity when combined with PD-L1 antibody [1].</p>
    Formula:C14H18N4O3
    Color and Shape:Solid
    Molecular weight:290.32

    Ref: TM-T87620

  • NLRP3-IN-29
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    NLRP3-IN-29

    CAS:
    <p>NLRP3-IN-29 (Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) with potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. It can be used for research on Alzheimer's disease [1].</p>
    Formula:C21H22N2O3S
    Color and Shape:Solid
    Molecular weight:382.48

    Ref: TM-T87020

  • cGAS-IN-2
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    cGAS-IN-2

    CAS:
    <p>cGAS-IN-2 (compound 109) serves as a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), exhibiting an IC50 of 0.01512 μM against h-cGAS [1].</p>
    Formula:C16H18Cl2N2O2
    Color and Shape:Solid
    Molecular weight:341.23

    Ref: TM-T86042