Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(134 products)
- CXCR(154 products)
- Cell wall(5 products)
- IL Receptor(75 products)
- IκB/IKK(58 products)
- LTR(3 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(399 products)
- NOD(23 products)
- NOS(61 products)
- Nrf2(82 products)
- PGE Synthase(31 products)
- ROS(70 products)
- TGF-beta/Smad(48 products)
- TLR(72 products)
- Thioredoxin(12 products)
- gp120/CD4(2 products)
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Found 3210 products of "Immunology and Inflammation"
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Heme Oxygenase-2-IN-1
Heme Oxygenase-2-IN-1 is a selective HO-2 inhibitor with IC50s: 14.9 μM (HO-1), 0.9 μM (HO-2).Formula:C19H17N3O2Color and Shape:SolidMolecular weight:319.36IL-17 modulator 1 disodium
CAS:Potent, orally active IL-17 Modulator 1 (disodium) from patent WO 2020127685, used in psoriasis and arthritis research.Formula:C28H37N6NaO6PColor and Shape:SolidMolecular weight:607.604SB24011
CAS:SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].Formula:C34H38N4O7Color and Shape:SolidMolecular weight:614.69α-Hydroxy alprazolam
CAS:α-Hydroxy alprazolam (U 40125), the primary metabolite of α-Hydroxy alprazolam, possesses pharmacological activity accounting for 60% of that of Alprazolam.Formula:C17H13ClN4OColor and Shape:SolidMolecular weight:324.76S-MTC acetate
CAS:S-MTC acetate (S-Methyl-L-thiocitrulline acetate) serves as a potent inhibitor of inducible nitric oxide synthases and is especially effective in inhibiting the constitutive (neuronal) type rather than the inducible (endothelial) type.Formula:C9H19N3O4SColor and Shape:SolidMolecular weight:265.33ALR-27
CAS:ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].Formula:C19H22O3Color and Shape:SolidMolecular weight:298.38TE-11
CAS:TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.Formula:C16H13NOColor and Shape:SolidMolecular weight:235.28Cryptopleurine
CAS:Cryptopleurine is an inhibitor of gene products associated with cell proliferation, survival, invasion and angiogenesis. It acts by targeting the NF-κB pathway.Formula:C24H27NO3Purity:98%Color and Shape:SolidMolecular weight:377.48DBMB
CAS:DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.Formula:C24H22N4OColor and Shape:SolidMolecular weight:382.458ABZI
CAS:(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.Formula:C23H24N6O3Color and Shape:SolidMolecular weight:432.48BIO-8169
CAS:BIO-8169, a selective interleukin receptor-associated kinase 4 (IRAK 4) inhibitor, demonstrates potent activity with an IC 50 value of 0.23 nM. Exhibiting strong pharmacokinetic properties, BIO-8169 effectively reduces pro-inflammatory cytokine production and mitigates autoimmune encephalomyelitis in the EAE mouse model. Additionally, it has notable blood-brain penetration, evidenced by a rat Kpu,u of 0.7.Formula:C24H27N5O4Color and Shape:SolidMolecular weight:449.50IKZF1-degrader-2
CAS:IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].Formula:C33H30FN5O5Color and Shape:SolidMolecular weight:595.62Carazostatin
CAS:Carazostatin is an antioxidant, free radical scavenger, and potent lipid peroxidation inhibitor.Formula:C20H25NOPurity:98%Color and Shape:Pale Yellow SolidMolecular weight:295.42COX-2/PI3K-IN-1
COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).Formula:C19H14ClN5S2Color and Shape:SolidMolecular weight:411.93Polvitolimod
CAS:Polvitolimod is a TLR7 agonist used to treat infectious disease and cancer.Formula:C13H14FN5O4Color and Shape:SolidMolecular weight:323.28CPDT
CAS:CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Formula:C6H6S3Color and Shape:SolidMolecular weight:174.307IL-6-IN-2
CAS:IL-6-IN-2 (Compound 15) is an inhibitor of the interaction between IL-6 and IL-6R proteins. The compound's binding free energy (∆G) is −36.50 kcal/mol. In its binding with IL-6, the contributions from Lys66, Phe74, Gln175, Ser176, and Arg179 are -1.10, -8.68, -6.91, -3.69, and -1.72 kcal/mol, respectively. IL-6-IN-2 exhibits low gastrointestinal (GI) absorption rates.Formula:C26H24N4O3Color and Shape:SolidMolecular weight:440.49oxLig-1
CAS:OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).Formula:C36H58O5Color and Shape:SolidMolecular weight:570.84MMG-11 quarterhydrate
MMG-11 quarterhydrate, a potent hTLR2 antagonist, inhibits TLR2/1 and TLR2/6 with IC50s of 1.7μM and 5.7μM; low toxicity.Formula:C15H16O8Color and Shape:SolidMolecular weight:310.78C-di-IMP
CAS:Cyclic-di-IMP (C-di-IMP), a STING agonist, serves as a research tool in tumor studies.Formula:C20H22N8O14P2Color and Shape:SolidMolecular weight:660.38
