Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(135 products)
- CXCR(154 products)
- Cell wall(5 products)
- IL Receptor(84 products)
- IκB/IKK(58 products)
- LTR(3 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(405 products)
- NOD(23 products)
- NOS(61 products)
- Nrf2(82 products)
- PGE Synthase(31 products)
- ROS(70 products)
- TGF-beta/Smad(49 products)
- TLR(73 products)
- Thioredoxin(12 products)
- gp120/CD4(2 products)
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Found 3249 products of "Immunology and Inflammation"
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IRAK4-IN-15
CAS:IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.Formula:C25H29FN10Color and Shape:SolidMolecular weight:488.56BMS-986458
CAS:BMS-986458 is a highly selective, orally active BCL6 PROTAC degrader. It specifically targets cereblon (CRBN) and the BCL6 N-terminal BTB domain to catalyze proximity-induced BCL6 degradation. BMS-986458 is applicable for research in B-cell non-Hodgkin lymphoma.Formula:C32H34ClN9O3Color and Shape:SolidMolecular weight:628.124ALR-6
CAS:ALR-6, an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP, possesses anti-inflammatory properties. It significantly inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without substantially affecting direct inhibition of 5-LOX [1].
Formula:C18H14O5Color and Shape:SolidMolecular weight:310.3AhR agonist 7
CAS:Compound 8, an AhR agonist 7, demonstrates potent activation of AhR with an EC50 of 13nM [1].Formula:C16H15ClFNO2Color and Shape:SolidMolecular weight:307.75AHR antagonist 5 hemimaleate
Potent oral AHR antagonist with IC50 < 0.5 μM, hinders tumor growth with anti-PD-1.Formula:C29H28FN7O4Color and Shape:SolidMolecular weight:499.55Creatine ethyl ester
CAS:Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.Formula:C6H13N3O2Color and Shape:SolidMolecular weight:159.186EGR-1-IN-3
CAS:EGR-1-IN-3 (Compound 36) is an inhibitor of early growth response 1 (EGR-1) binding to DNA. It effectively suppresses the binding of EGR-1 to DNA and the expression of inflammation-related genes (such as TSLP, IL-31, IL-6, and CCL2) induced by TNFα. This compound is applicable to the study of inflammatory diseases.Formula:C31H31N3O6SColor and Shape:SolidMolecular weight:573.659COX-2/PI3K-IN-2
COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).Formula:C16H17N5O2Color and Shape:SolidMolecular weight:311.34Gardiquimod hydrochloride
CAS:Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.Formula:C17H24ClN5OColor and Shape:SolidMolecular weight:349.858MSA-2 dimer
CAS:MSA-2 dimer: selective oral non-nucleotide STING agonist, Kd=145 μM, long-term antitumor effect, non-covalent, higher permeability.Formula:C29H28O8S2Color and Shape:SolidMolecular weight:568.66Ac5GalNTGc
CAS:Ac5GalNTGc, an analog of hexosamine, inhibits mucin-type O-linked glycosylation biosynthesis [1].Formula:C18H25NO11SColor and Shape:SolidMolecular weight:463.46Anti-inflammatory agent 9
Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.Formula:C18H15N5O2SColor and Shape:SolidMolecular weight:365.41NLRP3-IN-57
NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.Formula:C44H60O7Color and Shape:SolidMolecular weight:700.94Galectin-3-IN-2
Galectin-3-IN-2 inhibits galactose lectin-3 (Gal-3) with an 8.3 μM IC50, impacting cancer-related metabolism.Formula:C24H30FN3O10SColor and Shape:SolidMolecular weight:571.57CD73-IN-7
CAS:CD73-IN-7: potent inhibitor of CD73, blocks adenosine production to treat tumors.
Formula:C13H11ClN4O2Color and Shape:SolidMolecular weight:290.7NIK-IN-2
CAS:NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Formula:C20H22N4O3Color and Shape:SolidMolecular weight:366.41Galectin-3-IN-4
CAS:Galectin-3-IN-4 (compound 5), a carboxamide analog, effectively and selectively inhibits both human and mouse galectin-3. This compound demonstrates notable potency with IC50 values of 21 nM for hGal-3 and 167 nM for mGal-3. It is also orally bioavailable. For other galectins, Galectin-3-IN-4 shows IC50 values of 1580 nM for hGal-1 and 2750 nM for hGal-9, respectively [1].Formula:C24H22ClF2N5O5SColor and Shape:SolidMolecular weight:565.98IKZF2-degrader 1
CAS:IKZF2-degrader 1 (Compound 31) is a molecular glue-type degrader of IKZF2 with a DC50 of 0.5 nM. It exhibits relatively low degradation activity against CK1α, with a DC50 of 210 nM. This compound is applicable in research focused on IKZF2-dependent cancers.Formula:C27H30FN7O3Color and Shape:SolidMolecular weight:519.57Balsalazide disodium
CAS:Balsalazide disodium is an aminosalicylate prodrug that releases mesalamine in the colon, providing diverse anti-inflammatory effects in regions affected by colitis. Additionally, it exhibits anticancer properties by modulating the IL-6/STAT3 pathway.Formula:C17H13N3Na2O6Color and Shape:SolidMolecular weight:401.281ZM514
ZM514 inhibits CD73 (hCD73 IC50: 1.39 μM, mCD73 IC50: 14.65 μM) with low cytotoxicity, suitable for cancer research.Formula:C36H57NO4Color and Shape:SolidMolecular weight:567.84
