Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(142 products)
- CXCR(159 products)
- Cell wall(5 products)
- IL Receptor(110 products)
- IκB/IKK(59 products)
- LTR(2 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(444 products)
- NOD(18 products)
- NOS(61 products)
- Nrf2(82 products)
- PGE Synthase(31 products)
- ROS(70 products)
- TGF-beta/Smad(60 products)
- TLR(76 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
Show 11 more subcategories
Found 3366 products of "Immunology and Inflammation"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
ARG1-IN-1
CAS:ARG1-IN-1 is a human arginase 1 inhibitor with an IC 50 of 29 nM.Formula:C11H21BN2O4Color and Shape:SolidMolecular weight:256.11Ocadusertib
CAS:Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).Formula:C25H25N5O4Color and Shape:SolidMolecular weight:459.50NLRP3-IN-57
NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.Formula:C44H60O7Color and Shape:SolidMolecular weight:700.94NIK-IN-2
CAS:NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Formula:C20H22N4O3Color and Shape:SolidMolecular weight:366.41AS2690168 (free base)
CAS:AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Formula:C17H13F3N4OColor and Shape:SolidMolecular weight:346.306FK-565
CAS:FK-565 is a ligand of nucleotide-binding oligomerization domain-1 (NOD1) that induces a mouse model of arteritis.Formula:C22H38N4O9Color and Shape:SolidMolecular weight:502.559mPGES1-IN-9
CAS:mPGES1-IN-9 (compound 1_8) is an mPGES1 inhibitor with an IC50 of 0.5 μM and is utilized in anti-inflammatory research.Formula:C25H18N4OSColor and Shape:SolidMolecular weight:422.502NLRP3-IN-58
CAS:NLRP3-IN-58 (Compound DS15) acts as an inhibitor of NLRP3 inflammasome activation, with an IC50 value of 3.85 μM, and is capable of inhibiting 33% of IL-1β release at a concentration of 10 μM.Formula:C22H18ClN3O3SColor and Shape:SolidMolecular weight:439.92(R)-cGAS-IN-4
CAS:(R)-cGAS-IN-4 (Compound 77A*) is the R-enantiomer of cGAS-IN-4, which acts as an orally active inhibitor of cyclic GMP-AMP synthase-adenosine synthase (cGAS).Formula:C19H18Cl2N4O3Color and Shape:SolidMolecular weight:421.28IRAK4-IN-12
IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).Formula:C24H31FN8OColor and Shape:SolidMolecular weight:466.55NP3-146 sodium
CAS:NP3-146 sodium is an inhibitor of the NLRP3 inflammasome.Formula:C20H26ClN2NaO5SColor and Shape:SolidMolecular weight:464.94CDA-IN-3
CAS:CDA-IN-3 (NCDI) is a chitin deacetylase (CDA) inhibitor with antiparasitic properties. It disrupts chitin metabolism in nematodes, increasing ROS levels within these organisms and causing cellular damage. CDA-IN-3 significantly inhibits all developmental stages of Caenorhabditis elegans and can be utilized in research focused on anti-infective applications.Formula:C16H27N3O3S2Color and Shape:SolidMolecular weight:373.534AMC-04
CAS:AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].Formula:C26H28N2O3Color and Shape:SolidMolecular weight:416.51TLR7/8 antagonist 2
TLR7/8 antagonist 2: potent, orally active, IC50: 4.9 nM (TLR7), 0.6 nM (TLR8); potential for lupus therapy research.Formula:C22H26FN5Color and Shape:SolidMolecular weight:379.47Anti-inflammatory agent 19
Anti-inflammatory agent 19: NO inhibitor (IC50: 36μM), blocks HMGB1, for late-stage inflammation, relevant for COVID-19, sepsis.Formula:C30H50O7Color and Shape:SolidMolecular weight:522.71Yoda2
CAS:Yoda2 (KC289), the potassium salt of Yoda1, is an agonist of PIEZO1 with an EC50 of 150 nM. It induces Ca2+ elevation in HeLa cells and can cause concentration-dependent and NO-dependent relaxation in mouse portal vein (EC50= 1.2 μM). Additionally, Yoda2 is capable of stimulating NOS3 and promoting NO production.Formula:C16H9Cl2KN2O2S2Color and Shape:SolidMolecular weight:435.39RIPK2-IN-6
CAS:RIPK2-IN-6 (Compound 15a) is an inhibitor of RIPK that specifically targets the phosphorylation of RIPK2, thereby suppressing the NF-κB and MAPK signaling pathways. It has demonstrated anti-inflammatory and anti-fibrotic activities in a mouse model of colitis induced by Dextran sodium sulfate.Formula:C26H21NO3Color and Shape:SolidMolecular weight:395.45IRAK4-IN-11
IRAK4-IN-11 (compound 6) is a potent inhibitor of IRAK4 with an IC 50 of 0.008 μM. IRAK4-IN-11 exhibits cell pIRAK4 potencies with an IC 50 of 0.19 μM [1].Formula:C16H19N7OColor and Shape:SolidMolecular weight:325.37Ocipumaltib
CAS:Ocipumaltib (Example 2) is an inhibitor of mucosa-associated lymphoid tissue protein 1 (MALT1). It functions as an antineoplastic agent and is utilized in the study of cancer, infections, neurological disorders, and hematological diseases.Formula:C20H16ClF3N8O2Color and Shape:SolidMolecular weight:492.84HEI3090
CAS:HEI3090 is an activator of the P2X7R receptor. This compound enhances the production of IL-18 by stimulating dendritic cells that express P2X7R, which in turn promotes the production of IFN-γ by natural killer cells and CD4T cells within tumors, triggering a sustained anti-tumor response. Additionally, HEI3090 can be used to improve the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC).Formula:C18H15Cl3N4O3Color and Shape:SolidMolecular weight:441.70
