NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Found 398 products of "NF-κB"
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NIK SMI1
CAS:NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).Formula:C20H19N3O4Purity:99.04% - 99.99%Color and Shape:SolidMolecular weight:365.38Ref: TM-T16290
1mg82.00€5mg173.00€10mg281.00€25mg563.00€50mg885.00€100mg1,425.00€200mg1,948.00€1mL*10mM (DMSO)410.00€α-Lipoic Acid
CAS:α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.Formula:C8H14O2S2Purity:98.39% - 99.83%Color and Shape:Forms Yellowish Flakes Light Yellow To Yellow PowderMolecular weight:206.33Metaxalone
CAS:Metaxalone, sold as Skelaxin by King Pharmaceuticals, is a muscle relaxant for pain from strains and sprains.Formula:C12H15NO3Purity:98.84% - 99.94%Color and Shape:White To Almost White Crystalline Powder SolidMolecular weight:221.25Lidocaine hydrochloride
CAS:Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.Formula:C14H23ClN2OPurity:99.81% - 99.92%Color and Shape:White Crystal PowderMolecular weight:270.798DCZ0415
CAS:DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.Formula:C23H20N2O2Purity:99.34% - 99.95%Color and Shape:SolidMolecular weight:356.42Ref: TM-T10981
1mg50.00€5mg110.00€10mg178.00€25mg334.00€50mg505.00€100mg707.00€200mg973.00€1mL*10mM (DMSO)119.00€Indacaterol maleate
CAS:Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.Formula:C28H32N2O7Purity:99.03% - 99.67%Color and Shape:SolidMolecular weight:508.56BAY-985
CAS:BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Formula:C27H30F3N9OPurity:99.62%Color and Shape:SolidMolecular weight:553.58Ref: TM-T10477
1mg163.00€5mg334.00€10mg502.00€25mg853.00€50mg1,161.00€100mg1,558.00€1mL*10mM (DMSO)408.00€Methylthiouracil
CAS:Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Formula:C5H6N2OSPurity:99.89% - >99.99%Color and Shape:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Molecular weight:142.18Erdosteine
CAS:Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.Formula:C8H11NO4S2Purity:99.65% - 99.94%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:249.31Mangiferin
CAS:Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.Formula:C19H18O11Purity:99.78% - 99.86%Color and Shape:Light Yellow PowderMolecular weight:422.34(E/Z)-BCI
CAS:(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROSFormula:C22H23NOPurity:99.94%Color and Shape:SolidMolecular weight:317.42Ref: TM-T11139
1mg80.00€5mg155.00€10mg283.00€25mg452.00€50mg638.00€100mg848.00€200mg1,121.00€1mL*10mM (DMSO)170.00€Sulindac
CAS:Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.Formula:C20H17FO3SPurity:99.09% - 99.15%Color and Shape:Yellow SolidMolecular weight:356.41Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Formula:C9H8O4Purity:99.78% - 99.91%Color and Shape:White Solid CrystallineMolecular weight:180.16Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formula:C23H34O5Purity:99.12%Color and Shape:White-Yellowish To Yellow Powder Solid PowderMolecular weight:390.51SN50 acetate (213546-53-3 free base)
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.Formula:C131H234N36O31SPurity:99.86%Color and Shape:SolidMolecular weight:2841.55IMD-0560
CAS:IMD-0560 is a novel inhibitor of IκB kinase β.Formula:C15H8BrF6NO2Purity:99.51%Color and Shape:SolidMolecular weight:428.12Theophylline
CAS:Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and centralFormula:C7H8N4O2Purity:99.65% - 99.98%Color and Shape:White Solid PowderMolecular weight:180.16Articaine hydrochloride
CAS:Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Formula:C13H21ClN2O3SPurity:99.76%Color and Shape:White Crystalline PowderMolecular weight:320.84Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formula:C14H22N2OPurity:99.95% - >99.99%Color and Shape:Needles From Benzene Or Alcohol SolidMolecular weight:234.34Urolithin B
CAS:Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormula:C13H8O3Purity:99.45%Color and Shape:SolidMolecular weight:212.2Oxaprozin
CAS:Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.Formula:C18H15NO3Purity:98.53%Color and Shape:SolidMolecular weight:293.325-Aminosalicylic Acid
CAS:5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!Formula:C7H7NO3Purity:98.88% - 99.49%Color and Shape:Purplish-Tan Solid PowderMolecular weight:153.14Asatone
CAS:Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Formula:C24H32O8Purity:99.84% - 99.92%Color and Shape:SolidMolecular weight:448.51Ref: TM-T10383
1mg77.00€5mg167.00€10mg260.00€25mg440.00€50mg628.00€100mg872.00€200mg1,153.00€1mL*10mM (DMSO)178.00€Naringin dihydrochalcone
CAS:Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.Formula:C27H34O14Purity:99.07% - 99.73%Color and Shape:Solid PowderMolecular weight:582.55Theophylline monohydrate
CAS:Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calciumFormula:C7H8N4O2·H2OPurity:99.78%Color and Shape:SolidMolecular weight:198.18Dihydroartemisinin
CAS:Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!Formula:C15H24O5Purity:98% - 99.41%Color and Shape:White SolidMolecular weight:284.354-Hydroxychalcone
CAS:4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.Formula:C15H12O2Purity:99.75%Color and Shape:Yellow PowderMolecular weight:224.25Nimbolide
CAS:Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.Formula:C27H30O7Purity:95.84% - 99.4%Color and Shape:SolidMolecular weight:466.52Ref: TM-T16324
1mg67.00€5mg167.00€10mg289.00€25mg595.00€50mg820.00€100mg1,108.00€200mg1,440.00€1mL*10mM (DMSO)180.00€Sulfasalazine
CAS:Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.Formula:C18H14N4O5SPurity:98.00% - 99.28%Color and Shape:Minute Brownish-Yellow CrystalsMolecular weight:398.39DMAPT
CAS:DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.Formula:C17H27NO3Purity:99.91%Color and Shape:SolidMolecular weight:293.4Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurity:99.95%Color and Shape:SolidMolecular weight:288.82TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Formula:C26H27N5O3Purity:98.89%Color and Shape:SolidMolecular weight:457.52Ref: TM-T15559
1mg87.00€5mg178.00€10mg289.00€25mg462.00€50mg625.00€100mg802.00€1mL*10mM (DMSO)178.00€Sinomenine hydrochloride
CAS:Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.Formula:C19H24ClNO4Purity:99.43%Color and Shape:SolidMolecular weight:365.85Sodium salicylate
CAS:Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.Formula:C7H5NaO3Purity:99.36% - 99.92%Color and Shape:White Solid AmorphousMolecular weight:160.11Baicalin
CAS:Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFormula:C21H18O11Purity:90.08% - 99.32%Color and Shape:Yellow PowderMolecular weight:446.36Ref: TM-T2775
1g80.00€2g102.00€5g152.00€50mg34.00€100mg49.00€200mg49.00€500mg55.00€1mL*10mM (DMSO)50.00€CDDO-dhTFEA
CAS:CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.Formula:C33H45F3N2O3Purity:95.61% - 99.59%Color and Shape:SolidMolecular weight:574.72Ref: TM-T13604
1mg70.00€2mg92.00€5mg153.00€10mg255.00€25mg512.00€50mg738.00€100mg1,035.00€500mg2,062.00€1mL*10mM (DMSO)187.00€DRI-C21045
CAS:Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).Formula:C32H24N2O7SPurity:97.20%Color and Shape:SolidMolecular weight:580.61Ergolide
CAS:Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.Formula:C17H22O5Purity:99.64%Color and Shape:SolidMolecular weight:306.35Ref: TM-T13686
1mg71.00€5mg139.00€10mg230.00€25mg374.00€50mg520.00€100mg697.00€1mL*10mM (DMSO)166.00€Guaiacol
CAS:Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.
Formula:C7H8O2Purity:99.95%Color and Shape:Colourless To Pale Yellow Solid CrystallineMolecular weight:124.14NF-κB-IN-9
NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dualFormula:C62H50N4O4SColor and Shape:SolidMolecular weight:947.15Murrayafoline A
CAS:Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.Formula:C14H13NOColor and Shape:SolidMolecular weight:211.264Ginger extract
CAS:Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).
Color and Shape:Solid12-Oxo phytodienoic acid
CAS:12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.
Formula:C18H28O3Purity:98%Color and Shape:SolidMolecular weight:292.41CAY10512
CAS:CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.Formula:C15H13FOColor and Shape:SolidMolecular weight:228.2663-(2-Hydroxyethyl) thio withaferin A
3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.Formula:C30H44O7SColor and Shape:SolidMolecular weight:548.73MJ210
MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.Color and Shape:Odour SolidIKKγ NBD Inhibitory Peptide
CAS:A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF
Formula:C170H259N49O42S1Purity:98%Color and Shape:SolidMolecular weight:3693.3R1-ICR-5
CAS:R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Formula:C54H70N8O7S2Color and Shape:SolidMolecular weight:1007.31Cyclo(L-Pro-L-Val)
CAS:Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.
Formula:C10H16N2O2Purity:98.18%Color and Shape:SolidMolecular weight:196.2517-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).
Formula:C22H32O3Color and Shape:SolidMolecular weight:344.495
