NF-κB

TBK1/IKK-IN-1 is a dual inhibitor of TBK1 and IKK (IC50s of <100 nM).

GSK 2983559 (RIP2 kinase inhibitor 1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.

Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of …

Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, …

Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.

Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum …

Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and …

Quinoclamine is a naphthoquinone derivative and is an NF-B inhibitor.

Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF--induced …

1-Caffeoylquinic acid is an important intermediate in lignin biosynthesis. 1-Caffeoylquinic acid has anti-influenza, and antioxidant …

Astilbin is actions Flavonoid phytochemical found in St. Johns wort and Traditional Chinese Medicine herbal …

IKK-IN-1 is an inhibitor of IKK.

1. Sanggenone C inhibits tumor cellular proteasomal activity and cell viability, via induction of cell …

Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI …

(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen and inhibits NF-B activation. (R)-(-)-Ibuprofen has anti-inflammatory and …

Wedelolactone inhibits NF-B-mediated gene transcription in cells by blocking the phosphorylation and degradation of IB.

1. Yangonin is a novel CB receptor ligand, it exhibits affinity for the human recombinant …

Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).

Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and …

PF06650833 is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) …

DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma …

Pyrrolidinedithiocarbamate ammonium, a selective NF-B inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent …

Eleutheroside E has anti-inflammatory effects by inhibiting NF-B activities. Eleutheroside E significantly decreases the inflammatory …

J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular …

TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction. TRAF-STOP 6877002 reduces leukocyte recruitment, …

Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.

CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-B (EC50: 0.47 …

Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKK.

BMS-066 is an IKK/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.

1. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. 2. Ginsenoside …

6'''-Feruloylspinosin may possess anti-inflammatory activity.

Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying …

IMD-0560 is a novel inhibitor of IB kinase .

1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in …

NF-B-IN-1 is a potent NF-B signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-B-IN-1 …

NIK SMI1 is an effective and selective NF-B inducing kinase (NIK) inhibitor. It also inhibits …

JSH-23, an NF-B inhibitorIC50= 7.1 μM, suppresses the transcriptional activity.

Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent …

Tyloxapol is a non-ionic liquid polymer used as a surfactant.

Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc …

1. Astragalin may be a potential agent in the treatment of osteoarthritis. 2. Astragalin can …

GSK319347A is a TBK1 and IKK dual inhibitor (IC50s: 93 nM and 469 nM, respectively). …

Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal …

BAY 11-7085 can irreversibly inhibit the IB phosphorylation induced by TNF (IC50: 10 μM).

Euphorbiafactor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation through inhibits NF-B activation.

CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory …

ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK- inhibitor (IC50: 8.5 …

Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood …

Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a …

Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-B, …

Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits …

(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.

BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's …

TBK1/IKK-IN-5 is a dual TBK1 and IKK inhibitor(IC50 of 1 nM and 5.6 nM, respectively).

BI605906 is an inhibitor of IKK. When assayed at 0.1 mM ATP, the IC50 value …

Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the …

(-)-Parthenolide, an inhibitor of the Nuclear Factor-B Pathway, also promotes the ubiquitination of MDM2 and …

INH14 is a novel inhibitor of the IKK/-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for …

Necrostatin 2 racemate is an potent and specific inhibitor of RIPK1.

Dehydrocostus shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.

5-hydroxy-7,8-dimethoxyflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone …

DMAPT (Dimethylamino Parthenol) is a water-soluble analogue of Parthenolide (PTL). It is an orally active …

BAPTA is a neuroprotective agent in cerebral ischemia, acting as an intercellular Ca2+ chelator.

LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM); IC50 for IKK1 …

Caffeic Acid Phenethyl Ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and …

Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also …

Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, …