NF-κB

CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory …

DMAPT is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor …

TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.

Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the …

SN50 acetate is a cell permeable inhibitor of NF-κB translocation.

RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic …

Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).

Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced …

IMD-0560 is a novel inhibitor of IκB kinase β.

Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.

Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.

Dri-c21045 showed concentration-dependent inhibition of NF-kB activation and all CD40L induced by B cell proliferation …

Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.

Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and …

DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma …

Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of …

BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε …

NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits …

(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.

Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced …

WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 …

Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.

Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.

Rubipodanone A is a natural product

Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental …

BI605906 is an inhibitor of IKKβ. When assayed at 0.1 mM ATP, the IC50 value …

Veraguensin is derived from Magnolia sp.. Veraguensin inhibits bone resorption and shows high antileishmanial activity.

8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-κB activity with the IC(50) value of 1.9 …

Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a …

1. Kamebakaurin has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both …

Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.

Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NF-kB activity. It inhibits the enzyme activity by competing …

Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for …

4-Methoxycinnamyl alcohol shows toxicity against MCF-7, HeLa and DU145 cancer cell line.

Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has …

Rubioncolin C shows good cytotoxicity with IC50 value of 1.53 μM and NF-κB inhibitory activity …

Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.

Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced …

IT-901 is an orally active and effective inhibitor of NF-κB subunit c-Rel (IC50s: 0.1 μM, …

TAT 14, a 14-mer peptide, is an Nrf2 activator with anti-inflammatory properties. TAT-14 increases Nrf2 …

SN50 is a cell permeable NF-κB translocation inhibitor.

Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in …

(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen and inhibits NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory and …

GSK319347A is a TBK1 and IKKε dual inhibitor (IC50s: 93 nM and 469 nM, respectively). …

Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, …

11-Hydroxytephrosin inhibits NF-kappaB activity.

TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).

Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced …

DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.

Physalin O possesses anti-inflammatory activity, it exhibited conjugating abilities with GSH and also showed significant …

Isosalvianolic acid B is a natural from Salviae miltiorrhizae

Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant …

Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than …

Dunnianol shows anti-inflammatory activity and moderate antibacterial activity.

Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.

BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.

Narasin induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells …

Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a …

Andrographolide is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of …

B022 is an inhibitor of NF-κB-inducing kinase (NIK) (Ki: 4.2 nM). B022 protects liver from …

IKK-IN-1 is an inhibitor of IKK.

Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of …

Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays …

Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and …

Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and …

SC75741 is a potent P65 inhibitor with IC50 of 200 nM

Schisantherin A is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been …

QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of …

Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.

Polydatin, the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The …