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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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  • Peficitinib
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    Peficitinib

    CAS:
    <p>Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.</p>
    Formula:C18H22N4O2
    Purity:98.67% - 99.4%
    Color and Shape:Solid
    Molecular weight:326.39

    Ref: TM-T6933

  • Protosappanin A
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    Protosappanin A

    CAS:
    <p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>
    Formula:C15H12O5
    Purity:99.42% - 99.82%
    Color and Shape:Solid
    Molecular weight:272.25

    Ref: TM-TJS1779

  • Momelotinib HCl
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    Momelotinib HCl

    CAS:
    <p>Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.</p>
    Formula:C23H24Cl2N6O2
    Color and Shape:Solid
    Molecular weight:487.38

    Ref: TM-T70823

  • Pacritinib hydrochloride
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    Pacritinib hydrochloride

    CAS:
    <p>Pacritinib HCl: strong JAK2/Wild-type &amp; JAK2V617F inhibitor (IC50: 23/19 nM), used in AML &amp; MF research.</p>
    Formula:C28H32N4O3·xClH
    Color and Shape:Solid

    Ref: TM-T64283

  • FM-381
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    FM-381

    CAS:
    <p>FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.</p>
    Formula:C24H24N6O2
    Purity:98.44%
    Color and Shape:Solid
    Molecular weight:428.49

    Ref: TM-T5091

  • Tofacitinib Citrate
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    Tofacitinib Citrate

    CAS:
    <p>Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).</p>
    Formula:C22H28N6O8
    Purity:99.19% - 99.75%
    Color and Shape:Solid
    Molecular weight:504.49

    Ref: TM-T2398

  • SHR0302
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    SHR0302

    CAS:
    <p>SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,</p>
    Formula:C18H22N8O2S
    Purity:99.11%
    Color and Shape:Solid
    Molecular weight:414.48

    Ref: TM-T9195

  • Gusacitinib HCl
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    Gusacitinib HCl

    CAS:
    <p>Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.</p>
    Formula:C24H29ClN8O2
    Color and Shape:Solid
    Molecular weight:497

    Ref: TM-T69766

  • Ruxolitinib (S enantiomer)
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    Ruxolitinib (S enantiomer)

    CAS:
    <p>Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.</p>
    Formula:C17H18N6
    Purity:99.37% - 99.79%
    Color and Shape:Solid
    Molecular weight:306.36

    Ref: TM-T6156

  • Abrocitinib
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    Abrocitinib

    CAS:
    <p>Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).</p>
    Formula:C14H21N5O2S
    Purity:99.09% - 99.91%
    Color and Shape:Solid
    Molecular weight:323.41

    Ref: TM-TQ0037

  • ZM39923 hydrochloride
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    ZM39923 hydrochloride

    CAS:
    <p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>
    Formula:C23H25NO·HCl
    Purity:98.05%
    Color and Shape:Solid
    Molecular weight:367.91

    Ref: TM-T6145

  • Ritlecitinib
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    Ritlecitinib

    CAS:
    <p>Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.</p>
    Formula:C15H19N5O
    Purity:98.82% - 99.92%
    Color and Shape:Solid
    Molecular weight:285.34

    Ref: TM-T5382

  • JAK3-IN-6
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    JAK3-IN-6

    CAS:
    <p>JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM</p>
    Formula:C19H18N4O3
    Purity:99.94% - 99.94%
    Color and Shape:Solid
    Molecular weight:350.37

    Ref: TM-T5492

  • Deucravacitinib
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    Deucravacitinib

    CAS:
    <p>Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.</p>
    Formula:C20H19D3N8O3
    Purity:98.52% - >99.99%
    Color and Shape:Solid
    Molecular weight:425.46

    Ref: TM-T14687

  • BD750
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    BD750

    CAS:
    <p>BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in</p>
    Formula:C14H13N3OS
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:271.34

    Ref: TM-T8546

  • TCS-PIM-1-4a
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    TCS-PIM-1-4a

    CAS:
    <p>SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).</p>
    Formula:C11H6F3NO2S
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:273.23

    Ref: TM-T4215

  • PF-06651600 malonate
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    PF-06651600 malonate

    CAS:
    <p>PF-06651600 is a potent and selective JAK3 inhibitor.</p>
    Formula:C18H23N5O5
    Color and Shape:Solid
    Molecular weight:389.41

    Ref: TM-T5382L

  • Upadacitinib
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    Upadacitinib

    CAS:
    <p>Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.</p>
    Formula:C17H19F3N6O
    Purity:98.96% - 99.94%
    Color and Shape:Solid
    Molecular weight:380.37

    Ref: TM-T7503

  • GLPG0634 analog
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    GLPG0634 analog

    CAS:
    <p>GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.</p>
    Formula:C23H18N6O2
    Purity:99.52% - >99.99%
    Color and Shape:Solid
    Molecular weight:410.43

    Ref: TM-T3076

  • Cerdulatinib
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    Cerdulatinib

    CAS:
    <p>Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.</p>
    Formula:C20H27N7O3S
    Purity:98.74% - 99.49%
    Color and Shape:Solid
    Molecular weight:445.54

    Ref: TM-T2487