JAK/STAT signaling
JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.
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Products of "JAK/STAT signaling"
S-Ruxolitinib
CAS:1160597-27-2
S-Ruxolitinib can be used in related research in the field of life sciences. Its product …
Formula:
C17H18N6
Purity:
98%
Color and Shape:
Solid
Molecular weight:
306.37
Ref: TM-T3066
| 2mg | 48.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Ifidancitinib
CAS:1236667-40-5
Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.
Formula:
C20H18FN5O3
Purity:
98.05%
Color and Shape:
Liquid
Molecular weight:
395.39
Ref: TM-T38623
| 1mg | 143.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Momelotinib sulfate
CAS:1056636-06-6
Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity …
Formula:
C23H26N6O10S2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
610.62
Ref: TM-T15038
| 2mg | 50.00 € | ||
| 5mg | 84.00 € | ||
| 1mL*10mM (DMSO) | 110.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
(2R)-Octyl-α-hydroxyglutarate
CAS:1391194-67-4
(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.
Formula:
C13H24O5
Color and Shape:
Solid
Molecular weight:
260.33
Ref: TM-T19611
| 2mg | 91.00 € | ||
| 1mL*10mM (DMSO) | 130.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Cerdulatinib hydrochloride
CAS:1369761-01-2
Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others …
Formula:
C20H28ClN7O3S
Purity:
99.23%
Color and Shape:
Solid
Molecular weight:
482
Ref: TM-T6104
| 2mg | 36.00 € | ||
| 5mg | 56.00 € | ||
| 10mg | 75.00 € | ||
| 25mg | 115.00 € | ||
| 50mg | 171.00 € | ||
| 100mg | 254.00 € | ||
| 200mg | 360.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CX-6258 hydrochloride
CAS:1353859-00-3
CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 …
Formula:
C26H24ClN3O3·HCl
Purity:
96.03% - 98.00%
Color and Shape:
Solid
Molecular weight:
498.4
Ref: TM-T6148
| 1mg | 42.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 125.00 € | ||
| 25mg | 232.00 € | ||
| 50mg | 371.00 € | ||
| 100mg | 559.00 € | ||
| 200mg | 794.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CHZ868
CAS:1895895-38-1
CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence …
Formula:
C22H19F2N5O2
Purity:
99.38%
Color and Shape:
Solid
Molecular weight:
423.42
Ref: TM-TQ0061
| 2mg | 72.00 € | ||
| 5mg | To inquire |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Pim-1/2 kinase inhibitor 1
CAS:6320-51-0
Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.
Formula:
C11H9NO3S
Purity:
99.89%
Color and Shape:
Solid
Molecular weight:
235.26
Ref: TM-T9229
| 1mg | 40.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 122.00 € | ||
| 25mg | 237.00 € | ||
| 50mg | 369.00 € | ||
| 100mg | 553.00 € | ||
| 500mg | 1,160.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
GS-829845
CAS:1257705-09-1
GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which …
Formula:
C17H19N5O2S
Purity:
99.78%
Color and Shape:
Liquid
Molecular weight:
357.43
Ref: TM-T67905
| 5mg | 46.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 92.00 € | ||
| 50mg | 123.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
DTP3
CAS:1809784-29-9
DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
Formula:
C26H35N7O5
Color and Shape:
Solid
Molecular weight:
525.6
Ref: TM-T22319
| 2mg | 82.00 € | ||
| 5mg | 124.00 € | ||
| 10mg | 214.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TCS-PIM-1-4a
CAS:327033-36-3
SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).
Formula:
C11H6F3NO2S
Purity:
99.89%
Color and Shape:
Solid
Molecular weight:
273.23
Ref: TM-T4215
| 5mg | 51.00 € | ||
| 10mg | 75.00 € | ||
| 25mg | 122.00 € | ||
| 50mg | 210.00 € | ||
| 100mg | 315.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
SHR0302
CAS:1445987-21-2
SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity …
Formula:
C18H22N8O2S
Purity:
99.11%
Color and Shape:
Solid
Molecular weight:
414.48
Ref: TM-T9195
| 1mg | 157.00 € | ||
| 5mg | 384.00 € | ||
| 10mg | 606.00 € | ||
| 25mg | 1,012.00 € | ||
| 50mg | 1,447.00 € | ||
| 100mg | 1,837.00 € | ||
| 1mL*10mM (DMSO) | 445.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
ZM39923 hydrochloride
CAS:1021868-92-7
ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and …
Formula:
C23H25NO·HCl
Purity:
98.05%
Color and Shape:
Solid
Molecular weight:
367.91
Ref: TM-T6145
| 5mg | 58.00 € | ||
| 10mg | 93.00 € | ||
| 25mg | 168.00 € | ||
| 50mg | 304.00 € | ||
| 100mg | 455.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
Peficitinib
CAS:944118-01-8
Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.
Formula:
C18H22N4O2
Purity:
98.67% - 99.4%
Color and Shape:
Solid
Molecular weight:
326.39
Ref: TM-T6933
| 2mg | 40.00 € | ||
| 5mg | 64.00 € | ||
| 10mg | 101.00 € | ||
| 25mg | 176.00 € | ||
| 50mg | 272.00 € | ||
| 100mg | 424.00 € | ||
| 200mg | 634.00 € | ||
| 1mL*10mM (DMSO) | 73.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
Protosappanin A
CAS:102036-28-2
Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV …
Formula:
C15H12O5
Purity:
100% - 99.42%
Color and Shape:
Solid
Molecular weight:
272.25
Ref: TM-TJS1779
| 1mg | 96.00 € | ||
| 5mg | 212.00 € | ||
| 10mg | 346.00 € | ||
| 25mg | 569.00 € | ||
| 50mg | 807.00 € | ||
| 100mg | 1,086.00 € | ||
| 1mL*10mM (DMSO) | 193.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
AG490
CAS:133550-30-8
AG490 inhibits EGFR (0.1 μM IC50), 135x >selective than ErbB2, blocks JAK2, spares Lyn, Lck, …
Formula:
C17H14N2O3
Purity:
98.6% - 99.7%
Color and Shape:
Yellow Solid
Molecular weight:
294.3
Ref: TM-T2600
| 10mg | 55.00 € | ||
| 25mg | 74.00 € | ||
| 50mg | 90.00 € | ||
| 100mg | 100.00 € | ||
| 200mg | 162.00 € | ||
| 500mg | 278.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
BMS-911543
CAS:1271022-90-2
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, …
Formula:
C23H28N8O
Purity:
97.69% - 99.98%
Color and Shape:
Solid
Molecular weight:
432.52
Ref: TM-T6790
| 1mg | 56.00 € | ||
| 2mg | 78.00 € | ||
| 5mg | 114.00 € | ||
| 10mg | 181.00 € | ||
| 25mg | 372.00 € | ||
| 50mg | 557.00 € | ||
| 1mL*10mM (DMSO) | 110.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
FM-381
CAS:2226521-65-7
FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.
Formula:
C24H24N6O2
Purity:
99.33%
Color and Shape:
Solid
Molecular weight:
428.49
Ref: TM-T5091
| 1mg | 52.00 € | ||
| 5mg | 110.00 € | ||
| 10mg | 157.00 € | ||
| 25mg | 315.00 € | ||
| 50mg | 458.00 € | ||
| 100mg | 672.00 € | ||
| 1mL*10mM (DMSO) | 123.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
Deucravacitinib
CAS:1609392-27-9
Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.
Formula:
C20H19D3N8O3
Purity:
100% - 99.43%
Color and Shape:
Solid
Molecular weight:
425.46
Ref: TM-T14687
| 1mg | 69.00 € | ||
| 5mg | 149.00 € | ||
| 10mg | 269.00 € | ||
| 25mg | 425.00 € | ||
| 50mg | 625.00 € | ||
| 100mg | 892.00 € | ||
| 200mg | 1,205.00 € | ||
| 500mg | 1,784.00 € | ||
| 1mL*10mM (DMSO) | 165.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
Momelotinib
CAS:1056634-68-4
Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT …
Formula:
C23H22N6O2
Purity:
97.47% - 99.56%
Color and Shape:
Solid
Molecular weight:
414.46
Ref: TM-T1849
| 1mg | 38.00 € | ||
| 2mg | 49.00 € | ||
| 5mg | 80.00 € | ||
| 10mg | 93.00 € | ||
| 25mg | 163.00 € | ||
| 50mg | 254.00 € | ||
| 100mg | 399.00 € | ||
| 200mg | 612.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
