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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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  • CymitQuimica logo
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    CMD178

    <p>CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.</p>
    Formula:C46H59N9O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:850.03

    Ref: TM-TP1770

  • STAT3 degrader-1
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    STAT3 degrader-1

    CAS:
    <p>STAT3 Degrader-1 (Compound 295) is a potent degrader of STAT3, utilized in anticancer research [1].</p>
    Formula:C58H63F5N9O12PS
    Color and Shape:Solid
    Molecular weight:1236.2

    Ref: TM-T74545

  • R8-T198wt
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    R8-T198wt

    CAS:
    <p>Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.</p>
    Formula:C111H211N59O26S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2820.33

    Ref: TM-TP2128

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    JAK3-IN-15

    <p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200631

  • SJ988497
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    SJ988497

    CAS:
    <p>SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.</p>
    Formula:C36H36N10O5
    Color and Shape:Solid
    Molecular weight:688.74

    Ref: TM-T74994

  • S-Ruxolitinib
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    S-Ruxolitinib

    CAS:
    <p>S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.</p>
    Formula:C17H18N6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:306.37

    Ref: TM-T3066

  • WDR5 ligand 2
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    WDR5 ligand 2

    CAS:
    <p>WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.</p>
    Formula:C29H31F3N4O4
    Color and Shape:Solid
    Molecular weight:556.576

    Ref: TM-T205322

  • CymitQuimica logo
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    JAK1/STAT3-IN-1

    <p>JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).</p>
    Formula:C30H33FN4O3S
    Color and Shape:Solid
    Molecular weight:548.67

    Ref: TM-T205385

  • CymitQuimica logo
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    STAT4-IN-1

    <p>STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206598

  • CymitQuimica logo
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    AK-2292

    <p>AK-2292: potent STAT5 PROTAC degrader, DC50 0.10 μM, degrades STAT5A/B, may shrink leukemia tumors in mice.</p>
    Formula:C52H54F2N7O10PS2
    Color and Shape:Solid
    Molecular weight:1070.13

    Ref: TM-T74749

  • CymitQuimica logo
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    TYD-68

    <p>TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206972

  • JAK-IN-15
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    JAK-IN-15

    CAS:
    <p>JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).</p>
    Formula:C22H23FN4O3S
    Color and Shape:Solid
    Molecular weight:442.51

    Ref: TM-T39400

  • CymitQuimica logo
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    STAT5-IN-3

    <p>STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.</p>
    Formula:C25H27N5O
    Color and Shape:Solid
    Molecular weight:413.51

    Ref: TM-T205367

  • Axltide
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    Axltide

    CAS:
    <p>Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.</p>
    Formula:C63H107N19O20S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1514.77

    Ref: TM-TP1713

  • JAK-STAT Compound Library
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    JAK-STAT Compound Library

    <p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>
    Color and Shape:Odour Solid

    Ref: TM-L3700

  • FDA-Approved Kinase Inhibitor Library
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    FDA-Approved Kinase Inhibitor Library

    <p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>
    Color and Shape:Liquid

    Ref: TM-L1610

  • Fulipiftide
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    Fulipiftide

    CAS:
    <p>Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.</p>
    Formula:C144H227N41O47
    Color and Shape:Solid
    Molecular weight:3284.59

    Ref: TM-TP3262

  • PM-81I
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    PM-81I

    CAS:
    <p>PM-81I: Potent STAT6 inhibitor for allergic and pulmonary conditions, cancer research. Reduces STAT6 phosphorylation.</p>
    Formula:C43H58F2N3O10P
    Color and Shape:Solid
    Molecular weight:845.91

    Ref: TM-T74646

  • Povorcitinib phosphate
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    Povorcitinib phosphate

    CAS:
    <p>Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.</p>
    Formula:C23H25F5N7O5P
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:605.45

    Ref: TM-T39113L

  • Kinase Inhibitor Library
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    Kinase Inhibitor Library

    <p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>
    Color and Shape:Odour Solid

    Ref: TM-L1600