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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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    JAK3-IN-15

    <p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200631

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    TYD-68

    <p>TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206972

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    Pim-1 kinase inhibitor 11

    <p>Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200676

  • Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
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    Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)

    CAS:
    <p>Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.</p>
    Formula:C88H138N20O34P2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2082.1

    Ref: TM-TP1269

  • JAK-IN-15
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    JAK-IN-15

    CAS:
    <p>JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).</p>
    Formula:C22H23FN4O3S
    Color and Shape:Solid
    Molecular weight:442.51

    Ref: TM-T39400

  • R8-T198wt
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    R8-T198wt

    CAS:
    <p>Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.</p>
    Formula:C111H211N59O26S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2820.33

    Ref: TM-TP2128

  • FDA-Approved Kinase Inhibitor Library
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    FDA-Approved Kinase Inhibitor Library

    <p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>
    Color and Shape:Liquid

    Ref: TM-L1610

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    AK-2292

    <p>AK-2292: potent STAT5 PROTAC degrader, DC50 0.10 μM, degrades STAT5A/B, may shrink leukemia tumors in mice.</p>
    Formula:C52H54F2N7O10PS2
    Color and Shape:Solid
    Molecular weight:1070.13

    Ref: TM-T74749

  • S-Ruxolitinib
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    S-Ruxolitinib

    CAS:
    <p>S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.</p>
    Formula:C17H18N6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:306.37

    Ref: TM-T3066

  • JAK1/TYK2-IN-1
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    JAK1/TYK2-IN-1

    CAS:
    <p>JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).</p>
    Formula:C18H20F3N7O
    Color and Shape:Solid
    Molecular weight:407.401

    Ref: TM-T39314

  • Kinase Inhibitor Library
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    Kinase Inhibitor Library

    <p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>
    Color and Shape:Odour Solid

    Ref: TM-L1600

  • SJ10542
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    SJ10542

    CAS:
    <p>SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.</p>
    Formula:C41H46N12O5S
    Color and Shape:Solid
    Molecular weight:818.95

    Ref: TM-T74429

  • SJ1008030
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    SJ1008030

    CAS:
    <p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>
    Formula:C42H43N13O7S
    Color and Shape:Solid
    Molecular weight:873.94

    Ref: TM-T74580

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    TYK2 activator-1

    <p>TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.</p>
    Formula:C23H21FN4O2
    Color and Shape:Solid
    Molecular weight:404.16485

    Ref: TM-T207637

  • PM-81I
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    PM-81I

    CAS:
    <p>PM-81I: Potent STAT6 inhibitor for allergic and pulmonary conditions, cancer research. Reduces STAT6 phosphorylation.</p>
    Formula:C43H58F2N3O10P
    Color and Shape:Solid
    Molecular weight:845.91

    Ref: TM-T74646

  • STAT3 degrader-1
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    STAT3 degrader-1

    CAS:
    <p>STAT3 Degrader-1 (Compound 295) is a potent degrader of STAT3, utilized in anticancer research [1].</p>
    Formula:C58H63F5N9O12PS
    Color and Shape:Solid
    Molecular weight:1236.2

    Ref: TM-T74545

  • Tyrosine Kinase Inhibitor Library
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    Tyrosine Kinase Inhibitor Library

    <p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>
    Color and Shape:Odour Solid

    Ref: TM-L2200

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    STAT4-IN-1

    <p>STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206598

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    CMD178

    <p>CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.</p>
    Formula:C46H59N9O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:850.03

    Ref: TM-TP1770

  • PROTAC STAT3 degrader-2
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    PROTAC STAT3 degrader-2

    CAS:
    <p>PROTAC STAT3 degrader-2 selectively breaks down STAT3 (DC50: 3.54μM, Molm-16) with cancer research potential.</p>
    Formula:C59H60F2N9O13P
    Color and Shape:Solid
    Molecular weight:1172.13

    Ref: TM-T75099