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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 322 products of "JAK/STAT signaling"

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  • WP1066
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    WP1066

    CAS:
    <p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>
    Formula:C17H14BrN3O
    Purity:98.92% - 99.73%
    Color and Shape:Solid
    Molecular weight:356.22

    Ref: TM-T2156

  • TP-3654
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    TP-3654

    CAS:
    <p>TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).</p>
    Formula:C22H25F3N4O
    Purity:99.8% - 99.95%
    Color and Shape:Solid
    Molecular weight:418.46

    Ref: TM-T4523

  • Protosappanin A
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    Protosappanin A

    CAS:
    <p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>
    Formula:C15H12O5
    Purity:99.42% - 99.82%
    Color and Shape:Solid
    Molecular weight:272.25

    Ref: TM-TJS1779

  • BD750
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    BD750

    CAS:
    <p>BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in</p>
    Formula:C14H13N3OS
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:271.34

    Ref: TM-T8546

  • Peficitinib
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    Peficitinib

    CAS:
    <p>Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.</p>
    Formula:C18H22N4O2
    Purity:98.67% - 99.4%
    Color and Shape:Solid
    Molecular weight:326.39

    Ref: TM-T6933

  • ZM39923 hydrochloride
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    ZM39923 hydrochloride

    CAS:
    <p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>
    Formula:C23H25NO·HCl
    Purity:98.05%
    Color and Shape:Solid
    Molecular weight:367.91

    Ref: TM-T6145

  • SHR0302
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    SHR0302

    CAS:
    <p>SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,</p>
    Formula:C18H22N8O2S
    Purity:99.11%
    Color and Shape:Solid
    Molecular weight:414.48

    Ref: TM-T9195

  • Napabucasin
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    Napabucasin

    CAS:
    <p>Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.</p>
    Formula:C14H8O4
    Purity:98.43% - 99.85%
    Color and Shape:Solid
    Molecular weight:240.21

    Ref: TM-T3218

  • Golotimod
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    Golotimod

    CAS:
    Golotimod (SCV 07) is an antimicrobial active dipeptide with immunomodulatory activity for the study of recurrent genital herpes simplex virus 2 infections.
    Formula:C16H19N3O5
    Purity:99.88% - 99.98%
    Color and Shape:Solid
    Molecular weight:333.34

    Ref: TM-T11449L

  • GS-829845
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    GS-829845

    CAS:
    <p>GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life</p>
    Formula:C17H19N5O2S
    Purity:99.93%
    Color and Shape:Solid
    Molecular weight:357.43

    Ref: TM-T67905

  • Cerdulatinib hydrochloride
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    Cerdulatinib hydrochloride

    CAS:
    <p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 &lt; 200 nM.</p>
    Formula:C20H28ClN7O3S
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:482

    Ref: TM-T6104

  • CX-6258 hydrochloride
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    CX-6258 hydrochloride

    CAS:
    <p>CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).</p>
    Formula:C26H24ClN3O3·HCl
    Purity:96.03% - 98.60%
    Color and Shape:Solid
    Molecular weight:498.4

    Ref: TM-T6148

  • NVP-BSK805
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    NVP-BSK805

    CAS:
    NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.
    Formula:C27H28F2N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:490.55

    Ref: TM-T5049

  • CymitQuimica logo
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    Solrikitug

    CAS:
    <p>Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.</p>
    Purity:95%
    Color and Shape:Liquid

    Ref: TM-T9901A-527

  • ZM39923
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    ZM39923

    CAS:
    <p>ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).</p>
    Formula:C23H25NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:331.45

    Ref: TM-T17295

  • TLC1566-0618
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    TLC1566-0618

    CAS:
    <p>TLC1566-0618 shows antitumor activity and targets stat.</p>
    Formula:C20H15NO3S3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:413.53

    Ref: TM-T121011

  • Golotimod TFA
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    Golotimod TFA

    CAS:
    <p>Golotimod TFA (SCV 07 TFA) is a dipeptide exhibiting immunomodulatory and antibacterial activity, alleviates radiation-induced oral mucositis.</p>
    Formula:C18H20F3N3O7
    Purity:98%
    Color and Shape:Soild
    Molecular weight:447.36

    Ref: TM-T11449L2

  • (3S,4S)-Tofacitinib
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    (3S,4S)-Tofacitinib

    CAS:
    <p>(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.</p>
    Formula:C16H20N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:312.37

    Ref: TM-T13426L

  • SD-1029
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    SD-1029

    CAS:
    <p>SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.</p>
    Formula:C25H32Br2Cl2N2O3
    Color and Shape:Solid
    Molecular weight:639.25

    Ref: TM-T24774

  • K00135
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    K00135

    CAS:
    <p>K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.</p>
    Formula:C18H18N4O
    Purity:98.16%
    Color and Shape:Solid
    Molecular weight:306.36

    Ref: TM-T27704