STAT
STAT proteins are critical components of the JAK/STAT signaling pathway, which transmits extracellular signals from cytokines and growth factors to the cell nucleus, influencing gene expression. STAT proteins are involved in regulating immune responses, cell growth, differentiation, and survival. Dysregulation of STAT signaling is implicated in various diseases, including cancer, autoimmune disorders, and chronic inflammation. At CymitQuimica, we provide a comprehensive range of STAT pathway modulators to support your research in signal transduction, immunology, and therapeutic development.
Found 98 products of "STAT"
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Artesunate
CAS:<p>Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.</p>Formula:C19H28O8Purity:97.67% - 99.9%Color and Shape:White Crystalline PowderMolecular weight:384.42Fludarabine
CAS:<p>Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.</p>Formula:C10H12FN5O4Purity:99.65% - 99.89%Color and Shape:White SolidMolecular weight:285.23STAT3-IN-1
CAS:<p>STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor</p>Formula:C28H29NO6Purity:95.89% - 95.89%Color and Shape:SolidMolecular weight:475.53Diosgenin
CAS:<p>Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.</p>Formula:C27H42O3Purity:98.87% - 99.87%Color and Shape:Flaky Or Needle CrystalMolecular weight:414.62L002
CAS:<p>L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.</p>Formula:C15H15NO5SPurity:98.59%Color and Shape:SolidMolecular weight:321.35Nifuroxazide
CAS:<p>Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.</p>Formula:C12H9N3O5Purity:99.79% - 99.95%Color and Shape:Yellow SolidMolecular weight:275.22Niclosamide olamine
CAS:<p>Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.</p>Formula:C15H15Cl2N3O5Purity:99.89%Color and Shape:Bright Yellow Crystalline Physical Description Yellow Solid Insoluble In Water (Ntp 1992)Molecular weight:388.20UC-514321
CAS:<p>UC-514321 directly targets STAT3/5 and represses TET1 expression.</p>Formula:C26H35NO5Purity:98.50%Color and Shape:SolidMolecular weight:441.56Garcinone C
CAS:<p>Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.</p>Formula:C23H26O7Purity:99.13% - 99.92%Color and Shape:SolidMolecular weight:414.45Niclosamide
CAS:<p>Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.</p>Formula:C13H8Cl2N2O4Purity:98.47% - 99.1%Color and Shape:Pale Yellow Crystals SolidMolecular weight:327.12STAT3-IN-41
<p>STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.</p>Formula:C22H30F3NO7Color and Shape:SolidMolecular weight:477.471Eflepedocokin alfa
CAS:<p>Eflepedocokin alfa is a recombinant IL-22/IgG2-Fc protein, potentially protecting cells and enhancing immune function and tissue repair.</p>Color and Shape:LiquidSTAT4-IN-1
<p>STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.</p>Color and Shape:Odour SolidNeocucurbitacin A
CAS:<p>Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].</p>Formula:C31H42O8Purity:98%Color and Shape:SolidMolecular weight:542.66STAT3-IN-39
CAS:<p>STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.</p>Formula:C20H17F3N2O3SColor and Shape:SolidMolecular weight:422.42(R)-Lisofylline
CAS:<p>(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).</p>Formula:C13H20N4O3Purity:99.50%Color and Shape:SolidMolecular weight:280.32JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Color and Shape:Odour SolidSTAT3 HiBiT degrader 1
CAS:<p>STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.</p>Formula:C58H63F4N10O14PSColor and Shape:SolidMolecular weight:1263.21Anticancer agent 259
<p>Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.</p>Formula:C30H26N2O2Color and Shape:SolidMolecular weight:446.54CMD178
<p>CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.</p>Formula:C46H59N9O7Purity:98%Color and Shape:SolidMolecular weight:850.03STAT3-IN-37
CAS:<p>STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.</p>Formula:C23H25Cl2N5O2Color and Shape:SolidMolecular weight:474.38Eupalinolide K
CAS:<p>Eupalinolide K is a natural product</p>Formula:C20H26O6Purity:98%Color and Shape:SolidMolecular weight:362.42STAT5-IN-3
<p>STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.</p>Formula:C25H27N5OColor and Shape:SolidMolecular weight:413.51STX-0119
CAS:<p>STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.</p>Formula:C22H14N4O3Purity:99.61%Color and Shape:SolidMolecular weight:382.37STAT3-IN-31
<p>STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).</p>Formula:C16H15NO3SColor and Shape:SolidMolecular weight:301.36STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Formula:C19H16N2O4SColor and Shape:SolidMolecular weight:368.41MNK8
CAS:<p>MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.</p>Formula:C15H12N2O2Purity:99.74%Color and Shape:SolidMolecular weight:252.27Stafib-1
CAS:<p>Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.</p>Formula:C26H24N2O11P2Purity:97.18%Color and Shape:SolidMolecular weight:602.42Balsalazide
CAS:<p>Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.</p>Formula:C17H15N3O6Purity:99.31%Color and Shape:Yellow To Orange Crystalline PowderMolecular weight:357.32SC-43
CAS:<p>SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).</p>Formula:C21H13ClF3N3O2Purity:98.44%Color and Shape:SolidMolecular weight:431.8SH-4-54
CAS:<p>SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.</p>Formula:C29H27F5N2O5SPurity:98% - 99.12%Color and Shape:SolidMolecular weight:610.59SC99
CAS:<p>SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.</p>Formula:C15H8Cl2FN3OPurity:99.56%Color and Shape:SolidMolecular weight:336.15Pimozide
CAS:<p>Pimozide: antipsychotic that blocks type 2 dopamine, alpha-adrenergic, and 5-HT2 receptors, reducing tics and delusions.</p>Formula:C28H29F2N3OPurity:99.63% - >99.99%Color and Shape:SolidMolecular weight:461.55WP1066
CAS:<p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>Formula:C17H14BrN3OPurity:98.92% - 99.73%Color and Shape:SolidMolecular weight:356.22Cucurbitacin I
CAS:<p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>Formula:C30H42O7Purity:96.69% - 99.8%Color and Shape:SolidMolecular weight:514.65RSVA405
CAS:<p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>Formula:C17H20N4O2Purity:99.30%Color and Shape:SolidMolecular weight:312.37Cryptotanshinone
CAS:<p>Cryptotanshinone: STAT3 inhibitor, IC50 4.6 μM; blocks STAT3 Tyr705 phosphorylation, minor effect on Ser727, no impact on STAT1/5.</p>Formula:C19H20O3Purity:97.94% - ≥95%Color and Shape:Orange Needle CrystalMolecular weight:296.36Scutellarin
CAS:<p>Scutellarin from Scutellaria inhibits RANKL in osteoclasts and STAT3/Girdin/Akt in HCC cells.</p>Formula:C21H18O12Purity:97.12% - 99.75%Color and Shape:SolidMolecular weight:462.36Brevilin A
CAS:<p>Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.</p>Formula:C20H26O5Purity:99.97% - >99.99%Color and Shape:SolidMolecular weight:346.42AS2863619
CAS:<p>AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.</p>Formula:C16H14Cl2N8OPurity:>99.99%Color and Shape:SolidMolecular weight:405.24Atranorin
CAS:<p>Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.</p>Formula:C19H18O8Purity:98.76% - 99.57%Color and Shape:SolidMolecular weight:374.34HO-3867
CAS:<p>HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.</p>Formula:C28H30F2N2O2Purity:91.18% - 99.21%Color and Shape:SolidMolecular weight:464.55S3I-201
CAS:<p>S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.</p>Formula:C16H15NO7SPurity:97.83%Color and Shape:SolidMolecular weight:365.36Morusin
CAS:<p>Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.</p>Formula:C25H24O6Purity:98.68% - 99.8%Color and Shape:SolidMolecular weight:420.45STAT5-IN-1
CAS:<p>STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.</p>Formula:C16H11N3O3Purity:99.44% - ≥95%Color and Shape:SolidMolecular weight:293.28Napabucasin
CAS:<p>Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.</p>Formula:C14H8O4Purity:98.43% - 99.85%Color and Shape:SolidMolecular weight:240.21Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Formula:C19H24O5Purity:96.66%Color and Shape:SolidMolecular weight:332.39Garcinone D
CAS:<p>Garcinone D is cytotoxic to CEM-SS cells (IC50=3.2 µg/ml), inhibits aromatase and p65 activation (IC50=3.2 µM).</p>Formula:C24H28O7Purity:99.94%Color and Shape:SolidMolecular weight:428.47Triacetylresveratrol
CAS:<p>Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.</p>Formula:C20H18O6Purity:99.81%Color and Shape:Off White PowderMolecular weight:354.35HJC0152 hydrochloride
CAS:<p>HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.</p>Formula:C15H14Cl3N3O4Purity:99.01% - 99.06%Color and Shape:SolidMolecular weight:406.64
