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JAK

JAK

JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.

Found 245 products of "JAK"

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  • XL019
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    XL019

    CAS:
    <p>XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.</p>
    Formula:C25H28N6O2
    Purity:99.19%
    Color and Shape:Solid
    Molecular weight:444.53

    Ref: TM-T3072

  • 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
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    2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

    CAS:
    <p>2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.</p>
    Formula:C16H13Cl2N3O2
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:350.2

    Ref: TM-T22338

  • Cerdulatinib
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    Cerdulatinib

    CAS:
    <p>Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.</p>
    Formula:C20H27N7O3S
    Purity:98.74% - 99.49%
    Color and Shape:Solid
    Molecular weight:445.54

    Ref: TM-T2487

  • Protosappanin A
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    Protosappanin A

    CAS:
    <p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>
    Formula:C15H12O5
    Purity:99.42% - 99.82%
    Color and Shape:Solid
    Molecular weight:272.25

    Ref: TM-TJS1779

  • AMG-47a
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    AMG-47a

    CAS:
    <p>AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.</p>
    Formula:C29H28F3N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:535.56

    Ref: TM-T7123

  • Decernotinib
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    Decernotinib

    CAS:
    <p>Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.</p>
    Formula:C18H19F3N6O
    Purity:99.28% - >99.99%
    Color and Shape:Solid
    Molecular weight:392.38

    Ref: TM-T2636

  • G5-7
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    G5-7

    CAS:
    <p>G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.</p>
    Formula:C22H19F2NO3
    Purity:97.3%
    Color and Shape:Solid
    Molecular weight:383.39

    Ref: TM-T8742

  • (E/Z)-Zotiraciclib
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    (E/Z)-Zotiraciclib

    CAS:
    <p>(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.</p>
    Formula:C23H24N4O
    Purity:97.75% - 99.92%
    Color and Shape:Solid
    Molecular weight:372.46

    Ref: TM-T21503

  • FLLL32
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    FLLL32

    CAS:
    <p>FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of &lt;5 μM).</p>
    Formula:C28H32O6
    Purity:97% - 97.90%
    Color and Shape:Solid
    Molecular weight:464.55

    Ref: TM-T6838

  • AG490
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    AG490

    CAS:
    <p>AG490 inhibits EGFR (0.1 μM IC50), 135x &gt; selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>
    Formula:C17H14N2O3
    Purity:98.6% - 99.39%
    Color and Shape:Yellow Solid
    Molecular weight:294.3

    Ref: TM-T2600

  • GDC-0214
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    GDC-0214

    CAS:
    <p>GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).</p>
    Formula:C28H28ClF2N9O3
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:612.03

    Ref: TM-T9826

  • Baricitinib
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    Baricitinib

    CAS:
    <p>Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.</p>
    Formula:C16H17N7O2S
    Purity:99% - >99.99%
    Color and Shape:Solid
    Molecular weight:371.42

    Ref: TM-T2485

  • Peficitinib
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    Peficitinib

    CAS:
    <p>Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.</p>
    Formula:C18H22N4O2
    Purity:98.67% - 99.4%
    Color and Shape:Solid
    Molecular weight:326.39

    Ref: TM-T6933

  • Pyridone 6
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    Pyridone 6

    CAS:
    <p>Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).</p>
    Formula:C18H16FN3O
    Purity:97.1% - 98.74%
    Color and Shape:Solid
    Molecular weight:309.34

    Ref: TM-T3080

  • WHI-P97
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    WHI-P97

    CAS:
    <p>WHI-P97 is a rationally designed potent inhibitor of JAK-3.</p>
    Formula:C16H13Br2N3O3
    Purity:99.93%
    Color and Shape:Solid
    Molecular weight:455.1

    Ref: TM-T4657

  • JANEX-1
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    JANEX-1

    CAS:
    <p>JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.</p>
    Formula:C16H15N3O3
    Purity:98% - 99.81%
    Color and Shape:Solid
    Molecular weight:297.31

    Ref: TM-T2045

  • WP1066
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    WP1066

    CAS:
    <p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>
    Formula:C17H14BrN3O
    Purity:98.92% - 99.73%
    Color and Shape:Solid
    Molecular weight:356.22

    Ref: TM-T2156

  • Fedratinib hydrochloride hydrate
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    Fedratinib hydrochloride hydrate

    CAS:
    <p>Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.</p>
    Formula:C27H40Cl2N6O4S
    Purity:98.96% - 99.87%
    Color and Shape:Solid
    Molecular weight:615.61

    Ref: TM-T9251

  • AZ960
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    AZ960

    CAS:
    <p>AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: &lt;3 nM and0.45 nM).</p>
    Formula:C18H16F2N6
    Purity:96.02% - 98.51%
    Color and Shape:Solid
    Molecular weight:354.36

    Ref: TM-T6309

  • ZM39923 hydrochloride
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    ZM39923 hydrochloride

    CAS:
    <p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>
    Formula:C23H25NO·HCl
    Purity:98.05%
    Color and Shape:Solid
    Molecular weight:367.91

    Ref: TM-T6145

  • BMS-911543
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    BMS-911543

    CAS:
    <p>BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.</p>
    Formula:C23H28N8O
    Purity:97.69% - 99.98%
    Color and Shape:Solid
    Molecular weight:432.52

    Ref: TM-T6790

  • SAR-20347
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    SAR-20347

    CAS:
    <p>SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).</p>
    Formula:C21H18ClFN4O4
    Purity:98.99% - 99.77%
    Color and Shape:Solid
    Molecular weight:444.84

    Ref: TM-T4210

  • FM-381
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    FM-381

    CAS:
    <p>FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.</p>
    Formula:C24H24N6O2
    Purity:98.44%
    Color and Shape:Solid
    Molecular weight:428.49

    Ref: TM-T5091

  • TG101209
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    TG101209

    CAS:
    <p>TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.</p>
    Formula:C26H35N7O2S
    Purity:99% - >99.99%
    Color and Shape:Solid
    Molecular weight:509.67

    Ref: TM-T3065

  • Deucravacitinib
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    Deucravacitinib

    CAS:
    <p>Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.</p>
    Formula:C20H19D3N8O3
    Purity:98.52% - >99.99%
    Color and Shape:Solid
    Molecular weight:425.46

    Ref: TM-T14687

  • RO495
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    RO495

    CAS:
    <p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>
    Formula:C17H14Cl2N6O
    Purity:97.94%
    Color and Shape:Solid
    Molecular weight:389.24

    Ref: TM-T22416

  • SC99
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    SC99

    CAS:
    <p>SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.</p>
    Formula:C15H8Cl2FN3O
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:336.15

    Ref: TM-T8719

  • Brevilin A
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    Brevilin A

    CAS:
    <p>Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.</p>
    Formula:C20H26O5
    Purity:99.97% - >99.99%
    Color and Shape:Solid
    Molecular weight:346.42

    Ref: TM-T4672

  • Cerdulatinib hydrochloride
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    Cerdulatinib hydrochloride

    CAS:
    <p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 &lt; 200 nM.</p>
    Formula:C20H28ClN7O3S
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:482

    Ref: TM-T6104

  • GS-829845
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    GS-829845

    CAS:
    <p>GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life</p>
    Formula:C17H19N5O2S
    Purity:99.93%
    Color and Shape:Solid
    Molecular weight:357.43

    Ref: TM-T67905

  • NVP-BSK805
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    NVP-BSK805

    CAS:
    <p>NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.</p>
    Formula:C27H28F2N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:490.55

    Ref: TM-T5049

  • CymitQuimica logo
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    Solrikitug

    CAS:
    <p>Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.</p>
    Purity:95%
    Color and Shape:Liquid

    Ref: TM-T9901A-527

  • ZM39923
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    ZM39923

    CAS:
    <p>ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).</p>
    Formula:C23H25NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:331.45

    Ref: TM-T17295

  • (3S,4S)-Tofacitinib
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    (3S,4S)-Tofacitinib

    CAS:
    <p>(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.</p>
    Formula:C16H20N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:312.37

    Ref: TM-T13426L

  • SD-1029
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    SD-1029

    CAS:
    <p>SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.</p>
    Formula:C25H32Br2Cl2N2O3
    Color and Shape:Solid
    Molecular weight:639.25

    Ref: TM-T24774

  • JAK-IN-11
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    JAK-IN-11

    CAS:
    <p>JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.</p>
    Formula:C23H22FN5O4S
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:483.52

    Ref: TM-T12549

  • JAK-IN-20
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    JAK-IN-20

    CAS:
    <p>JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.</p>
    Formula:C28H30FN7O2
    Color and Shape:Solid
    Molecular weight:515.58

    Ref: TM-T63581

  • JAK-2/3-IN-2
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    JAK-2/3-IN-2

    CAS:
    <p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 &amp; JAK3 inhibitor with IC50s of 23.85 nM (JAK2) &amp; 18.9 nM (JAK3).</p>
    Formula:C19H19ClN2OS
    Color and Shape:Solid
    Molecular weight:358.89

    Ref: TM-T61323

  • Peficitinib hydrochloride
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    Peficitinib hydrochloride

    CAS:
    <p>Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).</p>
    Formula:C18H23ClN4O2
    Color and Shape:Solid
    Molecular weight:362.86

    Ref: TM-T61365

  • TK4b
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    TK4b

    CAS:
    <p>TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) &amp; 19.40 nM (JAK2).</p>
    Formula:C21H22N2O2
    Color and Shape:Solid
    Molecular weight:334.41

    Ref: TM-T61020

  • TK4g
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    TK4g

    CAS:
    <p>TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) &amp; 15.80 nM (JAK3); promising for lymphoid diseases &amp; leukemia research.</p>
    Formula:C19H19N3O4S
    Color and Shape:Solid
    Molecular weight:385.44

    Ref: TM-T61698

  • JAK-IN-14
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    JAK-IN-14

    CAS:
    <p>JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.</p>
    Formula:C19H15FN4O
    Purity:98.27%
    Color and Shape:Solid
    Molecular weight:334.35

    Ref: TM-T9764

  • TyK2-IN-2
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    TyK2-IN-2

    CAS:
    <p>TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).</p>
    Formula:C16H18N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:310.35

    Ref: TM-T13232

  • JAK-IN-18
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    JAK-IN-18

    CAS:
    <p>"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."</p>
    Formula:C27H28F2N6O3
    Color and Shape:Solid
    Molecular weight:522.55

    Ref: TM-T63658

  • JAK3-IN-12
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    JAK3-IN-12

    CAS:
    <p>JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.</p>
    Formula:C19H19N5O4S
    Color and Shape:Solid
    Molecular weight:413.45

    Ref: TM-T62114

  • Tyk2-IN-5
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    Tyk2-IN-5

    CAS:
    <p>Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).</p>
    Formula:C21H19FN8O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:434.43

    Ref: TM-T13234

  • EP009
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    EP009

    CAS:
    <p>EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies.</p>
    Formula:C14H24O2
    Color and Shape:Solid
    Molecular weight:224.34

    Ref: TM-T27274

  • Tyk2-IN-7
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    Tyk2-IN-7

    CAS:
    <p>Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).</p>
    Formula:C18H15D3N6O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:401.46

    Ref: TM-T13235

  • MS-1020
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    MS-1020

    CAS:
    <p>MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.</p>
    Formula:C21H18N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:346.38

    Ref: TM-T28113

  • 1,2,3,4,5,6-Hexabromocyclohexane
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    1,2,3,4,5,6-Hexabromocyclohexane

    CAS:
    <p>Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.</p>
    Formula:C6H6Br6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.54

    Ref: TM-T22462