MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 893 products of "MAPK"
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ETC-206
CAS:ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).
Formula:C25H20N4O2Purity:99.72% - 99.79%Color and Shape:SolidMolecular weight:408.45ACBI3
CAS:ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.Formula:C50H62N14O6S2Purity:99.24%Color and Shape:SolidMolecular weight:1019.25MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formula:C33H39N7O2Purity:97.3% - 99.07%Color and Shape:SolidMolecular weight:565.71Ref: TM-T16143
1mg60.00€2mg85.00€5mg124.00€10mg195.00€25mg351.00€50mg512.00€100mg743.00€200mg982.00€1mL*10mM (DMSO)166.00€CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Formula:C22H21F3N6O2Purity:99.42%Color and Shape:SolidMolecular weight:458.44K-Ras G12C-IN-4
CAS:K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Formula:C31H33ClN4O4Purity:99.00%Color and Shape:SolidMolecular weight:561.07Ref: TM-T11738
1mg71.00€5mg161.00€10mg236.00€25mg403.00€50mg532.00€100mg783.00€200mg1,054.00€1mL*10mM (DMSO)192.00€(R)-Ketorolac
CAS:(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity.Formula:C15H13NO3Purity:99.55%Color and Shape:SolidMolecular weight:255.27Ref: TM-T12624
1mg38.00€2mg50.00€5mg84.00€10mg113.00€25mg222.00€50mg313.00€100mg437.00€1mL*10mM (DMSO)93.00€B-Raf IN 2
CAS:B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.Formula:C20H17F2N5O4SPurity:98.86%Color and Shape:SolidMolecular weight:461.44(R)-BI-2852
CAS:(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.Formula:C31H28N6O2Purity:97.80%Color and Shape:SoildMolecular weight:516.59TINK-IN-1
CAS:TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.Formula:C24H24N4O3Purity:99.4%Color and Shape:SoildMolecular weight:416.47Ref: TM-T77660
1mg39.00€2mg50.00€5mg82.00€10mg120.00€25mg236.00€50mg353.00€100mg517.00€500mg1,099.00€INH154
CAS:INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.Formula:C22H24N4OSPurity:99.95%Color and Shape:SolidMolecular weight:392.52Ref: TM-T11657
2mg34.00€5mg54.00€10mg82.00€25mg136.00€50mg203.00€100mg299.00€200mg416.00€1mL*10mM (DMSO)59.00€SU3327
CAS:SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Formula:C5H3N5O2S3Purity:98.39%Color and Shape:SolidMolecular weight:261.3BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Formula:C23H25F3N4O3Purity:99.2% - 99.66%Color and Shape:SolidMolecular weight:462.46Ref: TM-T12979
1mg73.00€5mg160.00€10mg250.00€25mg464.00€50mg663.00€100mg919.00€500mg1,833.00€1mL*10mM (DMSO)170.00€ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Formula:C21H17ClF2N4O2Purity:97.78%Color and Shape:SolidMolecular weight:430.84Ref: TM-T10376
1mg38.00€5mg86.00€10mg112.00€25mg216.00€50mg310.00€100mg408.00€200mg580.00€1mL*10mM (DMSO)88.00€HI-TOPK-032
CAS:HI-TOPK-032 is an effective and specific inhibitor of TOPK.
Formula:C20H11N5OSPurity:98.52%Color and Shape:SolidMolecular weight:369.4Azelnidipine
CAS:Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.Formula:C33H34N4O6Purity:99.78%Color and Shape:Light Yellowish PowderMolecular weight:582.65Ref: TM-T0121
2mg34.00€5mg49.00€10mg64.00€25mg103.00€50mg167.00€100mg260.00€200mg385.00€1mL*10mM (DMSO)59.00€Cephradine
CAS:Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.Formula:C16H19N3O4SPurity:99.63%Color and Shape:White Crystalline Powder; Polymorphic SolidMolecular weight:349.40KRAS G12C inhibitor 19
CAS:KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.Formula:C25H19ClF2N4O3SPurity:97.46%Color and Shape:SolidMolecular weight:528.96LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Formula:C27H19F3N8OPurity:99.03%Color and Shape:SolidMolecular weight:528.49Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Formula:C24H19ClN4O4Purity:95.77% - 98.83%Color and Shape:SolidMolecular weight:462.89MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Formula:C21H18N4O2Purity:99.58%Color and Shape:SolidMolecular weight:358.39Ref: TM-T12058
1mg35.00€5mg64.00€10mg93.00€25mg180.00€50mg264.00€100mg369.00€200mg507.00€1mL*10mM (DMSO)78.00€Tanzisertib
CAS:Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Formula:C21H23F3N6O2Purity:98.66% - 99.28%Color and Shape:SolidMolecular weight:448.44Ref: TM-T14895
1mg39.00€5mg93.00€10mg138.00€25mg268.00€50mg530.00€100mg705.00€200mg973.00€1mL*10mM (DMSO)92.00€MAP4K4-IN-3
CAS:MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.Formula:C15H12ClN5Purity:98.07%Color and Shape:SolidMolecular weight:297.74Ref: TM-T11942
5mg44.00€10mg74.00€25mg144.00€50mg222.00€100mg354.00€200mg523.00€500mg797.00€1mL*10mM (DMSO)48.00€PF-3644022
CAS:PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Formula:C21H18N4OSPurity:98.13%Color and Shape:SolidMolecular weight:374.46Ref: TM-T16501
1mg37.00€5mg111.00€10mg202.00€25mg416.00€50mg620.00€100mg832.00€500mg1,663.00€1mL*10mM (DMSO)187.00€Regorafénib N-oxyde (M2)
CAS:Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.
Formula:C21H15ClF4N4O4Purity:98.03% - 98.26%Color and Shape:SolidMolecular weight:498.81AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Formula:C32H40N8O5SPurity:98.96%Color and Shape:SolidMolecular weight:648.78Ref: TM-T14360
1mg54.00€2mg77.00€5mg114.00€10mg167.00€25mg281.00€50mg401.00€100mg567.00€500mg1,161.00€1mL*10mM (DMSO)164.00€ERK5-IN-6
CAS:ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.Formula:C23H21N3Purity:98.59%Color and Shape:SoildMolecular weight:339.43Divarasib
CAS:Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.
Formula:C29H32ClF4N7O2Purity:99.237% - 99.83%Color and Shape:SolidMolecular weight:622.06MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Formula:C22H24N6OPurity:99.69%Color and Shape:SolidMolecular weight:388.47JNK-IN-13
CAS:JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.
Formula:C13H7ClN4SPurity:98.74%Color and Shape:SolidMolecular weight:286.74ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Formula:C19H16ClN3OPurity:99.89%Color and Shape:SoildMolecular weight:337.8Ref: TM-T77734
1mg86.00€2mg111.00€5mg180.00€10mg279.00€25mg562.00€50mg917.00€100mg1,454.00€500mg2,822.00€MRTF-A-IN-1
MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Formula:C22H21N3Color and Shape:SolidMolecular weight:327.42NK7-902
NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.Color and Shape:Odour SolidAnti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Formula:C19H30O3Color and Shape:SolidMolecular weight:306.44PROTAC KRAS G12C degrader-1
PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cellsFormula:C50H54ClFN8O6Purity:98%Color and Shape:SolidMolecular weight:917.47Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Color and Shape:Odour SolidRef: TM-L1600
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireAntimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFormula:C18H13N3OSPurity:99.82%Color and Shape:SolidMolecular weight:319.38Ref: TM-T67942
1mg54.00€5mg116.00€10mg172.00€25mg278.00€50mg371.00€100mg510.00€200mg687.00€1mL*10mM (DMSO)180.00€Edaxeterkib
CAS:Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.Formula:C26H27N7O2Color and Shape:SolidMolecular weight:469.549CC-401
CAS:CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).
Formula:C22H24N6OPurity:98%Color and Shape:SolidMolecular weight:388.47PROTAC SOS1 degrader-1
CAS:PROTAC SOS1 degrader-1: potent, DC50 98.4 nM, inhibits KRAS mutant cancer cells, low-toxic antitumor.Formula:C57H76O4ClFN10SColor and Shape:SoildMolecular weight:1050.54443Rutamycin
CAS:Rutamycin: a macrolide antibiotic from Streptomyces rutgersensis; blocks ATPases, uncouples oxidative phosphorylation.Formula:C44H72O11Purity:98%Color and Shape:SolidMolecular weight:777.049Pan-RAS-IN-7
CAS:Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.Formula:C59H76N8O8Color and Shape:SolidMolecular weight:1025.28MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Formula:C28H23F3IN3O4Color and Shape:SolidMolecular weight:649.4JIP-1(153-163)
CAS:Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.Formula:C61H104N20O14Purity:98%Color and Shape:SolidMolecular weight:1341.6p38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Formula:C16H13FN2OS2Purity:98.53%Color and Shape:SolidMolecular weight:332.42Murrayafoline A
CAS:Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.Formula:C14H13NOColor and Shape:SolidMolecular weight:211.264PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.Formula:C46H55F2N9O9SColor and Shape:SolidMolecular weight:948.05PROTAC K-Ras Degrader-1
CAS:PROTAC K-Ras Degrader-1 is a PROTAC degrader based on the Cereblon E3 ligase ligand, capable of degrading K-Ras.Formula:C53H62N10O10Purity:98.05%Color and Shape:SolidMolecular weight:999.12Rineterkib hydrochloride
CAS:Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.Formula:C26H28BrClF3N5O2Color and Shape:SolidMolecular weight:614.89PDE4-IN-26
PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.Formula:C22H18F2N4O3SColor and Shape:SolidMolecular weight:456.47LC 2 Epimer
CAS:Negative control for LC 2.Formula:C59H71ClFN11O7SColor and Shape:SolidMolecular weight:1132.8Tagarafdeg
CAS:Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.Formula:C45H49F2N11O9SPurity:>99.99% - ＞99.99%Color and Shape:SolidMolecular weight:958DB-10
DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.Color and Shape:Odour SolidMEK/RAF-IN-1
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.Formula:C28H29F3N6O5SColor and Shape:SolidMolecular weight:618.63RM-018
CAS:RM-018 inhibits active KRAS G12C & G12C/Y96D, possibly beating resistance with unique traits.Formula:C56H72N8O8Color and Shape:SolidMolecular weight:985.24L-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Formula:C164H286N66O40Purity:98%Color and Shape:SolidMolecular weight:3822.44MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Color and Shape:Odour SolidRef: TM-L1400
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireGNE-9815
CAS:GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selectiveFormula:C26H22FN5O2Purity:99.08% - 99.1%Color and Shape:SolidMolecular weight:455.48Ref: TM-T9585
1mg60.00€5mg138.00€10mg215.00€25mg358.00€50mg510.00€100mg692.00€500mg1,386.00€1mL*10mM (DMSO)138.00€SS47
CAS:SS47 is a PROTAC that degrades immunosuppressive HPK1 via proteasome; boosts BCMA CAR-T cell cancer therapy.Formula:C49H56N6O12SColor and Shape:SolidMolecular weight:953.07Z16078526
CAS:Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.Formula:C18H17N3O4SPurity:99.18%Color and Shape:SolidMolecular weight:371.41Debromohymenialdisine
CAS:Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.Formula:C11H11N5O2Color and Shape:SolidMolecular weight:245.242S6 Kinase Substrate Peptide 32
S6 Kinase Substrate Peptide 32 is a peptide that measures the activity of kinases that phosphorylate ribosomal protein S6. It can also be used as a substrate.Formula:C149H270N56O49Purity:98%Color and Shape:SolidMolecular weight:3630.1MAP4K4-IN-6
MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).Color and Shape:Odour SolidMitogen-activated protein kinase 1
CAS:Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Purity:98%Color and Shape:SolidSOS1-IN-18
SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.Formula:C26H29F3N4O2Color and Shape:SolidMolecular weight:486.53ERK1/2 inhibitor 3
CAS:ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.Formula:C28H31ClFN5O6SColor and Shape:SolidMolecular weight:620.09KRAS G12D inhibitor 7
CAS:KRAS G12D inhibitor 7, is a highly potent inhibitor specifically targeting KRAS G12D.Formula:C32H38N8O3Color and Shape:SolidMolecular weight:582.709NecroX-2
CAS:NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.Formula:C25H32N4O4S2Purity:97.12%Color and Shape:SolidMolecular weight:516.68Ras Inhibitory Peptide acetate
Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.
Formula:C55H95N19O13Purity:96.63%Color and Shape:SolidMolecular weight:1230.46Cobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Formula:C21H21F3IN3O2Purity:98%Color and Shape:SolidMolecular weight:531.318SIAIS562055
SIAIS562055, a potent cereblon-based SOS1PROTAC, exhibits a dissociation constant (Kd) of 95.9 nM. It effectively degrades SOS1 and inhibits the downstream ERK pathway. SIAIS562055 disrupts the interaction between KRASG12C or KRASG12D and SOS1, with IC50 values of 95.7 nM and 134.5 nM, respectively. This compound demonstrates strong anticancer activity.Formula:C49H62F3N7O5SColor and Shape:SolidMolecular weight:918.12IPS-06061
IPS-06061 is an orally active molecular glue that forms a ternary complex with CRBN and KRASG12D, capable of degrading KRAS G12D, with a DC50 of less than 500 nM.Formula:C22H26O3Color and Shape:SolidMolecular weight:338.44PROTAC K-Ras Degrader-6
CAS:Pan-KRAS degrader 5 (compound 102) is a cereblon-based PROTAC KRAS degrader with a DC50 value less than 100 nM, exhibiting anticancer activity.Formula:C57H65F2N11O5Color and Shape:SolidMolecular weight:1022.19Vacquinol-1
CAS:Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.Formula:C21H21ClN2OPurity:99.92%Color and Shape:SolidMolecular weight:352.86HPK1-IN-39
HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes theFormula:C26H27N7O2Color and Shape:SolidMolecular weight:469.54LYMTAC-2
LYMTAC-2 is a lysosome-targeting chimera (LYMTAC) developed to degrade membrane-associated proteins through lysosomal membrane proteins (LMP) such as RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with target proteins like KRASG12D, facilitating their relocation to lysosomes and resulting in ubiquitin-dependent degradation. This compound has potential for studying membrane protein regulation and devising strategies to counter resistance in KRAS-driven signaling pathways.Color and Shape:SolidMolecular weight:1248.44BAS 00489700
CAS:BAS 00489700 is a N-UTR interaction inhibitor. BAS 00489700 inhibits virus replication in cell culture.Formula:C19H16N2O4Purity:99.78%Color and Shape:SolidMolecular weight:336.34Ref: TM-T67854
1mg85.00€5mg170.00€10mg250.00€25mg371.00€50mg522.00€100mg712.00€200mg954.00€1mL*10mM (DMSO)170.00€PROTAC MEK1 Degrader-1
CAS:PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Formula:C53H66FIN8O11S2Purity:98%Color and Shape:SolidMolecular weight:1201.17YN14
YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with lowPurity:98%Color and Shape:Odour SolidADT-007
CAS:ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Formula:C26H24FNO5Purity:97.75%Color and Shape:SoildMolecular weight:449.47Ref: TM-T85316
1mg47.00€5mg96.00€10mg124.00€25mg200.00€50mg353.00€100mg602.00€200mg982.00€1mL*10mM (DMSO)104.00€KRAS G12C inhibitor 69
KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.Formula:C29H29ClF3N5O3Color and Shape:SolidMolecular weight:588.02KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formula:C51H65F4N9O9S2Color and Shape:SolidMolecular weight:1088.24NUCC-0200808
NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.Color and Shape:Odour SolidHPK1-IN-8
CAS:HPK1-IN-8 is an allosteric, inactive, conformation-selective triazolopyrimidine ketone HPK1 inhibitor.Formula:C19H17FN6O2SPurity:99.68%Color and Shape:SolidMolecular weight:412.44RTIL 13
CAS:RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).Formula:C30H55BrN2O3Color and Shape:SolidMolecular weight:571.685FAM49B (190-198) mouse
CAS:FAM49B (190-198) mouse represents a peptide fragment of the mitochondria-localized protein FAM49B, which is instrumental in regulating mitochondrial fission, function, and integrity, in addition to influencing tumor progression. Beyond its role in mitochondrial dynamics, FAM49B serves as a negative regulator of T cell activation by inhibiting GTPase Rac activity and affecting cytoskeleton reorganization.Formula:C49H71N9O14SColor and Shape:SolidMolecular weight:1042.2DS03090629
DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.Formula:C25H26ClN5O2Color and Shape:SolidMolecular weight:463.96KG5
CAS:KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).
Formula:C20H16F3N7OSPurity:98.32%Color and Shape:SolidMolecular weight:459.45BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Formula:C47H62N8O4SColor and Shape:SolidMolecular weight:835.11KRAS inhibitor-38
CAS:KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.Formula:C53H68ClF2N9O8SColor and Shape:SolidMolecular weight:1064.68Setidegrasib
CAS:KRAS G12D inhibitor 17, a quinazoline-linked prolinamide, degrades mutant KRAS protein; a PROTAC.Formula:C60H65FN12O7SColor and Shape:SolidMolecular weight:1117.3MC 976
CAS:MC 976 is a derivative of Vitamin D3.Formula:C27H42O3Purity:98%Color and Shape:SolidMolecular weight:414.63Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Formula:C46H60N8O5SColor and Shape:SolidMolecular weight:837.08PROTAC K-Ras Degrader-2
CAS:PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V/RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.Formula:C52H60F4N8O5Color and Shape:SolidMolecular weight:953.077HSND80
HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.Color and Shape:Odour SolidKRAS inhibitor-33
KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.Formula:C33H39ClF2N6O3Color and Shape:SolidMolecular weight:641.15R18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Formula:C101H157N27O29S3Purity:98%Color and Shape:SolidMolecular weight:2309.69(S)-BAY-293
CAS:(S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers.
Formula:C25H28N4O2SPurity:98%Color and Shape:SolidMolecular weight:448.58KRAS G12C inhibitor 60
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, andFormula:C31H30F5N7O2Purity:98%Color and Shape:SolidMolecular weight:627.61JNK3 inhibitor-8
JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.Formula:C32H30FN7O3Color and Shape:SolidMolecular weight:579.62KRAS G12D inhibitor 6
CAS:KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.Formula:C32H37ClN8O2Color and Shape:SolidMolecular weight:601.15
