Raf

LXH254 is a potent C-Raf and B-Raf inhibitor.

Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-4/B-Raf).

LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions …

PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC …

Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for …

PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is …

B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor.

BMS-214662 is an effective and selective inhibitor of farnesyl transferase with potent antitumor activity (IC50: …

SOS1-IN-1 is an inhibitor of SOS1.

LY2452473 is an orally bioavailable and selective androgen receptor modulator.

Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has …

6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).

I-37 is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.

BRAF inhibitor is an inhibitor of B-Raf extracted from patent WO/2011103196 A1 (Compound P-0850).

PLX-4032 is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.

GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of …

CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, …

BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).

LGX818 is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.

BI-882370 is a specific RAF kinase inhibitor. BI-882370 inhibits the oncogenic BRAFV600E-mutant, the WT BRAF …

Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, …

Kobe0065 is a novel and effective small-molecule compound inhibiting Ras-Raf interaction by SBDD; shows potent …

ZM 336372 is a potent and selective c-Raf inhibitor.

RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for …

K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).

RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, …

NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR …

AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 …

K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).

I-37 free base is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.

N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant …

PLX8394 is an orally active inhibitor of serine/threonine-protein kinase B-Raf (BRAF) protein. PLX8394 can selectively …

GDC-0879 is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with …

GW5074(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the …

SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay). The selectivity …

MLN2480 is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.

CID-25014542 is novel inhibitor of Raf kinases.

PLX-4720 is a potent and selective inhibitor of B-Raf (V600E) (IC50: 13 nM), equally potent …

BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase …

B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor.

Rineterkib is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.

L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, > 30 and …

KRPEP-2D acetate was identified as a K-Ras(G12D) selective inhibitory peptide against the G12D mutant of …

TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E …

Compound 23 selectively induces degradation of BRAF-V600E but not wildtype BRAF.

Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor (IC50s: 1.5/2.5/4.2/7/13/22 nM for RET/C-RAF/VEGFR2/c-Kit/VEGFR1/PDGFRβ).

Belvarafenib is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of …

Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.

LY03009120 is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 …

K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% …

B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.

Dabrafenib is a selective inhibitor of mutated forms of BRAF kinase (IC50s: 0.7/5 nM for …

Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase …

ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that …

Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).

AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and …