Membrane Transporter/Ion Channel

Radequinil is a benzodiazepine receptor partial inverse agonist. Rade quinil binds to GABA(-) and GABA(+) …

E 0747 (E0747) is a new antiarrhythmic compound that inhibits arrhythmias by inhibiting Na channels …

EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel …

Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker. And it …

TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological …

Bamaluzole is an agonist of GABA receptor.

(2R/S)-6-PNG (6-Prenylnaringenin) is a novel natural histone deacetylase inhibitor with anticancer and antitumor activity, and …

(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB …

Dasolampanel (NGX-426) is an orally available ionotropic glutamate receptor AMPA and Kainate receptor antagonist for …

Sodium Channel inhibitor 2 is a blocker of sodium channel.

NBI-921352 (XEN901) is a potent sodium channel inhibitor, specifically targeting Na_v1.6 channels. It effectively treats …

Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin …

GW791343 trihydrochloride (GW791343 3HCl) is aHCl salt form of GW791343, which is a non-competitive allosteric …

Teludipine hydrochloride is a blocker of lipophilic calcium channel.

JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of …

Temiverine hydrochloride is a potential calcium channel antagonist with anticholinergic effects that inhibits some of …

CP-100356 hydrochloride is an orally active and low micromolar dual inhibitor of MDR1 (P-gp) and …

Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was …

AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive …

Dofequidar (MS-209) is a quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.

SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective antagonist of dopamine D1-like receptor (1 …

Palonidipine is an antagonist of calcium, is potential for the therapy of angina-pectoris and hypertension.

ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels …

UK51656 is an antagonist of calcium (IC50: 4 nM).

SB-237376 HCl (SB-237376 hydrochloride) is a calcium and potassium channel antagonist used in the treatment …

Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs …

TTA-Q6 is a selective T-type Ca2+ channel antagonist with potential antitumor and immunomodulatory activity for …

inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX)

GLUK5 kainate receptor antagonist

A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.

URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 …

NP-1815-PX is a selective P2X4R antagonist with demonstrated anti-inflammatory effects and the capability to alleviate …

α,β-Methylene ATP trisodium, a phosphonate analog of ATP, is a selective P2X agonist that induces …

PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of …

CP-409092 is a partial GABAA receptor agonist. It has anti-anxiety activity.

GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: …

N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block …

(-)-Bicuculline methochloride is a potent antagonist of GABAA receptor.

Compound 38, also known as Compound 4, is a potent, orally active P2X3 antagonist that …

VMAT2-IN-2 tosylate is a potent inhibitor of VMAT2 and is applicable in the research of …

Xilmenolone acts as a positive allosteric modulator of the GABA_A receptor [1].

(S)-Verapamil hydrochloride is an inhibitor of leukotriene C4 (LTC4) and calcein transport by MRP1,and leads …

MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as …

(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA is an agonist of effective and selective excitatory …

Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 …

Soyacerebroside II exhibits ionophoretic activity for Ca2+ ion. Soyacerebrosides I and II have modulating the …

SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nM

CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of …

GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: …

Valbenazine tosylate, the tosylate salt of valbenazine, is a vesicular monoamine transporter 2 (VMAT2) inhibitor …

TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate …

Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, …

Probenecid (Benemid) is a benzoic acid derivative with antihyperuricemic property.

Ouabain octahydrate (Acocantherine) is a cardiac glycoside that inhibits Na(+)/K(+) ATPase. Ouabain octahydrate regulates transcription …

Gabapentin (Neurontin) is an Anti-epileptic Agent. The physiologic effect of gabapentin is by means of …

Voacangine is a selective and potent antagonist of TRPV1 and TRPM8, and an agonist of …

4-Aminopyridine (Dalfampridine) is a nonselective potassium (K+) channel blocker that binds to the cytoplasmic side …

DL-Borneol ((endo)-Borneol) is a small molecule extracted from traditional Chinese medicine (TCM). It is an …

N-Arachidonyl-GABA (NA-GABA) is a novel active fatty amino acid related to anandamide (ANA) found in …

Lopirazepam is a potent small molecule GABAA receptor agonist, which can be used to treat …

Pagoclone (IP456) is a GABA receptor agonist and can be used for studies on the …

T-2000 (DMMDPB) is a GABA receptor agonist that can be used to study myoclonus and …

Indiplon is a short-acting hypnotic with high-affinity allosteric potentiator of GABAA responses that demonstrates preference …

DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human …

Bretazenil is a GABAA benzodiazepine site partial agonist. Bretazenil shows an EC50 of 10 nM …

Zuranolone is an agonist of GABAA receptor.

Gabapentin hydrochloride (Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain.

Fasoracetam is a modulator of GABA receptor potentially for the treatment of attention deficit hyperactivity …