HIF/HIF Prolyl-Hydroxylase

IDF-11774 is a HIF-1 inhibitor.It reduces hif-1 HRE luciferase activity (IC50 = 3.65 μM).

BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).

SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.

DMOG, an antagonist of the -ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.

TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 …

(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2)(IC50 of 0.01 μM).

JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD …

GN44028 is an inhibitor of HIF-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1 transcriptional activity. …

Pantoprazole Sodium is the sodium salt form of a substituted benzimidazole with proton pump inhibitor …

TC-S 7009 is more selective for HIF-2 than HIF-1 (Kd 5 μM). TC-S 7009 is …

Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of …

HIF-2-IN-2 is a hypoxia-inducible factor (HIF-2) inhibitor (IC50: 16 nM in scintillation proximity assay).

PT-2385 is a selective HIF-2 inhibitor (Kd<50 nM).

HIF-2-IN-3 is an allosteric inhibitor of HIF-2 (IC50: 0.4 µM; KD: 1.1 µM) with anticancer …

Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y …

MK-8617 is an orally available HIF PHD13 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).

2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by …

(-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced …

Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence …

PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977 is an …

Molidustat(BAY-85-3934), an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH), stimulates erythropoietin (EPO) production and …

1. Cinnamaldehyde has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive …

Desidustat is an inhibitor of HIF hydroxylase.

IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)

YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of …

2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF- prolyl hydroxylase (HIF-PH)

M1001 is a HIF-2 agonist.

PT2399 is a first-in-class, orally available, small molecule inhibitor of HIF-2 that selectively disrupts the …

PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).

Sodium Aescinate is extracted from Aesculus wilsonii.

ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).

Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for …

AFP464 (NSC710464) free base is an active HIF-1 inhibitor (IC50: 0.25 μM) and a potent …

Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.

Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking …

LW6 is a novel HIF-1 inhibitor.

Roxadustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.

KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.

FG-2216 is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally …

IOX2 is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in …

Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic …