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Lipoxygenase

Lipoxygenase

Lipoxygenases are a family of enzymes that catalyze the oxygenation of polyunsaturated fatty acids, leading to the production of bioactive lipid mediators such as leukotrienes and lipoxins. These mediators play critical roles in inflammation, immune responses, and cancer. Inhibitors of lipoxygenase are used to study their role in inflammatory diseases, asthma, and cancer. At CymitQuimica, we provide a variety of lipoxygenase inhibitors to support your research in inflammation, oncology, and lipid metabolism.

Found 151 products for "Lipoxygenase".

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  • ThioLox
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    ThioLox

    CAS:
    ThioLox, a 15-LOX-1 inhibitor (IC50: 12 μM), has anti-inflammatory, neuroprotective benefits, and guards against glutamate toxicity.
    Formula:C15H18N2OS
    Purity:99.98%
    Color and Shape:Solid
    Molecular weight:274.381

    Ref: TM-T67908

  • Zileuton
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    Zileuton

    CAS:
    Zileuton (A 64077) inhibits 5-lipoxygenase, reduces leukotrienes, aids bronchodilation, lessens mucus/edema, and helps manage asthma symptoms.
    Formula:C11H12N2O2S
    Purity:98.72% - 99.86%
    Color and Shape:White Solid
    Molecular weight:236.29

    Ref: TM-T0477

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    5-LOX/NO-IN-1

    5-LOX/NO-IN-1 (Compound 7e) is a dual inhibitor of 5-LOX and nitric oxide release. It exhibits an IC50 value of 2.833 μM for 5-LOX and demonstrates anti-inflammatory properties.
    Formula:C22H18N6O4
    Color and Shape:Solid
    Molecular weight:430.42

    Ref: TM-T205230

  • 15-LOX-1 inhibitor 1
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    15-LOX-1 inhibitor 1

    CAS:
    9c(i472) blocks 15-LO-1 (IC50=0.19μM), lowers NF-κB in RAW-Blue cells, & cuts Nos2/lipid peroxidation in RAW 264.7 at 0.2-5μM.
    Formula:C22H21ClN2O4
    Color and Shape:Solid
    Molecular weight:412.866

    Ref: TM-T36169

  • CymitQuimica logo
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    mPGES-1/5-LOX-IN-1

    mPGES-1/5-LOX-IN-1 (compound 3j) is a potent, orally active dual inhibitor of mPGES-1 and 5-LOX, with IC50 values of 0.92 and 1.89 µM, respectively. Additionally, mPGES-1/5-LOX-IN-1 exhibits anti-inflammatory properties.
    Formula:C20H22N4O6S
    Color and Shape:Solid
    Molecular weight:446.12601

    Ref: TM-T210277

  • Myxochelin A
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    Myxochelin A

    CAS:
    Myxochelin A from A. disciformis fights Gram-positive bacteria, inhibits 5-LO with IC50 of 1.9 μM, and is cytotoxic to colon cancer cells.
    Formula:C20H24N2O7
    Color and Shape:Solid
    Molecular weight:404.419

    Ref: TM-T35692

  • CMI977
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    CMI977

    CAS:
    CMI977 is a potent inhibitor of 5-Lipoxygenase (5-LO).
    Formula:C16H19FN2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:322.33

    Ref: TM-T14986

  • KKII5
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    KKII5

    CAS:
    KKII5 is a potent inhibitor of the lipoxygenase LOX-1 with an IC50 of 19 μM.KKII5 inhibits lipid peroxidation and enhances the ability of the active centers of
    Formula:C16H14N2S
    Purity:99.44%
    Color and Shape:Solid
    Molecular weight:266.361

    Ref: TM-T77288

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    h15-LOX-2 inhibitor 2

    Compound 10 (h15-LOX-2 inhibitor 2) suppresses h15-LOX activity, exhibiting IC 50 and K i values of 26.9 μM and 16.4 μM, respectively.
    Formula:C22H30Cl2N6O3
    Color and Shape:Solid
    Molecular weight:497.42

    Ref: TM-T200017

  • DKI5
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    DKI5

    CAS:
    DKI5, a LOX-1 inhibitor with 22.5 μM IC50, may exhibit anti-inflammatory, antioxidant, and anti-lipid peroxidation effects in vitro.
    Formula:C8H10N4S
    Purity:97.08%
    Color and Shape:White Solid
    Molecular weight:194.26

    Ref: TM-T67870

  • CBS-1114 HCl
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    CBS-1114 HCl

    CAS:
    CBS-1114 HCl: 5-lipoxygenase inhibitor, anti-inflammatory, improves heart function, reduces heart's fat.
    Formula:C13H14ClN3
    Purity:99.93%
    Color and Shape:Soild
    Molecular weight:247.723

    Ref: TM-T68037L

  • 1-Naphthyl 3,5-dinitrobenzoate
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    1-Naphthyl 3,5-dinitrobenzoate

    CAS:
    1-Naphthyl 3,5-dinitrobenzoate (JMC-4) is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.
    Formula:C17H10N2O6
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:338.2711

    Ref: TM-T21838

  • Lagunamycin
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    Lagunamycin

    CAS:
    Lagunamycin is used as a novel 5-lipoxygenase inhibitor.
    Formula:C19H21N3O4
    Color and Shape:Solid
    Molecular weight:355.39

    Ref: TM-T25601

  • 13-epi-12-oxo Phytodienoic Acid
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    13-epi-12-oxo Phytodienoic Acid

    CAS:
    13-epi-12-oxo PDA is a lipoxygenase derivative of α-linolenic acid in green plant leaves, often isomerizing during extraction and storage.
    Formula:C18H28O3
    Color and Shape:Solid
    Molecular weight:292.41

    Ref: TM-T37396

  • E 6080 HCl
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    E 6080 HCl

    CAS:
    E 6080 HCl is a 5-lipoxygenase inhibitor and can be used to study bronchial diseases.
    Formula:C17H20ClN3O3S2
    Purity:99.78%
    Color and Shape:White Solid
    Molecular weight:413.94

    Ref: TM-T10508L

  • 5-Lipoxygenase-IN-3
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    5-Lipoxygenase-IN-3

    CAS:
    Compound 14, a <1 μM 5-lipoxygenase inhibitor, researches inflammation, cancer, stroke, Alzheimer's.
    Formula:C19H16ClN5O
    Color and Shape:Solid
    Molecular weight:365.82

    Ref: TM-T75122

  • (±)15-HEDE
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    (±)15-HEDE

    CAS:
    (±)15-HEDE is produced by non-enzymatic oxidation of 11,14-eicosadienoic acid.
    Formula:C20H36O3
    Color and Shape:Solid
    Molecular weight:324.505

    Ref: TM-T35510

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    Ruthenoleuton

    Ruthenoleuton is a 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 3.49 μM and a Ki of 0.80 μM. It possesses antioxidant properties and is applicable in research on inflammatory diseases.
    Formula:C13H16N2O2Ru
    Color and Shape:Solid
    Molecular weight:333.35

    Ref: TM-T205654

  • ZD-2138
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    ZD-2138

    CAS:
    ZD-2138: Selective 5-LOX inhibitor, eases allergen-induced asthma attacks and airway constriction in guinea pigs.
    Formula:C23H24FNO4
    Purity:99.68% - >99.99%
    Color and Shape:Solid
    Molecular weight:397.4394

    Ref: TM-T68173

  • BLX3887
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    BLX3887

    CAS:
    BLX3887 selectively inhibits 15-LO-1 (IC50 = 32 nM), not 15-LO-2, less on 5-LO/12-LO, and affects eosinophils and dendritic cells.
    Formula:C10H5Cl3FN3O
    Color and Shape:White Solid
    Molecular weight:308.52

    Ref: TM-T37273