Neuroscience
Neuroscience inhibitors are compounds designed to modulate the activity of specific proteins, enzymes, or receptors within the nervous system. These inhibitors are crucial for studying the molecular mechanisms underlying neural function, synaptic transmission, and neurodegenerative diseases. By targeting neurotransmitter receptors, ion channels, and signaling pathways, neuroscience inhibitors aid in the exploration of brain function and the development of therapeutic strategies for neurological disorders such as Alzheimer's, Parkinson's, and epilepsy. At CymitQuimica, we offer a comprehensive range of high-quality neuroscience inhibitors to support your research in neurobiology, neuropharmacology, and cognitive sciences.
Subcategories of "Neuroscience"
- 5-HT Receptor(940 products)
- ACK(1 products)
- AChR(574 products)
- ATP Citrate Lyase(16 products)
- Adrenergic Receptor(2,939 products)
- BACE(36 products)
- Beta Amyloid(204 products)
- CaMK(68 products)
- Cyclooxygenase (COX) Inhibitors(562 products)
- Dopamine Receptor(407 products)
- GABA Receptor(336 products)
- Gamma-secretase(59 products)
- GluR(255 products)
- GlyT(24 products)
- Histamine Receptor(358 products)
- LRRK2(33 products)
- Melatonin Receptor(24 products)
- NMDAR(28 products)
- OX Receptor(40 products)
- Opioid Receptor(296 products)
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Found 5400 products of "Neuroscience"
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HW161023
CAS:<p>HW161023 (compound) is an orally active inhibitor of AP2 associated protein kinase 1 (AAK1), exhibiting IC50 values of 5.4 nM for AAK1 and 11.9 μM for hERG. HW161023 can suppress pain response in a rat model of chronic sciatic nerve compression injury.</p>Formula:C20H24F2N4OColor and Shape:SolidMolecular weight:374.428LY 215840
CAS:<p>5-HT2/5-HT7 receptor antagonist</p>Formula:C24H33N3O2Purity:98%Color and Shape:SolidMolecular weight:395.54DA-8031
CAS:<p>DA-8031 is a selective and orally active serotonin reuptake inhibitor. It is utilized in research related to premature ejaculation (PE).</p>Formula:C21H24N2O2Color and Shape:SolidMolecular weight:336.43Dual AChE-MAO B-IN-1
<p>Dual AChE-MAO B-IN-1: orally active CNS-permeable, safe, stable neuroprotective agent; AChE IC50=550 nM, MAO-B IC50=8.2 nM.</p>Formula:C23H25F2NO4Color and Shape:SolidMolecular weight:417.45Notch inhibitor 1
CAS:<p>Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.</p>Formula:C26H25F7N4O3Purity:98%Color and Shape:SolidMolecular weight:574.49(9R)-RO7185876
CAS:<p>(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.</p>Formula:C25H28F3N7Color and Shape:SolidMolecular weight:483.532S-8510 phosphate
CAS:<p>S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).</p>Formula:C12H13N4O6PPurity:98%Color and Shape:SolidMolecular weight:340.23MADAM
CAS:<p>MADAM demonstrates high affinity and selectivity for 5-HTT, with a Ki value of 1.6 nM. It is utilized as a PET radiotracer for visualizing serotonin transporters.</p>Formula:C16H20N2SColor and Shape:SolidMolecular weight:272.408LY3020371 hydrochloride
CAS:<p>LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.</p>Formula:C15H16ClF2NO5SColor and Shape:SolidMolecular weight:395.81BChE-IN-38
CAS:<p>BChE-IN-38 (compound 13) is a potent BChE inhibitor, with Ki values of 62.05, 28.78, 14.09, and 1.15 nM for hCAI, hCAII, AChE, and BChE, respectively. BChE-IN-38 also demonstrates cytotoxic activity.</p>Formula:C27H20N4Color and Shape:SolidMolecular weight:400.474Sulamserod hydrochloride
CAS:<p>Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.</p>Formula:C19H29Cl2N3O5SColor and Shape:SolidMolecular weight:482.42BPN-15606 besylate
<p>BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).</p>Formula:C29H29FN6O4SColor and Shape:SolidMolecular weight:576.642,6-Dimethoxybenzylamine hydrochloride
CAS:<p>2,6-Dimethoxybenzylamine hydrochloride (Compound 5) exhibits reversible inhibitory activity against copper amine oxidase (CAO) and inhibits benzylamine oxidase (BAO) and monoamine oxidase B (MAO B) with IC50 values of 120 μM and 190 μM, respectively.</p>Formula:C9H14ClNO2Color and Shape:SolidMolecular weight:203.666FP0429
CAS:<p>FP0429 is an agonist of mGlu4.</p>Formula:C10H12N2O7Purity:98%Color and Shape:SolidMolecular weight:272.21(RS)-AMPA hydrochloride
CAS:<p>(RS)-AMPA ((±)-AMPA) hydrochloride is a glutamate analog and serves as an efficient selective agonist for the excitatory neurotransmitter L-glutamic acid (L-glutamic acid). It does not interfere with the binding sites of alginate or NMDA receptors.</p>Formula:C7H11ClN2O4Color and Shape:SolidMolecular weight:222.63(+)-Cevimeline hydrochloride hemihydrate
<p>(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.</p>Formula:C10H19ClNO1·5SPurity:98%Color and Shape:SolidMolecular weight:244.78DSP-1053 benzenesulfonate
CAS:<p>DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.</p>Formula:C32H38BrNO7SColor and Shape:SolidMolecular weight:660.62PF-06648671
CAS:<p>PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.</p>Formula:C25H23ClF4N4O3Purity:98%Color and Shape:SolidMolecular weight:538.92AAZ-A 154
CAS:<p>AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.</p>Formula:C14H20N2OColor and Shape:SolidMolecular weight:232.32LRRK2-IN-5
<p>LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.</p>Formula:C24H26F2N4O2SColor and Shape:SolidMolecular weight:472.55PXS-5153A monohydrochloride
CAS:<p>PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 <40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.</p>Formula:C20H25Cl2FN4O2SPurity:98%Color and Shape:Odour SolidMolecular weight:475.41SB 224289
CAS:<p>SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.</p>Formula:C32H32N4O3Purity:98%Color and Shape:SolidMolecular weight:520.62Rocavorexant
CAS:<p>Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.</p>Formula:C18H19F3N8OColor and Shape:SolidMolecular weight:420.392PF-06751979
CAS:<p>PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).</p>Formula:C18H19F2N5O3S2Purity:98%Color and Shape:SolidMolecular weight:455.5AChE/BChE-IN-1
<p>AChE/BChE-IN-1: dual AChE/BChE inhibitor, IC50 of 1.06 nM/7.3 nM, crosses blood-brain barrier, with antioxidant properties for Alzheimer's research.</p>Formula:C32H35ClN6O3Color and Shape:SolidMolecular weight:587.11LY2794193
CAS:<p>LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.</p>Formula:C16H18N2O6Purity:98.15%Color and Shape:SolidMolecular weight:334.32Pomaglumetad methionil
CAS:<p>Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.</p>Formula:C12H20N2O8S2Purity:98%Color and Shape:SolidMolecular weight:384.43Lu 26-046
CAS:<p>Lu 26-046 is a muscarinic receptor agonist.</p>Formula:C10H12N2OSColor and Shape:SolidMolecular weight:208.28eeAChE-IN-1
<p>eeAChE-IN-1 is a strong inhibitor of eeAChE (IC50: 23 nM).</p>Formula:C27H30N6O5SColor and Shape:SolidMolecular weight:550.63AChE/BChE-IN-3 hydrochloride
<p>AChE/BChE-IN-3 (BMC-1) HCl is a dual inhibitor with IC50s: eqBChE 0.383 μM, elAChE 6.08 μM.</p>Formula:C15H25ClN2O3Color and Shape:SolidMolecular weight:316.82AZD 2066 hydrate
<p>AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].</p>Formula:C19H18ClN5O3Color and Shape:SolidMolecular weight:386.33AChE/BChE/MAO-B-IN-5
CAS:<p>AChE/BChE/MAO-B-IN-5 is a multi-target inhibitor capable of crossing the blood-brain barrier, targeting cholinesterases (AChE and BChE) and monoamine oxidase MAO-B. It exhibits IC50 values of 0.24 µM for AChE, 6.29 µM for BChE, and 0.11 µM for MAO-B. AChE/BChE/MAO-B-IN-5 holds potential for research in neurodegenerative diseases such as Alzheimer's disease.</p>Formula:C22H14F3NO2Color and Shape:SolidMolecular weight:381.347DAPM
CAS:<p>DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.</p>Formula:C20H20F2N2O4Purity:99.76%Color and Shape:SolidMolecular weight:390.38(-)-5-HT2C agonist-3
CAS:<p>Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.</p>Formula:C19H23ClFNO2Color and Shape:SolidMolecular weight:351.845-HT6R/MAO-B modulator 1
<p>5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.</p>Formula:C33H38N4O3SColor and Shape:SolidMolecular weight:570.74LRRK2-IN-2
CAS:<p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>Formula:C23H23Cl2F3N6O2Color and Shape:SolidMolecular weight:543.37K027
<p>K027 is a potent organophosphate (OP) inhibitor of acetylcholinesterase (AChE) reactivation. k027 can be used to study Alzheimer's disease.</p>Formula:C15H18Br2N4O2Color and Shape:SolidMolecular weight:446.145-HT6/5-HT2AR antagonist-1
<p>Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.</p>Formula:C21H26N6SColor and Shape:SolidMolecular weight:394.54Alixorexton
CAS:<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Formula:C21H30N2O5SColor and Shape:SolidMolecular weight:422.538AM-6494
CAS:<p>AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).</p>Formula:C22H21F2N5O3SPurity:98%Color and Shape:SolidMolecular weight:473.5Etoperidone
CAS:<p>Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).</p>Formula:C19H28ClN5OColor and Shape:SolidMolecular weight:377.91Aβ aggregation-IN-1
CAS:<p>Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.</p>Formula:C9H8BF3O2Color and Shape:SolidMolecular weight:215.965(S)-Norfluoxetine
CAS:<p>(S)-Norfluoxetine, the S enantiomer of Norfluoxetine, functions as a selective serotonin reuptake inhibitor. It enhances allopregnanolone levels and reduces aggression in socially isolated mice.</p>Formula:C16H16F3NOColor and Shape:SolidMolecular weight:295.3Tuclazepam
CAS:<p>Tuclazepam (KC 1956) is a derivative of the benzodiazepine class of drugs, exhibiting anti-anxiety and sedative properties.</p>Formula:C17H16Cl2N2OColor and Shape:SolidMolecular weight:335.23AChE-IN-79
<p>AChE-IN-79 (compound 3i) is an acetylcholinesterase inhibitor with an IC50 of 2.7 µM, suitable for studies related to Alzheimer's disease.</p>Formula:C29H27NO6SColor and Shape:SolidMolecular weight:517.59Tiprenolol hydrochloride
CAS:<p>Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.</p>Formula:C13H22ClNO2SColor and Shape:SolidMolecular weight:291.84AChE-IN-10
<p>AChE-IN-10 (24r) inhibits AChE (IC50=2.4 nM), reducing amyloid buildup, tau phosphorylation, and promotes neuron health.</p>Formula:C23H27F2NO4SColor and Shape:SolidMolecular weight:451.53Desmethylflunitrazepam
CAS:<p>Desmethylflunitrazepam (Norflunitrazepam) is a benzodiazepine derivative and an active metabolite of Flunitrazepam.</p>Formula:C15H10FN3O3Color and Shape:SolidMolecular weight:299.26BMS-901715
CAS:<p>BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM).</p>Formula:C22H28N10OPurity:98%Color and Shape:SolidMolecular weight:448.52BACE-1 inhibitor 2
CAS:<p>BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].</p>Formula:C21H21F4N5O3Color and Shape:SolidMolecular weight:467.42
