Beta Amyloid
Beta Amyloid inhibitors are compounds that target and prevent the formation or aggregation of beta-amyloid peptides, which are implicated in the pathogenesis of Alzheimer's disease. The accumulation of beta-amyloid plaques in the brain is a hallmark of the disease, leading to neuronal dysfunction and cognitive decline. Inhibitors of beta-amyloid aggregation are being explored as potential therapeutic agents to slow or prevent the progression of Alzheimer's disease. At CymitQuimica, we provide a range of beta-amyloid inhibitors to support your research in neurodegeneration, protein aggregation, and Alzheimer's therapy.
Found 204 products of "Beta Amyloid"
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ALZ-801
CAS:<p>ALZ-801, an oral valine-prodrug of tramiprosate, enhances treatment of Alzheimer's by inhibiting β-amyloid aggregation with better PK and tolerance.</p>Formula:C8H18N2O4SPurity:99.36%Color and Shape:SolidMolecular weight:238.3Eprodisate disodium
CAS:<p>Eprodisate disodium (NC-503) is a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis.</p>Formula:C3H6Na2O6S2Purity:99.88%Color and Shape:White Coarse PowderMolecular weight:248.19Cromolyn sodium
CAS:<p>Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.</p>Formula:C23H14Na2O11Purity:99.4% - 99.95%Color and Shape:Colorless Crystals From Ethanol + Ether White Crystalline PowderMolecular weight:512.33LY 2389575 hydrochloride
CAS:<p>LY2389575 hydrochloride is a selective mGlu3 NAM with 190 nM IC50, increases Mrc1, and aids Alzheimer's research.</p>Formula:C15H16BrCl3N4Purity:99.45%Color and Shape:SolidMolecular weight:438.58Glimepiride
CAS:<p>Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.</p>Formula:C24H34N4O5SPurity:97.84% - 98.87%Color and Shape:White Cyrstalline SolidMolecular weight:490.62Lecanemab
CAS:<p>Lecanemab (BAN-2401) is an IgG1 monoclonal antibody targeting soluble aggregated beta amyloid (Abeta) for the study of cognitive disorders.</p>Purity:95% - 97.3% (SEC-HPLC)Color and Shape:LiquidGantenerumab
CAS:<p>Gantenerumab (R-1450) is a humanized antibody targeting amyloid-β (Aβ), used in studies of Alzheimer's disease.</p>Purity:>95%Color and Shape:LiquidBirtamimab
CAS:<p>Birtamimab (NEOD001) is a monoclonal antibody selectively targeting and depleting amyloid protein, used in research on light chain amyloidosis.</p>Purity:>95%Color and Shape:LiquidDonanemab
CAS:<p>Donanemab (LY3002813), a humanized IgG1 antibody, targets N-terminal Aβ for potential early Alzheimer's research.</p>Purity:95%Color and Shape:LiquidChlorzoxazone
CAS:<p>Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.</p>Formula:C7H4ClNO2Purity:99.49% - 99.6%Color and Shape:SolidMolecular weight:169.57β-Amyloid (35-25)
CAS:<p>β-Amyloid (35-25) is the reverse sequence of β-Amyloid (25-35).</p>Formula:C45H81N13O14SMolecular weight:1060.27FITC-β-Ala-Amyloid β-Protein (1-42)
CAS:<p>FITC-β-Ala-Amyloid β-Protein (1-42) is a polypeptide identified through peptide screening. This screening method predominantly utilizes immunoassays to gather active polypeptides and is used in studying protein interactions, conducting functional analyses, and screening antigen epitopes, with particular application in the research and development of active molecules.</p>Formula:C227H327N57O66S2Molecular weight:4971.34251β-Amyloid (1-16)
CAS:<p>β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid.</p>Formula:C84H119N27O28Purity:98%Color and Shape:SolidMolecular weight:1955.04FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
<p>FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium) is a FITC-labeled amyloid beta monomer, Alzheimer’s research, drug screening, and biomolecular studies.</p>Formula:C227H330N58O66S2Color and Shape:SolidMolecular weight:4991.53Acetyl-Tau Peptide (273-284) amide
CAS:<p>Acetyl-Tau Peptide (273-284) amide inhibits Ac-Aβ(25–35)-NH2 aggregation and models Aβ/Tau interaction.</p>Formula:C64H116N18O17Color and Shape:SolidMolecular weight:1409.72(D-Asp1)-Amyloid β-Protein (1-42)
CAS:<p>(D-Asp1)-Amyloid β-Protein (1-42), a peptide fragment of amyloid β-protein (Aβ), serves as the primary constituent of vascular and parenchymal amyloid deposits</p>Formula:C203H311N55O60SColor and Shape:SolidMolecular weight:4514.04(Glu20)-Amyloid β-Protein (1-42)
CAS:<p>(Glu20)-Amyloid β-Protein (1-42) represents a variant of amyloid β-protein (Aβ) that fibrillizes more slowly.</p>Formula:C199H309N55O62SColor and Shape:SolidMolecular weight:4495.98G923-0271
CAS:<p>G923-0271 is a TDP-43 inhibitor that improves disease phenotypes in TDP-43 nematode models and reduces the overexpression of human TDP-43, ALS FTD.</p>Formula:C28H23FN4OColor and Shape:SolidMolecular weight:450.51Amyloid-Forming peptide GNNQQNY
CAS:<p>Amyloid-Forming peptide GNNQQNY, a biologically active heptapeptide derived from the N-terminal prion-determining domain of yeast Sup35, is instrumental in</p>Formula:C33H48N12O14Color and Shape:SolidMolecular weight:836.81Dalidnetug
CAS:<p>Dalidnetug is a humanized monoclonal antibody that targets human β-amyloid precursor protein (APP). By specifically binding to APP, Dalidnetug reduces the production of β-amyloid (Aβ), thereby demonstrating activity in clearing β-amyloid. This compound holds potential for research in Alzheimer's disease.</p>Color and Shape:LiquidAβ1-14-εK-KKK-MvF5 Th
<p>Aβ1-14-εK-KKK-MvF5 Th (UB311 immunogen I) is a biologically active peptide and one of the Aβ1–14 targeting peptides (B-cell epitope) used in UB-311.</p>Formula:C199H318N56O55Molecular weight:4372.38081Amyloid β-Protein (1-24)
CAS:<p>Amyloid β-Protein (1-24) is a peptide identified through peptide screening. This tool predominantly employs immunoassays to gather and analyze active peptides. Peptide screening is utilized in studies involving protein interactions, functional analysis, and epitope screening, particularly relevant in the research and development of active molecules.</p>Formula:C130H183N35O40Molecular weight:2876.05Trontinemab
CAS:<p>Trontinemab, a bispecific humanized IgG1-κ antibody, targets the amyloid beta A4 precursor protein (APP) and transferrin receptor p90, CD71 (TFRC).</p>Purity:96.77% - 99%Color and Shape:LiquidCHF-5022
CAS:<p>CHF-5022 is a nonsteroidal anti-inflammatory drug that selectively inhibits the production of beta-amyloid protein (1-42) (ABETA42).</p>Formula:C17H12F4O2Color and Shape:SolidMolecular weight:324.272,3-Dehydrosilybin A
CAS:<p>2,3-Dehydrosilybin A is a useful organic compound for research related to life sciences and the catalog number is T125202.</p>Formula:C25H20O10Color and Shape:SolidMolecular weight:480.4255-FAM-β-Amyloid (1-28)
<p>5-FAM-β-Amyloid (1-28) is a fluorescently-labeled peptide corresponding to the first 28 amino acids of the β-Amyloid protein.</p>Formula:C166H219N41O52Color and Shape:SolidMolecular weight:3620.76β-Amyloid (1-17)
CAS:<p>This synthetic peptide consists of amino acids 1 to 17 of beta amyloid protein. This peptide can be employed in beta amyloid solubility studies.</p>Formula:C90H130N28O29Purity:98%Color and Shape:SolidMolecular weight:2068.2Amyloid β Peptide (42-1)(human) acetate
<p>Amyloid β Peptide (42-1)(human) acetate is the inactive form of Amyloid β Peptide (1-42).</p>Purity:95.20%Color and Shape:SoildAducanumab
CAS:<p>Aducanumab (BIIB037) is an IgG1 antibody targeting amyloid beta to treat Alzheimer's; it's brain-permeable.</p>Purity:95% - 97.10%Color and Shape:LiquidMolecular weight:145.93 kDaSabirnetug
CAS:<p>Sabirnetug is a humanized IgG2κ monoclonal antibody that specifically targets the amyloid-β (A4) precursor protein.</p>Color and Shape:LiquidSQ-3
<p>SQ-3, a quinoline analogue, prefers α-syn (Ki=39.3nM) to Aβ (Ki=230nM), and [18F]SQ3 is a lead for α-syn probes. [1]</p>Formula:C21H21FN2OColor and Shape:SolidMolecular weight:336.4Davunetide
CAS:<p>Davunetide: neuroprotective 8-amino acid peptide, improves daily function in schizophrenia, boosts memory in mild cognitive impairment.</p>Formula:C36H60N10O12Purity:98%Color and Shape:SolidMolecular weight:824.92BIBD-124
CAS:<p>BIBD-124, with an IC50 value of 9.51 nM, effectively binds to amyloid beta (Aβ) plaques.</p>Formula:C19H24FN3O3Color and Shape:SolidMolecular weight:361.41β-Amyloid (1-34)
CAS:<p>This is a fragment of beta-amyloid peptide. It has amino acids 1 through 34.</p>Formula:C170H253N47O52Purity:98%Color and Shape:SolidMolecular weight:3787.2Crenezumab
CAS:<p>Crenezumab (MABT 5102A) is a fully humanized anti-amyloid-beta antibody that binds to multiple forms of amyloid-beta (Aβ) for the study of Alzheimer's disease.</p>Purity:97.5% (SDS-PAGE); 95.3% (SEC-HPLC) - 97.5% (SDS-PAGE); 95.3% (SEC-HPLC)Color and Shape:Liquidβ-Amyloid (1-20)
CAS:<p>This synthetic peptide consists of amino acids 1 to 20 of beta amyloid protein.</p>Formula:C113H157N31O32Purity:98%Color and Shape:SolidMolecular weight:2461.7β-Amyloid (12-20)
CAS:<p>β-Amyloid (12-20) is a peptide fragment of β-Amyloid.Thsis peptide contain the amino acid residues VFF at position (18-20), suggesting that this triad has</p>Formula:C57H83N15O11Purity:98%Color and Shape:SolidMolecular weight:1154.36β-Amyloid (35-42)
CAS:<p>β-Amyloid (35-42) is a peptide derived from the beta-amyloid protein, encompassing amino acids 35 through 42.</p>Formula:C33H60N8O9SPurity:98%Color and Shape:SolidMolecular weight:744.94β-Amyloid (33-40)
CAS:<p>β-Amyloid (33-40) is a peptide comprising amino acids 33 to 40 of the beta-amyloid protein.</p>Formula:C32H58N8O9SPurity:98%Color and Shape:SolidMolecular weight:730.92β-Amyloid (1-9)
CAS:<p>This is an N-terminal fragment of beta amyloid.</p>Formula:C42H60N14O17Purity:98%Color and Shape:SolidMolecular weight:1033.01GSK-3β inhibitor 27
<p>GSK-3β inhibitor27 (Compound 1c) is a reversible, competitive inhibitor of GSK-3β with an IC50 value of 2.2 μM. It inhibits tau hyperphosphorylation and reduces Aβ protein aggregation, demonstrating metal chelation and neuroprotective potential. GSK-3β inhibitor27 is promising for research into neurodegenerative diseases, such as Alzheimer's disease.</p>Formula:C16H17ClN4O2Color and Shape:SolidMolecular weight:332.79AC 253
CAS:<p>Amylin (AMY3) receptor antagonist; blocks cAMP, Ca2+, PKA, MAPK, Akt, and cFOS activity; prevents Aβ-induced neuronal death. Cyclic AC 253 variant exists.</p>Formula:C122H196N40O39Purity:98%Color and Shape:SolidMolecular weight:2847.11Biotinoyl tripeptide-1
CAS:<p>Biotinoyl tripeptide-1 can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging.</p>Formula:C24H38N8O6SPurity:98%Color and Shape:SolidMolecular weight:566.67Methoxy-X04
CAS:<p>Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).</p>Formula:C23H20O3Purity:98.96%Color and Shape:SolidMolecular weight:344.4β-Amyloid (18-28)
CAS:<p>Intracerebroventricular administration of synthetic peptides Beta-amyloid (12-20), (12-28), and (18-28) causes amnesia in mice.</p>Formula:C55H81N13O18Purity:98%Color and Shape:SolidMolecular weight:1212.31β-Amyloid (1-11)
CAS:<p>Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluid</p>Formula:C56H76N16O22Purity:98%Color and Shape:SolidMolecular weight:1325.3β-Amyloid (10-20)
CAS:<p>Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-</p>Formula:C71H99N17O16Purity:98%Color and Shape:Lyophilized PowderMolecular weight:1446.65Aβ-IN-7
<p>Aβ-IN-7 (compound 5a) acts as a potent inhibitor of Aβ aggregation, stabilizing Aβ monomers at 50 μM concentration to prevent them from forming larger oligomers</p>Formula:C14H10N2SColor and Shape:SolidMolecular weight:238.31Aβ-IN-8
<p>Aβ-IN-8, also known as compound 7e, is a potent inhibitor of Aβ aggregation [1].</p>Formula:C22H16F3N3O3SColor and Shape:SolidMolecular weight:459.44β-Amyloid (10-35), amide
CAS:<p>β-Amyloid (10-35), amide, is a chemical compound consisting of 26 amino acids, specifically residues 10-35 of the Aβ peptide.</p>Formula:C133H205N35O36SPurity:98%Color and Shape:SolidMolecular weight:2902.33p-HTAA
CAS:<p>Pentamer Hydrogen Thiophene Acetic Acid (p-HTAA) is a compound that specifically targets and labels amyloid-beta (Aβ) deposits in the brains of living mice [1].</p>Formula:C24H16O4S5Color and Shape:SolidMolecular weight:528.71DDC 2′,3′-O-disulfate
<p>DDC 2′,3′-O-disulfate (compound 4) inhibits the fibrillization and oligomerization of Aβ42, showing promise for Alzheimer's disease (AD) research [1].</p>Formula:C17H16O11S2Color and Shape:SolidMolecular weight:460.43AZD4694 Precursor
CAS:<p>AZD4694 Precursor used for synthesizing [18F]AZD4694, a high-affinity amyloid-β imaging agent.</p>Formula:C22H25N3O7Color and Shape:SolidMolecular weight:443.45Glycerophosphorylethanolamine (sodium salt)
CAS:<p>Glycerophosphorylethanolamine, a phosphatidylethanolamine metabolite, elevates in Alzheimer's and promotes Aβ40 aggregation.</p>Formula:C5H13NNaO6PColor and Shape:SolidMolecular weight:237.12Anti-Amyloid β Antibody (scFv59)
<p>Anti-Amyloid Beta Antibody (scFv59) is a human-derived antibody produced in CHO cells that targets Amyloid-β. For isotype control, please refer to Human IgG1 kappa, Isotype Control.</p>Color and Shape:Odour Liquid(Gln22)-Amyloid β-Protein (1-42)
CAS:<p>(Gln22)-Amyloid β-Protein (1-42), a Dutch mutation (E22Q) variant of β-Amyloid (1-42), demonstrates increased fibrillogenic and pathogenic characteristics [1].</p>Formula:C203H312N56O59SColor and Shape:SolidMolecular weight:4513.05JNK3 inhibitor-9
<p>JNK3inhibitor-9 (Compound 24a) is a potent, selective JNK3 inhibitor capable of crossing the blood-brain barrier (BBB), demonstrating an IC50 value of 12 nM. It effectively inhibits GSK3α/β, which is involved in Tau phosphorylation, with IC50 values of 14 nM and 35 nM, respectively. JNK3inhibitor-9 also reduces the phosphorylation of c-Jun and APP and protects neurons from Aβ1-42 toxicity.</p>Formula:C25H27N7O2Color and Shape:SolidMolecular weight:457.528Amyloid β-Protein (3-42)
CAS:<p>Amyloid β-Protein (3-42), the precursor of Pyr peptide, serves as the foundation of the amyloid template block in Alzheimer's disease when modified to</p>Color and Shape:Solid(Met(O2)35)-Amyloid β-Protein (1-42)
<p>(Met(O2)35)-Amyloid β-Protein (1-42) is a peptide [1] .</p>Formula:C203H311N55O62SColor and Shape:SolidMolecular weight:4546.04(Met(O)35)-Amyloid β-Protein (1-42)
<p>(Met(O)35)-Amyloid β-Protein (1-42) represents the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution akin to that of</p>Formula:C203H311N55O61SColor and Shape:SolidMolecular weight:4530.04Biphenyl-3′,3,4,4′-tetrol
CAS:<p>Biphenyl-3′,3,4,4′-tetrol (BPT) is a potent inhibitor of Aβ40 aggregation and can be utilized in research related to neurodegenerative diseases such as Alzheimer's.</p>Formula:C12H10O4Color and Shape:SolidMolecular weight:218.21mcK6A1
<p>mcK6A1 serves as an inhibitor of amyloid-β (Aβ) aggregation, selectively binding to the 16KLVFFA21 fragment of Aβ42, leading to the formation of an extended β-sheet structure and preventing the formation of Aβ42 oligomers. This compound is valuable for research into Alzheimer's disease and other amyloid-related disorders.</p>Formula:C71H99N17O16Color and Shape:SolidMolecular weight:1446.65Biotin-β-Amyloid (1-42), human TFA
<p>Biotin-β-Amyloid (1-42), human TFA, also known as Biotin-Amyloid β-Peptide (1-42) (human) TFA, is a biotin-labeled 42-amino acid peptide implicated in the</p>Formula:C215H326F3N57O64S2Color and Shape:SolidMolecular weight:4854.36AChE/Aβ-IN-6
<p>BACE1-IN-15 (compound 4j) serves as an effective inhibitor of BACE1 (β-secretase), efficiently mitigating the copper-induced toxicity of Aβ, with an EC50 value of 0.68 μM.</p>Color and Shape:Odour Solidβ-Amyloid (1-43)(human) TFA
<p>β-Amyloid (1-43)(human) TFA exhibits greater aggregation tendencies and heightened toxicity compared to its well-established counterpart, Aβ1-42.</p>Formula:C209H319F3N56O64SColor and Shape:SolidMolecular weight:4729.21BSBM6
CAS:<p>BSBM6 is an inhibitor of Aβ aggregation and neuronal toxicity that acts by reversing the aggregation and toxicity of amyloid-β peptides.</p>Formula:C23H29N3O5Purity:98%Color and Shape:SolidMolecular weight:427.492002-H20
CAS:<p>2002-H20 is an Aβ42-induced cytotoxicity inhibitor. It acts by binding the Alzheimer's Aβ peptide and reducing its cytotoxicity.</p>Formula:C20H15N3O3Purity:98%Color and Shape:SolidMolecular weight:345.358LPYFD-NH2
CAS:<p>neuroprotective peptide that binds to amyloid beta (Aβ)</p>Formula:C33H44N6O8Purity:98%Color and Shape:SolidMolecular weight:652.74β-Amyloid (22-35)
CAS:<p>β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells.</p>Formula:C59H102N16O21SPurity:98%Color and Shape:SolidMolecular weight:1403.62β-Amyloid (22-40)
CAS:<p>This synthetic peptide consists of amino acids 22 to 40 of beta amyloid protein.</p>Formula:C78H135N21O26SPurity:98%Color and Shape:SolidMolecular weight:1815.1β-Amyloid (13-27)
CAS:<p>β-Amyloid (13-27) is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein.</p>Formula:C84H126N24O24Purity:98%Color and Shape:SolidMolecular weight:1856.05β-Amyloid (1-38), mouse, rat
CAS:<p>β-Amyloid (1-38), derived from mice and rats, is a chemical compound comprising 38 amino acids, specifically residues 1-38 of the Aβ peptide.</p>Color and Shape:SolidC18 L-erythro Ceramide (d18:1/18:0)
CAS:<p>C18 L-erythro Ceramide, a natural stereoisomer, inhibits rat brain mt-CDase with IC50 of 8.8 μM.</p>Formula:C36H71NO3Color and Shape:SolidMolecular weight:565.95Chemerin-9 (149-157) TFA
<p>Chemerin-9 (149-157) TFA is a peptide located at positions 149-157 of chemerin-9, acting as a ChemR23/CMKLR1 agonist.</p>Formula:C56H67F3N10O15Purity:99.77%Color and Shape:SolidMolecular weight:1177.18β-Amyloid Protein Precursor 770 (135-155)
CAS:<p>Beta-Amyloid Protein Precursor 770 (135-155)Aβ Protein Precursor 770 (135-155)</p>Formula:C116H172N35O31S2Purity:98%Color and Shape:SolidMolecular weight:2617.96β-Amyloid (4-10)
CAS:<p>Antibodies corresponding to beta-amyloid (4-10) are effective in vivo inhibitors of cytotoxicity, amyloid plaque formation and special memory disturbances in</p>Formula:C39H52N12O12Purity:98%Color and Shape:SolidMolecular weight:880.9β-Amyloid (12-28)
CAS:<p>Amyloid β-peptide fragment; minimum section required to bind to brain proteins.</p>Formula:C89H135N25O25Purity:98%Color and Shape:SolidMolecular weight:1955.18RAGE antagonist peptide
CAS:<p>RAGE antagonist blocks S100P/A4, HMGB-1; hinders glioma growth, metastasis; reduces PDAC cell growth, NF-κB activity; counters TDI effects in mice.</p>Formula:C57H101N13O17SPurity:98%Color and Shape:SolidMolecular weight:1272.561H-Indole-3-carboxylic acid, 5-[2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propoxy]-2-methyl-1-(4-methylphenyl)-, ethyl ester
CAS:<p>Compound 5936-0108对β-淀粉样蛋白可能具有调节作用。</p>Formula:C26H34N2O7Purity:99.44%Color and Shape:SoildMolecular weight:486.56β-Amyloid (1-28)
CAS:<p>β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding.</p>Formula:C145H209N41O46Purity:98%Color and Shape:SolidMolecular weight:3262.51β-Amyloid (1-40)
CAS:<p>Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor protein by β and γ secretases.</p>Formula:C194H295N53O58SPurity:98%Color and Shape:SolidMolecular weight:4329.82γ-Secretase Modulators
CAS:<p>gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β.</p>Formula:C26H24F3N3O3Purity:98%Color and Shape:SolidMolecular weight:483.48Aβ-IN-6
<p>Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's</p>Formula:C28H31N3O4Color and Shape:SolidMolecular weight:473.56β-Amyloid (29-40)
CAS:<p>β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties</p>Formula:C49H88N12O13SPurity:98%Color and Shape:SolidMolecular weight:1085.36δ-secretase inhibitor 11
CAS:<p>δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.</p>Formula:C10H12N4O2Purity:99.84%Color and Shape:SolidMolecular weight:220.23BSB
CAS:<p>BSB is a Congo red-derived fluorescent probe, an amyloid protein imaging agent, interacting with amyloid fibrils formed by Aβ (1-40) peptides in rodents.</p>Formula:C24H17BrO6Purity:95.53%Color and Shape:SolidMolecular weight:481.29β-Amyloid (11-22)
CAS:<p>β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s</p>Formula:C70H102N18O18Purity:98%Color and Shape:SolidMolecular weight:1483.677-Deoxy-trans-dihydronarciclasine
CAS:<p>7-Deoxy-trans-dihydronarciclasine is an alkaloid that functions as a tobacco mosaic virus (TMV) inhibitor with an IC50 of 1.80 μM and also serves as an anti-</p>Formula:C14H15NO6Color and Shape:SolidMolecular weight:293.27SEN177
CAS:<p>SEN177 shows the potential in the research of Huntington's disease that is a potent inhibitor of glutaminyl cyclase (QPCT) with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). The Ki value of SEN177 for human glutaminyl cyclase (hQC) is 20 nM. SEN177 significantly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates [1].</p>Formula:C18H19FN6Color and Shape:SolidMolecular weight:338.38TH-237A
CAS:<p>TH-237A is a novel neuroprotective agent exhibiting favorable permeation across the blood-brain barrier.</p>Formula:C18H17F2NO3Purity:98%Color and Shape:SolidMolecular weight:333.335AZD4694
CAS:<p>Flutafuranol (AZD4694/NAV4694) binds beta-amyloid, potential PET tracer for Alzheimer's. Non-F18 version supplied.</p>Formula:C14H11FN2O2Color and Shape:SolidMolecular weight:258.25Cu(II)GTSM
CAS:<p>Cu(II)GTSM is a cell permeable copper complex inhibits GSK3β activity and suppresses levels of neurotoxic amyloid β-trimers and phosphorylated tau.</p>Formula:C6H10CuN6S2Purity:99.21%Color and Shape:SolidMolecular weight:293.86(Rac)-Z-Phe-Phe-FMK
CAS:<p>(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) is a cathepsin L inhibitor that inhibits the tendency of β-amyloid to induce apoptotic changes .</p>Formula:C27H27FN2O4Purity:98.27%Color and Shape:SolidMolecular weight:462.51Begacestat
CAS:<p>Begacestat (GSI-953) is a potent and selective gamma-secretase inhibitor that inhibits Amyloid-beta, inhibits cleavage of APP,,Alzheimer's disease.</p>Formula:C9H8ClF6NO3S2Color and Shape:SolidMolecular weight:391.74Benzenesulfonamide
CAS:<p>Benzenesulfonamide (Benzosulfonamide) ia an inhibitor of carbonic anhydrases.</p>Formula:C6H7NO2SPurity:99.42% - 99.99%Color and Shape:White Crystalline PowderMolecular weight:157.19Semax acetate(80714-61-0 free base)
CAS:<p>Semax acetate is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.</p>Formula:C39H55N9O12SPurity:99.46%Color and Shape:SolidMolecular weight:873.98Edonerpic maleate
CAS:<p>Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).</p>Formula:C20H25NO6SPurity:98.24%Color and Shape:SolidMolecular weight:407.48Azeliragon
CAS:<p>Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-</p>Formula:C32H38ClN3O2Purity:96.7% - 98.33%Color and Shape:SolidMolecular weight:532.12Dihydroergocristine mesylate
CAS:<p>DHEC mesylate is a vasodilator and α-adrenergic antagonist used for vascular dementia and as a geroprotector.</p>Formula:C36H45N5O8SPurity:98.9% - 99.65%Color and Shape:SolidMolecular weight:707.84FPS-ZM1
CAS:<p>FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.</p>Formula:C20H22ClNOPurity:99.32% - 99.52%Color and Shape:SolidMolecular weight:327.85Semagacestat
CAS:<p>Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).</p>Formula:C19H27N3O4Purity:97.1% - 99.9%Color and Shape:SolidMolecular weight:361.44Aftin-4
CAS:<p>Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.</p>Formula:C20H28N6OPurity:98.51%Color and Shape:SolidMolecular weight:368.48LX2343
CAS:<p>LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.</p>Formula:C22H19ClN2O6SPurity:99.45%Color and Shape:SolidMolecular weight:474.91LY2811376
CAS:<p>LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).</p>Formula:C15H14F2N4SPurity:99% - 99.01%Color and Shape:SolidMolecular weight:320.36Anle138b
CAS:<p>Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease</p>Formula:C16H11BrN2O2Purity:98.88% - 99.82%Color and Shape:SolidMolecular weight:343.17MK-0752
CAS:<p>MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).</p>Formula:C21H21ClF2O4SPurity:98% - 99.55%Color and Shape:SolidMolecular weight:442.9PiB
CAS:<p>PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.</p>Formula:C14H12N2OSPurity:97.02%Color and Shape:SolidMolecular weight:256.32Frentizole
CAS:<p>Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction</p>Formula:C15H13N3O2SPurity:99.82%Color and Shape:SolidMolecular weight:299.35RO4929097
CAS:<p>RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).</p>Formula:C22H20F5N3O3Purity:98.5% - 99.51%Color and Shape:SolidMolecular weight:469.4ARN2966
CAS:<p>ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.</p>Formula:C12H12N2OPurity:99.52% - 99.86%Color and Shape:SolidMolecular weight:200.24CRANAD 2
CAS:<p>CRANAD-2, a near-infrared probe, detects amyloid-beta in vivo, increasing fluorescence 70x and shifting blue 90 nm upon binding.</p>Formula:C23H25BF2N2O2Purity:99.44%Color and Shape:Dark Blue To Black PowderMolecular weight:410.271,1'-Methylenedi-2-naphthol
CAS:<p>1,1'-Methylenedi-2-naphthol target CYP2C19 - cytochrome P450 family 2 subfamily C member 19 (human).</p>Formula:C21H16O2Purity:98.91%Color and Shape:Light Pink To Light Brown Crystalline PowderMolecular weight:300.35TAE-1
CAS:<p>TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.</p>Formula:C39H51I3N6O9Purity:94.58%Color and Shape:SolidMolecular weight:1128.57Pyridoxal 5'-phosphate hydrate
CAS:<p>Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,</p>Formula:C8H10NO6PPurity:97.52%Color and Shape:SolidMolecular weight:247.14PBD-150
CAS:<p>PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)</p>Formula:C15H20N4O2SPurity:99.68%Color and Shape:SolidMolecular weight:320.41Miridesap
CAS:<p>Miridesap (GSK2315698) rapidly depletes SAP in blood, cerebrospinal fluid, and amyloid deposits via liver clearance.</p>Formula:C16H24N2O6Purity:≥95%Color and Shape:SolidMolecular weight:340.37Azeliragon HCl
CAS:<p>Azeliragon: potent oral RAGE inhibitor, blocks Alzheimer's-linked amyloid brain entry.</p>Formula:C32H40Cl3N3O2Color and Shape:SolidMolecular weight:605.04EUK-134
CAS:<p>EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.</p>Formula:C18H18ClMnN2O4Purity:98.39%Color and Shape:SolidMolecular weight:416.74JLK6
CAS:<p>JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling</p>Formula:C10H8ClNO3Purity:96.50%Color and Shape:SolidMolecular weight:225.63Cromoglicic acid
CAS:<p>Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.</p>Formula:C23H16O11Purity:99.55% - >99.99%Color and Shape:Colorless Crystals From Ethanol + Ether Physical Description Solid (Ntp 1992)Molecular weight:468.37PE859
CAS:<p>PE859 is a potent inhibitor of both tau and Aβ aggregation.</p>Formula:C28H24N4O2Purity:98.8% - 99.09%Color and Shape:SolidMolecular weight:448.52Solanezumab
CAS:<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>Purity:96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Color and Shape:LiquidMolecular weight:144.1 (kDa)γ-Secretase modulator 13
CAS:<p>γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.</p>Formula:C22H23FN6SPurity:99.79%Color and Shape:SolidMolecular weight:422.52Remternetug
CAS:<p>Remternetug is a humanized IgG1-kappa monoclonal antibody that targets the N3pGlu peptide of the amyloid beta A4 precursor protein (APP) Aβ42.</p>Purity:95% - 95%Color and Shape:LiquidDezamizumab
CAS:<p>Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.</p>Purity:95% - 95%Color and Shape:LiquidBapineuzumab
CAS:<p>Bapineuzumab (AAB-001) is a humanised monoclonal antibody targeting amyloid-beta (Aβ), soluble and oligomeric forms of amyloid β, Alzheimer's disease (AD).</p>Purity:95%Color and Shape:LiquidHomotaurine-d6
CAS:<p>Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.</p>Formula:C3D6H3NO3SColor and Shape:SolidMolecular weight:145.214-(6-Bromo-2-benzothiazolyl)benzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.</p>Formula:C13H9BrN2SPurity:98%Color and Shape:SolidMolecular weight:305.19Nicardipine pyridine metabolite II
CAS:<p>Nicardipine pyridine metabolite II is a biaoctive chemical.</p>Formula:C26H27N3O6Color and Shape:SolidMolecular weight:477.514-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).</p>Formula:C14H11BrN2SPurity:98%Color and Shape:SolidMolecular weight:319.22Aftin-5
CAS:<p>Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.</p>Formula:C19H26N6OColor and Shape:SolidMolecular weight:354.45AZ4800
CAS:<p>AZD4800 is a gamma secretase modulators.</p>Formula:C24H29N5O3Color and Shape:SolidMolecular weight:435.52THK-523
CAS:<p>THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.</p>Formula:C17H15FN2OColor and Shape:SolidMolecular weight:282.31BChE-IN-8
CAS:<p>BChE-IN-8, compound 20, is a potent oral BChE inhibitor effective on eqBChE and hBChE, crosses blood-brain barrier, and may help in Alzheimer's research.</p>Formula:C18H12BrN7O2Color and Shape:SolidMolecular weight:438.24JNJ-40418677
CAS:<p>JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.</p>Formula:C26H22F6O2Purity:98%Color and Shape:SolidMolecular weight:480.44Glutaminyl Cyclase Inhibitor 2
CAS:<p>Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).</p>Formula:C19H20FN3Purity:98%Color and Shape:SolidMolecular weight:309.38Chrysamine G
CAS:<p>Chrysamine G, Congo red analog, blocks Aβ toxicity, probes Alzheimer's amyloid.</p>Formula:C26H16N4Na2O6Color and Shape:SolidMolecular weight:526.416K 01-162
CAS:<p>K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.</p>Formula:C15H14BrNColor and Shape:SolidMolecular weight:288.18YIAD-0205
CAS:<p>YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial</p>Formula:C26H16Br2ClN3Color and Shape:SolidMolecular weight:565.69OAB-14
CAS:<p>OAB-14, a Bexarotene derivative, enhances β-amyloid clearance and cognitive function in APP/PS1 mice, improving Alzheimer's symptoms.</p>Formula:C32H46N4O2Color and Shape:SolidMolecular weight:518.73TC-E 5006
CAS:<p>γ-secretase modulator</p>Formula:C29H29F4NO2Purity:98%Color and Shape:SolidMolecular weight:499.54ELND006
CAS:<p>ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.</p>Formula:C20H14F5N3O2SColor and Shape:SolidMolecular weight:455.4Neuroinflammatory-IN-2
CAS:<p>Neuroinflammatory-IN-2: anti-neuroinflammatory, inhibits MAO-B (IC50: 10.30µM), 96.33% Aβ1-42 aggregation reduction, neuroprotective in PC-12 cells.</p>Formula:C25H27FN2O3Color and Shape:SolidMolecular weight:422.49Aβ Fibrillization modulator 1
CAS:<p>Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.</p>Formula:C17H12N4O3SSeColor and Shape:SolidMolecular weight:431.33Astrophloxine
CAS:<p>Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and</p>Formula:C27H33IN2Purity:99.89%Color and Shape:SolidMolecular weight:512.47RU-505
CAS:<p>RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.</p>Formula:C28H32FN5OPurity:98%Color and Shape:SolidMolecular weight:473.58γ-Secretase modulator 12
CAS:<p>γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM.</p>Formula:C25H23N3O2Color and Shape:SolidMolecular weight:397.47Glutaminyl Cyclase Inhibitor 5
<p>Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of</p>Formula:C22H30N6OColor and Shape:SolidMolecular weight:394.51AY1511
CAS:<p>AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].</p>Formula:C17H14O6Color and Shape:SolidMolecular weight:314.29SEN-1269
CAS:<p>SEN-1269 prevents amyloid-β aggregation, shields neurons, and improves memory by hindering Aβ(1-42)-induced issues.</p>Formula:C18H18N4O2Purity:98%Color and Shape:SolidMolecular weight:322.36BACE1/2-IN-1
CAS:<p>BACE1/2-IN-1 inhibits BACE1/2 with IC50s of 0.01μM/0.0053μM, has better permeability and lower Pgp efflux but reduced metabolic stability.</p>Formula:C21H31N5OSColor and Shape:SolidMolecular weight:401.57Antioxidant agent-2
CAS:<p>Antioxidant agent-2 (3c), BBB-permeable, selectively chelates metals; shows neuroprotection, fights liver damage in Alzheimer's research.</p>Formula:C23H26N2O7Color and Shape:SolidMolecular weight:442.46SV5
CAS:<p>SV5: potent anti-Alzheimer's, protects SHSY-5Y from Aβ1-42 death, stable with optimal pharmacology in plasma, antioxidant, neuroprotective.</p>Formula:C21H30N2O4S2Color and Shape:SolidMolecular weight:438.6TML-6
CAS:<p>TML-6, an oral derivative of curcumin, may help in Alzheimer's research by targeting amyloid production and various molecular pathways.</p>Formula:C30H37NO7Purity:99.71%Color and Shape:SolidMolecular weight:523.62BuChE-IN-2
CAS:<p>BuChE-IN-2 inhibits BuChE (IC50: 1.28 μM), NO (0.67 μM), Aβ, ROS, chelates Cu2+, penetrates BBB, used in Alzheimer's research.</p>Formula:C28H20F4N6O3Color and Shape:SolidMolecular weight:564.49Caprospinol
CAS:<p>Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity.</p>Formula:C33H52O4Purity:98%Color and Shape:SolidMolecular weight:512.76RS-0466
CAS:<p>RS-0466 is an β-amyloid-induced cytotoxicity inhibitor.</p>Formula:C17H17N5O2Purity:98%Color and Shape:SolidMolecular weight:323.35KMS88009
CAS:<p>KMS88009 is an amyloid-β aggregation inhibitor that acts by ameliorating neurodegenerative disorder.</p>Formula:C19H19NO2Color and Shape:SolidMolecular weight:293.36Ezeprogind disulfate
CAS:<p>Ezeprogind disulfate: neurotrophic inducer targeting neurodegeneration causes like Abeta, tau; for neurological disorder research.</p>Formula:C25H48N6O8S2Purity:99.72%Color and Shape:SolidMolecular weight:624.81Aleplasinin
CAS:<p>Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic</p>Formula:C28H27NO3Purity:99.21%Color and Shape:SolidMolecular weight:425.52PPI-1019
CAS:<p>PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).</p>Formula:C36H54N6O5Purity:95.16% - 98.16%Color and Shape:SolidMolecular weight:650.85Buntanetap
CAS:<p>Buntanetap ((+)-Phenserine) is an inhibitor of TINAPs used in the study of neurological disorders, endocrine and metabolic disorders, and cardiovascular disease</p>Formula:C20H23N3O2Purity:98.2%Color and Shape:SolidMolecular weight:337.42Fenlean
CAS:<p>"Fenlean (FLZ) in phase I trial at Chinese Academy's Institute of Pharmacy for Parkinson's treatment."</p>Formula:C26H27NO6Purity:98.99%Color and Shape:SolidMolecular weight:449.5Aβ-IN-1
CAS:<p>Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).</p>Formula:C35H49NPurity:99.1%Color and Shape:SoildMolecular weight:483.77MK-3328
CAS:<p>MK-3328, a potential Alzheimer's drug, binds β-Amyloid with strong affinity (IC50:10.5 nM) and may serve as a PET ligand to gauge plaque load.</p>Formula:C14H9FN4OPurity:99.70% - >99.99%Color and Shape:SolidMolecular weight:268.25Glutaminyl Cyclase Inhibitor 1
CAS:<p>Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.</p>Formula:C21H24FN3O2Purity:99.81%Color and Shape:SolidMolecular weight:369.43MAO-B-IN-9
CAS:<p>MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence.</p>Formula:C18H24N2O2Purity:99.93%Color and Shape:SolidMolecular weight:300.4DSS30
CAS:<p>DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.</p>Formula:C16H14ClNO3S2Purity:99.19% - 99.4%Color and Shape:SolidMolecular weight:367.87BI-1408
CAS:<p>BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).</p>Formula:C22H23FN6Purity:99.63%Color and Shape:SolidMolecular weight:390.46amyloid P-IN-1
CAS:<p>amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, and</p>Formula:C30H44N2O14Purity:99.76%Color and Shape:SolidMolecular weight:656.68Anti-amyloid agent-1
CAS:<p>Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].</p>Formula:C21H17F3N2O3Color and Shape:SolidMolecular weight:402.37Aβ/tau aggregation-IN-3
CAS:<p>Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functional</p>Formula:C23H22N4O3Color and Shape:SolidMolecular weight:402.45QM-FN-SO3
CAS:<p>QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].</p>Formula:C29H25N4NaO3S2Color and Shape:SolidMolecular weight:564.65BMS 433796
CAS:<p>BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.</p>Formula:C21H20F2N4O4Purity:99.17%Color and Shape:SolidMolecular weight:430.4RAGE/SERT-IN-1
CAS:<p>RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and</p>Formula:C38H41ClN4OSColor and Shape:SolidMolecular weight:637.28QR-0217
CAS:<p>QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40.</p>Formula:C19H13NO3Color and Shape:SolidMolecular weight:303.31ELND007
CAS:<p>ELND007 is a Gamma secretase inhibitor.</p>Formula:C19H14F4N4O2SColor and Shape:SolidMolecular weight:438.4PQM130
CAS:<p>PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.</p>Formula:C23H27NO4Purity:98.73%Color and Shape:SolidMolecular weight:381.46TRV-1387
CAS:<p>TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].</p>Formula:C23H25F3N4O2Color and Shape:SolidMolecular weight:446.47NNC 26-9100
CAS:<p>Somatostatin sst4 receptor agonist</p>Formula:C22H25BrCl2N6SPurity:98%Color and Shape:SolidMolecular weight:556.35γ-Secretase-IN-1
CAS:<p>γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.</p>Formula:C27H24F2N4O3Purity:99.56%Color and Shape:SolidMolecular weight:490.5MDR-1339
CAS:<p>MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.</p>Formula:C20H22O4Purity:98.57%Color and Shape:SolidMolecular weight:326.39BF-168
CAS:<p>BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).</p>Formula:C18H17FN2O2Color and Shape:SolidMolecular weight:312.34Amyloid-β-IN-3
CAS:<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Formula:C22H21F2N3O2Color and Shape:SolidMolecular weight:397.42(9R)-RO7185876
CAS:<p>(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.</p>Formula:C25H28F3N7Color and Shape:SolidMolecular weight:483.532cSPM
<p>cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.</p>Formula:C27H57N7Color and Shape:SolidMolecular weight:479.79Aβ-IN-2
<p>Aβ-IN-2 is a peptide inhibitor of Aβ1-42.</p>Formula:C37H51NOColor and Shape:SolidMolecular weight:525.81Amilo-5MER
CAS:<p>Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.</p>Formula:C23H40N6O9SColor and Shape:SolidMolecular weight:576.664γ-secretase modulator 6
CAS:<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Formula:C25H26N6O2Color and Shape:SolidMolecular weight:442.513Antioxidant agent-8
<p>Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.</p>Formula:C13H12O5Color and Shape:SolidMolecular weight:248.23MAO-B-IN-10
<p>MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.</p>Formula:C23H26N2O4Color and Shape:SolidMolecular weight:394.46Aβ aggregation-IN-1
CAS:<p>Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.</p>Formula:C9H8BF3O2Color and Shape:SolidMolecular weight:215.965Amyloid-β-IN-2
CAS:<p>Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.</p>Formula:C22H21F2N3O2Color and Shape:SolidMolecular weight:397.42Anti-Aβ agent 1A
<p>Anti-Aβ agent 1A is a potent anti-amyloid-β agent.</p>Formula:C35H49NO4Color and Shape:SolidMolecular weight:547.77QP5020
CAS:<p>QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.</p>Formula:C20H19FN6Molecular weight:362.40Buntanetap L-Tartrate
CAS:<p>Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].</p>Formula:C24H29N3O8Color and Shape:SolidMolecular weight:487.50Aβ42 agonist-1
CAS:<p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>Formula:C15H11NO2Purity:99.77%Color and Shape:SolidMolecular weight:237.252002-G12
CAS:<p>2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.</p>Formula:C20H16N6Color and Shape:SolidMolecular weight:340.381Glutaminyl Cyclase Inhibitor 3
CAS:<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Formula:C24H32N6O2SPurity:98%Color and Shape:SolidMolecular weight:468.61γ-secretase modulator 5
<p>Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.</p>Color and Shape:Solid
![1H-Indole-3-carboxylic acid, 5-[2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propoxy]…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT67751.webp&w=3840&q=75)
