GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Found 261 products of "GluR"
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VU 0360223
CAS:VU 0360223 is a negative allosteric modulator of mGlu5.Formula:C15H9FN2SPurity:98%Color and Shape:SolidMolecular weight:268.31L-AP4 monohydrate
CAS:L-AP4 (L-APB) is a group III mGluR agonist with EC50s: 0.13μM (mGlu4), 0.29μM (mGlu8), 1.0μM (mGlu6), 249μM (mGlu7).Formula:C4H12NO6PColor and Shape:SolidMolecular weight:201.115VU 0469650
CAS:VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).Formula:C22H28N4OPurity:98.03%Color and Shape:SolidMolecular weight:364.48CBiPES hydrochloride
CAS:CBiPES hydrochloride (CBiPES HCl) is an orthosteric modulator of the mGlu2 receptor and is used to study neurological disorders like epilepsy.Formula:C21H20ClN3O2SPurity:99.66%Color and Shape:SolidMolecular weight:413.92(E/Z)-SIB-1893
CAS:<p>(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893.</p>Formula:C14H13NPurity:99.92%Color and Shape:SolidMolecular weight:195.26Dasolampanel
CAS:Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.Formula:C17H20ClN5O3Purity:98.70%Color and Shape:SolidMolecular weight:377.83Troriluzole
CAS:Troriluzole is a glutamate modulator with anticancer activity and is used in the study of spinocerebellar ataxia.Formula:C15H16F3N5O4SPurity:97.14%Color and Shape:SolidMolecular weight:419.38AZD6538
CAS:AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease.Formula:C15H6FN5OPurity:98.68%Color and Shape:SolidMolecular weight:291.24S 18986
CAS:S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties inFormula:C10H12N2O2SPurity:99.64%Color and Shape:SolidMolecular weight:224.28VU 0285683
CAS:VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.Formula:C14H7FN4OPurity:99.98%Color and Shape:SolidMolecular weight:266.23Valiglurax
CAS:Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.Formula:C16H10F3N5Purity:98.29%Color and Shape:SolidMolecular weight:329.28AZD 9272
CAS:<p>AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.</p>Formula:C14H6F2N4OPurity:98.29%Color and Shape:SolidMolecular weight:284.22MNI 137
CAS:<p>MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.</p>Formula:C15H9BrN4OPurity:97.49%Color and Shape:SolidMolecular weight:341.16LY-2300559
CAS:<p>LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.</p>Formula:C26H26O6Purity:99.51%Color and Shape:SolidMolecular weight:434.48ABP688
CAS:ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.Formula:C15H16N2OPurity:98.63%Color and Shape:SolidMolecular weight:240.3LSN2463359
CAS:LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.Formula:C16H15N3OPurity:99.26%Color and Shape:SolidMolecular weight:265.31Dipraglurant
CAS:Dipraglurant: a blood-brain permeable mGluR5 NAM, orally active, selective, IC50 = 21 nM, treats PD-LID.Formula:C16H12FN3Purity:98.7%Color and Shape:SolidMolecular weight:265.29CPCCOEt
CAS:CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1bFormula:C13H13NO4Purity:99.91%Color and Shape:SolidMolecular weight:247.25AMPA receptor modulator-2
CAS:<p>AMPA receptor modulator-2 is a modulator of AMPA receptor. The pIC50 value for TARPγ2 dependent AMPA receptor is 10.1.</p>Formula:C15H6F6N4OSPurity:99.8%Color and Shape:SolidMolecular weight:404.29VU0360172
CAS:VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).Formula:C18H15FN2OPurity:99.56%Color and Shape:SolidMolecular weight:294.32JNJ-46281222
CAS:JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.Formula:C23H25F3N4Color and Shape:SolidMolecular weight:414.47MGS-0039
CAS:MGS-0039: Group II mGluR2/3 antagonist, non-serotonergic antidepressant-like effect, AMPA involvement, regulates dopamine in NAc.Formula:C15H14Cl2FNO5Purity:98%Color and Shape:SolidMolecular weight:378.18VU6012962
CAS:VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).Formula:C21H19F3N4O4Purity:99.61% - 99.74%Color and Shape:SolidMolecular weight:448.4Biphenylindanone A
CAS:Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.Formula:C30H30O4Purity:98%Color and Shape:SolidMolecular weight:454.56MFZ 10-7
CAS:MFZ 10-7 is anegative allosteric modulator of the mGluR5.Formula:C15H9FN2Purity:99.80%Color and Shape:SolidMolecular weight:236.24mGluR5 antagonist-1
CAS:mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].Formula:C23H18N4O2Color and Shape:SolidMolecular weight:382.41VU6005649
CAS:VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).Formula:C16H12F5N3OPurity:99.87%Color and Shape:SolidMolecular weight:357.28L-AP4
CAS:L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).Formula:C4H10NO5PPurity:98%Color and Shape:White To Off-White Crystalline PowderMolecular weight:183.1(2R,4R)-APDC
CAS:(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. It has anticonvulsant and neuroprotective effects.Formula:C6H10N2O4Purity:98%Color and Shape:SolidMolecular weight:174.15MTPG
CAS:Group II/group III metabotropic glutamate receptor antagonistFormula:C10H11N5O2Purity:98%Color and Shape:SolidMolecular weight:233.23VU0029251
CAS:VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 μM.Formula:C10H11N3S2Color and Shape:SolidMolecular weight:237.34MK-8768
CAS:MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized byFormula:C21H22F3N5O2Color and Shape:SolidMolecular weight:433.43Pomaglumetad methionil hydrochloride
CAS:LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.Formula:C12H19ClN2O7S2Purity:98.57%Color and Shape:SolidMolecular weight:402.87Licostinel
CAS:<p>Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.</p>Formula:C8H3Cl2N3O4Purity:98.02%Color and Shape:SolidMolecular weight:276.03FPTQ
CAS:FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].Formula:C17H12FN5Purity:99.68% - 99.88%Color and Shape:SolidMolecular weight:305.31cis-PDA
CAS:<p>cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.</p>Formula:C7H11NO4Purity:98.71%Color and Shape:White SolidMolecular weight:173.17VU6004909
CAS:VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.Formula:C21H15FN2O4Purity:96.68% - 98.44%Color and Shape:SolidMolecular weight:378.35Philanthotoxin 74 dihydrochloride
CAS:<p>Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.</p>Formula:C24H44Cl2N4O3Purity:99.75%Color and Shape:SolidMolecular weight:507.54LY-2979165
CAS:LY-2979165 is a metabotropic glutamate receptor agonist prodrug.Formula:C13H17N5O5SColor and Shape:SolidMolecular weight:355.37Pomaglumetad methionil
CAS:Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.Formula:C12H20N2O8S2Purity:98%Color and Shape:SolidMolecular weight:384.43LY2794193
CAS:LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.Formula:C16H18N2O6Purity:98.15%Color and Shape:SolidMolecular weight:334.32Azotomycin
CAS:Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.Formula:C17H23N7O8Purity:98%Color and Shape:SolidMolecular weight:453.41FP0429
CAS:FP0429 is an agonist of mGlu4.Formula:C10H12N2O7Purity:98%Color and Shape:SolidMolecular weight:272.21LY367385 hydrochloride
CAS:<p>LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.</p>Formula:C10H12ClNO4Color and Shape:SolidMolecular weight:245.66LY3020371 hydrochloride
CAS:LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.Formula:C15H16ClF2NO5SColor and Shape:SolidMolecular weight:395.81CPPG
CAS:CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.Formula:C11H14NO5PColor and Shape:SolidMolecular weight:271.21mG2N001
CAS:mG2N001, a negative allosteric modulator (NAM) of the metabotropic glutamate receptor mGluR2, has an IC50 of 93 nM and binds to mGluR2 as an antagonist with a Ki of 63 nM. This compound is microparticle- and plasma-stable, and its radioisotope [11C] mG2N001 can be utilized in PET imaging. [11C] mG2N001 exhibits good brain heterogeneity and penetration, selectively accumulating in mGluR2-rich regions to produce high-contrast brain images [1].Formula:C18H19FN2O3Color and Shape:SolidMolecular weight:330.35YM-202074
CAS:YM-202074: Selective mGlu1 antagonist, binds allosteric site (Ki=4.8 nM), inhibits mGlu1 (IC50=8.6 nM).Formula:C22H30N4O2SColor and Shape:SolidMolecular weight:414.56YM 202074
CAS:metabotropic glutamate receptor type 1 (mGlu1) antagonistFormula:C56H72N8O16S2Purity:98%Color and Shape:SolidMolecular weight:1177.34PF470
CAS:PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.Formula:C18H16N6OColor and Shape:SolidMolecular weight:332.36LY 541850
CAS:LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from humanFormula:C9H13NO4Purity:98%Color and Shape:SolidMolecular weight:199.2CVN636
CAS:CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for humanFormula:C19H20FNO4SColor and Shape:SolidMolecular weight:377.43LY2979165
CAS:LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.Formula:C13H22N6O6SPurity:98.41%Color and Shape:SolidMolecular weight:390.42Eglumegad
CAS:Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).Formula:C8H11NO4Color and Shape:SolidMolecular weight:185.18(RS)-APICA
CAS:group II metabotropic glutamate receptor antagonistFormula:C10H12NO5PColor and Shape:SolidMolecular weight:257.18YM-298198 hydrochloride
CAS:mGlu1 receptor antagonistFormula:C18H23ClN4OSPurity:98%Color and Shape:SolidMolecular weight:378.919Eglumegad hydrochloride
Eglumegad (LY354740) hydrochloride is a potent, selective agonist for group II (mGlu2/3) receptors, showing IC50 values of 5 nM for mGlu2 and 24 nM for mGlu3 receptors in transfected human cells. This compound provides neuroprotection against NMDA-induced toxicity and exhibits anxiolytic- and antipsychotic-like properties [1].Formula:C8H12ClNO4Color and Shape:SolidMolecular weight:221.64VU0080241
CAS:VU0080241 is a positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4).Formula:C19H23N5Color and Shape:SolidMolecular weight:321.42CMPDA
CAS:CMPDA is a positive allosteric modulator of AMPA receptors [EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor].Formula:C16H28N2O4S2Purity:98%Color and Shape:SolidMolecular weight:376.53YM 298198 Hydrochloride
CAS:YM 298198 HCl: non-competitive mGlu1 antagonist, Ki=19 nM. Inactive on mGlu2-7, stronger than CPCCOEt.Formula:C18H22N4OSColor and Shape:SolidMolecular weight:342.46UBP1112
CAS:group III mGlu receptor antagonistFormula:C10H14NO5PPurity:98%Color and Shape:SolidMolecular weight:259.2
