GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Found 255 products of "GluR"
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Troriluzole
CAS:<p>Troriluzole is a glutamate modulator with anticancer activity and is used in the study of spinocerebellar ataxia.</p>Formula:C15H16F3N5O4SPurity:97.14%Color and Shape:SolidMolecular weight:419.38Dipraglurant
CAS:<p>Dipraglurant: a blood-brain permeable mGluR5 NAM, orally active, selective, IC50 = 21 nM, treats PD-LID.</p>Formula:C16H12FN3Purity:98.7%Color and Shape:SolidMolecular weight:265.29LSN2463359
CAS:<p>LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.</p>Formula:C16H15N3OPurity:99.26%Color and Shape:SolidMolecular weight:265.31(E/Z)-SIB-1893
CAS:<p>(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893.</p>Formula:C14H13NPurity:99.92%Color and Shape:SolidMolecular weight:195.26Dasolampanel
CAS:<p>Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.</p>Formula:C17H20ClN5O3Purity:98.70%Color and Shape:SolidMolecular weight:377.83LY-2300559
CAS:<p>LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.</p>Formula:C26H26O6Purity:99.51%Color and Shape:SolidMolecular weight:434.48Valiglurax
CAS:<p>Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.</p>Formula:C16H10F3N5Purity:98.29%Color and Shape:SolidMolecular weight:329.28CBiPES hydrochloride
CAS:<p>CBiPES hydrochloride (CBiPES HCl) is an orthosteric modulator of the mGlu2 receptor and is used to study neurological disorders like epilepsy.</p>Formula:C21H20ClN3O2SPurity:99.66%Color and Shape:SolidMolecular weight:413.92CPCCOEt
CAS:<p>CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1b</p>Formula:C13H13NO4Purity:99.91%Color and Shape:SolidMolecular weight:247.25S 18986
CAS:<p>S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in</p>Formula:C10H12N2O2SPurity:99.64%Color and Shape:SolidMolecular weight:224.28VU 0285683
CAS:<p>VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.</p>Formula:C14H7FN4OPurity:99.98%Color and Shape:SolidMolecular weight:266.23ABP688
CAS:<p>ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.</p>Formula:C15H16N2OPurity:98.63%Color and Shape:SolidMolecular weight:240.3AZD 9272
CAS:<p>AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.</p>Formula:C14H6F2N4OPurity:98.29%Color and Shape:SolidMolecular weight:284.22AZD6538
CAS:<p>AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease.</p>Formula:C15H6FN5OPurity:98.68%Color and Shape:SolidMolecular weight:291.24MNI 137
CAS:<p>MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.</p>Formula:C15H9BrN4OPurity:97.49%Color and Shape:SolidMolecular weight:341.16VU0029251
CAS:<p>VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 μM.</p>Formula:C10H11N3S2Color and Shape:SolidMolecular weight:237.34MTPG
CAS:<p>Group II/group III metabotropic glutamate receptor antagonist</p>Formula:C10H11N5O2Purity:98%Color and Shape:SolidMolecular weight:233.23L-AP4
CAS:<p>L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).</p>Formula:C4H10NO5PPurity:98%Color and Shape:White To Off-White Crystalline PowderMolecular weight:183.1mGluR5 antagonist-1
CAS:<p>mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].</p>Formula:C23H18N4O2Color and Shape:SolidMolecular weight:382.41VU0360172
CAS:<p>VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).</p>Formula:C18H15FN2OPurity:99.56%Color and Shape:SolidMolecular weight:294.32Biphenylindanone A
CAS:<p>Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.</p>Formula:C30H30O4Purity:98%Color and Shape:SolidMolecular weight:454.56MFZ 10-7
CAS:<p>MFZ 10-7 is anegative allosteric modulator of the mGluR5.</p>Formula:C15H9FN2Purity:99.80%Color and Shape:SolidMolecular weight:236.24JNJ-46281222
CAS:<p>JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.</p>Formula:C23H25F3N4Color and Shape:SolidMolecular weight:414.47MGS-0039
CAS:<p>MGS-0039: Group II mGluR2/3 antagonist, non-serotonergic antidepressant-like effect, AMPA involvement, regulates dopamine in NAc.</p>Formula:C15H14Cl2FNO5Purity:98%Color and Shape:SolidMolecular weight:378.18FPTQ
CAS:<p>FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].</p>Formula:C17H12FN5Purity:99.68% - 99.88%Color and Shape:SolidMolecular weight:305.31VU6005649
CAS:<p>VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).</p>Formula:C16H12F5N3OPurity:99.87%Color and Shape:SolidMolecular weight:357.28VU6012962
CAS:<p>VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).</p>Formula:C21H19F3N4O4Purity:99.61% - 99.74%Color and Shape:SolidMolecular weight:448.4Pomaglumetad methionil hydrochloride
CAS:<p>LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.</p>Formula:C12H19ClN2O7S2Purity:98.57%Color and Shape:SolidMolecular weight:402.87Licostinel
CAS:<p>Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.</p>Formula:C8H3Cl2N3O4Purity:98.02%Color and Shape:SolidMolecular weight:276.03cis-PDA
CAS:<p>cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.</p>Formula:C7H11NO4Purity:98.71%Color and Shape:White SolidMolecular weight:173.17(2R,4R)-APDC
CAS:<p>(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. It has anticonvulsant and neuroprotective effects.</p>Formula:C6H10N2O4Purity:98%Color and Shape:SolidMolecular weight:174.15AMPA receptor modulator-2
CAS:<p>AMPA receptor modulator-2 is a modulator of AMPA receptor. The pIC50 value for TARPγ2 dependent AMPA receptor is 10.1.</p>Formula:C15H6F6N4OSPurity:99.8%Color and Shape:SolidMolecular weight:404.29MK-8768
CAS:<p>MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized by</p>Formula:C21H22F3N5O2Color and Shape:SolidMolecular weight:433.43Philanthotoxin 74 dihydrochloride
CAS:<p>Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.</p>Formula:C24H44Cl2N4O3Purity:99.75%Color and Shape:SolidMolecular weight:507.54VU6004909
CAS:<p>VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.</p>Formula:C21H15FN2O4Purity:96.68% - 98.44%Color and Shape:SolidMolecular weight:378.35Azotomycin
CAS:<p>Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.</p>Formula:C17H23N7O8Purity:98%Color and Shape:SolidMolecular weight:453.41CVN636
CAS:<p>CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for human</p>Formula:C19H20FNO4SColor and Shape:SolidMolecular weight:377.43LY2794193
CAS:<p>LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.</p>Formula:C16H18N2O6Purity:98.15%Color and Shape:SolidMolecular weight:334.32LY367385 hydrochloride
CAS:<p>LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.</p>Formula:C10H12ClNO4Color and Shape:SolidMolecular weight:245.66AZD 2066 hydrate
<p>AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].</p>Formula:C19H18ClN5O3Color and Shape:SolidMolecular weight:386.33CPPG
CAS:<p>CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.</p>Formula:C11H14NO5PColor and Shape:SolidMolecular weight:271.21FP0429
CAS:<p>FP0429 is an agonist of mGlu4.</p>Formula:C10H12N2O7Purity:98%Color and Shape:SolidMolecular weight:272.21LY 541850
CAS:<p>LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human</p>Formula:C9H13NO4Purity:98%Color and Shape:SolidMolecular weight:199.2LY3020371 hydrochloride
CAS:<p>LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.</p>Formula:C15H16ClF2NO5SColor and Shape:SolidMolecular weight:395.81PF470
CAS:<p>PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.</p>Formula:C18H16N6OColor and Shape:SolidMolecular weight:332.36Pomaglumetad methionil
CAS:<p>Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.</p>Formula:C12H20N2O8S2Purity:98%Color and Shape:SolidMolecular weight:384.43YM 202074
CAS:<p>metabotropic glutamate receptor type 1 (mGlu1) antagonist</p>Formula:C56H72N8O16S2Purity:98%Color and Shape:SolidMolecular weight:1177.34LY2979165
CAS:<p>LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.</p>Formula:C13H22N6O6SPurity:98.41%Color and Shape:SolidMolecular weight:390.42Eglumegad
CAS:<p>Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).</p>Formula:C8H11NO4Color and Shape:SolidMolecular weight:185.18YM-298198 hydrochloride
CAS:<p>mGlu1 receptor antagonist</p>Formula:C18H23ClN4OSPurity:98%Color and Shape:SolidMolecular weight:378.919(RS)-APICA
CAS:<p>group II metabotropic glutamate receptor antagonist</p>Formula:C10H12NO5PColor and Shape:SolidMolecular weight:257.18Eglumegad hydrochloride
<p>Eglumegad (LY354740) hydrochloride is a potent, selective agonist for group II (mGlu2/3) receptors, showing IC50 values of 5 nM for mGlu2 and 24 nM for mGlu3 receptors in transfected human cells. This compound provides neuroprotection against NMDA-induced toxicity and exhibits anxiolytic- and antipsychotic-like properties [1].</p>Formula:C8H12ClNO4Color and Shape:SolidMolecular weight:221.64VU0080241
CAS:<p>VU0080241 is a positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4).</p>Formula:C19H23N5Color and Shape:SolidMolecular weight:321.42CMPDA
CAS:<p>CMPDA is a positive allosteric modulator of AMPA receptors [EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor].</p>Formula:C16H28N2O4S2Purity:98%Color and Shape:SolidMolecular weight:376.53UBP1112
CAS:<p>group III mGlu receptor antagonist</p>Formula:C10H14NO5PPurity:98%Color and Shape:SolidMolecular weight:259.2
