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GluR

GluR

Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.

Found 265 products for "GluR".

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  • Dasolampanel
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    Dasolampanel

    CAS:
    Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.
    Formula:C17H20ClN5O3
    Purity:98.70%
    Color and Shape:Solid
    Molecular weight:377.83

    Ref: TM-T31208

  • AZD6538
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    AZD6538

    CAS:
    AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease.
    Formula:C15H6FN5O
    Purity:98.76%
    Color and Shape:Solid
    Molecular weight:291.24

    Ref: TM-T26719

  • CPCCOEt
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    CPCCOEt

    CAS:
    CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1b
    Formula:C13H13NO4
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:247.25

    Ref: TM-T22692

  • S 18986
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    S 18986

    CAS:
    S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in
    Formula:C10H12N2O2S
    Purity:99.64%
    Color and Shape:Yellow Solid
    Molecular weight:224.28

    Ref: TM-T16816

  • Pomaglumetad methionil hydrochloride
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    Pomaglumetad methionil hydrochloride

    CAS:
    LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.
    Formula:C12H19ClN2O7S2
    Purity:98.57%
    Color and Shape:Solid
    Molecular weight:402.871

    Ref: TM-T61972

  • VU6012962
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    VU6012962

    CAS:
    VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
    Formula:C21H19F3N4O4
    Purity:99.61% - 99.74%
    Color and Shape:Solid
    Molecular weight:448.3952

    Ref: TM-T13323

  • FPTQ
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    FPTQ

    CAS:
    FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].
    Formula:C17H12FN5
    Purity:99.68% - 99.88%
    Color and Shape:Solid
    Molecular weight:305.3091

    Ref: TM-T5509

  • Licostinel
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    Licostinel

    CAS:
    Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.
    Formula:C8H3Cl2N3O4
    Purity:97.10%
    Color and Shape:Yellow Solid
    Molecular weight:276.033

    Ref: TM-T27828

  • MK-8768
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    MK-8768

    CAS:
    MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized by
    Formula:C21H22F3N5O2
    Color and Shape:Solid
    Molecular weight:433.43

    Ref: TM-T79302

  • VU0029251
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    VU0029251

    CAS:
    VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 μM.
    Formula:C10H11N3S2
    Color and Shape:Solid
    Molecular weight:237.344

    Ref: TM-T78600

  • Biphenylindanone A
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    Biphenylindanone A

    CAS:
    Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.
    Formula:C30H30O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:454.56

    Ref: TM-T14615

  • Talaglumetad hydrochloride
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    Talaglumetad hydrochloride

    CAS:
    Talaglumetad hydrochloride, a prodrug of Eglumegad, targets mGluR2/3 to treat psychiatric disorders.
    Formula:C11H17ClN2O5
    Color and Shape:Solid
    Molecular weight:292.72

    Ref: TM-T60611

  • cis-PDA
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    cis-PDA

    CAS:
    cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.
    Formula:C7H11NO4
    Purity:98.71%
    Color and Shape:Solid
    Molecular weight:173.1665

    Ref: TM-T20571

  • VU6005649
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    VU6005649

    CAS:
    VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).
    Formula:C16H12F5N3O
    Purity:99.87%
    Color and Shape:Yellow Solid
    Molecular weight:357.278

    Ref: TM-T13321

  • MGS-0039
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    MGS-0039

    CAS:
    MGS-0039: Group II mGluR2/3 antagonist, non-serotonergic antidepressant-like effect, AMPA involvement, regulates dopamine in NAc.
    Formula:C15H14Cl2FNO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:378.18

    Ref: TM-T28034

  • (1S,3R)-ACPD
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    (1S,3R)-ACPD

    CAS:
    (1S,3R)-ACPD is a group I and II mGlu receptor agonist.
    Formula:C7H11NO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:173.17

    Ref: TM-T22488

  • (2R,4R)-APDC
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    (2R,4R)-APDC

    CAS:
    (2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. It has anticonvulsant and neuroprotective effects.
    Formula:C6H10N2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:174.15

    Ref: TM-T10095

  • MTPG
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    MTPG

    CAS:
    Group II/group III metabotropic glutamate receptor antagonist
    Formula:C10H11N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:233.23

    Ref: TM-T23033

  • mGluR5 antagonist-1
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    mGluR5 antagonist-1

    CAS:
    mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].
    Formula:C23H18N4O2
    Color and Shape:Solid
    Molecular weight:382.41

    Ref: TM-T81801

  • VU0360172
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    VU0360172

    CAS:
    VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).
    Formula:C18H15FN2O
    Purity:99.56%
    Color and Shape:Yellow Solid
    Molecular weight:294.3229

    Ref: TM-T29126