Proteasome
Proteasome inhibitors are compounds that inhibit the proteasome, a large protein complex responsible for degrading unwanted or damaged proteins within the cell. Inhibition of the proteasome leads to the accumulation of proteins, which can induce cell cycle arrest and apoptosis, particularly in rapidly dividing cells like cancer cells. Proteasome inhibitors are crucial in cancer research and therapy, especially in the treatment of multiple myeloma and other hematologic malignancies. At CymitQuimica, we offer proteasome inhibitors to support your research in oncology, cell biology, and drug development.
Found 94 products of "Proteasome"
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Trelagliptin
CAS:<p>Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.</p>Formula:C18H20FN5O2Purity:98.88%Color and Shape:SolidMolecular weight:357.38RA190
CAS:<p>RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.</p>Formula:C28H23Cl5N2O2Purity:97.7%Color and Shape:SolidMolecular weight:596.76Gabexate mesylate
CAS:<p>Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.</p>Formula:C17H27N3O7SPurity:99.2% - 99.64%Color and Shape:White CrystalMolecular weight:417.48Saxagliptin hydrate
CAS:<p>Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).</p>Formula:C18H25N3O2·H2OPurity:99.52%Color and Shape:SolidMolecular weight:333.43Arimoclomol maleate
CAS:<p>Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.</p>Formula:C18H24ClN3O7Purity:99.44% - 99.98%Color and Shape:SolidMolecular weight:429.85UT-34
CAS:<p>UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild</p>Formula:C15H12F4N4O2Purity:98.12%Color and Shape:SolidMolecular weight:356.27RAMB4
CAS:<p>RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.</p>Formula:C19H13Cl4NOPurity:98.89% - 99.38%Color and Shape:SolidMolecular weight:413.12Sitagliptin
CAS:<p>Sitagliptin (MK0431), an oral DPP-4 inhibitor, treats type 2 diabetes alone or with metformin/thiazolidinedione by increasing incretins and insulin.</p>Formula:C16H15F6N5OPurity:99.33% - 99.83%Color and Shape:Yellow GreaseMolecular weight:407.31ML604440
CAS:<p>ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.</p>Formula:C17H24BF3N2O4Purity:97.06%Color and Shape:SolidMolecular weight:388.19Pepstatin
CAS:<p>Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.</p>Formula:C34H63N5O9Purity:96.74% - 99.94%Color and Shape:SolidMolecular weight:685.89DBPR108
CAS:<p>DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.</p>Formula:C16H25FN4O2Purity:99.68%Color and Shape:SolidMolecular weight:324.39Dazcapistat
CAS:<p>Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.</p>Formula:C21H18FN3O4Purity:99.11%Color and Shape:SolidMolecular weight:395.38Acetyl-Calpastatin(184-210)(human)
CAS:<p>Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.</p>Formula:C142H230N36O44SPurity:98%Color and Shape:SolidMolecular weight:3177.65Phepropeptin B
CAS:<p>Phepropeptin B is a secondary metabolite derived from microorganisms, functioning as a proteasome (proteasome) inhibitor with an IC50 value of 11 μg/mL.</p>Formula:C40H56N6O6Color and Shape:SolidMolecular weight:716.91Acetyl-Calpastatin(184-210)(human) TFA
<p>Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.</p>Formula:C144H231F3N36O46SColor and Shape:SolidMolecular weight:3291.65LMP7/LMP2-IN-1
CAS:<p>LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.</p>Formula:C16H27BN4O3Color and Shape:SoildMolecular weight:334.22Procizumab
<p>Procizumab is a humanized IgG1 antibody that targets dipeptidyl peptidase 3 (DPP3). It shows potential for investigating sepsis. For the isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Color and Shape:Odour LiquidPhepropeptin C
CAS:<p>Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.</p>Formula:C38H60N6O6Color and Shape:SolidMolecular weight:696.92VAMP
<p>VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.</p>Formula:C18H32N4O5SColor and Shape:SolidMolecular weight:416.535Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Color and Shape:Odour SolidGly-Pro-pNA hydrochloride
CAS:<p>Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase</p>Formula:C13H17ClN4O4Purity:99.84%Color and Shape:SolidMolecular weight:328.75LXE408 fumarate
<p>LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.</p>Formula:C27H22FN7O6Purity:99.89%Color and Shape:SoildMolecular weight:559.51PROTAC 20S proteasome subunit β5 degrader 2
<p>PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader targeting the 20S proteasome subunit β5 (20Sproteasomesubunit β5), with a DC50 of 0.16 μM. It inhibits the proliferation of FaDu cancer cells, showcasing an IC50 of 0.23 μM. Additionally, PROTAC20Sproteasomesubunit β5 degrader 2 demonstrates antitumor activity in a mouse model.</p>Color and Shape:Odour Solidβ5i-IN-1
<p>β5i-IN-1 is a selective inhibitor of β5i, exhibiting potent activity with an IC50 of 8.463 nM.</p>Purity:98%Color and Shape:Odour SolidPhepropeptin D
CAS:<p>Phepropeptin D is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 7.8 μg/mL.</p>Formula:C41H58N6O6Color and Shape:SolidMolecular weight:730.94Bortezomib analog
<p>Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.</p>Color and Shape:Odour SolidDPP-4-IN-14
<p>DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.</p>Formula:C33H27N7O3Color and Shape:SolidMolecular weight:569.613Phepropeptin A
CAS:<p>Phepropeptin A is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 21 μg/mL.</p>Formula:C37H58N6O6Color and Shape:SolidMolecular weight:682.89DPP8/9-IN-1
<p>DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.</p>Color and Shape:Odour SolidProteasome-IN-7
<p>Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.</p>Formula:C48H56N6O10SColor and Shape:SolidMolecular weight:909.06Cerpegin
CAS:<p>Cerpegin, a pyridine ketone fused c-lactone, acts as an inhibitor of the 20S proteasome. It possesses pharmacological properties as a neuropsychiatric sedative, anti-inflammatory, analgesic, and exhibits anti-ulcer activity.</p>Formula:C10H11NO3Color and Shape:SolidMolecular weight:193.2H-Pro-Lys-OH TFA
<p>H-Pro-Lys-OH TFA is a dipeptide composed of proline and lysine, serving as a substrate for imino dipeptidase (prolinase). Additionally, it can be utilized in peptide synthesis.</p>Formula:C13H22F3N3O5Color and Shape:SolidMolecular weight:357.335-Amino-8-hydroxyquinoline
CAS:<p>5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.</p>Formula:C9H8N2OPurity:99.69%Color and Shape:SolidMolecular weight:160.17Alogliptin (13CD3)
CAS:<p>Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.</p>Formula:C18H21N5O2Purity:98%Color and Shape:SolidMolecular weight:343.4Teneligliptin D8
CAS:<p>Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.</p>Formula:C22H30N6OSPurity:98%Color and Shape:SolidMolecular weight:434.63Brensocatib
CAS:<p>Brensocatib (AZD7986) is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively).</p>Formula:C23H24N4O4Purity:97.55%Color and Shape:SolidMolecular weight:420.4618α-Glycyrrhetinic acid
CAS:<p>18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.</p>Formula:C30H46O4Purity:98.54% - 99.68%Color and Shape:SolidMolecular weight:470.68TCH-165
CAS:<p>TCH-165 boosts 20S proteasome levels, enhancing IDP breakdown.</p>Formula:C39H37N3O3Purity:98.2% - 98.75%Color and Shape:SolidMolecular weight:595.73Ixazomib citrate
CAS:<p>Ixazomib citrate (MLN9708), a prodrug of Ixazomib (MMLN-2238), is an oral 2nd-gen proteasome inhibitor with anti-cancer potential (IC50: 3.4 nM).</p>Formula:C20H23BCl2N2O9Purity:98.37% - >99.99%Color and Shape:SolidMolecular weight:517.12MG-132
CAS:<p>MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!</p>Formula:C26H41N3O5Purity:95% - 99.99%Color and Shape:White To Off-White PowderMolecular weight:475.62Alloxan monohydrate
CAS:<p>Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.</p>Formula:C4H4N2O5Purity:99.01% - 99.42%Color and Shape:Off-White To Beige-Yellowish Crystalline PowderMolecular weight:160.09ARV-471
CAS:<p>ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.</p>Formula:C45H49N5O4Purity:97.15% - >99.99%Color and Shape:SolidMolecular weight:723.9Omarigliptin
CAS:<p>Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. Cost-effective and quality-assured.</p>Formula:C17H20F2N4O3SPurity:99.68% - 99.77%Color and Shape:SolidMolecular weight:398.43Calpeptin
CAS:<p>Calpeptin is a potent, cell-permeable calpain inhibitor.</p>Formula:C20H30N2O4Purity:97.06% - 98.33%Color and Shape:White To Off-White PowderMolecular weight:362.46Talabostat mesylate
CAS:<p>Talabostat mesylate (PT100): Oral DPP4 inhibitor, IC50 0.18 nM, targets tumor-linked proteins, boosts hematopoiesis.</p>Formula:C10H23BN2O6SPurity:98% - 99.91%Color and Shape:SolidMolecular weight:310.18PI-1840
CAS:<p>PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.</p>Formula:C22H26N4O3Purity:98.82%Color and Shape:SolidMolecular weight:394.474'-Hydroxychalcone
CAS:<p>4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity</p>Formula:C15H12O2Purity:99.86% - 99.87%Color and Shape:Yellow-Cream PowderMolecular weight:224.25ONX-0914
CAS:<p>ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.</p>Formula:C31H40N4O7Purity:98.24% - 99.31%Color and Shape:SolidMolecular weight:580.67Bortezomib
CAS:<p>Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.</p>Formula:C19H25BN4O4Purity:97.79% - >99.99%Color and Shape:Yellow SolidMolecular weight:384.24Epoxomicin
CAS:<p>Epoxomicin, a selective proteasome inhibitor, chiefly blocks CH-L activity, mildly affecting T-L and PGPH at lower rates.</p>Formula:C28H50N4O7Purity:98.65% - 98.86%Color and Shape:White To Off-White SolidMolecular weight:554.72Carfilzomib
CAS:<p>Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome.</p>Formula:C40H57N5O7Purity:99.6% - 99.84%Color and Shape:SolidMolecular weight:719.91MDL-28170
CAS:<p>MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.</p>Formula:C22H26N2O4Purity:95.06%Color and Shape:SolidMolecular weight:382.45ISOGINKGETIN
CAS:<p>ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.</p>Formula:C32H22O10Purity:98% - 99.72%Color and Shape:SolidMolecular weight:566.51Oprozomib
CAS:<p>Oprozomib inhibits 20S proteasome β5/LMP7, is orally available, and may have cancer-fighting properties. IC50: β5 - 36 nM; LMP7 - 82 nM.</p>Formula:C25H32N4O7SPurity:98% - 99.87%Color and Shape:SolidMolecular weight:532.61UAMC00039 dihydrochloride
CAS:<p>UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM.</p>Formula:C16H26Cl3N3OPurity:>99.99%Color and Shape:SolidMolecular weight:382.76MUN57694
CAS:<p>MUN57694 is an inhibitor of 26S proteasome.</p>Formula:C23H25N3O4Purity:99%Color and Shape:SolidMolecular weight:407.46Saxagliptin
CAS:<p>Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.</p>Formula:C18H25N3O2Purity:99.17% - 99.95%Color and Shape:SolidMolecular weight:315.41Tomatine
CAS:<p>Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells.</p>Formula:C50H83NO21Purity:98.42% - 99.94%Color and Shape:White To Light YellowMolecular weight:1034.19MG-101
CAS:<p>MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.</p>Formula:C20H37N3O4Purity:98% - ≥98%Color and Shape:SolidMolecular weight:383.53Bortezomib-pinanediol
CAS:<p>Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.</p>Formula:C29H39BN4O4Purity:97.5%Color and Shape:Yellow SolidMolecular weight:518.46DD1
CAS:<p>DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.</p>Formula:C16H14N2O3Purity:99.57%Color and Shape:SolidMolecular weight:282.29Tripterin
CAS:<p>Tripterin (Celastrol) is an proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with antioxidant and anti-inflammatory effects.</p>Formula:C29H38O4Purity:98.56% - 99.8%Color and Shape:Red Crystalline PowderMolecular weight:450.61Cilastatin
CAS:<p>Cilastatin (MK0791): protects imipenem from renal breakdown; inhibits leukotriene D4 metabolism.</p>Formula:C16H26N2O5SPurity:97.76% - 99.71%Color and Shape:SolidMolecular weight:358.45Proteasome inhibitor IX
CAS:<p>Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).</p>Formula:C20H21B2NO5Purity:99.77%Color and Shape:SolidMolecular weight:377.01VR23
CAS:<p>VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.</p>Formula:C19H16ClN5O6SPurity:98.99% - 99.22%Color and Shape:SolidMolecular weight:477.88Anagliptin
CAS:<p>Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.</p>Formula:C19H25N7O2Purity:97.59% - 99.98%Color and Shape:SolidMolecular weight:383.45Ixazomib
CAS:<p>Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.</p>Formula:C14H19BCl2N2O4Purity:98% - 98.92%Color and Shape:SolidMolecular weight:361.03Trelagliptin succinate
CAS:<p>Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (</p>Formula:C22H26FN5O6Purity:99.27% - 99.92%Color and Shape:SolidMolecular weight:475.47(R)-MG-132
CAS:<p>(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.</p>Formula:C26H41N3O5Purity:98.45%Color and Shape:SolidMolecular weight:475.62Delanzomib
CAS:<p>Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.</p>Formula:C21H28BN3O5Purity:95.52% - 99.46%Color and Shape:SolidMolecular weight:413.28Sitagliptin phosphate monohydrate
CAS:<p>Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.</p>Formula:C16H15F6N5O·H3PO4·H2OPurity:99.85% - 99.98%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:523.33KZR-504
CAS:<p>KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).</p>Formula:C21H23N3O6Color and Shape:SolidMolecular weight:413.42Diprotin B
CAS:<p>Diprotin B is a dipeptidyl peptidase IV inhibitor.</p>Formula:C16H29N3O4Purity:98%Color and Shape:White Lyophilized PowderMolecular weight:327.42Gemigliptin Tartrate(911637-19-9 free base)
CAS:<p>Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4).</p>Formula:C22H25F8N5O8Purity:>99.99%Color and Shape:SolidMolecular weight:639.45BC-23
CAS:<p>BC-23 (NSC 45382) is a proteasome inhibitor with antitumor and antimicrobial activity for the study of leukemia and small cell lung cancer.</p>Formula:C21H14ClN3O4SPurity:98%Color and Shape:SolidMolecular weight:439.87Z-LLF-CHO
CAS:<p>Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.</p>Formula:C29H39N3O5Purity:98%Color and Shape:SolidMolecular weight:509.64Proteasome-IN-1
CAS:<p>Proteasome-IN-1 is an inhibitor of proteasome.</p>Formula:C42H35N5O3Purity:98%Color and Shape:SolidMolecular weight:657.7620S Proteasome activator 1
CAS:<p>20S Proteasome activator 1: IC50—0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein A53T, aids neurodegenerative studies.</p>Formula:C27H19ClF2N2OSPurity:99.82%Color and Shape:SolidMolecular weight:492.97Gemigliptin
CAS:<p>Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)</p>Formula:C18H19F8N5O2Purity:99.72%Color and Shape:SolidMolecular weight:489.36Arimoclomol
CAS:<p>Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (</p>Formula:C14H20ClN3O3Purity:99.15%Color and Shape:SolidMolecular weight:313.78Proteasome-IN-5
CAS:<p>Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].</p>Formula:C20H30BN5O7Purity:98%Color and Shape:SolidMolecular weight:463.29Proteasome β2c/i-IN-1
CAS:<p>Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].</p>Formula:C32H48N4O7Purity:98%Color and Shape:SolidMolecular weight:600.75LU-002i
CAS:<p>LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].</p>Formula:C35H52N4O7Purity:98%Color and Shape:SolidMolecular weight:640.81TCL1
CAS:<p>TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.</p>Formula:C19H14BrClN4O2SColor and Shape:SolidMolecular weight:477.762ZINC09518833
CAS:<p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>Formula:C24H25N3O5Color and Shape:SolidMolecular weight:435.47RBx-0597
CAS:<p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>Formula:C19H20F2N4O2Color and Shape:SolidMolecular weight:374.384(2S,4R)-Teneligliptin
CAS:<p>(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.</p>Formula:C22H30N6OSColor and Shape:SolidMolecular weight:426.578DPP-4-IN-15
CAS:<p>DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.</p>Formula:C17H14F3N3O2SColor and Shape:SolidMolecular weight:381.372Boc3Arg
<p>Boc 3 Arg is a tert-butyl carbamate-protected arginine compound. It serves as an efficient tag that induces degradation by directly targeting proteins to the 20S proteasome.</p>Formula:C21H39N5O7Color and Shape:SolidMolecular weight:473.56Marizomib
CAS:<p>Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.</p>Formula:C15H20ClNO4Purity:98.03% - 99.41%Color and Shape:SolidMolecular weight:313.78Immunoproteasome activator 1
CAS:<p>Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.</p>Formula:C24H23N3O3Color and Shape:SolidMolecular weight:401.46PB01
CAS:<p>PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.</p>Formula:C18H21N5O3Color and Shape:SolidMolecular weight:355.391BI-1942
CAS:<p>BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.</p>Formula:C24H26N4O4Color and Shape:SolidMolecular weight:434.488Davelizomib
CAS:<p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>Formula:C21H26BF2N3O7Purity:98%Color and Shape:SolidMolecular weight:481.25
