PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(159 products)
- ATM/ATR(71 products)
- DNA-PK(51 products)
- EGFR(572 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(242 products)
- S6 Kinase(9 products)
- gsk-3(112 products)
- mTOR(144 products)
Show 2 more subcategories
Found 1038 products of "PI3K/Akt/mTOR Signaling"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
EAI045
CAS:<p>EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.</p>Formula:C19H14FN3O3SPurity:98.00% - 99.12%Color and Shape:SolidMolecular weight:383.4Chrysophanol
CAS:<p>Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.</p>Formula:C15H10O4Purity:99.44% - 99.91%Color and Shape:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CMolecular weight:254.24PI-3065
CAS:<p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>Formula:C27H31FN6OSPurity:99.84% - ≥95%Color and Shape:SolidMolecular weight:506.64TBB
CAS:<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Formula:C6HBr4N3Purity:98.51% - 99.45%Color and Shape:Off-White SolidMolecular weight:434.71Linperlisib
CAS:<p>Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ</p>Formula:C28H37FN6O5SPurity:99.01%Color and Shape:SolidMolecular weight:588.69TGX-221
CAS:<p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>Formula:C21H24N4O2Purity:99.68% - >99.99%Color and Shape:SolidMolecular weight:364.44WZ4003
CAS:<p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>Formula:C25H29ClN6O3Purity:99.65% - >99.99%Color and Shape:SolidMolecular weight:496.99RSVA405
CAS:<p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>Formula:C17H20N4O2Purity:99.30%Color and Shape:SolidMolecular weight:312.37SU5214
CAS:<p>SU5214 is a modulator of tyrosine kinase signal transduction.</p>Formula:C16H13NO2Purity:99.45% - 99.55%Color and Shape:SolidMolecular weight:251.28OTSSP167
CAS:<p>OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.</p>Formula:C25H28Cl2N4O2Purity:98.22% - 99.47%Color and Shape:SolidMolecular weight:487.42Bikinin
CAS:<p>Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.</p>Formula:C9H9BrN2O3Purity:99.86% - >99.99%Color and Shape:SolidMolecular weight:273.08Tyrphostin AG 528
CAS:<p>Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).</p>Formula:C18H14N2O3Purity:99.64%Color and Shape:SolidMolecular weight:306.32Eganelisib
CAS:<p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>Formula:C30H24N8O2Purity:99.04% - 99.28%Color and Shape:SolidMolecular weight:528.56Epitinib
CAS:<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Formula:C24H26N6O2Color and Shape:SolidMolecular weight:430.5AMG 511
CAS:<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>Formula:C22H28FN9O3SPurity:≥98%Color and Shape:SolidMolecular weight:517.58PD153035 hydrochloride
CAS:<p>PD153035 hydrochloride (ZM 252868) is a effective and selective inhibitor of EGFR; few influence against FGFR, PGDFR, InsR, CSF-1, and Src.</p>Formula:C16H15BrClN3O2Purity:99.39% - ≥95%Color and Shape:SolidMolecular weight:396.67PI-103
CAS:<p>PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).</p>Formula:C19H16N4O3Purity:97.79% - 99.3%Color and Shape:SolidMolecular weight:348.36Gefitinib-based PROTAC 3
CAS:<p>Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).</p>Formula:C47H57ClFN7O8SPurity:97.29% - 98.25%Color and Shape:SolidMolecular weight:934.51ZM39923 hydrochloride
CAS:<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Formula:C23H25NO·HClPurity:98.05%Color and Shape:SolidMolecular weight:367.91A66
CAS:<p>A66 is a specific and effective p110α inhibitor(IC50=32 nM).</p>Formula:C17H23N5O2S2Purity:99.51% - ≥95%Color and Shape:SolidMolecular weight:393.53
