PI3K
PI3K inhibitors are compounds that block the activity of Phosphoinositide 3-Kinases (PI3Ks), a family of enzymes involved in a wide range of cellular processes, including growth, proliferation, survival, and metabolism. The PI3K/Akt/mTOR pathway is often dysregulated in cancer, making PI3K a key target for cancer therapy. PI3K inhibitors are critical tools for studying signal transduction, cancer biology, and the development of targeted therapies. At CymitQuimica, we provide a variety of PI3K inhibitors to support your research in cell signaling, oncology, and therapeutic development.
Found 231 products of "PI3K"
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Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Formula:C23H30N8O3SPurity:98.28% - 99.64%Color and Shape:SolidMolecular weight:498.6Brevianamide F
CAS:Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.
Formula:C16H17N3O2Purity:97.30% - 98.82%Color and Shape:SolidMolecular weight:283.33HS-173
CAS:HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).Formula:C21H18N4O4SPurity:99.33% - 99.64%Color and Shape:SolidMolecular weight:422.46Ref: TM-T2308
2mg34.00€5mg52.00€1mL*10mM (DMSO)52.00€10mg77.00€25mg128.00€50mg200.00€100mg296.00€200mg425.00€PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Formula:C16H14BrN5O4S·HClPurity:97.82%Color and Shape:SolidMolecular weight:488.74YS-49
CAS:YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).Formula:C20H20BrNO2Purity:99.65%Color and Shape:SolidMolecular weight:386.28Ref: TM-T13376
1mg46.00€2mg58.00€1mL*10mM (DMSO)92.00€5mg95.00€10mg137.00€25mg260.00€50mg386.00€100mg560.00€500mg1,153.00€Glaucocalyxin A
CAS:Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.Formula:C20H28O4Purity:99.55% - 99.80%Color and Shape:SolidMolecular weight:332.43Rigosertib
CAS:Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.Formula:C21H25NO8SPurity:99.53%Color and Shape:SolidMolecular weight:451.49Flupentixol dihydrochloride
CAS:Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.Formula:C23H27Cl2F3N2OSPurity:98.76% - >99.99%Color and Shape:White Or Off-White SolidMolecular weight:507.43Erucic acid
CAS:Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).Formula:C22H42O2Purity:99.64%Color and Shape:Needles From Alcohol Liquid OthersolidMolecular weight:338.57NIBR-17
CAS:NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.Formula:C18H20N8O2Purity:97.79%Color and Shape:SolidMolecular weight:380.4Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formula:C36H56O13Purity:99.66% - 99.74%Color and Shape:SolidMolecular weight:696.82Ref: TM-T5S1982
1mg35.00€5mg77.00€10mg106.00€1mL*10mM (DMSO)107.00€25mg170.00€50mg253.00€100mg375.00€500mg892.00€ETP-46321
CAS:ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).Formula:C20H27N9O3SPurity:99.8%Color and Shape:SolidMolecular weight:473.55Ref: TM-TQ0229
1mg37.00€5mg82.00€1mL*10mM (DMSO)86.00€10mg116.00€25mg212.00€50mg298.00€100mg408.00€200mg552.00€Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Formula:C25H17F2N5O3SPurity:98% - 99.8%Color and Shape:SolidMolecular weight:505.5AMG 511
CAS:AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).Formula:C22H28FN9O3SPurity:≥98%Color and Shape:SolidMolecular weight:517.58Desmethylglycitein
CAS:Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFormula:C15H10O5Purity:97.93%Color and Shape:SolidMolecular weight:270.24PF-4989216
CAS:PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.Formula:C18H13FN6OSPurity:99.85%Color and Shape:SolidMolecular weight:380.4Ref: TM-T6938
2mg37.00€5mg62.00€1mL*10mM (DMSO)64.00€10mg96.00€25mg177.00€50mg311.00€100mg376.00€200mg535.00€PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formula:C19H16N4O3Purity:97.79% - 99.3%Color and Shape:SolidMolecular weight:348.36GNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Formula:C21H28N8O3S2Purity:98.88% - 99.55%Color and Shape:SolidMolecular weight:504.63Ref: TM-T3692
1mg44.00€2mg57.00€1mL*10mM (DMSO)92.00€5mg93.00€10mg138.00€25mg286.00€50mg447.00€100mg677.00€AS-605240
CAS:AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).Formula:C12H7N3O2SPurity:97% - 99.91%Color and Shape:SolidMolecular weight:257.27Serabelisib
CAS:Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).Formula:C19H17N5O3Purity:98.41% - 99.5%Color and Shape:SolidMolecular weight:363.37GDC0084
CAS:GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.
Formula:C18H22N8O2Purity:99.72% - 99.87%Color and Shape:SolidMolecular weight:382.42Taurolithocholic acid sodium salt
CAS:Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, butFormula:C26H44NNaO5SPurity:99.79% - 99.93%Color and Shape:SolidMolecular weight:505.69ZSTK474
CAS:PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potentialFormula:C19H21F2N7O2Purity:98.29% - 99.95%Color and Shape:White PowderMolecular weight:417.41Hederacolchiside A1
CAS:Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.Formula:C47H76O16Purity:98.76% - 99.92%Color and Shape:SolidMolecular weight:897.1Ref: TM-T2P2806
1mg46.00€5mg114.00€1mL*10mM (DMSO)161.00€10mg167.00€25mg268.00€50mg408.00€100mg587.00€200mg825.00€Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Formula:C21H22O11Purity:98.63% - 99.54%Color and Shape:SolidMolecular weight:450.393-Methyladenine
CAS:3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).Formula:C6H7N5Purity:98% - 99.51%Color and Shape:SolidMolecular weight:149.15Vps34-PIK-III
CAS:Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.Formula:C17H17N7Purity:98.39% - 98.43%Color and Shape:SolidMolecular weight:319.36Ref: TM-T6945
1mg49.00€2mg67.00€5mg110.00€1mL*10mM (DMSO)110.00€10mg192.00€25mg429.00€50mg628.00€100mg893.00€500mg1,791.00€(E)-Akt inhibitor-IV
CAS:(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.Formula:C31H29IN4SPurity:99.74% - 99.9%Color and Shape:SolidMolecular weight:616.56Ref: TM-T9393
1mg52.00€5mg110.00€1mL*10mM (DMSO)148.00€10mg170.00€25mg319.00€50mg444.00€100mg620.00€200mg875.00€Rigosertib sodium
CAS:Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.Formula:C21H24NNaO8SPurity:98% - 99.37%Color and Shape:SolidMolecular weight:473.47Idelalisib
CAS:Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).Formula:C22H18FN7OPurity:98% - 99.39%Color and Shape:SolidMolecular weight:415.42Ref: TM-T1894
5mg34.00€10mg48.00€1mL*10mM (DMSO)50.00€25mg71.00€50mg88.00€100mg103.00€200mg133.00€500mg213.00€iMDK
CAS:iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.Formula:C21H13FN2O2SPurity:99.99%Color and Shape:SolidMolecular weight:376.4Fimepinostat
CAS:Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.Formula:C23H24N8O4SPurity:98.27% - 99.87%Color and Shape:SolidMolecular weight:508.55Ref: TM-T2078
2mg44.00€5mg66.00€1mL*10mM (DMSO)74.00€10mg92.00€25mg172.00€50mg295.00€100mg485.00€500mg1,035.00€Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Formula:C17H20F3N7O2Purity:97.58% - 98.92%Color and Shape:SolidMolecular weight:411.38TASP0415914
CAS:TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TFormula:C13H17N5O3SPurity:98.14%Color and Shape:SolidMolecular weight:323.37Ref: TM-T7879
1mg52.00€5mg111.00€1mL*10mM (DMSO)127.00€10mg177.00€25mg299.00€50mg424.00€100mg587.00€200mg792.00€GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormula:C17H20N6O2SPurity:98%Color and Shape:SolidMolecular weight:372.44SKI V
CAS:SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),
Formula:C15H10O4Purity:98.78%Color and Shape:SolidMolecular weight:254.24NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Formula:C20H14F3N3SPurity:99.84% - 99.9%Color and Shape:SolidMolecular weight:385.41Ref: TM-T3556
2mg35.00€5mg51.00€1mL*10mM (DMSO)55.00€10mg75.00€25mg133.00€50mg225.00€100mg323.00€200mg447.00€Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Formula:C23H24O8Purity:95.84% - 99.77%Color and Shape:White SolidMolecular weight:428.43Ref: TM-T6283
1mg35.00€2mg50.00€5mg75.00€1mL*10mM (DMSO)84.00€10mg113.00€25mg224.00€50mg385.00€100mg570.00€AS-252424
CAS:AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.Formula:C14H8FNO4SPurity:99.06% - 99.09%Color and Shape:SolidMolecular weight:305.28Ref: TM-T6208
1mg37.00€2mg52.00€5mg77.00€1mL*10mM (DMSO)84.00€10mg128.00€25mg205.00€50mg309.00€100mg447.00€500mg973.00€1,3-Dicaffeoylquinic acid
CAS:1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.Formula:C25H24O12Purity:98% - 98.81%Color and Shape:SolidMolecular weight:516.45Ref: TM-T5736
1mg37.00€5mg71.00€10mg90.00€1mL*10mM (DMSO)103.00€25mg147.00€50mg208.00€100mg309.00€200mg447.00€PF-04691502
CAS:PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Formula:C22H27N5O4Purity:96.27% - ≥95%Color and Shape:SolidMolecular weight:425.48Ref: TM-T6251
1mg34.00€2mg43.00€5mg63.00€1mL*10mM (DMSO)65.00€10mg88.00€25mg117.00€50mg187.00€100mg333.00€Oroxin B
CAS:Oroxin B (Hypocretin-2) has antioxidant activity.Formula:C27H30O15Purity:98.22% - 99.87%Color and Shape:SolidMolecular weight:594.52BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Formula:C28H25F3N6O2Purity:95.74% - 99.78%Color and Shape:SolidMolecular weight:534.53Ref: TM-T6072L
1mg47.00€2mg62.00€5mg92.00€1mL*10mM (DMSO)107.00€10mg147.00€25mg295.00€50mg485.00€100mg737.00€PIK-294
CAS:PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).Formula:C28H23N7O2Purity:97.22% - >99.99%Color and Shape:SolidMolecular weight:489.53PI-3065
CAS:PI-3065 is a novel potent and selective PI3K p110δ inhibitor.Formula:C27H31FN6OSPurity:99.84% - ≥95%Color and Shape:SolidMolecular weight:506.64Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purity:96.66% - 99.93%Color and Shape:SolidMolecular weight:332.39AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Formula:C18H20N8O2Purity:99.03% - 99.85%Color and Shape:SolidMolecular weight:380.4Ref: TM-T7122
1mg38.00€5mg84.00€1mL*10mM (DMSO)93.00€10mg113.00€25mg177.00€50mg295.00€100mg447.00€200mg650.00€1-Deoxynojirimycin
CAS:1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.Formula:C6H13NO4Purity:99.65% - 99.98%Color and Shape:White-Beige Solid CrystallineMolecular weight:163.17Ref: TM-T3675
2mg43.00€1mL*10mM (DMSO)57.00€5mg58.00€10mg74.00€25mg140.00€50mg248.00€100mg321.00€500mg773.00€1-Deoxynojirimycin hydrochloride
CAS:1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves.Formula:C6H14ClNO4Purity:99.88%Color and Shape:SolidMolecular weight:199.63Copanlisib
CAS:Copanlisib (BAY 80-6946), a PI3K inhibitor, may block tumor growth and improve cancer treatment efficacy.Formula:C23H28N8O4Purity:99% - 99.88%Color and Shape:SolidMolecular weight:480.52
