PI3K
PI3K inhibitors are compounds that block the activity of Phosphoinositide 3-Kinases (PI3Ks), a family of enzymes involved in a wide range of cellular processes, including growth, proliferation, survival, and metabolism. The PI3K/Akt/mTOR pathway is often dysregulated in cancer, making PI3K a key target for cancer therapy. PI3K inhibitors are critical tools for studying signal transduction, cancer biology, and the development of targeted therapies. At CymitQuimica, we provide a variety of PI3K inhibitors to support your research in cell signaling, oncology, and therapeutic development.
Found 242 products of "PI3K"
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PF-06843195
CAS:<p>PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .</p>Formula:C20H25F3N8O4Purity:98.01%Color and Shape:SolidMolecular weight:498.46VS-5584
CAS:<p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>Formula:C17H22N8OPurity:97.82% - 99.54%Color and Shape:SolidMolecular weight:354.41Apitolisib
CAS:<p>Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).</p>Formula:C23H30N8O3SPurity:98.28% - 99.64%Color and Shape:SolidMolecular weight:498.6PIK-108
CAS:<p>PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).</p>Formula:C22H24N2O3Purity:98.92%Color and Shape:SolidMolecular weight:364.44PIK-75 hydrochloride
CAS:<p>PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.</p>Formula:C16H14BrN5O4S·HClPurity:97.82%Color and Shape:SolidMolecular weight:488.74YS-49
CAS:<p>YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).</p>Formula:C20H20BrNO2Purity:99.65%Color and Shape:SolidMolecular weight:386.28Brevianamide F
CAS:<p>Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.</p>Formula:C16H17N3O2Purity:97.30% - 98.82%Color and Shape:SolidMolecular weight:283.33Alpelisib
CAS:<p>Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.</p>Formula:C19H22F3N5O2SPurity:98% - 99.73%Color and Shape:SolidMolecular weight:441.47Glaucocalyxin A
CAS:<p>Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.</p>Formula:C20H28O4Purity:99.55% - 99.80%Color and Shape:SolidMolecular weight:332.43Flupentixol dihydrochloride
CAS:<p>Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.</p>Formula:C23H27Cl2F3N2OSPurity:98.76% - >99.99%Color and Shape:White Or Off-White SolidMolecular weight:507.43Rigosertib
CAS:<p>Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.</p>Formula:C21H25NO8SPurity:99.53%Color and Shape:SolidMolecular weight:451.49NIBR-17
CAS:<p>NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.</p>Formula:C18H20N8O2Purity:97.79%Color and Shape:SolidMolecular weight:380.41-Deoxynojirimycin hydrochloride
CAS:<p>1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves.</p>Formula:C6H14ClNO4Purity:99.88%Color and Shape:SolidMolecular weight:199.63Omipalisib
CAS:<p>Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.</p>Formula:C25H17F2N5O3SPurity:98% - 99.8%Color and Shape:SolidMolecular weight:505.5Erucic acid
CAS:<p>Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).</p>Formula:C22H42O2Purity:99.64%Color and Shape:Needles From Alcohol Liquid OthersolidMolecular weight:338.57AZD-7648
CAS:<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Formula:C18H20N8O2Purity:99.03% - 99.85%Color and Shape:SolidMolecular weight:380.4Desmethylglycitein
CAS:<p>Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has</p>Formula:C15H10O5Purity:97.93%Color and Shape:SolidMolecular weight:270.24Taurolithocholic acid sodium salt
CAS:<p>Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but</p>Formula:C26H44NNaO5SPurity:99.79% - 99.93%Color and Shape:SolidMolecular weight:505.69ZSTK474
CAS:<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Formula:C19H21F2N7O2Purity:98.29% - 99.95%Color and Shape:White PowderMolecular weight:417.41PI-103
CAS:<p>PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).</p>Formula:C19H16N4O3Purity:97.79% - 99.3%Color and Shape:SolidMolecular weight:348.36TG 100713
CAS:<p>TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.</p>Formula:C12H10N6OPurity:98.17%Color and Shape:SolidMolecular weight:254.25BEBT-908
CAS:<p>BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).</p>Formula:C23H25N9O3SPurity:99.67%Color and Shape:SolidMolecular weight:507.573-Methyladenine
CAS:<p>3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).</p>Formula:C6H7N5Purity:98.02% - 99.65%Color and Shape:SolidMolecular weight:149.15Flavanomarein
CAS:<p>Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.</p>Formula:C21H22O11Purity:98.63% - 99.54%Color and Shape:SolidMolecular weight:450.39Eganelisib
CAS:<p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>Formula:C30H24N8O2Purity:99.04% - 99.28%Color and Shape:SolidMolecular weight:528.56SKI V
CAS:<p>SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),</p>Formula:C15H10O4Purity:98.78%Color and Shape:SolidMolecular weight:254.24Idelalisib
CAS:<p>Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).</p>Formula:C22H18FN7OPurity:98% - 99.39%Color and Shape:SolidMolecular weight:415.421-Deoxynojirimycin
CAS:<p>1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.</p>Formula:C6H13NO4Purity:99.65% - 99.98%Color and Shape:White-Beige Solid CrystallineMolecular weight:163.17Vps34-PIK-III
CAS:<p>Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.</p>Formula:C17H17N7Purity:98.39% - 98.43%Color and Shape:SolidMolecular weight:319.36Bimiralisib
CAS:<p>Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.</p>Formula:C17H20F3N7O2Purity:97.58% - 98.92%Color and Shape:SolidMolecular weight:411.38GNE-493
CAS:<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Formula:C17H20N6O2SPurity:98%Color and Shape:SolidMolecular weight:372.44NIH-12848
CAS:<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Formula:C20H14F3N3SPurity:99.84% - 99.9%Color and Shape:SolidMolecular weight:385.41Sapanisertib
CAS:<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Formula:C15H15N7OPurity:99.19% - >99.99%Color and Shape:SolidMolecular weight:309.33PF-04691502
CAS:<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Formula:C22H27N5O4Purity:96.27% - ≥95%Color and Shape:SolidMolecular weight:425.48BGT226
CAS:<p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>Formula:C28H25F3N6O2Purity:95.74% - 99.51%Color and Shape:SolidMolecular weight:534.53Fimepinostat
CAS:<p>Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.</p>Formula:C23H24N8O4SPurity:98.27% - 99.87%Color and Shape:SolidMolecular weight:508.55Rigosertib sodium
CAS:<p>Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.</p>Formula:C21H24NNaO8SPurity:98% - 99.37%Color and Shape:SolidMolecular weight:473.47TASP0415914
CAS:<p>TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T</p>Formula:C13H17N5O3SPurity:98.14%Color and Shape:SolidMolecular weight:323.37Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Formula:C19H24O5Purity:96.66%Color and Shape:SolidMolecular weight:332.39PI-3065
CAS:<p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>Formula:C27H31FN6OSPurity:99.84% - ≥95%Color and Shape:SolidMolecular weight:506.64Wortmannin
CAS:<p>Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.</p>Formula:C23H24O8Purity:95.84% - 99.76%Color and Shape:White SolidMolecular weight:428.43GDC0084
CAS:<p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>Formula:C18H22N8O2Purity:99.72% - 99.87%Color and Shape:SolidMolecular weight:382.42AS-252424
CAS:<p>AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.</p>Formula:C14H8FNO4SPurity:99.06% - 99.09%Color and Shape:SolidMolecular weight:305.28Hederacolchiside A1
CAS:<p>Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.</p>Formula:C47H76O16Purity:98.76% - 99.92%Color and Shape:SolidMolecular weight:897.1PI3K-IN-1
CAS:<p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>Formula:C31H29N5O6SPurity:97.03% - 98%Color and Shape:SolidMolecular weight:599.66PF-4989216
CAS:<p>PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.</p>Formula:C18H13FN6OSPurity:99.85%Color and Shape:SolidMolecular weight:380.4Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Formula:C21H25F3N6O2Purity:99.88%Color and Shape:SolidMolecular weight:450.46Copanlisib
CAS:<p>Copanlisib (BAY 80-6946), a PI3K inhibitor, may block tumor growth and improve cancer treatment efficacy.</p>Formula:C23H28N8O4Purity:99% - 99.88%Color and Shape:SolidMolecular weight:480.52(E)-Akt inhibitor-IV
CAS:<p>(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.</p>Formula:C31H29IN4SPurity:99.74% - 99.9%Color and Shape:SolidMolecular weight:616.56BQR-695
CAS:<p>BQR-695 (NVP-BQR695) is a PI4K inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.</p>Formula:C19H20N4O3Purity:98.91% - 99.69%Color and Shape:SolidMolecular weight:352.39
