mTOR
mTOR inhibitors are compounds that inhibit the activity of Mammalian Target of Rapamycin (mTOR), a central regulator of cell growth, proliferation, metabolism, and survival. The mTOR pathway is frequently altered in cancer and other diseases, making mTOR a critical target for therapeutic intervention. Inhibitors of mTOR are widely used in research related to cancer, aging, and metabolic disorders. At CymitQuimica, we offer a variety of mTOR inhibitors to support your research in signal transduction, oncology, and therapeutic development.
Found 163 products of "mTOR"
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Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
Formula:C30H23N5OPurity:97.64% - 99.85%Color and Shape:SolidMolecular weight:469.54PQR620
CAS:PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.Formula:C21H25F2N7O2Purity:97.61%Color and Shape:SolidMolecular weight:445.47CDC25B-IN-2
CAS:BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.Formula:C15H12N2O3Purity:99.12%Color and Shape:SolidMolecular weight:268.27GNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Formula:C21H28N8O3S2Purity:98.88% - 99.55%Color and Shape:SolidMolecular weight:504.63Ref: TM-T3692
1mg44.00€2mg57.00€5mg93.00€10mg138.00€25mg286.00€50mg447.00€100mg677.00€1mL*10mM (DMSO)92.00€Salidroside
CAS:Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.Formula:C14H20O7Purity:97.81%Color and Shape:Red-Brown Fine PowderMolecular weight:300.30Ref: TM-T2717
2mg34.00€5mg50.00€10mg81.00€25mg130.00€50mg178.00€100mg268.00€200mg408.00€1mL*10mM (DMSO)55.00€Corynoxine
CAS:Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.Formula:C22H28N2O4Purity:96.83% - 99.93%Color and Shape:SolidMolecular weight:384.47Mito-LND
CAS:Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.Formula:C43H45BrCl2N3OPPurity:97.25% - 98.34%Color and Shape:SolidMolecular weight:801.62Rotundic acid
CAS:Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.Formula:C30H48O5Purity:96.91% - 99.97%Color and Shape:SolidMolecular weight:488.70Ref: TM-T5S0506
2mg34.00€5mg49.00€10mg75.00€25mg137.00€50mg215.00€100mg319.00€200mg474.00€1mL*10mM (DMSO)49.00€Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Formula:C20H18O5Purity:98.92%Color and Shape:SolidMolecular weight:338.35Serabelisib
CAS:Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).Formula:C19H17N5O3Purity:98.41% - 99.5%Color and Shape:SolidMolecular weight:363.373BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Formula:C18H17NO5Purity:97.76%Color and Shape:SolidMolecular weight:327.33Ref: TM-T14033
1mg34.00€2mg44.00€5mg64.00€10mg92.00€25mg195.00€50mg313.00€100mg467.00€1mL*10mM (DMSO)71.00€Temsirolimus
CAS:Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.Formula:C56H87NO16Purity:97.76% - >99.99%Color and Shape:White Crystalline PowderMolecular weight:1030.29GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Formula:C19H22N6O3SPurity:98.42% - 99.54%Color and Shape:SolidMolecular weight:414.48Ref: TM-T6845
2mg46.00€5mg66.00€10mg97.00€25mg202.00€50mg279.00€100mg358.00€200mg525.00€1mL*10mM (DMSO)73.00€CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Formula:C15H19N7O3SPurity:99.41% - 99.87%Color and Shape:SolidMolecular weight:377.42Ref: TM-T2619
1mg60.00€2mg92.00€5mg137.00€10mg215.00€25mg399.00€50mg590.00€100mg838.00€500mg1,693.00€LY 303511 hydrochloride
CAS:LY 303511 hydrochloride is a potent mTOR inhibitorFormula:C19H19ClN2O2Purity:98.47%Color and Shape:SolidMolecular weight:342.82BGT226 maleate
CAS:BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .
Formula:C28H25F3N6O2·C4H4O4Purity:97.75% - 98.78%Color and Shape:SolidMolecular weight:650.6LY 303511
CAS:LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.Formula:C19H18N2O2Purity:98%Color and Shape:SolidMolecular weight:306.36PKI-179
CAS:PKI-179: Dual PI3K/mTOR inhibitor, orally active, IC50s: 0.42-77 nM, targets E545K and H1047R, antitumor in vivo.Formula:C25H28N8O3Color and Shape:SolidMolecular weight:488.54mTOR inhibitor-2
CAS:mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).Formula:C23H21N7OPurity:98%Color and Shape:SolidMolecular weight:411.46PP30
CAS:PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.Formula:C18H19N7OSPurity:98%Color and Shape:SolidMolecular weight:381.45PI3K/mTOR Inhibitor-4
CAS:Oral PI3K/mTOR Inhibitor-4 targets PI3Kα, γ, δ, mTOR; IC50s: 0.63, 22, 9.2, 13.85 nM. Used in cancer research.Formula:C27H22FN3O6SColor and Shape:SolidMolecular weight:535.54PI-540
CAS:PI-540 is a potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K).Formula:C22H27N5O2SColor and Shape:SolidMolecular weight:425.55PI3K/mTOR Inhibitor-3
CAS:PI3K/mTOR Inhibitor-3, a potent dual-action anti-cancer imidazoline, targets PI3K and mTOR.Formula:C22H23N5OColor and Shape:SolidMolecular weight:373.45PI3K/mTOR Inhibitor-9
CAS:PI3K/mTOR Inhibitor-9 acts on mTOR (38 nM IC50) and PI3Kα/γ (6.6 nM IC50), PI3Kδ (0.8 nM IC50).Formula:C23H27N7O2Color and Shape:SolidMolecular weight:433.51PI3Ka-IN-5
CAS:PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .Formula:C30H35N9O5Color and Shape:SolidMolecular weight:601.66NVP-BBD130
CAS:NVP-BBD130 is a stable, ATP-competitive, potent, orally active inhibitor of PI3K and mTOR.Formula:C28H21N5OColor and Shape:SolidMolecular weight:443.5PKI-179 hydrochloride
CAS:PKI-179: oral PI3K/mTOR inhibitor; IC50: PI3Kα/β/δ/γ (8-74 nM), PI3Kα mutants (11-14 nM), mTOR (0.42 nM); selective; inhibits cancer cell growth.Formula:C25H29ClN8O3Color and Shape:SolidMolecular weight:525PI3K/mTOR Inhibitor-8
CAS:PI3K/mTOR Inhibitor-8: Dual PI3Kα (IC50: 0.46 nM) & mTOR (IC50: 12 nM) inhibitor; blocks G1/S phase & induces apoptosis in HCT-116 cells.Formula:C23H22N8O4SColor and Shape:SolidMolecular weight:506.54eCF-309
CAS:eCF-309 is a potent mTOR inhibitor with IC50 value of 15 nM.Formula:C18H21N7O3Color and Shape:SolidMolecular weight:383.4PI3K/mTOR Inhibitor-13
CAS:PI3K/mTOR Inhibitor-13, an oral dual blocker of PI3K and mTOR, may treat sexual diseases, solid tumors, and IPF.Formula:C20H13F2N5O3SColor and Shape:SolidMolecular weight:441.41PI3-Kinase α Inhibitor 2
CAS:Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 andFormula:C16H15N3O2SColor and Shape:SolidMolecular weight:313.37OXA-01
CAS:OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC 50 values of 29 nM and 7 nM, respectively [1]. OXA-01 demonstrates broad anti-tumor activity.Formula:C21H20ClN5O2Color and Shape:SolidMolecular weight:409.87P-2281
CAS:P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cellFormula:C9H8ClN3OPurity:99.98%Color and Shape:SolidMolecular weight:209.63PI3K/mTOR Inhibitor-2
CAS:Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Formula:C20H13ClF2N4O4SPurity:96.16%Color and Shape:SolidMolecular weight:478.86Ref: TM-T12459
1mg55.00€5mg138.00€10mg215.00€25mg358.00€50mg512.00€100mg692.00€200mg888.00€1mL*10mM (DMSO)144.00€QNN33358
CAS:QNN33358 is an alkylacylglycerol acts as a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist.Formula:C21H42O4Color and Shape:SolidMolecular weight:358.56WJD008
CAS:WJD008 inhibits PI3K/mTOR, blocks cancer cell growth, and has tumor-fighting properties.Formula:C19H21N5O2Color and Shape:SolidMolecular weight:351.4AP1867
CAS:AP1867 (FK506-binding protein) is a synthetic FKBP12 F36V-directed ligand coupled to THOX derivatives, facilitating targeted protein interactions and intracellular modulation studies.Formula:C38H47NO11Purity:99.86%Color and Shape:SolidMolecular weight:693.78Ref: TM-T14297
1mg150.00€5mg362.00€10mg502.00€25mg947.00€50mg1,487.00€100mg2,164.00€1mL*10mM (DMSO)545.00€PI3Kα/mTOR-IN-1
CAS:PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.Formula:C16H18N6OPurity:99.89%Color and Shape:SolidMolecular weight:310.35JR-AB2-011
CAS:JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.Formula:C17H14Cl2FN3OSPurity:98.33% - 99.41%Color and Shape:SolidMolecular weight:398.28Ref: TM-T11728
1mg90.00€5mg192.00€10mg326.00€25mg597.00€50mg895.00€100mg1,198.00€1mL*10mM (DMSO)212.00€FT-1518
CAS:FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.Formula:C20H26N8OPurity:98.34% - 98.80%Color and Shape:SolidMolecular weight:394.47mTOR inhibitor-3
CAS:mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.Formula:C25H30N8O2Purity:99% - 99.64%Color and Shape:SolidMolecular weight:474.56Ref: TM-T12123
1mg57.00€5mg120.00€10mg170.00€25mg290.00€50mg439.00€100mg620.00€500mg1,288.00€1mL*10mM (DMSO)128.00€PI3K/mTOR Inhibitor-1
CAS:PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)Formula:C18H22FN5O3SPurity:98%Color and Shape:SolidMolecular weight:407.46mTOR inhibitor 9d
CAS:mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,Formula:C21H23N5O3SPurity:98.91%Color and Shape:SoildMolecular weight:425.5GNE-490
CAS:GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Formula:C18H22N6O2SPurity:99.77%Color and Shape:SolidMolecular weight:386.47Ref: TM-T22339
1mg85.00€2mg115.00€5mg188.00€10mg321.00€25mg509.00€50mg702.00€100mg932.00€200mg1,283.00€1mL*10mM (DMSO)205.00€mTOR inhibitor 9b
CAS:mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTORFormula:C21H23N5O2SPurity:99.89%Color and Shape:SoildMolecular weight:409.5PI3K/mTOR Inhibitor-7
CAS:Potent PI3K/mTOR inhibitor, 4.7x stronger than gedatolisib; IC50: 1.4 μM (PI3K), 0.3 μM (mTOR); impacts PI3K/Akt/mTOR pathway; research in cancer.Formula:C29H33N9O4Color and Shape:SolidMolecular weight:571.63PI3K/mTOR Inhibitor-5
CAS:PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.Formula:C32H40N10O3Color and Shape:SolidMolecular weight:612.73mTOR inhibitor-11
CAS:mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.Formula:C21H26N6O2Purity:98%Color and Shape:SolidMolecular weight:394.47WYE-23
CAS:WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).Formula:C26H32N8O4Color and Shape:SolidMolecular weight:520.58PI3K/mTOR Inhibitor-12
CAS:PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.Formula:C27H27F2N9O4SPurity:98%Color and Shape:SolidMolecular weight:611.62WYE-132
CAS:WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.Formula:C27H33N7O4Purity:99.16%Color and Shape:SolidMolecular weight:519.6MTI-31
CAS:MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.Formula:C26H30N6O3Purity:99.97%Color and Shape:SolidMolecular weight:474.55PI3K/mTOR Inhibitor-14
CAS:PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, andFormula:C28H30N8O3SPurity:98%Color and Shape:SolidMolecular weight:558.66PI3K/mTOR Inhibitor-6
CAS:Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.Formula:C30H34N10O4Color and Shape:SolidMolecular weight:598.66WAY-600
CAS:WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308).Formula:C28H30N8OPurity:99.88%Color and Shape:SolidMolecular weight:494.59Ref: TM-T6730
1mg35.00€2mg60.00€5mg92.00€10mg133.00€25mg233.00€50mg344.00€100mg480.00€500mgTo inquire1mL*10mM (DMSO)105.00€Rheb inhibitor NR1
CAS:Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.Formula:C25H19BrCl2N2O3SPurity:99.72%Color and Shape:SolidMolecular weight:578.3Ref: TM-T16741
1mg87.00€5mg178.00€10mg295.00€25mg595.00€50mg895.00€100mg1,513.00€1mL*10mM (DMSO)44.00€PKI-402
CAS:PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.Formula:C29H34N10O3Purity:99.94%Color and Shape:SolidMolecular weight:570.65PF-04979064
CAS:PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
Formula:C24H26N6O3Purity:98.20% - ≥98%Color and Shape:SolidMolecular weight:446.5GDC-0349
CAS:GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.Formula:C24H32N6O3Purity:96.00% - 98.49%Color and Shape:SolidMolecular weight:452.55PD-M6
CAS:PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.Formula:C30H39N9O6Color and Shape:SolidMolecular weight:621.69PI3K-IN-37
CAS:PI3K-IN-37 inhibits PI3K α/β/δ (IC50: 6/8/4 nM) and mTOR (IC50: 4 nM).Formula:C25H26N6O2Color and Shape:SolidMolecular weight:442.51AZD 3147
CAS:AZD 3147 inhibits mTORC1 (40.7 nM), mTORC2 (5.75 nM), and PI3Kα/β/δ/γ (912/5495/9333/6310 nM IC50s).
Formula:C24H31N5O4S2Purity:99.99%Color and Shape:SolidMolecular weight:517.66mTORC1-IN-1
mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseases
Purity:98%Color and Shape:Odour Solid
