Polycyclic Compounds

<p>Applications 6-Fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas# 117685-48-0) is a useful research chemical.<br></p>

<p>Applications Indole analogue; shows pharmacological activity.<br>References Mohammadi, M., et al.: Science, 276, 955 (1997), Bramson, H., et al.: J. Med. Chem., 44, 4339 (2001), Lane, M., et al.: Cancer Res., 61, 6170 (2001), Yu, B., et al.: Biochem. Pharmacol., 64, 1091 (2002),<br></p>

<p>Applications Purine (cas# 120-73-0) is a useful research chemical.<br></p>

<p>Applications 6-(Methylamino)purine, 6-methylade is a reagent for substitution of adenine nucleotide analogs containing bicyclohexane ring system locked in northern conformation enhanced potency as py receptor antagonists. Adenine methylation as an epigenic mark has been observed in single-celled organisms and also rarely in mamalian cells.<br>References Nandanan et al.: J. Med. Chem., 43, 829 (2000); Kim, H. S. et al.: J. Med. chem., 46, 4974 (2003); Chem. and Eng. News p.6 Apr. 4 (2016)<br></p>

<p>Applications 9-oxo-9H-Thioxanthene-4-carboxylic acid (cas# 51762-56-2) is a useful research chemical.<br></p>

<p>Applications 2-BROMOPHENANTHRENE (cas# 62162-97-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 2-Amino-6-mercaptopurine-9-D-riboside Hydrate (cas# 345909-25-3) is a compound useful in organic synthesis.<br></p>

<p>Applications A useful intermediate for drug discovery research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Caldwell, J., et al.: Tet. Lett., 48, 1527 (2007)<br></p>

<p>Applications 2-(Aminomethyl)-4-((7-chloroquinolin-4-yl)amino)phenol is a metabolite of Amodiaquine (A634200), an antimalarial agent.<br>References Mariga, S.T., et. al.: Acta Tropica, 93, 221 (2005); Natarajan, L., et al.: Arzneim.-Forsch., 22, 1230 (1972); Kracmer, J., et al.: Pharmazie, 29, 773 (1974); Ahmad, I., et al.: Anal. Profiles Drug Subs., 21, 43 (1992)<br></p>

<p>Applications 4'-Bromo-2,2':6',2''-terpyridine (cas# 149817-62-9) is a useful research chemical.<br></p>

<p>Applications 3(6R,7R)--Hydroxy-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Diphenylmethyl Ester is a useful synthetic intermediate. It was used to prepare cephalosporin-derived inhibitors. It can also be used to synthesize Ceftaroline Fosamil which is a cephalosporin antibiotic.<br>References Buynak, J., et al.: Bioorg. Med. Chem. Lett., 12, 1663 (2002); Kanafani, Z., et al.: Future Microbiology, 4, 25 (2009); Parish, D,, et al.: Curr. Opinion Invest. Drugs, 9, 201 (2000)<br></p>

<p>Applications 5,6,7,8-Tetrahydroquinoline (cas# 10500-57-9) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-6-[N,N-di(2-hydroxybenzyl)amino]-9-isopropylpurine (cas# 1076199-83-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,3-Diiminoisoindoline is a useful compound in the production of colouring compositions. Dyes and metabolites.<br>References Matsumoto, T., et al.: PCT Int. Appl. (2020), WO 2020218262 A1<br></p>

<p>Applications 2-Chloro-6-(2-hydroxybenzylamino)-9-isopropylpurine (cas# 500568-72-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-NITROQUINOLINE N-OXIDE (cas# 56-57-5) is a useful research chemical.<br></p>

<p>Applications Intermediate in the preparation of P2X7 antagonists<br>References Donnelly-Roberts, D., et al.: Neuropharmacol., 56, 223 (2009), Perez-Medrano, A., et al.: J. Med. Chem., 52, 3366 (2009),<br></p>

<p>Applications 6-Benzylaminopurine can be used as reagent/reactant in pharmacological activity and synthesis preparation for modification of the length and structure of the linker of N6-benzyladenosine modulates its selective antiviral activity against enterovirus 71.<br>References Drenichev, M., S.: Eur. J. Med. Chem., 111, 84-94 (2016);<br></p>

<p>Applications 1-Phenanthrol-d9 has been used as a reactant for the preparation of stable isotope-labeled internal standards of PAH metabolites from urine of smokers and nonsmokers.<br>References Jacob, P. III, et. al.: Anal. Chem., 79, 587 (2007)<br></p>

<p>Applications Tricyclene, is one of the main constituent of many essential oils having antioxidant activities.<br>References Tamta, A., et al.: Cogent Chemistry, Vol.2, issue1 (2016);<br></p>

<p>Applications 3-Mercaptoindole (cas# 480-94-4) is a compound useful in organic synthesis.<br>References Harris, R.L.N.: Tetrahedron Letters, 51, 4465 (1969)<br></p>

<p>Applications 6-​Benzyloxy-​7-​methoxy-​3,​4-​dihydro-​isoquinoline is a reactant used in the synthesis of VMAT2 imaging agents.<br>References Liu, C. et al.: Chiral., 25, 215 (2013);<br></p>

<p>Applications 3-Amino-4,5,6,7-tetrahydro-1H-indazole (cas# 55440-17-0) is a useful research chemical.<br></p>

<p>Applications Indole-3-pyruvic Acid is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmental changes.<br>References Kong, W., et al.: Plant Cell Physiol, 56, 715-726 (2015)<br></p>

<p>Applications 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (cas# 5807-14-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,​2-​Dihydro-​2-​oxo-4-​quinolinecarboxylic Acid is a chemical constituent of vinegar Schisandra chinensis and is used as a indicator reagent in marking security documents.<br>References Chen, P., et al.: Zhongyaocai, 34, 1728 (2011); Kuryatnikov, A.B., et al.: Russ., RU 2581882 C1 20160420 (2016)<br></p>

<p>Applications Halquinol is an antimicrobial compound belonging to the group of hydroxyl-quinolines indicated for use in poultry and swine. It depresses the activity of the gastro-intestinal tract, causing longer transit time of feed through the intestine, thereby enhancing digestion and absorption of nutrients. It increases weight gain and improve feed conversionprevent and control nonspecific diarrhea or wet dropping in farming animals.<br>References Costa, M. et al.: PLoS One, Vol. 12, (2017);<br></p>

<p>Applications 6-Benzylamino-7-deazapurine (cas# 60972-04-5) is a compound useful in organic synthesis.<br>References Tedder, M., et al.: Bioorg. Med. Chem. Lett., 14, 3165 (2004),<br></p>

<p>Applications 3-BROMOPHENANTHRENE (cas# 715-50-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 6-(gamma,gamma-Dimethylallylamino)purine riboside hemihydrate<br></p>

<p>Stability Hygroscopic<br>Applications 3-Amino-3-azabicyclo[3,3,0]octane is used as a reactant in the synthesis of Gliclazide (G409875), a sulfonylurea hypoglycemic agent. Used as an antidiabetic.<br>References Duhault, J., et al.: Arzneimittel-Forsch., 22, 1686 (1972); Holmes, B., et al.: Drugs, 27, 301 (1984)<br></p>

<p>Applications 6-Chloropurine-9-(2,3-isopropylidene-β-D-ribofuranoside) (cas# 39824-26-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 8-Azaxanthine Monohydrate (cas# 59840-67-4) is a compound useful in organic synthesis.<br>References Balnk, U.H., et al.: JOC, 35, 4, 1131 (1970)<br></p>

<p>Applications A chelating agent, forming complexes with most metal ions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References El-Didamony, A., et al.: Drug Test. Anal., 2, 122 (2010), Chan, A., et al.: J. Med. Chem., 53, 3086 (2010), Ehrman, T., et al.: Bioorg. Med. Chem., 18, 2204 (2010),<br></p>

<p>Applications Indoleacetic Acid is the most common and naturally occuring plant hormone in the auxin class of hormones. It effects cell elongation, cell division as well as plant growth and development.<br></p>

<p>Applications Methyl indole-3-carboxylate is a reagent in the preaparation of oncrasin-1 derivatives which is a novel inhibitor of the C-terminal domain of RNA polymerase II.<br>References Wu, S., et al.: J. Med. Chem., 54, 2668 (2011);<br></p>

<p>Applications 1-Ethyl-1,2-dihydro-2,2,4-trimethyl-7-quinolinol is a reagent used in the preparation of fluorescent dyes and can be applied toward labeling of biological macromolecules.<br>References Liu, W., et.al., Faming Zhuanli Shenqing, 21, (2020);<br></p>

<p>Applications 2-azaspiro[4.5]decane-1,3-dione (cas# 1197-80-4) is related to gabapentin (G117250).<br></p>

<p>Applications 3,6-Diiodo-1H-indazole is used to prepare aryl-substituted indazole derivatives as modulators and inhibitors of protein kinases in the treatment of tumor growth, cellular proliferation, and angiogenesis.<br>References Kania, R., et al.: PCT Int. Appl., WO 2001002369 A2 20010111 (2001)<br></p>

<p>Impurity Famciclovir USP Related Compound F<br>Applications Famciclovir USP Related Compound F<br></p>

<p>Applications 5-Fluoroindole is a reactant used in various syntheses. It was used in the synthesis of Spirotetrahydro β-Carbolines (Spiroindolones), which is a new class of potent and orally efficacious compounds for the treatment of malaria. 5-Fluoroindole was also a reactant in direct indole and pyrrole couplings to carbonyl compound in total synthesis of Acremoauxin A and Oxazinin 3.<br>References Richter, J., et al.: J. Am. Chem. Soc., 129, 12857 (2007); Yeung, B., et al.: J. Med. Chem., 53, 5155 (2010);<br></p>

<p>Applications Ethyl Indole-3-acetate is a compound used in the synthesis of 9H-Pyrrolo[1,2-α]Indoles via Michael Addition-Condensation with α,β-Unsaturated Ketimines.<br>References Zhang, M., et al.: J. Heterocyclic Chem. (2016)<br></p>

<p>Applications Methyl 4-Quinuclidinecarboxylate is a reactant used in the synthesis ofoxadiazole and indolyloxadiazole 5-HT3 hydroxytryptamine) antagonists.<br>References Swain, C.J., et. al.: J. med. Chem., 34, 140 (1991)<br></p>

<p>Stability Hygroscopic<br>Applications Oxythiamine HCl (cas# 136-16-3) is a useful research chemical.<br></p>

<p>Applications 5,6-Dihydroxyindole is an intermediate in melanogenesis, the production of melanin which is found in our skin, eyes, hair, and inner ear.<br>References S. Ito., et al.: Photochem. Photobiol., 84, 582-92 (2008);<br></p>

<p>Stability Light Sensitive<br>Applications 5,6-Dibromo-1,10,11,12,13,13-hexachloro-11-tricyclo[8.2.1.02,9]tridecene is a flame retardant and a standard for environmental testing and research.<br>References EPA. Method 1668, (EPA 821-R-00-002) (1999); Dodson, R. E., et al.: Environ. Sci. Technol. 51, 4860 (2017)<br></p>

<p>Applications A metabolite of 6-Mercaptopurine (M225450).<br>References Zimm, S., et al.: Biochem. Pharmacol., 33, 4089 (1984), Lennard, L., et al.: Clin. Pharmacol. Ther., 46, 149 (1989), Knoester, P., et al.: Anticancer Res., 13, 1795 (1993), McLeod, H., et al.: Leukemia, 14, 567 (2000),<br></p>

<p>Applications 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRIMIDIN-2-ONE (cas# 5439-14-5) is a useful research chemical.<br></p>

<p>Applications 6-Chloroisatin (cas# 6341-92-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Indole-3-acetamide is a compound that is converted to indole-3-acetic acid by indole-3-acetamide hydrolase in auxin biosynthesis in plants.<br>References Mano, Y., et al.: J. Exp. Bot., 61, 25 (2010)<br></p>