Polycyclic Compounds

<p>3-Indolemethanol is a chemical compound that is used for chemiluminescent reaction. It can be used as an experimental model for studying the effects of 3-indolemethanol on murine hepatoma and human osteosarcoma cells in vitro. This compound has been shown to have oral hypoglycemic activity and to inhibit cancer cell growth. 3-Indolemethanol has also been shown to modulate signal pathways, such as the MAPK pathway, which may lead to pro-apoptotic protein activation or inhibition of physiological effects.</p>

(3-Formyl-1-indolyl)acetic acid is a small molecule that has been shown to inhibit the activity of various enzymes, including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and histamine N-methyltransferase (HNMT). The crystal structure of (3-formyl-1-indolyl)acetic acid was determined by X-ray crystallography. The active conformation of the molecule was found to be a nonplanar chair conformation with a hydrogen bond acceptor at C8. This conformation is stabilized by a hydrogen bond donor at C7, which also creates an additional hydrogen bond acceptor at O2. These interactions stabilize the molecule in its active form. The docking studies showed that the ligand binds to AChE with high affinity, while binding to BChE and HNMT with lower affinity. The inhibition effects on these

<p>6-Amino-2-chloropurine (6AC) is a nucleoside analogue that inhibits the synthesis of DNA, RNA, and protein by inhibiting the activity of polymerase chain reaction. It has been used to study the molecular mechanisms of pandemic influenza A virus and HIV infection. 6AC has also been shown to be effective in treating solid tumours and metastatic colorectal cancer in mice. This drug is also used as a competitive inhibitor for measuring endonuclease activity in polymerase chain reactions. 6AC binds to the enzyme's active site and prevents it from cleaving the DNA strands during replication, resulting in incomplete replication of the viral genome.</p>

7-Bromoindole is a synthetic compound that has been used as an analog for indole. It has been shown to have some biological activity in vivo, but it is not known if this activity is due to the drug itself or its breakdown products. 7-Bromoindole can be decarboxylated under acid conditions and saponified with sodium hydroxide. The isolated yield of this reaction is about 2 grams per mole of reactant. 7-Bromoindole shows hemolytic activity against human pathogens such as Staphylococcus aureus and Escherichia coli, but not against Bacillus subtilis or Pseudomonas aeruginosa.

<p>Ethyl indole-6-carboxylate is a chiral compound with nitrogen atoms. It has a topology and substituents, so it can be substituted in several positions. It also has nitrate, which is an ion that can carry an electric charge. This molecule can form channels and crystals with a single-crystal x-ray diffraction pattern. The hydrocarbon part of the molecule has a crystal system and framework, making it porous. The x-ray diffraction pattern of ethyl indole-6-carboxylate shows its chemistry as well.</p>

<p>Please enquire for more information about 4,4'-Dinitro-2,2'-bipyridine-N,N'-dioxide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(6-Benzyloxyindolyl)acetonitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Methyl indole-4-carboxylate is a synthetic compound that is a potent agonist for cytochrome P450 enzymes. It can be used to study the human cytochrome system, which is responsible for metabolizing drugs and other chemicals. Methyl indole-4-carboxylate has been shown to react with aldehydes, such as formaldehyde, leading to fluorescence. This compound also has the ability to bind to x-ray structures of human cytochrome p450. The addition of methyl indole-4-carboxylate to tissue culture cells leads to an increase in activity of tuberculosis by inhibiting the growth of Mycobacterium tuberculosis and Mycobacterium avium complex.</p>

<p>Isoindoline is a compound that is used to treat bowel diseases. It is an inhibitor of jak1 and has been shown to be effective in the treatment of inflammatory bowel disease. The reaction mechanism of this drug is not fully understood, but it has been hypothesized that its activity may be due to inhibition of dpp-iv, which blocks the activation of T cells. Isoindoline was found to have low toxicity in h9c2 cells and redox potentials are expected to be low. This drug has also been shown to inhibit the synthesis of fatty acids by inhibiting the action of acyl-coenzyme A: diacylglycerol acyltransferase 2 (ACADS).</p>

<p>1,3-Diacetylindole is an alkene that belongs to the class of organic compounds. It can be prepared by Friedel-Crafts acylation of cyclopentenone with formaldehyde and hydrogen chloride gas. The molecule has a molecular electrostatic potential of -0.8 eV and a molecular weight of 126.1 g/mol. 1,3-Diacetylindole has been shown to react with Grignard reagent in an electrochemical study. Additionally, it has been used as a starting material for the synthesis of other molecules such as 2-methylquinoline and 1,2-dihydroquinoline. The vibrational and spectral data for 1,3-diacetylindole have been obtained using both experimental and computational methods. These data are useful for understanding the structure and reactivity of this compound at the molecular level.br&gt;br&gt; br&gt;br&gt;</p>

<p>Please enquire for more information about 4,5-Dicyanoimidazole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Clioquinol is a topical corticosteroid that is used to treat skin disorders such as pemphigoid, psoriasis, and eczema. It is also used to treat the inflammation associated with acne. Clioquinol has been shown to be effective in treating bacterial infections of the skin by inhibiting the growth of bacteria. This drug also has anti-inflammatory properties and can be used for the treatment of various inflammatory skin conditions. Clioquinol is not absorbed through the skin and does not affect the blood's ability to clot.</p>

<p>N-(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyloxycarbonyl-1,8-diamino-3,6-dioxaoctane is a polymerase that has been developed for use in vaccines and as an agrochemical for the control of plant diseases. This enzyme has been shown to have high activity against cancer cells, including lung cancer cells and breast cancer cells. It is also autofluorescent and can be used as a cell marker in flow cytometry experiments. N-(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyloxycarbonyl-1,8-diamino-3,6-dioxaoctane also has antiinflammatory effects on macrophages by inhibiting the production of proinflammatory cytokines such as IL 12p</p>

<p>5,5'-Diamino-2,2'-bipyridine is an acidic metalloporphyrin that has been shown to react with epoxides to form nucleophilic adducts. This compound can be used as a ligand for lanthanide ions and reacts with aminopyridine to form bromoethane. 5,5'-Diamino-2,2'-bipyridine has been shown to have carcinogenic properties and may induce bromoethane mutagenicity in the liver. This compound is also mutagenic when added to propylene carbonate. 5,5'-Diamino-2,2'-bipyridine is luminescent in air or water when exposed to UV light.</p>

<p>Hypoxanthine is a nucleoside that is found in human cells. It is synthesized from guanine by the enzyme, xanthine oxidoreductase. Hypoxanthine is also produced from xanthine by adenosine deaminase and converted back to xanthine, which can then be reused for DNA synthesis. Hypoxanthine has been shown to inhibit the growth of photosynthetic bacteria, such as Rhodopseudomonas viridis and Rhodobacter sphaeroides. This inhibition may be due to an equilibrative nucleotide effect on the folate receptor. The x-ray diffraction data collected from the chrysanthemum flower (a source of hypoxanthine) showed that hypoxanthine has a calcium salt structure.</p>

<p>Columbianadin is a coumarin derivative, which is a natural compound primarily extracted from plants in the Apiaceae family, such as Angelica species. This natural product possesses a unique molecular structure characterized by the presence of a coumarin skeleton, which is responsible for its diverse biological activities.</p>

<p>5-Ethylindole-2-carboxylic acid is an organic compound that is a decarboxylation product of indole. It can be obtained by catalytic dehydrogenation of ethyl ester or 5-ethylindole-2-carboxylic acid. It has been shown to inhibit the growth of bacteria and fungi, as well as to have anti-inflammatory properties.</p>

<p>6-Methylpurine is a product of the nucleotide metabolism in E. coli, which is a model organism for protein synthesis. 6-Methylpurine inhibits protein synthesis and exerts significant cytotoxicity. It has been shown to inhibit the enzyme activities of DNA polymerase alpha, DNA ligase, and RNA polymerase, as well as other enzymes involved in nitrogen metabolism. 6-Methylpurine has been shown to be an analog of adenine and has a similar reaction mechanism. The uptake of 6-methyl purine by cells is mediated by hydrogen bonds with amino acid residues on the cell membrane surface. This molecule also forms glycosidic bonds with ribose sugar groups on cellular surfaces. 6-Methylpurine plays an important role in energy metabolism through its incorporation into glucose and glycogen molecules.</p>

Scopoletin is a naturally occurring coumarin derivative, which is primarily isolated from plants such as those in the Solanaceae and Asteraceae families. It exhibits a diverse range of biological activities due to its multifaceted mode of action, which includes antioxidant, anti-inflammatory, and antimicrobial properties. As a phytochemical, scopoletin can modulate various biochemical pathways, influencing both enzymatic and receptor-mediated processes.

5-Fluoroindole-2-carboxylic acid is a new substance that has been found to be an inhibitor of the influenza virus. It prevents the virus from replicating by inhibiting the synthesis of viral proteins and nucleic acids. 5-Fluoroindole-2-carboxylic acid can be prepared by dispersive solid phase extraction of a mixture of fluoroindole, fumaric acid, and potassium hydroxide in water. The compound has also been shown to potentiate the effects of carbamazepine on caspases and enhance mass spectrometric analysis for gaseous hydrochloric acid. 5-Fluoroindole-2-carboxylic acid produces antinociceptive effects in animals.

<p>4-Amino isoquinoline is a synthetic chemical that has a pyridine ring and chlorine atom. It can be synthesized by reacting 2,4-dichlorobenzene with acetaldehyde and hydrochloric acid. 4-Amino isoquinoline binds to the receptor that it interacts with, such as the ligand, dimethyl acetylenedicarboxylate, or taraxasterol acetate. This binding process can be used for treatment purposes. The ligand is usually introduced into the body through injection or ingestion of a drug. The ligand can also be attached to an antibody in order to target specific cells. The ligand has shown efficacy in treating cancerous tumors and other diseases like Parkinson's disease and Alzheimer's disease.</p>

<p>Lauryl isoquinolinium bromide is a pyridinium cationic surfactant that is used as a diagnostic agent and pharmaceutical preparation. It is also used as an antimicrobial agent in liquid chromatography, which is a technique to separate chemical compounds. Lauryl isoquinolinium bromide has been shown to be effective against Gram-positive bacteria such as Staphylococcus aureus and Enterococcus faecalis, and Gram-negative bacteria such as Pseudomonas aeruginosa. Lauryl isoquinolinium bromide has also been shown to be effective against yeast such as Candida albicans. Lauryl isoquinolinium bromide is not effective against viruses or fungi. This agent can be used to enhance the permeability of membranes during cross-linking reactions between polymers.</p>

Ferene is an iron chelate that has been shown to have a number of beneficial effects on iron homeostasis. Ferene has been used in the treatment of chronic viral hepatitis, and it has also been shown to be effective against galleria mellonella. Ferene is a metal chelate, which means that it is a type of molecule that contains two metal ions. The metal ions are usually connected by a central atom, such as oxygen or nitrogen. Ferene disodium salt can be synthesized in the lab using the chemiluminescence method and polymerase chain reaction (PCR). It is also possible to isolate ferene from human serum or from a model system.

<p>6-(Dimethylamino)purine (6-DAP) is a purine nucleoside that acts as an inhibitor of the transcription factor leukemia inhibitory factor (LIF). 6-DAP binds to the response element in the promoter region of LIF and blocks the binding of LIF to this site. This prevents transcription of LIF, which leads to cell cycle arrest. 6-DAP also has inhibitory effects on skin cells and inhibits the formation of fetal bovine serum protein in a model system. 6-DAP binds to nuclear DNA and alters its structure, which may cause problems with DNA replication or transcription.</p>

5-Chloro-1,10-phenanthroline (5CP) is a molecule that has been used in the study of DNA oxidation. 5CP has been shown to be an effective inhibitor of oxidative dna damage and can be used for the prevention of mutations caused by reactive oxygen species. This compound was also found to inhibit the growth of L1210 murine leukemia cells, which is due to its ability to bind to potassium ions. 5CP has been shown to have significant binding constants with DNA and protein molecules. It also has a very high level of ancillary activity and can be used as a catalyst in transfer reactions.

<p>Indole-2-carboxylic acid ethyl ester is a synthetic compound that binds to cancer cells. It has been shown to inhibit the growth of leukemia cells and breast cancer cells in vitro. Indole-2-carboxylic acid ethyl ester inhibits the binding of collagen to cells, which may be due to its ability to bind to β-carboline alkaloids on collagen. The binding of indole-2-carboxylic acid ethyl ester with these alkaloids prevents them from binding to collagen, thereby preventing the formation of new collagen fibers. This drug also inhibits aldehyde production, which is important for DNA synthesis in cancer cells.</p>

<p>2-Acetamido-6-chloropurine (2ACAP) is a nucleophilic agent that inhibits cancer cells by binding to the enzyme cholinesterase. It is used in the treatment of T-cell leukemia and herpes simplex virus. 2ACAP binds to the amine group of cholinesterase, which prevents it from breaking down acetylcholine. This inhibition leads to accumulation of acetylcholine, which has been shown to induce apoptosis in k562 cells. The molecular modeling study showed that 2ACAP binds to both chlorine atom and benzyl groups in the active site of cholinesterase. 2ACAP also has a potent inhibitory effect on cancer cell proliferation and can be used as an anti-cancer agent for many types of cancers including colon, breast, and prostate cancer.</p>

(9R,11S,14S,16R,17R)-6,6,9-Trifluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-8,11,12,14,15,16-hexahydro-7H-cyclopenta[a]phenanthrene 3-one is a congestive heart failure drug that belongs to the group of cardiotonic drugs. It has high resistance to elution and is used in the diagnosis of autoimmune diseases. (9R,11S) 6-(1′Hexahydrocyclohexa[b]pyrrolo[2′1′b]indolizinium bromide) is a nitrogenous compound that has been employed as a pharmaceutical preparation for the treatment of cardiac disorders. The biological properties of (9R) 11-(2′Hydroxyacetyl

<p>7-[(Dimethylamino)methyl]-2,2,4-trimethyl-1,2-dihydroquinolin-6-ol is a chemical compound that belongs to the group of fine chemicals. It is a versatile building block and useful intermediate for research chemicals. 7-[(Dimethylamino)methyl]-2,2,4-trimethyl-1,2-dihydroquinolin-6-ol is also a speciality chemical with high purity and quality. CAS No. 300690-44-2</p>

1,1'-Dimethyl-4,4'-bipyridinium diiodide (DMBI) is a hydrophobic compound that is soluble in organic solvents. It has been validated as a new optical probe for the detection of hydrogen peroxide by spectroscopic techniques. DMBI reacts with hydrogen peroxide to form an excited state molecule (a radical species) which produces a photocurrent when irradiated with light. The wavelength of the photogenerated current can be used to determine the concentration of hydrogen peroxide present. DMBI can also be used to detect hydrophilic compounds such as urea or creatinine. The reduction products formed by the reaction with these compounds are more hydrophilic and can be detected by this technique.

<p>Please enquire for more information about 3-(1,1-Dimethylethyl)-3α,8β-dihydro-8β-hydroxy-4H-indeno[2,1-d]isoxazol-4-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Alloisoimperatorin is a naturally occurring furanocoumarin compound, which is extracted from certain plant species, primarily those belonging to the Apiaceae family. As a type of coumarin derivative, it is synthesized through intricate plant metabolic pathways involving the precursors umbelliferone and isopentenyl pyrophosphate, among others.</p>

<p>5-Aminoindole is a hydrogen bond acid. It has been shown to have an optimum concentration of 0.1 mM in the presence of 0.2 mM potassium chloride and 2 mM magnesium chloride, which is similar to the pH range for biological systems. 5-Aminoindole also acts as a competitive inhibitor of quinoline derivatives, such as chloroquine and hydroxychloroquine, which are used in the treatment of malaria and rheumatoid arthritis. The compound has been shown to be active against primary cells grown in culture, including mouse erythrocytes and human hepatocytes. When used with agarose gel electrophoresis or electrochemical impedance spectroscopy, 5-aminoindole shows excellent selectivity for kinases over other enzymes. 5-Aminoindole is not reactive under physiological conditions because it does not have any redox potentials that can be measured by Langmuir adsorption isother</p>

<p>p-Nitrobenzyl 6-(1'-hydroxyethyl)-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate is a drug substance that is used in the manufacture of carbapenem antibiotics. It can be detected by a chloride ion chromatographic method, and the detection limit is 0.5 mg/L in the presence of zinc powder as a modifier. This material is used to prepare carbapenems using an analytical method that includes reaction monitoring by optical rotation, diastereomer chromatography, and transfer.</p>

<p>Ethyl 4,5-dichloro-1H-indole-2-carboxylate is an organic chemical compound that is a reaction component, reagent, and useful scaffold in the synthesis of pharmaceuticals. It has been shown to have high quality and be a versatile building block for the synthesis of complex compounds. This chemical can be used as a speciality chemical or research chemical.</p>

<p>6-Chloroisatin is a potent inhibitor of bacterial growth that binds to the 50S ribosomal subunit. It has been shown to have strong inhibitory activity against tuberculosis and sulphamethoxazole-resistant strains of Mycobacterium tuberculosis. 6-Chloroisatin inhibits bacterial growth by binding to the 50S ribosomal subunit, thereby preventing protein synthesis and cell division. The electron deficient form of 6-chloroisatin reacts with the electron rich sulphamethoxazole by displacement of chloride ion from the sulphonamide ring, forming a regiospecific product that inhibits bacterial respiration. This reaction system is inhibited by activated carbon, which may be a potential therapeutic strategy for patients with drug resistant tuberculosis.</p>

<p>N-(4-Hydroxyphenyl)-5-methyl-2-1H-pyridone is a molecule that is found in plasma samples and has been shown to inhibit the growth of cells. It is a potent inhibitor of tubulointerstitial injury, which is the most common type of kidney disease. The mechanism of this drug has been shown to involve the inhibition of primary amino acid uptake. This compound also inhibits urea synthesis and decreases plasma concentrations by increasing the rate of elimination. In addition, it has been shown to have an inhibitory effect on growth factors such as EGF, bFGF, IGF-1, and PDGF. N-(4-Hydroxyphenyl)-5-methyl-2-1H-pyridone can be synthesized by heating at high temperatures (thermally activated).</p>

<p>7-Methylcoumarin is an organic compound classified as a coumarin derivative, which is sourced from various plants and synthesized chemically. Its basic structure consists of a benzopyrone, with a methyl group at the seventh position on the coumarin core, distinguishing it from naturally occurring coumarins.</p>

<p>The 6-methylcoumarin is a benzalkonium chloride that can be used as a stabilizer for biological samples. It has been shown to inhibit the activity of coumarin derivatives, which are receptors that are involved in the transmission of pain signals in the brain. The 6-methylcoumarin is also able to inhibit signal peptide, which is a protein that is secreted by cells and functions as a messenger between cells. This compound was found to have hypoglycemic effects due to its ability to stimulate glucose uptake in the body.</p>

<p>2-Oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid is a carboxylic acid that is an intermediate in the chemical synthesis of 2H and 3H tetrahydroquinolines. It can be synthesized by the oxidation of 2-(N,N-dimethylamino)benzaldehyde with hydrogen peroxide in methanol. The compound has been used to label animals for use in mass spectrometry studies and as a reactant in electron and nuclear magnetic resonance (NMR) spectroscopy experiments. In addition, 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid has been used to study equilibrium and reversible reactions as well as to identify the abundances of different spectral peaks. 2-Oxo-1,2,3,4-tetrahydroquinoline-4</p>

<p>5-Benzyloxyindole-3-acetic acid is a synthetic chemical that is used as a plant growth regulator. It inhibits the uptake of other plant nutrients, such as nitrates and phosphate ions by roots, which leads to decreased plant growth. This compound also has an inhibitory effect on membranes and morphology. The inhibition of membrane transport can lead to cell death, which can be seen in the case of plants treated with this chemical. 5-Benzyloxyindole-3-acetic acid has been shown to affect the response pathway of plants at temperatures between c1-c3 degrees Celsius.</p>

<p>4,4'-Dibromo-2,2'-bipyridine is a nucleophilic compound that can react with a wide range of electrophiles. It has been used in medications as a thermally stable and non-toxic ligand for metal ions. 4,4'-Dibromo-2,2'-bipyridine is an efficient ligand for the coordination of many transition metals. This compound also has high values in light emission and is used in crystallography to study protein binding sites. The n-oxide form of 4,4'-dibromo-2,2'-bipyridine has biological properties that have not yet been studied.</p>

<p>4-Hydroxyindole is an inorganic acid that is produced by the oxidation of 4-hydroxyphenylacetic acid. It is a metabolite of the synthetic cannabinoids, JWH-018 and JWH-073. The production of 4-hydroxyindole has been shown to be dependent on the presence of a nucleophilic attack on the diazonium salt, which leads to protonation. The fluorescence properties of this molecule are dependent on its hydroxyl group, which allows for detection using magnetic resonance spectroscopy. Hydrochloric acid can be used as an alternate solvent to produce 4-hydroxyindole from 4-hydroxyphenylacetic acid. 4-Hydroxyindole has been shown to have pharmacokinetic properties that are similar to those of THC, but it does not bind well to cannabinoid receptors or activate them.br&gt; br&gt; The structure of this molecule can be seen below</p>

<p>N,N'-4,4'-Bis(benzyl-2-boronic acid)-bipyridinium dibromide is a high quality reagent that can be used as an intermediate for the synthesis of complex organic compounds. It is a complex compound that contains boronic acid and bipyridinium moieties. N,N'-4,4'-Bis(benzyl-2-boronic acid)-bipyridinium dibromide is useful in the synthesis of fine chemicals and speciality chemicals. It has versatile building block properties and can be used as a reaction component in many chemical reactions.</p>

<p>Indole-7-carboxylic acid is a tetrahydropyridine that can be prepared by formylation of indole-7-carboxylic acid with formaldehyde and hydroxylamine. It is also the reaction product of dimethoxybenzene and cyanoindole in the presence of a base. Indole-7-carboxylic acid has been used in the synthesis of several drugs, including metronidazole and nitrofurantoin.</p>

1,1'-Bicyclohexyl]-1-carboxylic acid (BCX) is a metal salt that is soluble in water. BCX has a quadratic structure and is a cyclohexanecarboxylic acid derivative. It can be made by the reaction between formic acid and chloride. BCX is used as an anti-diarrheal agent for the treatment of chronic diarrhea. It has been shown to have high entrapment efficiency and high efficiency when synthesized with dicyclomine. This technique uses formic acid as the solvent, which reacts with chloride to produce BCX.

<p>(+/-)-Heraclenin is a naturally occurring coumarin, which is a class of organic compounds notable for diverse biological activities. This compound is primarily sourced from various plant species belonging to the family Apiaceae, such as Heracleum species. Coumarins like (+/-)-heraclenin are known for their ability to modify biological responses due to their chemical structure.</p>

<p>1,3,9-Trimethylxanthine is a naturally occurring purine alkaloid that has been shown to have cytosolic calcium ion-antagonistic properties. It can also act as an antioxidant by donating electrons to free radicals and inhibiting lipid peroxidation. This compound is found in coffee beans and other sources of caffeine. It binds to the receptor for adenosine, which causes the antagonistic effects on intracellular calcium concentration. Trimethylxanthine can also be used to treat ventricular arrhythmias and increase locomotor activity in mammals. Trimethylxanthine has been shown to be effective in wastewater treatment as it removes organic pollutants from water by oxidizing them with hydrogen peroxide or chlorine gas.</p>

<p>Byakangelicol is a naturally occurring furanocoumarin, which is a type of organic compound found predominantly in the roots of certain plants, such as Angelica dahurica. This compound is synthesized through the plant's secondary metabolic pathways, primarily as a defense mechanism against herbivores and pathogens. Byakangelicol exerts its biological effects primarily through the inhibition of various enzymatic pathways, such as cytochrome P450s and monoamine oxidase, which are key in processes like drug metabolism and neurotransmitter regulation.</p>

<p>Brequinar sodium is a drug that belongs to the class of quinoline carboxylic acid derivatives. It has been shown to be effective in the treatment of infectious diseases and bowel disease. Brequinar sodium inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Brequinar also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.</p>