Toxicology

<p>Applications A labelled Desfuroyl Ceftiofur-related metabolite that have the potential to be microbiologic active in swine muscle, kidney, liver and fat.<br>References Gilbertson, T., et al.: J. Agric. Food Chem., 43, 229 (1995), Olson, S., et al.: Vet. Pharmacol. Therap., 21, 112 (1998), Hornish, R., et al.: Curr. Top Med. Chem., 2, 717 (2002),<br></p>

<p>Stability Very Hygroscopic<br>Applications Labelled Oseltamivir Acid (O700980). Oseltamivir Acid is a metabolite of Oseltamivir (O701000). It is a COVID19-related research product.<br>References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998), Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998), Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999), Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)<br></p>

<p>Applications (1R,3R,4R)-Entecavir is an isomeric impurity of Entecavir (E558900).<br></p>

<p>Applications Oseltamivir Acid Hydrochloride is a metabolite of Oseltamivir (O701000), an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug. It is a COVID19-related research product.<br>References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998); Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998); Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999); Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications The main metabolite of Omeprazole.<br>References Renberg, L., et al.: Drug Metab. Dispos., 17, 69 (1989), Calabresi, L., et al.: Pharmacol. Res., 49, 493 (2004), Yin, O., et al.: J. Clin. Pharmacol., 44, 582 (2004),<br></p>

<p>Applications A metabolite of Ceftiofur (C244700), which is microbiologic active.<br>References Washburn, K., et al.: J. Vet. Pharm. Ther., 28, 247 (2005),<br></p>

<p>Applications Methoprene-d7, is the labeled analogue of Methoprene, which is a juvenile hormone (JH) analog which can be used as an insecticide that acts as a growth regulator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xiao-li, M., et al.: Nongyao, 52, 380 (2013); Anon.IP.com Journal, 12, 9 (2012);<br></p>

<p>Applications Azimilide Dihydrochloride is an oral type III potassium channel blocker agent that blocks both the rapid activating component and the slow activating component of the delayed rectifier potassium current. Both preclinical and clinical studies have demonstrated the efficacy of azimilide and its safety in the treatment of supraventricular and ventricular tachyarrhythmia. Azimilide also is being studied in a worldwide multicenter trial for prevention of sudden cardiac death in patients after myocardial infarction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tran, H.T., et al.: Heart. Dis., 1, 114 (1999); Conway, E., et al.: Am. J. Cardiol., 102, 12 (2008); Carlson, M., et al.: Exp. Rev. Cardio. Therap., 3, 387 (2005); Dorian, P., et al.: J. Cardio. Pharm. Therap., 7, 211 (2002);<br></p>

<p>Applications A metabolite of L-Carnitine (C184110).<br>References Millington, D., et al.: J. Inherit. Metab. Dis., 13, 321 (1990), Chace, D., et al.: Clin. Chem., 49, 1797 (2003),<br></p>

<p>Applications Lercanidipine-d3 is a labeled dihydropyridine calcium channel blocker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bianchi, G., et al.: Pharmacol. Res., 21, 193 (1989); Rimoldi, E., et al.: Acta Therap., 200, 23 (1994)<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications Anhydrochlortetracycline is the anhydro analogue and impurity of Chlortetracycline (C426500). Anhydrochlortetracycline is an antimicrobial and antibacterial.<br>References Diana, J. et al.: J. Pharmac. Biomed. Anal., 39, 523 (2005); Sanniez, W.H.K. et al.: J. Pharmac. Sci., 69, 5 (1980); Oliva, B. et al.: Antimircob. Agents Chemother., 36, 913 (1992);<br></p>

<p>Stability Hygroscopic<br>Applications Avilamycin is an antimicrobial agent used against methicillin resistant Staphylococcus.<br>References Flora, D. et al.: J. Coastal Life Med., 3, 193 (2015);<br></p>

<p>Applications Pexidartinib Hydrochloride is RTK inhibitor. It can be used in pharmacological activity, therapeutic use, and biological study of inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.<br>References Mok, S., et al.: BMC Cancer, 15, 1, 2015<br></p>

<p>Stability Moisture Sensitive, Light Sensitive<br>Applications A metabolite of Ketorolac.<br>References Mroszczak, E., et al.: Drug Metab. Dispos., 15, 618 (1987), Brocks, D., et al.: Clin. Pharmacokinet., 23, 415 (1992), Vakily, M., et al.: Pharm. Res., 12, 1652 (1995), Gillis, J., et al.: Drugs, 53, 139 (1997),<br></p>

<p>Applications Labelled analogue of Chlorocholine Chloride, a plant growth regulator that is primarily used on ornamental plants.<br>References Pinto, A.C.R. et al.: Acta Horticult., 683, 399 (2005); Gu, Z. et al.: Hun. Nong. Dax. Xueb., 35, 383 (2009); Xing, S. et al.: J. Med. pLant Res., 5, 1962 (2011);<br></p>

<p>Applications A metabolite of 5-Hydroxytryptamine, also known as Serotonin (S274990).<br>References Uutela, P. et al.: Anal. Chem., 81, 8417 (2009); Koehle, C. et al.: Biochem. Pharmacol., 69, 1397 (2005); Krishnaswamy, S. et al.: Xenobiotica, 33, 169 (2003);<br></p>

<p>Stability Hygroscopic<br>Applications A biodegradation product of Malathion (M111000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);<br></p>

<p>Applications Normorphine is a metabolite of Morphine (M652290). This is a controlled substance (opium derivative). Analgesic (narcotic).<br>References Coffman, B., et al.: Drug Metab. Dispos., 25, 1 (1997), Hanks, G., et al.: Br. J. Cancer, 84, 587 (2001), Projean, D., et al.: Xenobiotica, 33, 841 (2003), Dale, O., et al.: Br. J. Clin. Pharmacol., 58, 156 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications Pyraclostrobin is a fungicide for use in seed grass and food crops. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gyldenkaerne, S., et al.: Pestic Sci., 55, 1210 (1999), Pennington, D., et al.: Environ. Sci. Technol., 39, 1119 (2005), Wang, S., et al.: Food Control., 18, 731 (2007),<br></p>

<p>Applications Rimantadine-d4 Hydrochloride is an isotope labeled version of Rimantadine Hydrochloride, an antiviral agent.<br>References Hayden, F.G., et al.: Antimicrob. Ag. Chemother., 19, 226 (1981), Zlydnikov, D.M., et al.: Rev. Infect. Dis., 3, 408 (1981),<br></p>

<p>Stability Hygroscopic<br>Applications Antiepileptic; increases levels of GABA in the brain.<br>References Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8, 529 (1979), Nau, H., et al.: Pharmacol. Toxicol., 69, 310 (1991), Loscher, W., et al.: Prog. Neurobiol., 58, 31 (1999)<br></p>

<p>Applications Nebivolol (N387896) metabolite.<br></p>

<p>Applications Phenacetin-d3 is the labeled analogue of Phenacetin (P294580), an analgesic, antipyretic; component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.<br>References Boyd, et al.: Toxicol. Appl. Pharmacol., 1, 240 (1959); Dubach, C.U., et al.: N. Engl. J. Med., 308, 357 (1983)<br></p>

<p>Applications Propyzamide-d3 (phenyl-2,4,6-d3) (CAS# 1219805-79-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Fenquinotrione is commonly involved in herbicidal mixtures and is commonaly used in soybean and cotton cultures.<br>References Zagar, C., et al.: PCT Int. Appl. 32 (2020)<br></p>

<p>Stability Hygroscopic<br>Applications A labelled isobaric and isomeric compound related to 3,4-methylenedioxymethamphetamine.<br>References Aalberg, L., et al.: J. Chromatogr. Sci., 38, 329 (2000),<br></p>

<p>Applications Pyrimitate is an organophosphorus pesticide.<br>References Askew, J., et al.: Analyst, 94, 1117 (1969), Gao, L., et al.: Zhongguo Weisheng Jianyan Zazhi, 23, 535 (2013), Zvinavashe, E., et al.: Chemosphere, 75, 1531 (2009),<br></p>

<p>Applications A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J. M., et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T., et al.: J. Thromb. Thrombol., 31, 310 (2011); Barrett, Y. C., et al.: Thromb. Haemos., 105, 181 (2011);<br></p>

<p>Applications Antilipemic; reducing lipid levels in the blood.<br>References Webb, S., et al.: Toxicol. Lett., 142, 157 (2003), Calabuig, C., et al.: Int. J. Pharm., 278, 111 (2004), El-Gindy, A., et al.: J. Pharm. Biomed. Anal., 43, 196 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Acarviosin is a part of the potent α-amylase inhibitor, Acarbose (A123500), an anti-diabetic drug used to treat type 2 diabetes mellitus (1,2,3).<br>References (1) Shibata, Y., et al.: Carbohydrate. Res., 228, 377 (1992) (2) Raimbaud, E., et al.: Carbohydrate. Res., 227, 351 (1992) (3) Geng, P., et al.: Carbohydr Res. 343, 882 (2008)<a href="https://www.ncbi.nlm.nih.gov/pubmed/18294624PMID" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pubmed/18294624PMID</a>: 18294624<br></p>

<p>Applications A natural product with significant antitumor activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sah, N., et al.: J. Biol. Chem., 278, 20593 (2003), Lu, D., et al.: J. Int. Med. Res., 32, 488 (2004), Yunmbam, M., et al.: Oncol. Rep., 11, 833 (2004), Shao, S., et al.: Cell Biol. Int., 32, 893 (2008),<br></p>

<p>Applications Mepanipyrim Phenyl-d5 is deuterium labelled Mepanipyrim (M223600).Mepanipyrim (M223600) is an anilinopyrimidine fungicide which have been used in the management of fungal diseases in strawberries.<br>References Tetada, M., et al.: Toxicol. Appl. Pharmacol., 154, 1 (1999); Hauke, K., et al.: Commun. Agri. Appl. Biol. Sci., 69, 743 (2004);<br></p>

<p>Applications Nonpeptide, direct thrombin inhibitor. Antithrombotic.<br>References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),<br></p>

<p>Applications beta-Estradiol 3-(beta-D-glucuronide) sodium salt is a non-cholestatic regioisomer of the estrogen metabolite, estradiol 17-(β-D-glucuronide).<br></p>

<p>Applications DL-Lauroylcarnitine Chloride is a permeation enhancer that has been used to enhance the intestinal absorption of salmon calcitonin.<br>References Welling, S.H., et. al.: Eur. J. Pharm. Biopharm., 86, 544 (2014); Song, K., et. al.: J. Control Release, 106, 298 (2005)<br></p>

<p>Applications Racemic Colchicine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A novel labelled metabolite of Perchloroethene (PER) in humans after inhalation. It is an important biomarker for the glutathione dependent biotransformation of PER.<br>References Urban, G., et al.: Xenobiotica, 24, 881 (1994), Birner, G., et al.: Drug Metab. Dispos., 24, 41 (1996), Dekant, W., et al.: Drug Metab. Dispos., 15, 702 (1987),<br></p>

<p>Applications Ametryn is a methylthiotriazine based herbicide which inhibits photosynthesis and other enzymatic processes. Ametryn is used to control broadleaf weeds and annual grasses in pineapple, sugarcane and bananas.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kasozi, G.N. et al.: Environ. Pollut., 169, 12 (2012); Megersa, N., et al.: 29, 789 (2012)<br></p>

<p>Applications Tralkoxidym<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Abiraterone is a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389 (2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005);<br></p>

<p>Applications Labelled synthetic peptide agonist analog of LH-RH. Triptoreline is a potent agonist of LH-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. Antineoplastic (hormonal). Used in the treatment of endometriosis and infertility.<br>References Sanders, L., et al.: Eur. J. Drug Metab. Pharmacokinet., 15, 95 (1990), Chiba, M., et al.: Biomaterials, 18, 893 (1997), Blanco, D., et al.: Eur. J. Pharm. Biopharm., 45, 285 (1998), Sinha, V., et al.: J. Control. Rel., 90, 261 (2003),<br></p>

<p>Applications A nonsedating type histamine H1-receptor antagonist. Antihistaminic.<br>References Vincent, J., et al.: Brit. J. Clin. Pharmacol., 26, 497 (1988)<br></p>

<p>Applications Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0 mM (52% inhibition occured at 100 mM).Methionine sulfoximine is also a toxic byproduct of nitrogen trichloride, a compound that was used to bleach unprocessed wheat flour prior to 1968. The compound has been investigated as a potential neurotoxin linked to diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease.<br>References Griffith, O.W., and Meister, A.: J. Biol. Chem. 254, 7558 (1979), Willard-Mack, C.L., et al: Neuroscience, 71, 2, 589 (1996)<br></p>

<p>Applications 3-Piperidinopropiophenone is a mono Mannich base derived from acetophenone with antibacterial, antifungal and antitumor activity. 3-Piperidinopropiophenone shows cytotoxicity againts Jurkat cells.<br>References Gul, H.I. et al.: Biol. Pharmac. Bull., 26, 631 (2003); Gul, M. et al.: Arzneim.-Forsch., 51, 679 (2001); Gul, H. et al.: Arzneim.-Forsch., 51, 72 (2001);<br></p>

<p>Impurity Nicardipine USP Related Compound B<br>Applications A pyridine metabolite M-5 of Nicardipine. Nicardipine USP Related Compound B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Triggle, A., et al.: J. Med. Chem., 23, 1442 (1980), Freedman, D., et al.: Drugs, 34, 578 (1987), Guengerich, F., et al.: Xenobiotica, 25, 689 (1995), Schleifer, K., et al.: Pharmazie, 54, 804 (1999),<br></p>

<p>Applications N6-Isopentenyladenosine has antiproliferative activity on MCF-7 breast cancer cells.<br>References Rajabi, M. et al.; DNA Cell Biol.; 29, 687 (2010)<br></p>

<p>Stability Hygroscopic<br>Applications An active carboxylate of Mevastatin (M340500). It is a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase with hypocholesterolemic activity. It has been shown to be effective in reducing cholesterol synthesis in vivo, and thereby in lowering cholesterol levels in blood.<br>References Endo, A. et al.: Atheroscler. Supp., 5, 39 (2004); Hosobuchi, M. et al.: J. Ferm. Bioeng., 76, 470 (1993);<br></p>

<p>Applications 6-Oxo Simvastatin is an analog of Simvastatin (S485000), a HMG-CoA reductase inhibitor.<br>References Joshua, H., et al.: J. Antibiot., 44, 366 (1991),<br></p>

<p>Impurity Betamethasone Dipropionate EP Impurity J<br>Applications Betamethasone 9,11-Epoxide 17,21-Dipropionate (Betamethasone Dipropionate EP Impurity F) is an impurity of Betamethasone (B327000), an antiinflammatory agent.<br>References Shou, M., et al.: J. Pharm. Biomed. Anal., 50, 356 (2009),<br></p>

<p>Applications Betamethasone 17-Butyrate is an impurity of Clobetasone 17-Butyrate (C583550), an glucocorticoid used for anti-inflammatory purposes.<br></p>

<p>Applications 5-Oxorosuvastatin methyl ester is an intermediate in the synthesis of Rosuvasatatin (calcium salt: R700500), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that decreases high-sensitivity C-reactive protein (hsCRP) and cholesterol concentrations in the blood.<br>References McTaggart, F., et al.: Am. J. Cardiol., 87, 28 (2001); Ridker, P., et al.: Lancet, 373, 1175 (2009)<br></p>

<p>Applications 6α-Methyl-9α-fluoro-11β,17α-dihydroxyprogesterone is an impurity of Fluorometholone (F593145), a glucocorticoid; anti-inflammatory.<br>References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982), Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984),<br></p>

<p>Applications Atorvastatin (A791750) impurity.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996);<br></p>

<p>Applications Sodium channel blocker, local anesthetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),<br></p>

<p>Stability Hygroscopic<br>Applications An intermediate in the production of Rosuvastatin (R700500) derivatives.<br></p>

<p>Applications The major metabolite of Deflazacort.<br>References Bernareggi, A., et al.: J. Pharma. Biomed. Anal., 5, 177-81 (1987), Assandri, A., et al.: Xenobiotica, 13(3), 185 (1983), Martinelli, E., et al.: Drug Metab. Dispos., 7, 335 (1979),<br></p>

<p>Applications A related compound of Desloratadine (D290250).<br>References Krishna, K., et al.: J. Pharm. Biomed. Anal., 32, 29 (2003), Qi, M., et al.: J. Pharm. Biomed. Anal., 38, 355 (2005),<br></p>

<p>Applications A metabolic intermediate in nucleic acid metabolism.<br>References Yoon, K., et al.: Nat. Prod. Sci., 14, 254 (2008), Ramazzina, I., et al.: J. Biol. Chem., 283, 23295 (2008), Kim, K., et al.: J. Mol. Biol., 387, 1067 (2009),<br></p>

<p>Applications Oxyphenisatin Diacetate is the pro-drug of Oxyphenisatin (O876965). Results confirm that Oxyphenisatin Diacetate inhibits the growth of breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.<br>References Morrison, B.L., et al.: Cancer Med., 2, 687-700 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications 6α-Chloro Testosterone is a derivative of Testosterone, the principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol.Testerone is a controlled substance (anabolic steroid). Androgen.This compound is a contaminant of emerging concern (CECs).<br>References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998), Themmen, A., et al.: Endocr. Rev. 21, 551 (2000), Kumar, R., et al.: Biol. Reprod., 65, 710 (2001),<br></p>

<p>Applications Testololactone, is the derivative of Testolactone (T154800), which is an antineoplastic agent that is a derivative of progesterone and is used to treat advanced stage breast cancer.<br>References Dunkel, L.: Mol. Cell. Endocrinol., 254, 207 (2006); Eugster, E. A.: Treat. Endocrinol., 3, 141 (2004); Holbeck, S.L. et al.: Mol. Cancer Therap., 9, 1451 (2010);<br></p>

<p>Stability Temperature and Light Sensitive, unstable in solution<br>Applications Vitamin K1 Hydroxide is a derivative of Vitamin K1 (V676080), which occurs widely in green plants, algae, and photosynthetic bacteria.<br>References Hassan, M.M.A., et al.: Anal. Profiles Drug Subs., 17, 449 (1988), Breton, J., et al.: Biochemistry, 33, 12405 (1994), Dowd, P., et al.: Science, 269, 1684 (1995),<br></p>

<p>Stability Hygroscopic<br>Applications Antihistaminic.<br>References Berthon, B., et al.: Biochem. Pharmacol., 47, 789 (1994), Hu, Q., et al.: J. Biol. Chem., 274, 33995 (1999),<br></p>

<p>Applications Prednisolone 21-β-D-Glucuronide Sodium Salt is a metabolite of Prednisolone (P703740).<br>References Hutzler, J., ET AL.: Drug Metab. Dispos., 30, 355 (2002), Sugiyama, D., et al.: J. Biol. Chem., 278, 43489 (2003), Hagenbuch, B., et al.: Xenobiotica, 38, 778 (2008),<br></p>

<p>Applications Cholesteryl Acetate Dibromide is an brominated intermediate in the synthesis of Cholesterol (C432501) derivatives.<br>References Kandutsch, A.A., et al.: J. Biol. Chem., 249, 6057 (1974);<br></p>

<p>Applications An antiarrhythmic agent isolated from Rauwolfia serpentina.<br>References Galarreta, B., et al.: Bioorg. Med. Chem., 16, 6689 (2008), Sun, L., et al.: Plant Mol. Biol., 67, 455 (2008), Ruiz-May, E., et al.: Mol. Biotechnol., 41, 278 (2009),<br></p>

<p>Impurity Clonidine EP Impurity A<br>Applications 1-Acetyl-2-imidazolidinone (Clonidine EP Impurity A) is a synthetic reagent used in the preparation of triple [14C]-labelled moxonidine which is an antihypertensive compound.<br>References Czeskis, B., et al.: J. Labelled Comp. Radiopharm., 47, 699 (2004)<br></p>

<p>Applications The main phase I metabolites of Azelastine.<br>References Adusumalli, V., et al.: Drug Metab. Dispos, 20, 530 (1992), Mano, N., et al.: J. Pharm. Biomed. Anal., 12, 557 (1994), Baldwin, S., et al.: Xenobiotica, 25, 261 (1995), Kobayashi, K., et al.: J. Pharmacol. Exp. Ther., 280, 927 (1997),<br></p>

<p>Applications An impurity in Simvastatin (S485000).<br>References Sankar, D. et al.: Asian J. Chem., 21, 4294 (2009); Vuletic, M. et al.: J. Pharmac. Biomed. Anal., 37, 715 (2005);<br></p>

<p>Applications Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive.<br>References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Applications A metabolite of Mifepristone.<br>References Heikinheimo, O., et al.: J. Steroid Biochem., 26, 279 (1987), Brogden, R., et al.: Drugs, 45, 384 (1993), Shi, Y., et al.: Contraception, 48, 133 (1993), Jang, G., et al.: Biochem. Pharmacol., 52, 753 (1996), Gainer, E., et al.: Steroids, 68, 1005 (2003),<br></p>

<p>Applications A synthetic adrenocorticosteroid that acts as an anti-inflammatory and anti-pruritic agents. It is used as a topical for the treatment of dermatologic disorders such as atopic dermatitis and psoriasis.<br>References Mason, J. et al.: Br. J. Dermatol., 146, 351 (2002); Sears, H.W. et al.: Clin. Therap., 19, 710 (1997); Otomo, Y.Z. et al.: Nip. Yakur. Zas., 78, 647 (1981);<br></p>

<p>Applications Benzthiazide is a diuretic, antihypertensive agent.<br>References Mollica, J., et al.: J. Pharm. Sci., 58, 635 (1969), Chienthavorn, O., et al.: J. Pharm. Biomed. Anal., 36, 477 (2004),<br></p>

<p>Applications Nicergoline-d3 is the labeled analogue of Nicergoline(N394550), a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia.<br>References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)<br></p>

<p>Applications A metabolite of Clomipramine.<br>References McTavish, D., et al.: Drugs, 39, 136 (1990), Chauret, N., et al.: Drug Metab. Dispos., 25, 1130 (1997), Gex-Fabry, M., et al.: Ther. Drug Monit., 22, 701 (2000), Herrera, D., et al.: J. Clin. Pharmacol., 40, 1488 (2000),<br></p>

<p>Applications Tirofiban intermediate.<br></p>

<p>Applications 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).<br>References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications An oxidized derivative of the visual pigment carotenoid.<br>References Wada, A., et al.: Chem. Pharm. Bull., 56, 112 (2008), Smolensky, E., et al.: Biochem., 48, 9170 (2009),<br></p>

<p>Applications 3-Cysteinylacetaminophen-D5 (major), Trifluoroacetic Acid Salt is deuterium labeled 3-Cysteinylacetaminophen Trifluoroacetic Acid Salt (C994750), which is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).Minimum isotopic incorporation d-3, no d-0 present. A representative lot has 64% isotopic incorporation at the 6-position, 89% at the 4-position.<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>

<p>Applications Campesteryl Ferulate is a component of γ-​oryzanol with antioxidant activities.<br>References Xu, Z., et al.: J. Agric. Food Chem., 49, 2077 (2001);<br></p>