Toxicology

<p>Applications Pyriproxyfen is a pyridine-based pesticide used against a variety of arthropoda, in particular to protect cotton crops against whitefly. Clariant has recently launched a pesticide-filled polymer using pyriproxyfen for the manufacture of mosquito nets.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amiri, A., et al.: J. Agri. Sci. Technol., 14, 1205 (2012); Basit, M., et al.: Crop. Protect., 44, 135 (2013); Chem. and Eng. News Page 12, May 6, 2019<br></p>

<p>Applications Dichloroacetic Acid, is a highly corrosive compound, but in a salt form is used therapeutically, due to their ability to inhibit the enzyme pyruvate dehydrogenase kinase. The studies has also shown, DCA has potential anticancer applications. This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kato, M., et al.: Structure, 15(8), 992 (2007); "Cheap, ‘safe’ drug kills most cancers". New Scientist. (2007); Michelakis, E. D., et al.: Sci. Transl. Med., 2(31) (2010);<br></p>

<p>Applications Labelled Irgarol (I764100). Irgarol is a highly specific and effective inhibitor of photosynthesis. This makes it ideal, combined with its very low water solubility, for use in long-life antifouling coatings for marine applications to prevent the growth of algae.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Okamura, H., et al.: J. Environ. Sci. Health, B34, 225 (1999), Comber, S., et al.: Sci. Total Environ., 286, 61 (2002), Gatidou, G, et al.: Environ. Int., 33, 70 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Organic reagent used to synthesize phthalates.<br>References Duchowicz, P.R., et al.: Bioorg. Med. Chem., 16, 7944 (2008), di Luccio, E., et al.: Biochem., 47, 4039 (2008), Lopez, Z., et al.: App. Microbiol. Biotechnol., 78, 739 (2008), Hong, Y., et al.: Toxicol. Lett., 184, 139 (2009),<br></p>

<p>Applications Labelled fluorinated quinolone antibacterial.<br>References Monk, J.P., et al.: Drugs, 33, 346 (1987), Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)<br></p>

<p>Applications Bis(2-ethylhexyl)adipate-d8 is an isotopic analog of Bis(2-ethylhexyl)adipate (B433810) which acts as a plasticizer in the preparation of personal care products. Also used in changing the physical properties of rubbers.<br>References Oh, J. et al.: J. App. Polym. Sci., 131, 39795 (2014); Llompart, M. et al.: J. Chrom. A., 1293, 10 (2013);<br></p>

<p>Applications Reproterol is an β2 adrenoceptor agonist for treating asthma. Reproterol is used as an bronchodilator.<br>References Sohda, T., et al.: Chem. Pharm. Bull., 30, 3580 (1982), Argenti, D., et al.: J. Clin. Pharmacol., 51, 400 (2001), Pearce, R., et al.: Drug Metab. Dispos., 34, 1035 (2006),<br></p>

<p>Applications A substituted 2,4,6-triiodobenzoic acid, an excellent contrast media for ventriculography, radiculography, lumbar myelography and x-rays of the cardiovascular system.<br>References Frocrain, L., et al.: Radiology, 170, 531 (1989), van Waes, P.F., et al.: Eur. J. Radiology, 9,179 (1989)<br></p>

<p>Applications Labelled analogue of Propionaldehyde 2,4-Dinitrophenylhydrazone, a dinitrophenylhydrazone (DNPH) derivative of an aliphatic aldehyde found in mainstream cigarette smoke and a breakdown product of lipid peroxidation.<br>References Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010); Enoiu, M. et al.: Anausis, 28, 285 (2000);<br></p>

<p>Applications A reagent used in the preparation of hepatitis C virus NS3 protease inhibitors and PMPA prodrugs with antiretroviral activity.<br>References Sheng, X. et al.: Bioorg, Med. Chem. Lett., 169, 3453 (2009); Arimilli, M.N. et al.: Antiviral Chem. Chemother., 8, 557 (1997);<br></p>

<p>Impurity Efavirenz USP Related Compound B<br>Applications (E)-Dihydro Efavirenz (Efavirenz USP Related Compound B) is an impurity of the nonnucleoside HIV-1 reverse transcriptase inhibitor Efavirenz (E425000).<br>References Weissburg, R.P. et al.: J. Pharmac. Biomed. Anal., 28, 45 (2002); Ribeiro, J.A.A. et al.: J. Pharmac. Biomed. Anal., 43, 298 (2007);<br></p>

<p>Applications Ethacrynic Acid is a diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.<br>References Beyer, et al.: J. Pharmacol. Exp. Ther., 147, 1 (1965); Kim., et al.: Am. J. Cardiol., 27, 407 (1971); Williamson, H.E., et al.: J. Clin. Pharmacol., 17, 663 (1977);<br></p>

<p>Applications (E)-Fenpyroximate is an acaricide and an inhibitor of mitochondrial electron transport at Complex I.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hamedi, N. and Fathipour, Y.: BioControl 55, 271 (2010); Sato, M. E., et al.: Appl. Entomol. Zool. 39, 293 (2004)<br></p>

<p>Applications Clindamycin 2-Phosphate Sulfoxide is a degradation product of Clindamycin phosphate (C580005) after the stressing test.Clindamycin phosphate impurity.<br></p>

<p>Applications 5-Desthiopropyl-5-hydroxy-ticagrelor is a related compound of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>

<p>Applications It is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor obtained from the Calabar bean, used to treat glaucoma and delayed gastric emptying.<br>References Engelhart, L., et al.: Arch. Exp. Pathol. Pharmakol., 150, 1 (1930), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 18, 289 (1989),<br></p>

<p>Applications Antibacterial.<br>References Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978), Roth, B., et al.: J. Med. Chem., 23, 379 (1980), Brogden, R.N., et al.: Drugs, 23, 405 (1982),<br></p>

<p>Applications Antioxidant in feed and food; antidegradation agent for rubber.<br>References Wilson, R.H., et al.: Agric. Food Chem., 7, 206 (1959), Skaare, J.U., et al.: Xenobiotica, 9, 649 (1979), Prochaska, H., et al.: Cancer Res., 48, 4776 (1988), Bammler, T., et al.: Toxicol. Sci., 54, 30 (2000), Hayes, J., et al.: Cancer, 174, 103 (2001),<br></p>

<p>Applications Antineoplastic; one derivative of cyclophosphamide (NSC-26271).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Potel, J., et al.: Arzneim.-Forsch., 21, 1250 (1971), Bria, E., et al.: Cancer Treat. Rev., 32, 583 (2006), Faivre, S., et al.: J. Clin. Oncol., 24, 25 (2006).<br></p>

<p>Stability Hygroscopic<br>Applications A biochemical marker of bone turnover for management of metabolic bone diseases.<br>References Turner, W., et al.: Biol. Psychiatry, 14, 177 (1979), Miyata, T., et al.: Kidney Int., 60, 2351 (2001), Politi, P., et al.: Neurosci. Lett., 396, 163 (2006),<br></p>

<p>Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol<br>References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995)Merck Index 12th ed. 43952. Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)<br></p>

<p>Applications Ketoconazole-d3 is the labeled analogue of Ketoconazole (K186000), which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986); Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989); Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988); Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>

<p>Applications Methotrexyl-N’-biotinylethylenediamine is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Promazine (P756300). Antipsychotic. Tranquilizer.<br>References Banci, L., et al.: Biochemistry, 38, 3205 (1999), Lawal, O., et al.: Food Chemi., 87, 205 (2004), Shleev, S., et al.: Bioorg. Chem., 35, 35 (2007),<br></p>

<p>Applications 3,4-Dichloroaniline is used in the preparation of the herbicide propanil (P760840).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase.<br></p>

<p>Applications Chloramphenicol Succinate Sodium is a derivative of Chloramphenicol (C325030) which are broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial.<br>References Bartz, et al.: J. Biol. Chem., et al.: 172, 445 (1948), Gottlieb, et al.: J. Bacteriol., 55, 409 (1948), Szulczewski, D., et al.: Anal. Profiles Drug Subs., 4, 47 (1975), Price, A., et al.: J. Antibiot., 43, 118 (1981), Shalit, I., et al.: Drugs, 28, 281 (1984),<br></p>

<p>Applications Labelled Abiraterone (A108490). A steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993), Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995), Denmeade, S., et al.: Nat. Rev., 2, 389(2002), Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005),<br></p>

<p>Applications Bis(butoxyethyl) Phosphate is used in biological studies as a metabolism of phosphate flame retardants and plasticizers using human liver fractions.<br>References Van den Eede, N., et al.: Toxicol. Lett., 223, 9 (2013)<br></p>

<p>Applications Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Newer research has been investigating the potential anticancer effects of atazanavir<br>References Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),<br></p>

<p>Impurity Levothyroxine EP Impurity D / T4-Acetic Acid (USP)<br>Applications Thyroid hormone analogue. A potent Thyroxine impurity. T4-Acetic Acid (USP).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Horst, C., et al.: Biochem. J., 261, 945 (1989), Kvetny, J., et al.: Horm. Metab. Res., 24, 322 (1992), Yamauchi, K., et al.: J. Biol. Chem., 274, 8460 (1999), Davis, P., et al.: J. Endocrinol. Invest., 25, 377 (2002),<br></p>

<p>Applications Labelled Secnidazole (S225000). Analog of Metronidazole. Antiamebic. Antiprotozoal (Trichomonas).<br>References Cosar, C., et al.: Arzneim.-Forsch., 16, 23 (1966), Videau, D., et al.: Br. J. Vener. Dis., 54, 77 (1978), Symonds, J., et al.: J. Antimicrob. Chemother., 5, 484 (1979),<br></p>

<p>Applications An acylamino acid fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ravelo-Perez, L., et al.: Food Chem., 111, 764 (2008), Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010),<br></p>

<p>Applications Cloxacillin is an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.<br>References Gibbs, D.L. et al.: Curr. Microbiol., 2, 239 (1979); Dmitrova, D. et al.: Farmat., 48, 28 (2001); CRaven, N. et al.: Res. Vet. Sci., 29, 57 (1980);<br></p>

<p>Applications Pefloxacinium (cas# 70458-92-3) is a useful research chemical.<br></p>

<p>Stability Very Hygroscopic<br>Applications S-3-p is the substrate for 5-Enolpyruvoyl-shikimate 3-phosphate synthase (EPSPS) which is the target for the broad-spectrum herbicide N-(phosphonomethyl)glycine(glyphosate).<br>References Chahoua, L., et al.: J. Org. Chem., 57, 5798 (1992)<br></p>

<p>Applications (R)-(+)-2-Amino-3-benzyloxy-1-propanol is used as a reagent to synthesize beta-amino alcohols, compounds that are used as therapeutic agents to treat heart disease. (R)-(+)-2-Amino-3-benzyloxy-1-propanol is also used as a reagent to synthesize 15-membered macrolide antibiotics, drugs that are used to treat respiratory tract infections.<br>References Fisher, G., et al.: J. Org. Chem., 60, 2026 (1995); Metro, T., et al.: J. Org. Chem., 72, 6556 (2007); Sugimoto, T., et al.: Bioorg. Med. Chem., 20, 5787 (2012)<br></p>

<p>Applications A metabolite of the fluorinated quinolone antibacterial Ciprofloxacin.<br></p>

<p>Stability Moisture Sensitive<br>Applications NSC 295642 acts as a potential inhiibitor of Caax protease disrupting yeast Ras localization.<br>References Manandhar, S. et al.: Yeast, 27, 327 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications Monosultap is a type of insecticide that is used in agricultural use to regulate insect growth against Pieris rapae.<br>References Zhong, G.H., et al.: J. Appl. Ent., 125, 563 (2001);<br></p>

<p>Applications R(-)-Methamphetamine is an intermediate in the synthesis of (R)-Benzphetamine Hydrochloride (B209870), the R-enantiomer of Benzphetamine (B209880). Controlled substance (stimulant). Anorexic.<br>References Stewart, J.T., et al.: J. Pharma. Sci., 60, 461 (1971),<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications A metabolite of vitamin A (Retinol) (R252000).<br>References Allo, S., et al.: J. Biol. Chem., 266, 22003 (1991), Brancolini, C., et al.: J. Cell Biol., 139, 759 (1997), Bubb, M., et al.: J. Biol .Chem., 269, 14869 (1994),<br></p>

<p>Applications Clindamycin Palmitate is a semi-synthetic antibiotic with high bioavailability. Clindamycin Palmitate is an antibacterial.<br>References Platzer, D., et al.: J. Pharm. Biomed. Anal., 41, 84 (2006),<br></p>

<p>Applications Systemic post-emergence herbicide for use in food crops and mesquite.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pik, A.J., J. Agric. Food Chem., 25, 1054 (1977), Bovey, R.W., et al.: Weed. Sci., 33, 349 (1985),<br></p>

<p>Applications A new Sildenafil (S435000) analogue detected as food adulterant.<br>References Gratz, S., et al.: J. Pharm. Biomed. Anal., 36, 525 (2004), Lai, K., et al.: J. Food Drug Anal., 14, 19 (2006), Oh, S., et al.: J. Toxicol. Environ. Health, 69, 1951 (2006),<br></p>

<p>Applications A labelled anticholinergic drug used in the treatment parkinson’s disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.<br>References Salako, L.A.: Arch. Int. Pharmacodyn, Ther., 184, 233 (1970); Vas, C.J. et al.: Neurol., 19, 234 (1969);<br></p>

<p>Impurity Vancomycin Impurity<br>Applications An impurity in Vancomycin.A representative lot was 75% by HPLC with less than 0.1% vancomycin.<br>References Marshall, F.J., et al.: J. Med. Chem., 8, 18 (1965), Sheldrick, G.M., et al.: Nature, 271, 223 (1987), Dutca-Melan, S., et al.: J. Clin. Microbiol., 33, 24 (1995),<br></p>

<p>Applications 4-Methyl-2-pentanol is used in the synthesis of 4-quinolone derivatives as high-affinity ligands for the brain GABAA receptors. Also used in the preparation of antimycotic imadazoles, as antifungals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lager, E. et al.: J. Med. Chem., 49, 2526 (2006); Heeres, J. et al.: J. Med. Chem., 22, 1003 (1979);<br></p>

<p>Applications Isotope labelled Molinate (M486477), which is a herbicide that is used to control broad-leaved and grassy plants in rice and other crops (1,2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Nacher-Mestre, J. et al.: J. Agri. Food. Chem. 2014 Mar 12;62(10):2165-742. Sugrue, E. et al.: Appl. Environ. Microbiol. 2015 Apr;81(7):2612-24.<br></p>

<p>Applications Dihexadecyl(dimethyl)azanium bromide is an ionic olefin derivative used in the preparation of metal-containing ionic liquids for use in particle synthesis and materials with magnetic or thermochromic properties.<br>References Zabel, A.; et al.: Int. J. Mol. Sci., 17, 596/1 (2016).<br></p>

<p>Applications A metabolite of Amitraz (A633320).<br>References Knowles, C., et al.: J. Sci. Health, 16, 547 (1981), Zhu, N., et al.: J. Pestic., 33, 32 (1994), Du, X., et al.: Environ. Chem., 14, 258 (1995),<br></p>

<p>Applications Labelled analogue of Glycopyrrolate Bromide, a novel pharmaceutical compound based on PDE IV inhibitors. Glycopyrrolate Bromide is used in the treatment of respiratory complaints.<br>References Gomez, et al.: Br. J. Anaesth., 74, 549 (1995);<br></p>

<p>Applications Desethyldesisopropyl Atrazine is a metabolite of Atrazine (A794600).<br>References Adams, N., et al.: J. Agric. Food Chem., 38, 1411 (1990), Abbas, R., et al.: Toxicol. Appl. Pharmacol., 147, 15, (1997), Cooper, R., et al.: Toxicol. Sci., 2000, 53, 297 (2000), Hossain, M., et al.: Toxicology, 248, 52 (2008),<br></p>

<p>Applications cis-Tetrahydrophthalimide is an intermediate to synthesize cis-Captafol (C175740), which was used as a fungicide.<br>References Knight, A., et al.: Regulatory Toxicol. Pharmacol., 55, 188 (2009); Rotroff, D., et al.: J. Toxicol. Environ. Health Part B Critical Rev., 13, 329 (2010)<br></p>

<p>Applications A Labelled metabolite of Dextrorphan.<br>References Gonzalez, F., et al.: Nature, 331, 442 (1988), Meyer, U., et al.: Pharmacol. Ther., 46, 297 (1990), Rogers, J., et al.: Am. J. Med., 113, 746 (2002), Huang, W., et al.: Drug Metab. Dispos., 32, 1434 (2004),<br></p>

<p>Applications A drug used to treat tuberculosis.<br>References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005),<br></p>

<p>Applications 2-Oxo Clopidogrel-d3 is he labelled analogue of 2-Oxo Clopidogrel (O869990). The essential intermediate metabolite from which the active metabolite of Clopidogel is formed.<br>References eliste, R., et al.: Thromb. Res., 48, 403 (1987); Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992); Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993); Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)<br></p>

<p>Impurity Amoxicillin EP Impurity C ; Amoxicillin USP Related Compound C<br>Applications Amoxicillin Diketopiperazine (Amoxicillin EP Impurity C) is a major metabolite of Amoxicillin (AMO)(A634235).<br>References Dewdney, J., et al.: Food Chem. Toxic, 29, 477 (1991), Connor, S., et al.: J. Pharm. Pharmacol., 46, 128 (1994), Hernandez, E., et al.: Vet. J., 170, 237 (2005),<br></p>

<p>Applications Cyhalodiamide is a diamide insecticide and an agrochemical compound.<br>References Zhang, Y., et al.: Int. J. Agric. Biol., 19, 1421 (2017); Xing, J., et al.: Nongyao, 54, 842 (2015)<br></p>

<p>Applications Labelled Dicloxacillin (D436650). A semi-synthetic antibiotic related to Penicillin. Antibacterial.<br>References Chalikian, T., et al.: J. Mol. Biol., 260, 588 (1996), Kharakoz, D., et al.: Biochemistry, 36, 10276 (1997), Taboada, P., et al.: Langmuir, 16, 3175 (2000),<br></p>

<p>Applications Labelled Robenidine (R639000). Robenidine is used as a coccidiostat.<br>References Kantor, et al.: Science, 373, 168 (1970), Wong, et al.: Biochem. Biophys. Res. Commun., 46, 621 (1972)<br></p>

<p>Applications Melperone is a neuroleptic butyrophenone. Melperone is also an antiarrhythmic agent. Melperone is an effective atypical antipsychotic drug used in the treatment of schizophrenia.<br>References Petersen, E.N. et al.: Acta Pharmacol. Toxicol., 42, 388 (1978); Platou, E. et al.: Acta Pharmacol. Toxicol., 50, 108 (1982); Bjerkenstedt, L. et al.: Acta Psych. Scand. Supp., 352, 35 (1989); Meltzer, H.Y. et al.: Psych. Res., 105, 201 (2001);<br></p>

<p>Applications Roflumilast-N-oxide is the active metabolite of Roflumilast (R639700).<br>References Chiba, M., et al.: Drug Metab. Dispos., 25, 1022 (1997), Jarvis, B., et al.: Drugs, 59, 891 (2000),<br></p>

<p>Applications A labelled Desfuroyl Ceftiofur-related metabolite that have the potential to be microbiologic active in swine muscle, kidney, liver and fat.<br>References Gilbertson, T., et al.: J. Agric. Food Chem., 43, 229 (1995), Olson, S., et al.: Vet. Pharmacol. Therap., 21, 112 (1998), Hornish, R., et al.: Curr. Top Med. Chem., 2, 717 (2002),<br></p>

<p>Applications Pyoluteorin is a pesticide used in the protection of crops from bacteria.<br>References Bakthavatchalu, S. et al.: J. Biol., 37, 289 (2013); Kumar, A.. et al.: Env. Microbiol., 15, 764 (2013);<br></p>

<p>Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Stability Hygroscopic<br>Applications 4-Hydroxyestradiol 4-O-β-D-Glucuronide Sodium Salt, is a glucuronide derivative of 4-Hydroxy-17β-estradiol (H941895); a metabolite of Estradiol (E888000) which is the major estrogen secreted by the premenopausal ovary.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985); Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991); Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998); Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000); Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986); Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987)<br></p>

<p>Applications Chlorexolone is a low-ceiling sulfonamide diuretic.<br>References Goebel, C., et al.: Anal. Chimica Acta, 502, 65 (2004); Smith, E., et al.: J. Chromat., 384, 259 (1987)<br></p>

<p>Applications Penicillin DF Potassium Salt, is used to characterize phenylacetate-CoA ligase from Penicillium chrysogenum.<br>References Koetsier, M., et al.: Biochem. J., 417, 467 (2009);<br></p>

<p>Stability Very Hygroscopic<br>Applications Labelled Oseltamivir Acid (O700980). Oseltamivir Acid is a metabolite of Oseltamivir (O701000). It is a COVID19-related research product.<br>References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998), Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998), Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999), Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)<br></p>

<p>Applications (1R,3R,4R)-Entecavir is an isomeric impurity of Entecavir (E558900).<br></p>

<p>Stability Hygroscopic<br>Applications EPTC is a pesticide, S-Ethyl-N,N-dipropylthiocarbamate<br></p>

<p>Applications An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>

<p>Stability Hygroscopic<br>Applications Piperacillin sodium is an antibiotic related to penicillin. Also, it possesses anti-microbial activity against enterobacteria.<br>References Zhang, Y., et al.: Linchuang Wuzhen Wuzhi, 27, 63-65 (2014)<br></p>

<p>Applications Mancozeb is a mixture of Maneb (M163500) and Zineb, a manganese and zinc (1:1) complex mixture with the ethylene bis(dithiocarbamate) anionic ligand. Mancozeb is a foliate fungicide used to protect crops in agriculture. Mancozeb has a broader and more effective fungacidal activity than either of its component on their own. Mancozeb also significantly enhances the copper activity against several bacteriosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tang, M. et al.: Turang Tong., 41, 1365 (2010); Navneet; M. et al.: J. Ind. Botan. Soc., 74, 19 (1995); Lecigne, P. et al.: Phytoma, 531, 13 (2000);<br></p>

<p>Applications Oseltamivir Acid Hydrochloride is a metabolite of Oseltamivir (O701000), an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug. It is a COVID19-related research product.<br>References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998); Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998); Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999); Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)<br></p>

<p>Applications L-3,6-Bis(β-chloroethyl)-2,5-diketopiperazine (cas# 1333325-25-9) is a compound useful in organic synthesis.<br></p>

<p>Stability Light Sensitive<br>Applications A highly sensitive reagent for α-keto acids. A fluorometric labeling reagent. Dyes and metabolites.<br>References Kajihara, Y., et al.: Carb. Res., 331, 455 (2001)<br></p>

<p>Applications Pre-emergence herbicide used for grass control in crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Robens, J.F., et al.: Vet. Hum. Toxicol., 22, 328 (1980),<br></p>

<p>Applications Fenchlorphos-D6 is a labelled analogue of Fenchlorphos (F247402). Fenchlorphos is an organophosphorus pesticide that is used to maintain pest control. Fenchlorphos is highly toxic, and is known to exhibit toxic effects on animals such as rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Curini, M., et al.: Talanta, 27, 45 (1980); Johnson, W. &amp; Langford, G.: J. Econ. Entomol., 53, 477 (1960); McCollister, D., et al.: J. Agr. Food Chem., 7, 689 (1959); Sulinski, A., et al.: Neuro. Pols., 14, 451 (1976)<br></p>

<p>Applications Antibacterial (tuberculostatic).<br>References Weiner, I.M., et al.: J. Pharmacol. Exp. Ther., 180, 411 (1972), Feldner, E., et al.: Anal. Profiles Drug Subs., 12, 433 (1983)<br></p>

<p>Applications 6-Hydroxy Warfarin β-D-Glucuronide Disodium Salt Hydrate, is a metabolite of Warfarin (W498500) in humans.<br>References Barbato, F., et al.: J. Pharm. Sci., 86, 225 (1997), Kavana, M., et al.: Biochemistry, 42, 10238 (2003), Franco, A., et al.: Environ. Toxicol. Chem., 28, 458 (2009),<br></p>

<p>Applications A metabolite of halopropanes.<br>References Barnsley, E.A.: Biochem. J., 100, 362 (1966)<br></p>

<p>Applications p-Salicylic Acid 4-Sulfate is a urine metabolite of Methylated paraben (B693600), an antimicrobial agent used in cosmetic products.<br>References Tsukamoto, H., et al: Chem. Pharma. Bull., 10, 86 (1962); Desai, N.B., et al.: J. Sci. Indust. Res., 14, 330 (1955);<br></p>

<p>Applications Bacitracin is a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Bacitracin also strongly inhibits proline endopeptidase from human muscle.<br>References Ward, J.B. et al.: Biochem. J., 141, 227 (1974); Anastasi, A. et al.: Biochem. J., 290, 601 (1993); Daly, D.J. et al.: Biochem. Soc. Trans., 13, 1161 (1985); Weinberg, E.D. et al.: Antibiot. Ber., 90, (1967);<br></p>