Toxicology

<p>Impurity Ketoconazole EP Impurity D<br>Applications Deacetyl Ketoconazole (Ketoconazole EP Impurity D) is a Ketoconazole derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications VANCOMYCIN (cas# 1404-90-6) is a useful research chemical.<br></p>

<p>Applications Stearoyl Ethanolamide is a prolific fatty acid ethanolamide produced by PLD hydrolysis of membrane phospholipids. Stearoyl Ethanolamide is also used for studying the effect on endocannabinoid signalling and BBB integrity in systemic inflammation.<br>References Kasatkina, L. A., et al.: Biochem. Pharmacol. 174, 113783 (2020)<br></p>

<p>Impurity Azithromycin Related Compound O<br>Applications Azithromycin N-Ethyl is an analogue of Azithromycin (A927000), an semi-synthetic macrolide antibiotic that is related to Erythromycin (E649950).<br>References Bright, G.M., et al.: J. Antibio., 41, 1029 (1988);<br></p>

<p>Impurity Ceftazidime EP Impurity A<br>Stability Hygroscopic, Light Sensitive<br>Applications ∆2-Ceftazidime, 90% (Ceftazidime EP Impurity A) is a Ceftazidime isomer, an impurity of Ceftazidime (C244100).<br>References Vilanova, B., et al.: Helv. Chim. Acta, 76, 2789 (1993), Zhou, M., et al.: J. Pharm. Sci., 84, 534 (1995), Baertschi, S., et al.: Chemother. 8, 353 (1997), Porra, R., et al.: J. Pharm. Biomed. Anal., 18, 241 (1998),<br></p>

<p>Applications 4-Chloro-3-pyridinesulfonamide is a building block that has been used as a reactant for the preparation of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives as inhibitors of four isoforms of zinc enzyme carbonic anhydrase.<br>References Slawinski, J., et. al.: Eur. J. Med. Chem., 69, 701 (2013)<br></p>

<p>Applications PSI-6130 is an experimental treatment for hepatitis C. PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI-6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B.<br>References Clark, J., et al.: J. Med. Chem., 48, 5504 (2005); Stuyver, L., et al.: Antiviral Chem. Chem., 17, 79 (2006)<br></p>

<p>Applications 2,2,4-Trimethyl-6(2H)-quinolinone 1-Oxide is a derivative of 2,6-Dihydro-2,2,4-trimethyl-6-quinolone (D449900) which is a metabolite of Ethoxyquin (E892800), an oxidation product of the antidegradant.<br>References Kahl, R., et al.: Toxicology, 28, 229 (1983), Burka, L., et al.: Xenobiotica, 26, 597 (1996), Bammler, T., et al.: Toxicol. Sci., 54, 30 (2000), Hayes, J., et al.: Cancer, 174, 103 (2001),<br></p>

<p>Applications Epitizide is a diuretic agent.<br>References Pilsbury, V., et al.: J. Pharm. Pharmacol., 18, 713 (1966), Tisdall, P., et al.: Clin. Chem., 26, 702 (1980),<br></p>

<p>Impurity Levofloxacin USP Related Compound B<br>Applications Levofloxacin intermediate.<br>References Liu, Bo; Y., et al.: Bioorg. Med. Chem., 13, 2451 (2005), Lalitha D., et al.: J. Pharm. Biomed. Anal., 50, 710 (2009),<br></p>

<p>Applications 5-phenyl-1,3-oxazolidin-2-one (cas# 7693-77-8) is a useful research chemical.<br></p>

<p>Applications Labelled Dodecyl Phthalate (D525380). Dodecyl Phthalate is used in the preparation of Cytarabine (C998100) derivatives as anticancer agents.<br>References Aoshima, M., et al.: Cancer Res., 36, 2726 (1976), Wang, N., et al.: Bioorg. Med. Chem. Lett., 15, 4064 (2005), Marie-Helene, G., et al.: Bioorg. Med. Chem., 2009, 17, 6340 (2009),<br></p>

<p>Impurity Mometasone Furoate EP Impurity B<br>Stability Light Sensitive<br>Applications (11β,16α,17α)-9-Chloro-17-(2,2-dioxido-5H-1,2-oxathiol-4-yl)-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-androsta-1,4-dien-3-one (Mometasone EP Impurity B) is an impurity of Mometasone Furoate, a topical corticosteroid used as an anti-inflammatory.<br>References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987); Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996)<br></p>

<p>Applications Medicagenic acid is a versatile compound extracted from some plants, such as the branches of Eucommia ulmoides. It has antifungal properties towards candida albicans.<br>References Xiong, W.; et al.: Chem. Nat. Compd., 54, 1009 (2018); Dorsaz, S.; et al.: Antimicrob. Agents Chemother., 61, 00829-17/1 (2017).<br></p>

<p>Impurity Cefpodoxime Proxetil EP Impurity E<br>Applications Cefotaxime Proxetil (Cefpodoxime Proxetil EP Impurity E) is an impurity of Cefotaxime (C242950), which is a broad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group.<br>References Wise, R., et al.: Antimicrob. Agents Chemother., 14, 807 (1978), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 11, 139 (1982),<br></p>

<p>Stability Hygroscopic<br>Applications Roxithromycin (R700850) structurally related substance in bulk samples. Roxithromycin impurity.<br>References Gasc, J., et al.: J. Antibiot., 44, 313 (1991, Chepkwony, H., et al.: J. Chromatogr., 914, 53 (2001),<br></p>

<p>Stability Hygroscopic<br>Applications Desacetyl Rifampicin Quinone is an impurity of Rifampicin (R508000).<br>References Wilson, W.L. et al.: J. Chrom., 144, 270 (1977);<br></p>

<p>Applications 2-Amino-4-chlorobenzoic Acid is used in the preparation of quinazolinone derivatives observed to be useful in the treatment of Alzheimer’s disease. Also it aids in the synthesis of non-nucleoside, thumb pocket 2 HCV NS5B polymerase inhibitors used in Hepatitis C therapy.<br>References Stammers, T. et al.: Bioorg, Med, Chem. Lett., 23, 2585 (2013);<br></p>

<p>Applications Ibudilast-d7 is the labeled analogue of Ibudilast (I125000), a leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral).<br>References Nishino, K., et al.: Japan J. Pharmacol., 33, 267 (1983); Ohashi, M., et al.: Arch. Int. Pharmacodyn., 280, 216 (1986); Armstead, W.M., et al.: J. Pharmacol., Exp. Ther., 244, 138 (1988)<br></p>

<p>Applications Labelled Ethambutol. Antibacterial (tuberculostatic).<br>References Wilkinson, et al.: J. Med. Chem., 5, 835 (1962), Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971), Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)<br></p>

<p>Applications Labelled Fenpropimorph (F249500). Systemic fungicide for control of powdery mildew, rust in cereal crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baloch, R.I., et al.: Phytochemistry, 23, 2219 (1984), Pommer, E.-H., et al.: Pestic. Sci., 15, 285 (1984),<br></p>

<p>Applications Carfentrazone-ethyl is a triazolone herbicides and is a derivative of Carfentrazone (C183465). Carfentrazone-ethyl was found to be suitable against complex weed flora in wheat.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bhullar, M.S., et al.: Crop. Protect., 43, 216 (2013); Malik, R.S., et al.: Environ. Ecol., 30, 717 (2012);<br></p>

<p>Applications Analgesic and anti-inflammatory compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cochin, J., et al.: J. Pharmacol. Exp. Ther., 139, 160 (1963),<br></p>

<p>Applications Gibberellic Acid is a pentacyclic diterpene acid. Gibberellic Acid is a hormone that is found in plants which promotes the growth and elongation of cells. Gibberellic acid acts as a plant growth regulator on account of its physiological and morphological effects in extremely low concentrations. Generally Gibberellic acid affects only the plant parts above the soil surface.<br>References Bayle, J. et al.: Chem. Biol., 13, 99 (2006); Ihara, S. et al.: J. Cell Sci., 119, 500 (2006); Suh, B. et al.: Science, 314, 1454 (2006); Rinaudo, K. et al.: Nat. Biotechnol., 25, 795 (2007);<br></p>

<p>Impurity Clobetasol Propionate EP Impurity G / Betamethasone EP Impurity B<br>Applications Clobetasol (Clobetasol Propionate EP Impurity G) is a topical corticosteroid. Glucocorticoid; anti-inflammatory.<br>References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),<br></p>

<p>Applications 3-(1-Ethylpropyl)phenyl Methylcarbamate is a component of the carbamate insecticide Bufencarb (B689385).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kmellar, B., et al.: Food Addit. Contam., 27, 1415 (2010); Kaufmann, A., et al.: Anal. Bioanal. Chem., 403, 1233 (2012);<br></p>

<p>Applications Ketotifen is used as an antiasthmatic. Ketotifen is an antiallergic agent.<br>References Tsuji, F., et al.: Biol. Pharm. Bull., 33, 1050 (2010), Al O., et al.: J., Mol., Liq., 155, 103 (2010), Uccello-Barretta, G., et al.: Int. J. Pharm., 395, 122 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled analogue of (-)-Inosine (I661000), compound that exhibits neuroprotective properties by improving axonal wiring and has also been used to treat stroke patients to restore neural function.<br>References Vandemeulebroucke, A., et al.: Biochem., 49, 8999 (2010), Nestor, G., et al.: J. Agric. Food Chem., 58, 10799 (2010),<br></p>

<p>Applications (1S,2R)-erythro-Dihydro Bupropion is a metabolite of Bupropion (B689625), a selective inhibitor of dopamine uptake.<br>References Writer, J.H., et. al.: Sci. Total Environ., 461 (2013)<br></p>

<p>Applications A benzodiazepine drug, which is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety.<br>References Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989), Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993), Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008),<br></p>

<p>Applications 9,10-Dihydroergocristine Methanesulfonate is an nontoxic and well tolerated drug that exerts agonistic and antagonistic activity on dopaminergic and adrenergic receptors. 9,10-Dihydroergocristine Methanesulfonate is known to exhibit protective properties to the brain against metabolic effects of ischemia by acting at a cellular level.<br>References Setti, M., et al.: Angiologia., 30, 98 (1978); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012); Benzi, G., et al.: Neurobiol. Aging., 9, 371 (1988);<br></p>

<p>Applications 2,4,5-Trichlorophenoxyacetic Acid is suitable for plant cell culture testing. Post-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smith, J., et al.: Science, 203, 1090 (1979), Salunkhe, C., et al.: Plant Cell Reports, 18, 670 (1999), Jheng, F., et al.: Plant Sci., 170, 1133 (2006),<br></p>

<p>Applications An N-alkylated Amphetamine (A634240) derivative. It shows the same toxicokinetic activity as amphetaminil, benzphetamine, clobenzorex, dimethylamphetamine, ethylamphetamine, famprofazone, fencamine, fenethylline, fenproporex, mefenorex, mesocarb, methamphetamine (M258785), prenylamine, and selegiline (D288641).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hiramatsu, M., et al.: J. Pharmacol. Exp. Ther., 254, 521 (1990), Lin, L., et al.: Drug Metab. Dispos., 25, 1059 (1997), Wu, D., et al.: Biochem. Pharmacol., 53, 1605 (1997),<br></p>

<p>Applications Labelled Cyclosporin A (C988901) derivative. An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005)<br></p>

<p>Applications Iodosulfuron Methyl Ester Sodium is used as a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klein, J., et al.: J. AOAC Intrnational, 86, 1015 (2003); Pang, G., et al.: J. Chromat. A, 1125, 1 (2006)<br></p>

<p>Stability Hygroscopic<br>Applications TAUROURSODEOXYCHOLIC ACID (cas# 14605-22-2) is a useful research chemical.<br></p>

<p>Applications (+)-trans-Allethrin is a synthetic pyrethroid derivative used as an insecticide. Allethrin is commonly used in many household insecticide products due to its low toxicity towards humans. Pesticide component.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Chatterjee, N. et al.: Food. Chem., 196, 1 (2016);<br></p>

<p>Applications Flupirtine-d5, is the labeled analogue of Flupirtine, an Analgesic, having substituted pyridine with central analgesic properties.<br>References Vaupel, D., et al.: Eur. J. Pharmacol., 162, 447 (1989), Nickel, B., et al.: Arzneim.-Forsch., 40, 909 (1990), Lunemann, J., et al.: J. Immunol., 168, 4881 (2002),<br></p>

<p>Applications The primary metabolite of Diazepam. A ligand for the GABAA receptor benzodiazepine modulatory site. Anxiolytic.Controlled substance (depressant).<br>References Klotz, U., et al.: Br. J. Clin. Pharmacol., 7, 119 (1979), Konishi, M., et al.: J. Pharm. Sci., 67, 1777 (1978), Andreoli, V., et al.: Arzneim.-Forsch., 27, 436 (1977), Miller, R.P., et al.: Toxicol. Appl. Pharmacol., 25, 453 (1973), Margolis, J., et al.: Drug Metab. Dispos., 31, 606 (2003),<br></p>

<p>Applications A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.<br>References Adams, J., et al.: Science, 281, 1322 (1998), Degterev, A., et al.: Nat. Cell. Biol., 3, 173 (2001), Kitada, S., et al.: J. Med. Chem., 46, 4259 (2003), Danial, N., et al.: Clin. Cancer Res., 13, 7254 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Serotonin (S274980). Serotonin is a monoamine neurotransmitter.<br>References Kuraishi, Y., et al.: Biol. Pharm. Bull., 31, 2143 (2008); Morera, E., et al.: Bioorg. Med. Chem. Lett., 19, 6806 (2009); Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010);<br></p>

<p>Applications (R,S)-Equol 7-β-D-Glucuronide is a glucuronide metabolite of isoflavone Daidzein (D103500).<br>References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008)<br></p>

<p>Applications A labelled form of Pirimicarb (P508768) which is a pesticide which is useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsuchiyama, T.; et al.: Journal of Chromatography A, 1524, 233 (2017).<br></p>

<p>Stability Unstable in Solution<br>Applications Dabigatran Acyl-β-D-Glucuronide Trifluoroacetic Acid Salt is a major metabolite of Dabigatran (D100090) in humans. Four isomeric acylglucuronides of Dabigatran were isolated and purified from urine of dosed rhesus monkeys.  NMR analysis confirmed the structures of the four metabolites as the 1-O-acylglucuronide (β anomer) and the 2-O-, 3-O-, and 4-O-acylglucuronides (α and β anomers).<br>References Becker, B., et al.: Biochem. J., 314, 249 (1996), Bailey, M., et al.: Chem. Biol. Interact., 145, 117 (2004), Blech, S., et al.: Drug Metab. Dispos., 2008, 36, 386 (2008),<br></p>

<p>Applications Testosterone (T155000) derivative. Intermediate in the preparation of Epostane (E588850).<br></p>

<p>Applications Acid Red 114 is an azo dye used in diagnostics and textiles industry. It is also present in wastewater and textile effluents contributing to environmental hazards.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Yang, S. et al.: J. Env. Sci. Health., 52, 682 (2017); Ring, M. et al.: PLoS One., 10, e0116488 ((2015);<br></p>

<p>Applications Cholinesterase inhibitor. Ectoparasiticide. This compound is a contaminant of emerging concern (CECs) and used in Pesticide detection.Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009), Raut, P., et al.: Pestol., 33, 21 (2009), Henseler, R., et al.: Toxicol., 261, 9 (2009), Banerjee, K., et al.: J. Agric. Food Chem., 57, 4068 (2009),<br></p>

<p>Applications Prometryn is a methylthiotriazine herbicide used for the control of several annual grasses and broadleaf weeds. Prometryn works by inhibiting the electron transport in target broadleaves and grasses.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Qu, J.R.,et al.: Food. Chem., 135, 1148 (2012); Fenoll, J., et al.: J. Photochem. Photobiol., 238, 81 (2012);<br></p>

<p>Stability Light Sensitive<br>Applications Trichlorfon is an irreversible organophosophate acetylcholinesterase inhibitor and the prodrug of Dichlorvos (D435950) (1,2). Trichlorfon have also shown potential actions to be utilized as an effective organophosphorus pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Li, R., et al.: App. Microbiol. Biotechnol., 94, 1553 (2012) (2) Bakirci, G.T., et al.: Food. Chem., 135, 1901 (2012)<br></p>

<p>Applications Used in treatment of dermatitis herpetiformis; antibacterial.<br>References Wien, R., et al.: J. Pharmacol. Exp. Ther., 84, 211 (1945), Stone, O.J., et al.: Med. Hypotheses, 31, 99 (1990), Elder, M.J., et al.: Br. J. Ophthalmol., 80, 549 (1996),<br></p>

<p>Applications Sudan II is a fat soluble red synthetic azo dye. Sudan II is reduced to potentially carcinogenic aromatic amines by human intestinal bacteria. Dyes and metabolites, Environmental Testing.<br>References Zhu, Y., et. al.: Food Chem., 145, 956 (2014); Xu, H. et. al.: Appl. Environ. Microb., 73, 7759 (2007)<br></p>

<p>Applications Carboxin Sulfoxide is an oxathiin systemic fungicide used on biological systems.<br>References Mathre, D. E.: Pestic. Biochem. Phys., 1, 216 (1971); Mathre, D. E.: Bull. Environ. Contam. Toxicol. , 8, 311 (1972)<br></p>

<p>Applications 4-[4-[2-(2-Pyridinyloxy)propoxy]phenoxy]phenol is a metabolite of Pyriproxyfen (P998850); a pyridine-based pesticide used against a variety of arthropoda, in particular to protect cotton crops against whitefly.<br>References Amiri, A., et al.: J. Agri. Sci. Technol., 14, 1205 (2012); Basit, M., et al.: Crop. Protect., 44, 135 (2013); Yoshino, H., et al.: J. Agr. Food Chem., 43, 2681 (1995); Zhang, L., et al.: Arch. Insect Biochem., 37, 215 (1998)<br></p>

<p>Applications Synthetic mu-opioid agonist. This is a controlled substance (opiate).<br>References James, M.K., et al.: J. Pharmacol. Exp. Ther., 259, 712 (1991), Hoffman, W.E., et al.: Anesthesiology, 79, 107 (1993), Selinger, K., et al.: J. Pharm. Biomed. Anal., 12, 243 (1994), Richardson, T.D., et al.: Expert Opin. Drug Saf., 4, 643 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled dimethyl phosphorothiolate derivatives used as insecticides.<br>References Suzuki, F., et al.: Jpn. Tokkyo Koho (1976), JP 51009007 B<br></p>

<p>Applications A metabolite of Naproxen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rettie, A., et al.: Chem. Res. Toxicol., 5, 54 (1992), Tracy, T., et al.: Biochem. Pharmacol., 52, 1305 (1996), Bonnabry, P., et al.: Eur. J. Clin. Pharmacol., 49, 305 (1996), Rao, S., et al.: J. Med. Chem., 43, 2789 (2000), Hutzler, J., et al.: Drug Metab. Dispos., 29, 1029 (2001),<br></p>

<p>Applications A labelled metabolite of Prochlorperazine.<br>References Finn, A., et al.: J. Clin. Pharmacol., 45, 1383 (2005),<br></p>

<p>Applications 6-(tert-Butylamino)-1,3,5-triazine-2,4(1H,3H)-dione is a metabolite of Terbuthylazine (T110500) a triazine herbicide.<br>References Schenck, F., et al.: Bull Environ. Contam. Toxicol., 73, 24 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications Methomyl is a carbamate insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Armes, N., et al.: Bull. Entomol. Res., 86, 499 (1996); Shono, T., et al.: Pest. Biochem. Physiol., 75, 1 (2003)<br></p>

<p>Applications Diltiazem is a potent vasodilator compound. Antihypertensive.<br>References Barrios, V. et al.: Exp. Rev. Cardiovasc. Ther., 9, 1375 (2011);<br></p>

<p>Applications S-Enantiomer of Baclofen. Specific GABA-B receptor agonist. Muscle relaxant (skeletal).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)<br></p>

<p>Applications (E)-Isomer of Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992); Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992); Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993);<br></p>

<p>Applications Bis(2-ethylhexyl)adipate-d8 is an isotopic analog of Bis(2-ethylhexyl)adipate (B433810) which acts as a plasticizer in the preparation of personal care products. Also used in changing the physical properties of rubbers.<br>References Oh, J. et al.: J. App. Polym. Sci., 131, 39795 (2014); Llompart, M. et al.: J. Chrom. A., 1293, 10 (2013);<br></p>

<p>Applications Reproterol is an β2 adrenoceptor agonist for treating asthma. Reproterol is used as an bronchodilator.<br>References Sohda, T., et al.: Chem. Pharm. Bull., 30, 3580 (1982), Argenti, D., et al.: J. Clin. Pharmacol., 51, 400 (2001), Pearce, R., et al.: Drug Metab. Dispos., 34, 1035 (2006),<br></p>

<p>Applications A substituted 2,4,6-triiodobenzoic acid, an excellent contrast media for ventriculography, radiculography, lumbar myelography and x-rays of the cardiovascular system.<br>References Frocrain, L., et al.: Radiology, 170, 531 (1989), van Waes, P.F., et al.: Eur. J. Radiology, 9,179 (1989)<br></p>

<p>Applications 3-Hydroxykynurenine is a metabolite of tryptophan. 3-Hydroxykynurenine filters UV light in the human lens. Studies suggest that Hydroxykynurenine is an endogenous oxidative stress generator and a potential endogenous neurotoxin.<br>References Malina, H.Z. et al.: Graefes. Arch. Clin. Exp. Ophthalmol., 233, 38 (1995); Okuda, S. et al.: J. Neurochem., 70, 299 (1998);<br></p>

<p>Applications Ledipasvir is most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.<br>References Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)<br></p>

<p>Applications BUTAN-2-YL 4-HYDROXYBENZOATE (cas# 17696-61-6) is a useful research chemical.<br></p>

<p>Applications Hexadecyl Acetate is a plant sex pheromone.<br>References Brasero, N., et al.: J. Chem. Ecol., 44, 9 (2018); Cuervo, M., et al.: J. Chem. Ecol., 43, 469 (2017)<br></p>