Toxicology

<p>Applications Lindane-d6 is very toxic. It was an effective insecticide on mosquitoes, house flies, and on German and American cockroaches.<br>References Tanaka, K., et al.: Pestic. Biochem. Physiol., 6, 386-391 (1976)<br></p>

<p>Applications Phosphfolan-methyl is an insecticide used in the treatment of crops and protection from pests.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, H. et al.: Sepu, 29, 409 (2011);<br></p>

<p>Applications 2-​Chloro-​N-​[4-​chloro-​2-​(2-​chlorobenzoyl)​phenyl]​acetamide is a potential anticancer agent and is used in the synthesis of 4-​Aryl-​6-​chloro-​quinolin-​2-​ones and 5-​Aryl-​7-​chloro-​1,​4-​benzodiazepines, anti-​hepatitis B virus compounds.<br>References Kamal, A., et al.: Indian Pat. Appl, IN 2007DE00698 A 20120217 (2012); Cheng, P., et all.: Biorg. Med. Chem. Lett., 18, 3787 (2008)<br></p>

<p>Impurity Oseltamivir EP Impurity F;<br>Applications 3-Des(1-ethylpropoxy)-3-(1-methylpropoxy) Oseltamivir (Oseltamivir EP Impurity F) is an impurity of the antiviral drug Oseltamivir (O700100). It is a COVID19-related research product.<br></p>

<p>Applications Troglitazone is an an oral hypoglycemic agent which improves insulin sensitivity and decreases hepatic glucose production. Antidiabetic.<br>References Ciaraldi, T.P., et al.: Metabolism, 39, 1056 (1990), Kuzuya, T., et al.: Diabetes Res. Clin. Pract., 11, 147 (1991), Kellerer, M., et al.: Diabetes, 43, 447 (1994),<br></p>

<p>Applications SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. SB 242084 displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors.SB 242084 os a brain penetrant; exerts anxiolytic-like activity.<br>References Bromidge, et al.: J. Med. Chem., 40, 3494 (1997), Kennet, et al.: Neuropharmacology, 36, 609 (1997), Dalton, et al.: Psychopharmacology, 185, 45 (2006),<br></p>

<p>Applications Cefpodoxime Proxetil-d7 is the labelled form of Cefpodoxime Proxetil (C243860), an antibacterial. Cefpodoxime Proxetil is a broad spectrum, orally absorbed third generation cephalosporin, ester prodrug of the active free acid metabolite, Cefpodoxime (C243850).<br>References Fujimoto, K., et al.: J. Antibiot., 40, 370 (1987), Utsui, Y., et al.: Antimicrob. Agents Chemother., 31, 1085 (1987),<br></p>

<p>Applications Hexazinone is a herbicide. It functions by inhibiting photosynthesis and thus is a nonselective herbicide. Hexazinone is a pervasive groundwater contaminant, due to its high water solubility.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kennedy, K., et al.: Weed Sci., 58, 317 (2010); Yanase, D., et al.: Pes. Biochem. Physio., 44, 60 (1992); Johnson, J., et al.: Tree Physio., 8, 371 (1991)<br></p>

<p>Applications A neonicotinoid; the active ingredient in certain neuro-active insecticides. Reports show that when exposed to neonicotinid pesticides honeybees have problems returning home after foraging and bumblebee colonies grow poorly and produce fewer queens. Imidacloprid is useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009), Patial, A., et al.: Env. Ecol., 27, 320 (2009), Fernandez-Bayo, J., et al.: J. Agric., Food Chem., 57, 5435 (2009), Tomizawa, M., et al.: J. Med. Chem., 52, 3735 (2009), Chem. and Eng. News 90: 10 (2012)<br></p>

<p>Applications An isotopically labelled, orally active antimycotic structurally related to Ketoconazole.A representative lot was 88% d5, 12% d4 with no d0. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M., et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>

<p>Applications 2-Methyl-4,6-dinitrophenol is a powerful toxicant with a long history of use in agriculture as a herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Heusinkveld, H. J., et al.: Toxicol. Lett., 252, 62 (2016), Bettiol, C., et al.: Environ. Sci. Pollut. Res., 23, 7398 (2016)<br></p>

<p>Stability Moisture Sensitive<br>Applications Fosthietan is used as a nematicide, to protect soils and crops from nematodes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Choudhari, K. &amp; Koli, S.: Pesticides, 12, 29 (1978); King, P., et al.: Anim. Prod. Sci., 22, 209 (1982); Murthy, M., et al.: Pesticides, 19, 40 (1985)<br></p>

<p>Applications Caffeidine is an impurity of Caffeine (C080100), a xanthine alkaloid that acts as a stimulant drug and a reversible acetylcholinesterase inhibitor. Caffeidine have also shown inhibitory activity towards cyclic nucleotide phosphodiesterases.<br>References Buchman, R., et al.: J. Medn. Chem., 17, 1168 (1974); Zubair, U.M., et al.: Anal. Profiles Drug Subs., 15, 71 (1986); Cherrah, Y., et al.: Biochem. Pharmacol., 37, 1311 (1988);<br></p>

<p>Applications Prucalopride is a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.<br>References Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008), McKinnell, R., et al.: J. Med. Chem., 52, 5330 (2009), Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008),<br></p>

<p>Applications Maneb is a complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. Maneb is a foliate fungicide used to protect crops in agriculture. Maneb is also useful in creating a toxin-based animal (usually primates) model of Parkinson's disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gent, D. et al.: Plant Disease, 87, 591 (2003); Valaskova, E. et al.: Agrochemia, 10, 178 (1970); Cicchetti F. et al.: Trends Pharmacol. Sci., 30, 475 (2009);<br></p>

<p>Applications A labelled nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) have been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.<br>References Mullane, K., et al.: Trends Cardiovasc Med., 3, 227 (1993), Browne, G.J., et al.: J. Biol. Chem., 279, 13, 12220 (2004)<br></p>

<p>Applications Fenpropidin-d10 is the labeled analogue of Fenpropidin (F249470), a fungicide.<br>References Leroux, P. Walker, A.: Eur. J. Plant Path., 135, 683 (2013); Zhao, H., et. al.: Ecotox. Environ. Safe., 77, 52 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Rebamipide, which shows antiulcer activity in rats.<br>References Uchida, M., et al.: Chem. Pharm. Bull., 33, 3775 (1985), Yamasaki, K., et al.: Eur. J. Pharmacol., 142, 23 (1987),<br></p>

<p>Applications Labelled analogue of Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon (PAH) and a known carcinogen. Indeno[ 1,2,3-cd]pyrene is listed as a priority pollutant by the Environmental Protection Agency (EPA). Indeno[1,2,3-cd]pyrene has been detected in automobile engine exhaust, charcoal broiled foods, ground water, river sediments as well as cigarette smoke condensate.<br>References Rice, J.E. et al.: J. Org. Chem., 51, 2428 (1986); Smith, C.J. et al.: Food Clin. Toxicol., 38, 637 (2000); Panalaks, T.: J. Environ. Sci. Health. Part B Pest. Food Cont. Agric. Wastes, B11, 299 (1976);<br></p>

<p>Applications Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.<br>References Park, W., et al.: Clin. Ther., 38, 2277 (2016); Kosaka, T., et al.: Cancer Sci., 104, 1017 (2013); Lonsdale, D., et al.: Med. Sci. Monit., 10, 199 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications A sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>

<p>Applications Butyrophenone derivative having neuroleptic activity, used as an antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shimoda, K., et al.: Pharmacol. Toxicol., 83, 164 (1998), Sekine, Y., et al.: Eur. J. Clin. Pharmacol., 55, 583 (1999), Oka, T., et al.: Life Sci., 76, 225 (2004), Fujikawa, M., et al.: Prog. Neuro-Psychopharmacol. Biol. Psych., 32, 755 (2008),<br></p>

<p>Applications 5β-Androsterone β-D-Glucuronide is a glucuronide metabolite of Testosterone (T155000).<br>References Weusten, J., et al.: J. Steroid Biochem., 32, 689 (1989), Antignac, J., et al.: Steroids, 70, 205 (2005),<br></p>

<p>Stability Not stable in solution<br>Applications Flazasulfuron, is a Trifluoro-pyridine derivative acting as a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deng, H., et al.: Zhejiang Huagong, 42, 1 (2011);<br></p>

<p>Applications Avermectin B1a, a natural product derived from the soil actinomycete Streptomyces avermitilis, is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lofgren, C.S., et al.: J. Econ. Entomol., 75, 798 (1982); Kass, I.S., et al.: P. Natl. Acad. Sci. USA, 77, 6211 (1980); Fritz, L.C., et al.: P. Natl. Acad, Sci. USA, 76, 2062 (1979);<br></p>

<p>Applications Labelled Clopidogrel, an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>

<p>Stability Moisture Sensitive<br>Applications Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ghassemi, F., et al.: JAMA Ophthalmol., 132, 936-941 (2014); Gao, L. P., et al.: Adv. Mater. Res., 781-784, 993-998 (2013);<br></p>

<p>Applications Desacetyllanatoside C is a derivative of Lanatoside C (L173800), glycosides isolated from various species of Digitalis. Cardiotonic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Novotny, J., et al.: J. Biol. Chem., 258, 14433 (1983), Farr, C., et al.: J. Med. Chem., 45, 3257 (2002), Van Dongen, M., et al.: Drug Discov. Today, 7, 471 (2002),<br></p>

<p>Applications A labelled dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral).<br>References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),<br></p>

<p>Applications Propargite is a pesticide used to control mite and is used on various crops from cotton to corn.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hou, X., et al.: Food. Chem., 138, 1198 (2013); Meena, N.K., et al.: Pestol., 36, 40 (2012);<br></p>

<p>Applications Labelled Pholedrine (P352000). An α-adrenergic agonist. Antihypotensive.<br>References Glennon, R., et al.: J. Med. Chem., 23, 294 (1980), de Letter, E., et al.: J. Anal. Toxicol., 26, 113 (2002), Lin, D., et al.: J. Anal. Toxicol., 31, 109 (2007),<br></p>

<p>Applications Chrysanthemic Acid is an intermediate in the synthesis of Chrysanthemic Acid (C903440); Dimethrin is a pesticide, a pyrethroid insecticide. An acaricide for agricultural purposes.<br>References Ford, M G.: Pestic. Sci., 10, 39 (1979); Gan, W., et al.: Zhonghua Yufang Yixue Zazhi, 35, 13 (2001); Wright, F. C.: Southwestern Entomol., 5, 222 (1980);<br></p>

<p>Applications Procaine is a sodium channel blocker and inhibitor of a variety of processes.<br></p>

<p>Applications Benzovindiflupyr can be used in biological study of method to predict and understand fish survival under dynamic chemical stress using standard ecotoxicity data. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Ashauer, R., et al.: Environ Toxicol Chem., 32, 954-965 (2013)<br></p>

<p>Applications Phenethylamine-d4 is labelled phenethylamine (P321335) which is a psychoactive drug and stimulant that affects dopamine levels. It uses a mechanism of inverse agonism at the D2 dopamine receptor to achieve this effect. Phenylethylamine (P321335) functions as a neuromodulator or neurotransmitter in the mammalian central nervous system.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wilson, J. et al.: J. Neurochem., 77, 493 (2001); Sotnikova, T. et al.: J. Neurochem., 91, 362 (2004); Schmitt, K. et al.: J. Neurochem., 112, 1605 (2010); Sabelli, H., et al.: Biol. Psychiat., 11, 481 (1976)<br></p>

<p>Applications A labelled metabolite of 1-Hydroxypyrene, which is found in human urine after exposure to coal tar and a coal derived product.<br>References Jongeneelen, F.J., et al.: Int. Arch. Occup. Environ. Health, 57, 47 (1985)<br></p>

<p>Impurity Ganciclovir EP Impurity I<br>Applications O,O'-Dipropanal Ganciclovir (Ganciclovir EP Impurity I) is derived from Ganciclovir (G235000), which is a nucleoside analog structurally related to Acyclovir (A192400). Ganciclovir is an antiviral.<br>References Halloran, P.J. and Fenton, R.G.: Cancer Res., 58, 3855 (1998), Rubsam, L.Z., et al.: Cancer Res., 59, 669 (1999), Yamasaki, H., et al.: C.R. Acad. Sci. III, 322, 151 (1999)<br></p>

<p>Stability Hygroscopic<br>Applications Lupulone is a hop plant (Humulus lupulus L.) acid that inhibits tumorigenicity of hepatocellular carcinoma cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Saugspier, M. et al.: Onc. Rep., 28, 1423 (2012); Kavalier, A. et al.: J. Agri. Food Chem., 59, 4783 (2011);<br></p>

<p>Applications Sulfoxaflor-d3 is the isotope analog of Sulfoxaflor. Sulfoxaflor, is a new insecticide which acts as an insect neurotoxin, and is the only member of class of chemicals called the sulfoximines which act on the central nervous system of insects with much lower toxicity to mammals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anon, IP.com J., 12, 19 (2011)<br></p>

<p>Applications Melatonin MT1/MT2 receptor agonist. Sedative, hypnotic.<br>References Yukuhiro, N., et al.: Brain Res., 59, 1027 (2004), Cajochen, C., et al.: Curr. Opin. Invest. Drugs, 6, 114 (2005), Kato, K., et al.: Neuropharmacology, 48, 301 (2005),<br></p>

<p>Applications Cyhalothrin solution is a synthetic insecticidal solution. Also, it is one of 124 pesticide residues in Chinese liquor-making raw materials (sorghum and rice hull).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Han, Y., et al.: Food Chem., 241, 258-267 (2018)<br></p>

<p>Impurity Ritonavir EP Impurity E<br>Applications Hydroxy Ritonavir (Ritonavir EP Impurity E) is a metabolite of Ritonavir (R535000), HIV-1 protease inhibitor. It is a COVID19-related research product.<br>References Eagling, V., et al.: Br. J. Clin. Pharmacol., 48, 543 (1999), Eagling, V., et al.: Xenobiotica, 32, 1 (2002), Meaden, E., et al.: J. Antimicrob. Chemother., 50, 583 (2002), Treijtel, N., et al.: Drug Metab. Dispos., 33, 1325 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications (R,R)-Ethambutol-d4 Dihydrochloride is the isotope labelled analog of (R,R)-Ethambutol Dihydrochloride (E889805); a compound that shows antitumor properties when complexed with platinum. Also an isomer of Ethambutol (E889800) which is an antibacterial (tuberculostatic).<br>References Coluccia, M. et al.: Anticanc. Res., 11, 281 (1991); Wilkinson, et al.: J. Med. Chem., 5, 835 (1962); Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971); Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)<br></p>

<p>Applications Labelled Triclocarban. Used as bacteriostat and antiseptic in soaps and other cleansing compositions. Antiseptic, disinfectant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rastogi, S., et al.: Contact Derm., 32, 28 (1995), Thomassin, M., et al.: J. Pharm. Biomed. Anal., 15, 831 (1997), Heath, R., et al.: J. Biol. Chem., 274, 11110 (1999), Dayan, A., et al.: Food Chem. Toxicol., 45, 125 (2007),<br></p>

<p>Applications A microorganism based antimicrobial with high efficiency, low toxicity and good environmental compatibility. A key effective component of the pesticide M18.<br>References Chen, Y. et al.: Sci China, Ser. C Life Sci., 51, 174 (2008); Xu, Y. et al.: Jin. Yu Zhuan. Huax., 12, 8 (2004); Badria, F.A. et al.: Scient. Pharmac., 62, 355 (1994);<br></p>

<p>Applications Clomazone is used in herbicidal combinations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zagar, C., et al.: PCT Int. Appl. 53pp. (2020)<br></p>

<p>Applications An orally active, antimycotic allylamine related to naftifine. A specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Petranyi, G., et al.: Science, 224, 1239 (1984), Ryder, N.S., et al.: Antimicrob. Agents Chemother., 27, 252 (1985), Evans, E.G.V., et al.: Br. Med. J., 318, 1031 (1999),<br></p>

<p>Impurity Ofloxacin EP Impurity E<br>Applications Desmethyl Ofloxacin (Ofloxacin EP Impurity E) is a metabolite of Ofoxacin (O245750), a fluorinated quinolone antibacterial.<br>References Leysen, D., et al.: Antimicrob. Agents Chemother., 33, 1 (1989); Polk, R., et al.: J. Antimicrob. Chemother., 27, 17 (1991); Todo, Y., et al.: Chem. Pharm. Bull., 42, 2049 (1994); Furuhata, K., et al.: Biol. Pharm. Bull., 21, 456 (1998); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)<br></p>

<p>Stability Hygroscopic<br>Applications Clarithromycin 9-Oxime is an impurity of Clarithromycin (C559750), a macrolide antibiotic.<br>References Stephanic, V. et al.: J. Med. Chem., 54, 719 (2011); Chen, X. et al.: Zhong. Yao., 17, 32 (2008);<br></p>

<p>Applications Etoposide-d4, is the labeled analogue of Etoposide (E933750), a DNA topoisomerase II inhibitor. Semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide. Antineoplastic.<br>References Burden, D.A., et al.: J. Biol. Chem., 271, 29238 (1996), Joel, S., et al.: Cancer Treat. Rev., 22, 179 (1996),<br></p>

<p>Applications Spirodiclofen is a tetronic acid acaricide fungicide used in controlling red mites. Spirodiclofen is used in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Kramer, T., et al.: Pest. Manage. Sci., 67, 1285 (2011); Ilias, A., et al.: Crop. Protect., 42, 305 (2012); Bretschneider, T., et al.: Modern. Crop. Protect. Compounds., 3, 1108 (2012)<br></p>

<p>Applications An isotopically labelled analog of a serum lipid regulating agent used as an antihyperlipoproteinemic.<br>References Kissebach, A.H., et al.: Atherosclerosis, 24, 199 (1976), Lewis, J.E., et al.: Pract. Cardiol., 9, 99 (1983), Rubins, H.B., et al.: N. Engl. J. Med., 341, 410 (1999)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Phosmet is used as a pesticide to protect crops and vegetation. Insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sipes, N. et al.: Chem. Res. Tox., 26, 878 (2013); Song, Y. et al.: J. Agri. Food Chem., 6, 2625 (2013); Sinderhauf, K. et al.: J. Label. Compd. Radiopharm., 47, 509 (2004);<br></p>

<p>Applications Oryzalin is an herbicide of the dinitroaniline class of compounds which works through the disruption of microtubules.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liang, Q. et al.: Plant. Biotechnol., 33, 59 (2016);<br></p>

<p>Applications β-Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma.<br>References Nakagawa, K., et al.: J. Med. Chem., 17, 529 (1974), Morita, S., et al.: Biochem. Pharmacol., 25, 1836 (1976), Chu, S.Y., et al.: J. Pharm. Sci., 67, 1623 (1978), Chiba, S., et al.: Arzneim.-Forsch., 29, 895 (1979), Chrisp, P., et al.: Drugs Aging, 2, 58 (1992),<br></p>

<p>Applications Methoxyfenozide-d9 is deuterium labelled Methoxyfenozide (M262765). It is used primarily as an insecticide, and pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhao, Q., et al.: J. Agricul, Food Chem., 56, 10799 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications Stearoyl-L-carnitine-d3 Hydrochloride is labelled Stearoyl Carnitine (S686515), A carnitine ester which was tested for its ability to inhibit protein kinase C (PKC).<br>References Sakata, K., et al.: Cardiovasc. Res., 23, 505 (1989), Fulceri, R., et al.: Biochem. J., 325, 423 (1997), Yu, L., et al.: J. Pharmacol. Exp. Ther., 286, (1998),<br></p>

<p>Applications Oxybenzone is an organic compound used in sunscreens. Oxybenzone is used as an ingredient in sunscreen and other cosmetics because it absorbs UVB and short-wave UVA (ultraviolet) rays. Oxybenzone was one of the first compounds incorporated into sunscreen formulations to offer enhanced UVA protection because its absorption spectrum extends to less than 350 nm.<br>References Auriol, M., et al.: Chemosphere, 70, 445 (2008); Balmer, M., et al.: Environ. Sci. Technol., 39, 953 (2005); Jeon, H., et al.: Toxicology, 248, 89 (2008); Campoy, S., et al.: Environ. Microbiol., 11, 99 (2009); Chem. and Eng. News page 22, Aug. 6 (2018)<br></p>

<p>Applications Labelled β-Hyodeoxycholic Acid. A potential bile acid metabolite.<br>References Abadie, C., et al.: Biochem. J., 299, 725 (1994), Taniguchi, T., et al.: J. Biol. Chem., 269, 10071 (1994), Davis, R., et al.: J. Lipid Res., 43, 533 (2002),<br></p>

<p>Stability Hygroscopic, Moisture Sensitive, Temperature Sensitive<br>Applications Labelled Myosmine (M835000). Myosmine is an alkaloid found in tobacco. Myosmine has been suspected to be a tobacco-independent carcinogenic source.<br></p>

<p>Applications: 3-Mesityl-2-oxo-1-oxaspiro[4.4]non-3-en-4-ol, is the metabolite of Spiromesifen, which is a Spirocyclic Tetronic Acid, environmentally friendly and novel structural pesticide.<br>Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jin-Hao, Zh., et al.: Pest Management Science, 68, 10 (2012);<br></p>

<p>Applications 6-Hydroxy Bromantane is a metabolite of Bromantane (B678450).<br>References Bi, H., et al.: J. Steroid Biochem. Mol. Biol., 42, 229 (1992), Pozo, O., et al.: Anal. Bioanal. Chem., 389, 1209 (2007), Kiousi, P., et al.: Bioanalysis, 1, 1209 (2009),<br></p>

<p>Applications Thiosultap Sodium Salt is used as an insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yan, X., et. al.: J. Plant Diseases Protection, 119, 152 (2012)<br></p>

<p>Applications Cefcapene Pivoxil (C242550) derivative. Δ2-Cephalosporins are potentially related compounds in cephalosporin antibacterial compounds.<br>References Chavette, R.R., J. Med. Chem., 9, 741 (1966), Miyouchi, M., et al.: J. Chem. Pharm. Bull., 38, 1906 (1990), Sugioka, T., et al.: Chem. Pharm. Bull., 38, 1998 (1990),<br></p>

<p>Applications Imatinib-III is derived from Imatinib (I268023), which is an inhibitor of multiple tyrosine kinases. It is a COVID19-related research product.<br></p>

<p>Applications Minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.<br>References Powell, R.G., et al.: Phytochemistry, 35, 335 (1994), Jeandet, P., et al.: J. Phytopathol., 143, 135 (1995), Mattivi, F., et al.: J. Agric. Food Chem., 43, 1820 (1995),<br></p>

<p>Applications A novel anti-tuberculosis drug.<br>References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);<br></p>

<p>Stability Hygrscopic<br>Applications A metabolite of Caffeic acid.<br>References Zhu, B., et al.: J. Biol. Chem., 269, 292 (1994), Azuma, K., et al.: J. Agric. Food Chem., 48, 5496 (2000), Stark, T., et al.: J. Agric. Food Chem., 54, 5530 (2006), Hensel, A., et al.: Planta Med., 73, 142 (2007),<br></p>

<p>Applications Reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.<br>References Kim, T.E., et al.: Drugs, 6, 886 (2003), Wood, E.R., et al.: Cancer Res., 64, 6652 (2004), Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005),<br></p>

<p>Applications Demephion is used in pesticidal compositions. A pesticide, and an organophosphate insecticide.<br>References Iacob, N., et al.: Analele Institutului de Cercetari pentru Protectia Plantelor, Academia de Stiinte Agricole si Silvice, 16, 357 (1981); Dimitrov, A., et al.: Bulgarski Tyutyun, 25, 16 (1980); Babrikova, T., et al.: Nauchni Trudove - Vissh Selskostopanski Institut--Plovdiv, 25, 31 (1980)<br></p>

<p>Applications Brexpiprazole S-Oxide is an impurity and potential metabolite of Brexpiprazole (B677385), a drug candidate useful in treatment and prevention of mental disorders including CNS disorders.<br>References Yamashita, H., et al.: PCT Int. Appl., WO 2006112464 A1 20061026 (2006);<br></p>

<p>Applications Methyl 1-naphthaleneacetate (cas# 2876-78-0) is a useful research chemical.<br></p>

<p>Applications Tridihexethyl Chloride, is an anticholinergic, antimuscarinic and antispasmodic drug.<br>References Gohil, V., et al.: Nature Biotech., 28, 249 (2010); Rider, J. A., et al.: Curr. therap. Res., 20, 142 (1976);<br></p>

<p>Applications A metabolite of 17β-Nandrolone (N315000).<br></p>

<p>Applications Phenothrin is a pesticide used in the control of pests and insects. It is used in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, Y. et al.: Chemopshere, 90, 848 (2013); Hirahara, Y. et al.: Japan. J. Toxicol. Env. Health, 44, 451 (1998);<br></p>

<p>Applications Levofloxacin-d3, is the labeled analogue of Levofloxacin (L360000), an antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),<br></p>