Biochemicals and Reagents

<p>Peptide corresponding to residues 206-214 of murine islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), the autoantigen targeted by pathogenic CD8+ T cells in non obese diabetic (NOD) mice. Cells that recognize IGRP(206-214) are present in the earliest islet infiltrates of NOD mice and undergo avidity maturation as islet inflammation progresses to overt disease.</p>

<p>HBeAg antibody was raised in mouse using recombinant HBeAg as the immunogen.</p>

<p>TMPRSS4 (199-207) fluorogenic peptide</p>

<p>Peptide H-SV^^LGQL^GITK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Galanin is a widely distributed neuropeptide in the central nervous system, peripheral regions and endocrine system. Galanin has a role in energy homeostasis. Central injections of galanin to the amygdala led to food intake in rats. Galanin also acts in the CNS to inhibit neurotransmitter release, such as acetylcholine. Galanin has been implicated in numerous neurological conditions, including Alzheimer's disease, depression, and epilepsy.Galanin interacts with 3 receptor subtypes, GalR1-3 G protein-coupled receptors which are inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the Galphai/o pathway- receptor activation leads to a cellular influx of potassium ions.The galanin active fragment (1-16) has been identified as a highly potent agonist for the galanin receptors from binding assays.  This has become a basis for galanin-based peptides, which are neuroactive. These are being investigated as a potential source for anticonvulsant neuropeptides as a therapeutic for conditions such as epilepsy. A library of galanin fragments has allowed screening of their properties to be assessed and used to generate chimeric peptides. Galanin fragments have different affinities for GalR receptors- however, the N-terminal (1-16) residues have been shown to have a conserved affinity for the receptors. This galanin (2-13) peptide is provided in the amide form. The acidic form is also available in our catalogue.</p>

<p>Sal-like4 (SALL4) derived peptide able to antagonise the SALL4-NuRD complex in hepatocellular carcinoma, turning SALL4 from a dual transcription repressor-activator to a singular transcription activator. Displays antitumour effects in xenograft mouse models.</p>

<p>Derived from fibronectin, integrin-binding cell adhesive peptide can be used as an adhesion ligand, it contains the cell binding motif RGD. Providing integrin-mediated cell adhesion is a valuable tool for a wide variety of research applications particularly in cell culture and implants. The integrin-binding cell adhesive peptide can also functionalise biomolecules. This has been successfully demonstrated by the generation of a protease-degradable hydrogel containing the integrin-binding cell adhesive peptide that can support skin formation in vitro. Integrin-binding cell adhesive peptide has also been used to form hydrogels to adhere numerous cell lines, for example to study extracellular vesicle secretion.</p>

<p>H-RCTRVGTED-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-RCTRVGTED-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-RCTRVGTED-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-RCTRVGTED-OH at the technical inquiry form on this page</p>

<p>Peptide H-WLGLSAEYGNLYR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>The CEA antibody is a highly specialized product in the field of Life Sciences. This monoclonal antibody is specifically designed to target and bind to carcinoembryonic antigen (CEA), a cytosolic protein that is overexpressed in various types of cancer cells. The CEA antibody has been extensively used for the detection and imaging of amyloid plaques, which are associated with neurodegenerative diseases such as Alzheimer's.</p>

<p>Venom peptidomes and proteomes have yielded significant novel drug discoveries. The non-disulphide bridge peptides (NDBPs) have become a particular focus due to their large range of structures as well biological activity while retaining high specificity.AcrAP2 was identified as a NDBP in A. crassicauda within highly conserved family of proteins. Data shows it has antimicrobial activity against bacteria and yeast while also capable of haemolysing horse erythrocytes. However, AcrAP2 did not affect the growth of cancerous cell lines tested. Therefore, this peptide could be a useful model for modification to improve its potency. Furthermore, it may allow researchers to identify specific targets in disease pathways for new drug designs. A significant example of this, bradykinin-potentiating peptide Captopril® manages hypertension and originated from the conserved NDBP family.</p>

<p>The HSA (41-50) peptide is derived from human serum albumin (HSA), a protein present in the blood plasma. It is involved in the transportation of compounds through the blood stream, the maintenance of osmotic blood pressure and could be used to improve drug delivery. The lysine residue at position 10 is isotopically labelled with carbon-13 (6) and nitrogen-15 (2).</p>

<p>Histone acetyltransferase inhibitor of p300/CBP; anti-proliferative</p>

<p>Phycocyanin dye is a versatile and vibrant pigment that is widely used in various applications. It is a natural blue pigment derived from algae, specifically phycocyanin. This dye has excellent stability and solubility, making it ideal for use in many different industries.</p>

<p>Peptide Ac-AVAGKAGAR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Amino acids 169-178 of microtubule-associated protein 1A (MAP1A) light chain. MAP1A is expressed from the Map1a gene which encodes a precursor polypeptide which is cleaved to produce MAP1A heavy chain and light chain.MAP1A is a structural protein essential for the organisation of neuronal microtubules (MTs) and is abundantly expressed in the mammalian brain. MAP1A is thought to help maintain the neuronal MT network, and modulate synaptic proteins and neuronal survival in the adult central nervous system (CNS). When MAP1A is disrupted in the body it results in problems in coordination, tremors, and late-onset degeneration of cerebellar Purkinje cells.The arginine residue at position 10 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (4), giving this peptide a mass increase of 10 compared to the unlabelled peptide.</p>

<p>Acetyl-Claudin-3 is derived from the tight junction protein Claudin-3 which is encoded by the CLDN3 gene located on chromosome 7q11.23 and can be found within epithelial cell to cell contacts. Structurally, the Claudin family are transmembrane proteins containing two extracellular loops and are involved in maintaining cell polarity and controlling paracellular ion flux.During cancer research reduction in the number of Claudins has been associated with tumour formation. This could be explained using Claudin role in maintaining cell detachment and migration although cancers such as breast and prostate have shown to overexpress both Claudin- 3 and Claudin-4. Similarly in ovarian cancer overexpression of Claudin 3 and 4 is thought to increase the motility of tumour cells and their survival through basement membrane degrading matrix metalloproteinase activation.Both Claudin 3 and 4 have potential to be used as diagnostic markers and their two extracellular loops may be used as targets for antibodies. As receptors for the Clostridium perfringens enterotoxin, Claudin 3 and 4 may have further use in targeting the enterotoxin as a therapeutic for ovarian cancers.</p>

<p>Fluorogenic substrate peptide of the 20S proteasome. In its intact state this peptide is non-fluorescent, however when aminomethylcoumarin (AMC) is released upon hydrolysation, fluorescence can be detected. This peptide is therefore a useful tool for analysing the activity of the 20S proteasome as well as other chymotrypsin-like proteases and calpains. This peptide is also a substrate for chymase, papain, carboxypeptidase Y, proteinase yscE (kexin) and ingensin.AMC is a fluorescent dye with excitation maxima at around 360 nm and emission maxima at around 450 nm. AMC can be excited with a mercury lamp and observed using a UV filter set.</p>

<p>Originally identified in Heloderma horridum horridum (Mexican beaded lizard), exendin-3 shares homology with vasoactive intestinal peptide (VIP), secretin, helospectin I and II and helodermin. Exendin-3 increases cellular cAMP levels and amylase release from pig pancreatic cells.Truncated exendin-3 is a potent and selective GLP-1 receptor antagonist. It inhibits cAMP production and insulin release induced by GLP-1, exendin-3, and exendin-4. It also blocks the inhibitory effect of GLP-1 on food intake in rats. Exendin 3 (9-39) amide is being considered for clinical use in obese patients. This is based on the extensive and consistent data demonstrating its effectiveness as a tool to improve fasting and postprandial levels of glucose and glucagon.</p>

<p>Tat (47-57) is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). Specifically TAT (47-57) is located within the arginine-rich basic domain 48-60 of the TAT peptide which as a whole has three domains which function to aid HIV through transactivation, DNA binding and nuclear transport. As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules and hence serves a valuable purpose in transduction methods. This property has been demonstrated through its ability of allowing toxins such as the neurotoxin Botulinum neurotoxin Type A, produced by the Clostridium botulinum type A bacteria to penetrate the skin barrier non-invasively. Additionally TAT (47-57) can be used to deliver proteins, fluorophores, chelators and DNA to target cells.</p>

<p>Amino acids 1-15 of β-amyloid protein (Aβ), this fragment represents one of many short Aβ species found in vivo and is formed by the cleavage of amyloid β precursor protein by β- and α-secretase.Aβ has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer disease (AD) and Down syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Minocycline HCL (USP grade powder) chemical reference substance</p>

<p>Amitryptylline is a tricyclic antidepressant that is used to treat depression and to relieve depression associated anxiety. Although its mechanism is not fully understood, it is suggested that this drug inhibits norepinephrine and serotonin thus increasing their concentrations at the synaptic clefts. Additionally, Amitryptylline has shown to have anticholinergic properties.</p>

<p>Peptide H-YISPDQLADLYK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>A20FMDV2, a peptide derived from the foot and mouth disease virus, inhibits the epithelial-specific integrin alphavβ6 and here is labelled with 4-fluorobenzoyl as the light version of the PET ligand 4-[18F]Fluorobenzoyl A20FMDV2 which can be used for in vivo imaging.</p>

<p>Acetyl-(Arg)9, derived from (Arg)9 is a cationic cell-penetrating peptide consisting of 9 arginines. Arginine rich CPPs enter cells in a passive manner through membrane multilamellarity and fusion. (Arg)9 can function to deliver specific molecules to target cells and can be used for drug delivery purposes.Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.</p>

<p>Angiotensin 1-7 (Ang-(1-7)) is a component of the renin angiotensin system RAS. Ang-(1-7) is produced by angiotensin-converting enzyme 2 (ACE2), from the angiotensin II (Ang-II) peptide, as well as by prolylendopeptidase (PEP) and neutral endopeptidase (NEP) which produce Ang1 7 directly from angiotensin I (Ang-I).Ang-(1-7) broadly opposes Ang-II actions. Ang-(1-7) has vasodilatory and anti-oxidative effects, and exerts protective actions in hypertension, diabetes, and other cardiovascular disorders. Ang-(1-7) represents a promising therapeutic target for cardiovascular and metabolic diseases. Ang (1-7) stimulate the secretion of atrial natriuretic peptide (ANP) and exerts its actions via its G protein-coupled receptor, Mas. ANP is part of an antagonistic hormonal system to RAS, which also participates in the regulation of body fluid and electrolytes balance. ANP is mainly released from the atrium, and its release results in natriuresis, anti-hypertension, and anti-proliferation.This novel arm of the RAS has effects that counterbalance those mediated by the classical ACE/Ang-II pathway. The isoleucine residue of this peptide is universally labelled with carbon-13 and nitrogen-15 stable isotopes, giving a mass increase of 7.</p>

<p>Peptide H-VLAIDHLNEDQLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>HTATIP antibody was raised in mouse using recombinant Human Hiv-1 Tat Interacting Protein, 60Kda (Htatip)</p>

<p>The AH1 peptide is a H2-Ld-restricted epitope derived from the sequence of the gp70 envelope protein of the ecotropic mammalian C-type retrovirus, murine leukaemia virus (MuLV, emv-1).The envelope gene products of MuLV are expressed in a variety of tumour cells, including B16 melanoma, lymphomas and leukaemia's. AH1 peptide is a tumour-associated antigen and is highly expressed on CT26 and C51 tumour cells.</p>

<p>Natural cleavage product of GLP-1 which, unlike GLP-1, does not affect either insulin secretion or glucose homeostasis.  GLP-1(9-36) has low affinity for, and acts as an antagonist to, the GLP-1 receptor.GLP-1 (9-36) does however display unique biological activities such as beneficial cardiovascular effects and reducing the production of reactive oxygen species (ROS). GLP-1 (9-36) also exerts important physiological effects on neuronal plasticity in the hippocampus, and inhibits chemokine-induced migration of human CD4-positive lymphocytes.GLP-1 (9-36) is formed from the breakdown of biologically active but highly unstable GLP-1 (7-36) amide by the ubiquitous serine protease, dipeptidyl peptidase-IV (DPP-IV).</p>

<p>H-GVSAYLSRPSPFDGGC-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GVSAYLSRPSPFDGGC-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GVSAYLSRPSPFDGGC-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GVSAYLSRPSPFDGGC-OH at the technical inquiry form on this page</p>

<p>Peptide H-LLDLLEGLTGQK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>H-WRCTRVGTE-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-WRCTRVGTE-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-WRCTRVGTE-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-WRCTRVGTE-OH at the technical inquiry form on this page</p>

<p>Peptide H-AR^PALEDLR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Antagonist of dopamine (D2/D4), histamine and serotonin receptors</p>

<p>Pp1A is an active form of a human protein that belongs to the class of peptide hormones. Pp1A has been shown to be involved in the regulation of axonal growth and brain functions, as well as being a potential drug target for diseases such as carcinoid syndrome and congestive heart failure. Pp1A may play a role in the regulation of serum prolactin levels, which is important for neural development and endocrine function. The kinetic energy of Pp1A has also been shown to be greater than that of other proteins, due to its higher structural stability. <br>Pp1A has a molecular weight of 5,879 Da and contains 473 amino acids. It is found in both pro-opiomelanocortin (POMC) and pro-enkephalin (PE) cells in the anterior pituitary gland.</p>

<p>Heptapeptide containing a cysteine residue whose thiol group makes it vulnerable to a range of oxidative modifications.</p>

<p>Serotonin 5-HT4 receptor agonist</p>

<p>Protein found in egg white</p>

<p>[Tyr0]-Apelin-13 is derived from the apelin peptide which acts as a ligand for the apelin receptor (APJ) G protein coupled receptor and is a substrate for angiotensin converting enzyme 2. Preprapelin, encoded for by APLN located on Xq25-26.1, is cleaved to form either apelin-36 or apelin-17, 12 and apelin-13. As a member of the adipokine hormone family, which are involved in processes such as vascular homeostasis and angiogenesis, apelin is secreted from adipose tissue.Apelin has been found to be expressed in the spinal cord and the human brain and when performing immunohistochemistry it was observed that Apelin-17 is significantly expressed in the human heart, brain, lungs and endothelial cells.Both apelin and the apelin receptor are widely distributed around the body thus apelin has been found to be associated with cardiovascular diseases, obesity, diabetes and cancer. Studies exploring myocardial infarction showed there to be greater apelin mRNA expression during human heart failure compared to in healthy tissue. Apelin protects against heart failure due to, the pyroglutamyl form of apelin, playing a role in decreasing infarct size of myocardial infarctions. Furthermore in rats with hypertension, the expression of apelin and APJ was decreased.</p>

<p>Amyloid beta peptide (Aβ) is a neurotrophic factor that is involved in the pathogenic mechanism of Alzheimer's disease. This drug inhibits the production of Aβ by binding to the enzyme, secretase. It has been shown that Aβ binds to a transporter protein and is transported into cells, where it accumulates in the cytoplasm. The physiological levels of Aβ are regulated by proteins called "gene chaperones" which prevent Aβ from aggregating into plaques. Dextran sulfate inhibits this process by binding to amyloid and preventing it from accumulating in the cytoplasm. Amyloid beta peptide trifluoroxalate (ATFX) has been shown to inhibit the production of Aβ with structural analysis, inhibition of cellular uptake and secretion, and inhibition of fibrillization. ATFX also has potential as a biomarker for Alzheimer's disease because it can be detected at low concentrations in urine or serum</p>

<p>Peptide H-LFEVIETEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Please enquire for more information about Anti-HSPB1 antibody - serum including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Peptide H-ASYPGLQFEIIAMSTTGDK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide Kemptide is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-MPPYLFT-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-MPPYLFT-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-MPPYLFT-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-MPPYLFT-OH at the technical inquiry form on this page</p>

<p>Docetaxel is a cytotoxic semi-synthetic taxane and is an anthracycline antibiotic. The compound is an anti-microtubule agent and has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.<br>Docetaxel trihydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Apolipoprotein A-I enables the efflux of fat molecules from within cells as high-density lipoprotein (HDL) particles for transport back into LDL particles or to the liver for excretion. HDLs are one of five major groups of lipoproteins.Increasing concentrations of HDL particles are strongly associated with decreasing accumulation of atherosclerosis within the walls of arteries. Apolipoprotein A-I is often used as a biomarker for prediction of cardiovascular diseases, such that low levels of APOA1 are associated with an increased risk of adverse events in patients with coronary artery disease. In such cases, APOA1 can be used as a biomarker to predict cardiovascular disease progression.</p>

<p>Cell penetrating peptides (CPPs) provide a delivery method for molecules across the membrane in an efficient manner without compromising the cell. FBP forms a sheet structure when interacting with a membrane forming a transmembranous pore. FBP, also known as Pβ, is rapidly internalised and localises primarily to the nucleus.FBP is provided here with a N-terminal alkyne attachment. Two of the most regularly encountered functional groups for click chemistry are azides and alkynes, and the azide-alkyne cycloaddition has become the most popular click reaction. The use of click chemistry with alkyne-FBP allows a wide variety of applications particularly for conjugation, modification, and peptide design.</p>

<p>MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC</p>

<p>The hCG protein is a monoclonal antibody that targets the necrosis factor-related apoptosis-inducing ligand (TRAIL). It is used in the field of Life Sciences to study and detect TRAIL receptors and their role in apoptosis. This protein can be used in various applications, including ELISA, Western blotting, immunohistochemistry, and flow cytometry. The hCG protein is highly specific and has a high affinity for its target molecule, making it a valuable tool for researchers in the field. Additionally, this protein has been found to have antiangiogenic properties and can inhibit endothelial growth. It is commonly used in studies related to cancer research and angiogenesis.</p>

<p>This is an incretin hormone that causes glucose dependent release of insulin by pancreatic beta cells. It is the cleavage product of GLP-1 (1-36) amide peptide.  This peptide, human GLP-1 (7–36), shares the same sequence with preproglucagon (78-107), amide, human.</p>

<p>HLA-A*02 is a class I major histocompatibility complex (MHC) allele which is part of the HLA-A group of human major histocompatibility complex (MHC) leukocyte antigens (HLA), found at the HLA-A locus. HLA-A is one of three major types of human MHC class I cell surface receptors. The receptor is a heterodimer, and is composed of a heavy alpha chain and smaller β chain. MHC Class I molecules such as HLA-A are part of a process that presents short polypeptides to the immune system. These polypeptides are typically 7-11 amino acids in length and originate from proteins being expressed by the cell. Cytotoxic T cells in the blood "read" the peptide presented by the complex and should only bind to non-self peptides. If binding occurs, a series of events is initiated culminating in cell death via apoptosis. This peptide corresponds to the Hepatitis B variant (HBV) core sequence which is presented on the MHC class I antigen HLA-A*02 and contains fluorescein, a widely used flourescent dye.</p>

<p>Peptide H-MPRHSRAKRAPRPSAC-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>CRP antibody was raised in mouse using human CRP derived from pleural/ascetic fluid or plasma as the immunogen.</p>

<p>Histatins are histidine rich cationic peptides produced in salivary glands and released into the saliva. The main histatins that make up more than 80% of histatins in saliva are histatin 1, histatin 3 and histatin 5. There are two histatin genes, one which encodes histatin 1, and one that encodes histatin 3, all other histatins are derivatives of these two histatins. Histatin 3 is a precursor of histatin 5, each with distinct roles.Histatin 5  is considered an antimicrobial peptide (AMP) as it has antibacterial activity as has been shown against opportunist infections such as P. aeruginosa, E. coli, and S. aureus. Histatin 5 also has potent anticandidal activity for example against Candida and Leishmania, it is shown to be the strongest antifungal of the histatins.  The antifungal activity functions by invasion of the microbe and entry to the mitochondria, histatin 5 then inhibits ATPase activity resulting in rapid depletion and ultimately bacterial cell death/apoptosis. As a salivary peptide, it inhibits Bacteroides gingivalis proteinase clostripain and protease activity microbe implicated in periodontal disease.</p>

<p>TAT contains a protein transduction domain which allows it to enter cells by crossing the cell membrane. The amino acid sequence of the protein transduction domain (PTD) and this property confers cell penetrating peptide properties on TAT and derivatives. TAT peptides have been widely used to deliver functional biomolecules into cells both in vitro and in vivo. The entire protein can be used but in practice it is more efficient to use truncated sequences containing only the basic residues required for transport. Through covalent attachment to TAT derived peptides, cargo molecules including proteins, nucleic acids, small molecules, oligonucleotides, enzymes, polymers, plasmid DNA and liposomes can be transported into cells with high efficiency.acfTAT is a fusion of the TAT PTD to a red fluorescent tag (TAMRA) at the carboxy terminal. This peptide is ideal for live cell localisation work using fluorescent microscopy as the TAT PTD can transduce small peptides into the cell efficiently without affecting the cell. Additionally, the fluorescent label is highly stable against photo bleaching and should be easily detectable under various excitation sources including mercury, arc, tungsten, and xenon lamps.</p>

<p>Peptide H-LLIYDASNLETGVPSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide Fluor-RGDK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>CMV antibody was raised in mouse using CMV as the immunogen.</p>

<p>Peptide H-FR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>CART1 antibody was raised in mouse using recombinant Human Cartilage Paired-Class Homeoprotein 1 (Cart1)</p>

<p>H-SSSPSSSSPSSSRRWRE-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-SSSPSSSSPSSSRRWRE-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-SSSPSSSSPSSSRRWRE-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-SSSPSSSSPSSSRRWRE-OH at the technical inquiry form on this page</p>

<p>Biotinylated aMp3 is a Mycobacterium avium subsp. Paratuberculosis (MAP) specific ligand. MAP can cause Johne disease (the wasting disease) in livestock. It is important therefore to detect the presence of MAP in animal milk and faeces.Biotinylated aMp3 can be used (along with aMptD peptides) to detect the viability of MAP cells in infected livestock through combined peptide-mediated magnetic separation phage display due to their high affinity for MAP. The addition of biotin to aMp3 asparagine residue, changes the orientation of aMp3 so that it can bind to the target bacteria with increased stability, thus achieving a high capture efficiency. A similar effect is observed on the addition of biotin to aMptD glycine residue.</p>

<p>Portion of EBV EBNA 3A</p>

<p>A human truncated analog of Obestatin, a 23 amino acid gastrointestinal peptide, encoded for by the ghrelin gene and is known to reduce food intake through supressing appetite. This peptide has been found to influence the pancreas, cardiovascular system and adipose tissues as well as the gastrointestinal system. One study showed that when high-fat diet fed rats were given chronic administration of obestatin it prevented the development of non-alcoholic fatty liver disease. Consequently Obestatin has the potential to be used in preventing obesity-related diseases.</p>

<p>There are three members of the p160 family of steroid receptor coactivators, SRC-1, SRC-2, and SRC-3. These steroid receptor coactivators control the functional output of numerous genetic programs and serve as pleiotropic rheostats for diverse physiological processes. Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.</p>

<p>Gluten Exorphin A5 is a δ opioid that has been synthetically produced. It binds to the μ-opioid receptor, which is found on cells in the gastrointestinal tract, and can be used to treat inflammatory diseases and autoimmune diseases. Gluten Exorphin A5 also has anti-cancer properties, as it inhibits cell proliferation and induces apoptosis in colon cancer cells by binding to their surface. Gluten Exorphin A5 is orally active and can be used for the treatment of infectious diseases. This drug also binds to bacterial surfaces and blocks the pain response induced by naloxone. The molecular weight of Gluten Exorphin A5 has been determined using a spectrometer after purification.</p>

<p>(Z)-10-Pentadecenoic acid methyl ester is a fatty acid ester, which serves as an important compound in chemical ecology. This ester is commonly sourced from natural plant and insect secretions, playing a critical role in the communication systems of various organisms. Its primary mode of action involves functioning as a pheromone, influencing insect behavior such as mating, aggregation, and territorial signaling.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Palmitoyl KTTKS pentapeptide.</p>

<p>Natriuretic; vasodilatory;diuretic; treats decompensated congestive hear failure</p>

<p>Teriflunomide isomer E is an antimicrobial agent which has been shown to inhibit the growth of bacteria by binding to basic proteins. This antibiotic has been used in vivo on humans and in vitro on human cells, and it has been shown to inhibit autophagy. Teriflunomide isomer E binds to uridine and inhibits the polymerase chain reaction (PCR) of DNA, preventing replication. It also inhibits the production of cyclin D2, an anti-inflammatory cytokine that limits inflammatory responses. In addition, teriflunomide isomer E binds to nonsteroidal anti-inflammatory drugs (NSAIDs), inhibiting their activity.</p>

<p>H-DFFVWLHYYSVRDTL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-DFFVWLHYYSVRDTL-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-DFFVWLHYYSVRDTL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-DFFVWLHYYSVRDTL-OH at the technical inquiry form on this page</p>

<p>Actin is a highly conserved key cytoskeletal protein involved in numerous structural and functional roles.Actin exists as soluble monomers (G-actin) as well as actin filaments (F-actin). G-actin monomers polymerise to form filaments that organise into dynamic networks with crucial roles in multiple and diverse cellular processes. Actin organisation varies greatly across cell types, and the ordered assembly and turnover of actin networks drive multiple cellular processes, including cell movement, cell adhesion, changes in cell morphology, vesicle trafficking, and cytokinesis.The clinical significance of actin is seen in congenital myopathies, which are characterised by muscle weakness. Mutations in smooth-muscle associated alpha-actin (ACTA2) have been seen to cause coronary heart disease, stroke and thoracic aortic disease. The vascular smooth muscle cell (SMC)-specific isoform of α-actin (ACTA2) is a major component of the contractile apparatus in SMCs located throughout the arterial system. By studying and manipulating the actin cytoskeleton, the underlying cause of these myopathies can be understood.The Arginine residue at position 11 is isotopically labelled with carbon-13 (6) and nitrogen-15 (4), giving this peptide a mass increase of 10 compared to the unlabelled peptide.</p>

<p>TNF alpha antibody was raised in goat using highly pure recombinant human TNF-alpha as the immunogen.</p>

<p>Peptide derived from the HIV transactivator of transcription protein. TAT is a cationic cell-penetrating peptide.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Histone H3.2 is a highly common variant of the core histone H3 which is found in all eukaryotes except budding yeast. H3.2 is replication-dependent and is associated with gene silencing. Histone variants can replace canonical histones in certain cells or stages of development and help regulate numerous nuclear processes including transcription, DNA repair and chromosome segregation.Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination.</p>

<p>Complement C3 is a fundamental factor featured in all three complement system pathways: the classical, lectin and alternative. To activate the complement cascade C3 associates with C3 convertase to produce C3a and C3b. It is also thought that C3 can be cleaved by proteases outside of the complement cascade. C3b can bind to carbohydrate and protein hydroxyl groups through a thioester bond generated by C3 convertase cleavage. This action allows C3b to be used as a 'marker of foreign molecules such as pathogens and ultimately leads to the assembly of the membrane attack complex (MAC) and anaphylatoxin production.Overall the main functions of the complement system are to mark cells for phagocytosis, the recruitment of inflammatory cells and the cell lysis of bacteria cell by the MAC. The anaphylatoxins C3a and C5a recruit neutrophils and causes the inflammatory response while the MAC produces pores in the bacterial membrane thus causing a Ca2+ influx into the cell and bacterial cell death.The complement system as a whole can be associated with the neurological diseases, bacterial meningitis, thrombotic disorders, neurological and autoimmune diseases.</p>

<p>Peptide H-GPRPC-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>C- terminal fragment of adrenocorticotropic hormone (ACTH) also known as corticotropin, and competitive antagonist of ACTH receptor (ACTHR), also known as melanocortin type 2 receptor (MC2R).ACTH is a member of the melanocortins-peptide family, this tropic hormone is produced and secreted by the anterior pituitary gland. ACTH is an important component of the hypothalamic-pituitary-adrenal (HPA) axis and is often produced in response to biological stress. ACTH acts to increase the production and release of cortisol via its interaction with ACTHR. Receptor activation increases the intracellular concentration of cAMP via adenylyl cyclase. Abnormal ACTH levels in the body have been linked to primary adrenal insufficiency/Addison's disease, Cushing's disease and secondary adrenal insufficiency.</p>

<p>Peptide H-GTYHTNEAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Angiotensin-IV is primarily produced from angiotensin-III by the removal of an arginine residue from the N-terminal by membrane alanyl aminopeptidase N (AP-N). Ang-IV can however also be formed by the action of aminopeptidases on Ang-I directly.Ang-IV has been shown to enhance cognitive functions, although how it does this in still unclear. It has been suggested that Ang-IV is able to inhibit the insulin-regulated aminopeptidase (IRAP) receptor in the brain (originally defined as the AT(4) receptor). IRAP is a single-spanning transmembrane zinc-metallopeptidase that belongs to the M1 family of aminopeptidases and its substrates include vasopressin, somatostatin, and cholecystokinin. The half-life of these compounds are prolonged when IRAP is inhibited by Ang-IV, and this may result in the enhanced cognitive abilities seen with Ang-IV treatment. c-Met, a tyrosine kinase receptor that binds hepatocyte growth factor (HGF) has also been proposed as an Ang IV targets. c-Met is associated with memory and learning consolidation.</p>

<p>H-RAFEEEYYRFYTPPC-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-RAFEEEYYRFYTPPC-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-RAFEEEYYRFYTPPC-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-RAFEEEYYRFYTPPC-NH2 at the technical inquiry form on this page</p>

<p>Peptide Biot-GRADSP-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Imiquimod is a toll-like receptor 7 agonist drug that is used for the treatment of genital warts, basal cell carcinoma and condyloma acuminata. This drug works by relieving and controlling wart production. Studies in mice have shown that this drug may induce cytokines such as interleukins. Imiquimod helps to increase apoptosis of diseased tissues and an infiltration of lymphocytes into tumor lesions.</p>

<p>C-terminal fragment of adrenocorticotropic hormone (ACTH), also known as corticotropin, with a C-terminal cysteine residue for conjugation. ACTH (7-39) is a competitive antagonist of ACTH receptor (ACTHR), also known as melanocortin type 2 receptor (MC2R).ACTH is a member of the melanocortins-peptide family, this tropic hormone is produced and secreted by the anterior pituitary gland. ACTH is an important component of the hypothalamic-pituitary-adrenal (HPA) axis and is often produced in response to biological stress. ACTH acts to increase the production and release of cortisol via its interaction with ACTHR. Receptor activation increases the intracellular concentration of cAMP via adenylyl cyclase. -Abnormal ACTH levels in the body have been linked to primary adrenal insufficiency/Addison's disease, Cushing's disease and secondary adrenal insufficiency.</p>

<p>The MHC class II allele I-Ag7 is the allele associated with diabetes in the non-obese diabetic (NOD) mouse. I-Ag7 is also associated with spontaneous mouse models of arthritis and multiple sclerosis. The peptide mimotope mimics the structure of an epitope and therefore causes an antibody response similar to the one elicited by the epitope.</p>

<p>GRGD-acid is a cell adhesive peptide containing the RGD motif. This enables it the ability to increase cell adhesion and rates of cell growth, differentiation and proliferation. When immobilised onto a Poly(etheretherketone) (PEEK) surface it has been shown to increase cell adhesion and proliferation in MC3T3-E1 cells. GRGD could therefore be used in dental implants.</p>

<p>Residues 696-707 of collagen III alpha 1 chain (α1(III)). Type III collagen represents about 20% of the collagen present in the dermis, although it is more abundant in the walls of distensible (expandable) organs and blood vessels. This peptide contains a hydroxylated proline residue, 4-hydroxyproline (4Hyp). 4Hyp residues help stabilize the collagen triple helix through water-bridged intramolecular hydrogen bonding.Type III collagen is a homotrimer, consisting of three α1(III) chains, that are cross-linked in a staggered array through lysine residues to form microfibrils. Collagen III fibrils assume a 'flexi-rod' structure with flexible zones interspersed with rod-like domains, essential for maintaining flexibility in young, pliable tissues and distensible organs. Collagen III has a nearly identical structural arrangement and charge distribution pattern as collagen I, allowing for its substitution by collagen I in embryonic development and wound healing.Collagen III participates in a variety of biological functions including: cell-binding- haemostasis and angiogenesis- tissue remodelling- foetal development, and wound healing. Collagen III is coded for by the COL3A1 gene and COL3A1 disease-causing sequence variants can result in vascular Ehlers-Danlos syndrome (EDS type IV), cerebral aneurysms, gastroesophageal reflux disease, and pelvic organ prolapse.The proline residue at position 5 of this peptide is isotopically labelled with carbon-13 (5) and nitrogen-15 (1), giving this peptide a mass increase of 6 compared to the unlabelled peptide.</p>

<p>[Nle12] alpha-factor is a cyclic analog of the Saccharomyces cerevisiae alpha-factor mating pheromone.</p>

<p>H-Leu-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin that has been used to synthesize peptides. It can be used as a building block for many other chemical reactions, such as cross-linking and oxidation. This resin is typically used in the synthesis of peptides with an amino acid sequence of H-Leu-2-ClTrt and contains 1% DVB. The resin can be used for the synthesis of small organic molecules, such as antibiotics, with a molecular weight between 500 and 2000 Da.</p>

<p>Apolipoprotein B-100 (apoB-100) is a highly expressed human protein, which is targeted by T- and B-cell immune responses in a subgroup of Lyme arthritis (LA) patients. ApoB-100 is present at high levels in the joint fluid of these patients. The high levels of apoB-100 in joints may lead to antigen presentation of apoB-100 peptides by human leukocyte antigen (HLA)-DR molecules, and to T- and B-cell responses to the protein making this protein a novel autoantigen. HLA-DR-presented peptides of apoB-100 have been shown to be immunoreactive.Lyme arthritis (LA) is a late manifestation of infection with the tick-borne spirochete,-Borrelia burgdorferi.The leucine residue at position seven of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.</p>

<p>This peptide is recognised and cleaved by the enzyme Sortase A (SrtA) from-Staphylococcus aureus. The catalytic cysteine residue in the active site of SrtA, serves as a nucleophile to cleave the peptide bond between threonine and glycine. Cleavage results in the formation of a thioacyl intermediate between the peptide and SrtA. This intermediate is then resolved by the N-terminus of an (oligo)glycine nucleophile, resulting in the creation of a new peptide bond that links the peptide and its-nucleophile, resulting in the creation of a new peptide bond that links the peptide and its fluorescent- to the incoming nucleophile.- This method of protein labelling is known as sortagging5-Carboxytetramethylrhodamine (5-TAMRA) is a widely used fluorescent dye which excites at 546 nm and emits at 579 nm</p>

<p>Oxythiamine chloride hydrochloride is an inhibitor of thiamine-dependent enzymes. It is used in cell factor binding and as a biological control for studies involving the effects of thiamine-dependent reactions. The compound has been shown to inhibit enzyme activities in plants and animal tissues, including those that are involved in energy metabolism. Oxythiamine chloride hydrochloride also has inhibitory properties that may be due to its ability to bind to integrin receptors on the cell surface or to its ability to inhibit DNA synthesis by binding to nuclear DNA.</p>

<p>Peptide H-TEAFIPFSLGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Liver-Expressed Antimicrobial Peptide 2 (LEAP2) is a peptide that belongs to the family of antimicrobial peptides. LEAP2 is a potent activator of ion channels, which are membrane proteins that regulate the passage of ions through the cell membrane. LEAP2 can also inhibit protein interactions by binding to receptors and ligands on the surface of cells. LEAP2 has been shown to be a receptor for Ligand-gated ion channels, which are involved in many cellular processes such as neurotransmitter release, muscle contraction, and hormone release.<br>LEAP2 can be used as an inhibitor of the hyperpolarization activated cyclic nucleotide-gated (HCN) channels in neurons. These channels are important for regulating neuronal excitability and inhibiting neuronal activity following action potentials.</p>

<p>C105Y is a cell penetrating peptide aiding in the delivery of DNA into cells.</p>

<p>Glucagon-like peptide (GLP)-1 is a gastrointestinal peptide hormone with multiple roles in relation to metabolism. The primary role of GLP-1 is increasing insulin secretion in the presence of high plasma glucose levels, in addition, GLP-1 also suppresses glucagon secretion from the pancreas. GLP-1 slows down gastric emptying and regulates appetite, both valuable in reducing food intake and body weight. These roles of GLP-1 make it a useful target in the management of type 2 diabetes mellitus (T2DM).GLP-1 exerts its effects by binding to and activating the class B G protein-coupled receptor (GPCR): GLP-1 receptor (GLP-1R). Receptor activation in turn activates signalling pathways which culminates in insulin secretion via CAMP and Ca2+ signalling.Recently evidence has increased for GLP-1 playing a cardio-protective role as well as regulating immune responses and even in kidney function. GLP-1 may also exert neuroprotective and neurotropic effects as it can decrease endogenous levels of amyloid-β (Aβ) and prevent Aβ-induced cell death.This peptide contains an N-terminal Biotin tag for simple detection and purification.</p>

<p>Peptide Ac-QIDVALSQDSTYQG-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>PAR2 plays a particular role in protecting the gastric mucosa mediated by capsaicin-sensitive sensory neurons. PAR2 also serves to aid in gut smooth muscle motility- colon inflammation pathway- hyperalgesia and is also anti-inflammatory in other circumstances.Development of selective agonists for PAR2 are crucial for research. (2-Furoyl)-LIGRL-amide is a far more potent agonist than the native PAR2 activating peptide SLIGRL-NH2. In mice, oral administration conferred cytoprotection from gastrointestinal lesions. However, it was inhibited by capsaicin pre-treatment.</p>

<p>H-TLAAWTSSG-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-TLAAWTSSG-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-TLAAWTSSG-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-TLAAWTSSG-OH at the technical inquiry form on this page</p>

<p>CMV IgM seroconversion panel 7 is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about CMV IgM seroconversion panel 7 including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>CMV IgM seroconversion panel 6 is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about CMV IgM seroconversion panel 6 including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>GFYPSDIAVEWESNGQPENNYK (375-396) the asparagine (N388) located within the Fc region of the heavy chain is identified as deamidation hot spot. The PENNY Peptide is used as an indicator for induced deamidation of mAbs.</p>

<p>Hepatitis C virus antibody was raised in mouse using highly pure HCV NS3 as the immunogen.</p>

<p>The CYFRA21-1 antibody is a highly specific monoclonal antibody used in the field of Life Sciences. It targets the CYFRA21-1 protein, which is an important biomarker for various types of cancer, including lung and bladder cancer. This antibody has been shown to inhibit the activity of interferon and collagen, two proteins involved in tumor growth and metastasis. Additionally, it has the ability to bind to alpha-fetoprotein in human serum, making it a valuable tool for diagnostic purposes. The CYFRA21-1 antibody also exhibits inhibitory effects on transferrin, a protein involved in iron transport, as well as lipoprotein lipase, which plays a role in lipid metabolism. With its high specificity and superior performance, this antibody is an essential component in cancer research and diagnostics.</p>

<p>Mca-Ala-Pro-Lys(Dnp)-OH trifluoroacetate salt is a high quality, versatile, and speciality chemical that is used as an intermediate in the synthesis of complex compounds. Mca-Ala-Pro-Lys(Dnp)-OH trifluoroacetate salt is also a useful scaffold for building block molecules and a versatile building block for peptide synthesis. This compound can be utilized in the manufacture of research chemicals and speciality chemicals.</p>

<p>Urate oxidase is a flavoenzyme that catalyses the oxidation of uric acid to allantoin. It is present in many organisms, including fungi and primates. Urate oxidase catalyzes the oxidation of uric acid to allantoin via the reduction of oxygen to water with concomitant production of hydrogen peroxide. There are four forms of urate oxidase found in nature: tetrameric, dimeric, monomeric, and recombinant. The recombinant form has been shown to be effective against hyperuricaemia in primates and humans with lymphoid malignancies.</p>

<p>Cellulose synthase is a crucial enzyme involved in the synthesis of cellulose. Cellulose is an aggregation of unbranched polymer chains made of β-(1-4)-linked glucose residues, and is a component of primary and secondary cell walls - functioning to primarily maintain strength and shape in cells. Cellulose is synthesised by large cellulose synthase complexes (CSCs), which consist of synthase protein isoforms (CesA) that are arranged into a unique hexagonal structure. Cellulose synthase 4 Light [Populus tomentosa] is specific to the Populus tomentosa species.</p>

<p>The Bmf-Y peptide is a short fragment derived from the protein Bmf (Bcl-2-modifying factor), which is a pro-apoptotic member of the BH3-only family of proteins. These proteins play crucial roles in regulating apoptosis by interacting with other members of the Bcl-2 family, such as Bax and Bak, to promote cell death.<br>The Bmf-Y peptide specifically refers to a portion of the Bmf protein that contains the BH3 domain—a critical region responsible for its interaction with anti-apoptotic Bcl-2 proteins. This interaction inhibits the survival-promoting activity of Bcl-2 proteins, thereby triggering apoptosis.<br>In research and therapeutic contexts, peptides like Bmf-Y are used to mimic the action of natural BH3-only proteins, promoting apoptosis in cancer cells or other diseased tissues by targeting the apoptotic pathways regulated by Bcl-2 family proteins. By doing so, they help in restoring the natural cell death process in cells that are evading apoptosis, such as in cancer.</p>

<p>Ac-PKTSSATPQETLISD-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-PKTSSATPQETLISD-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-PKTSSATPQETLISD-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-PKTSSATPQETLISD-NH2 at the technical inquiry form on this page</p>

<p>Peptide H-HLNILSTLWKYR-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>The CYP2B1 antibody is a highly specialized monoclonal antibody used in the field of Life Sciences. It specifically targets and binds to the CYP2B1 enzyme, which plays a crucial role in drug metabolism and detoxification processes. This antibody has been extensively studied and proven to have high affinity and specificity for its target. One of the key features of this antibody is its ability to bind with various proteins, including collagen, serum albumin, alpha-fetoprotein, erythropoietin, fibronectin, and growth factors. This versatility makes it an invaluable tool in research and diagnostic applications. Furthermore, the CYP2B1 antibody has shown excellent performance in glycosylation studies. It can effectively detect and analyze glycosylated proteins in human serum samples, providing valuable insights into various physiological processes. In summary, the CYP2B1 antibody is a powerful tool that offers researchers precise targeting capabilities and reliable results. Its broad binding spectrum and exceptional performance</p>

<p>Serotonin receptor 5-HT3 antagonist</p>

<p>Proteosome inhibitor; pro-apoptotic; has anti-myeloma activity</p>

<p>Purified recombinant p17 Treponema pallidum protein</p>

<p>Calcipotriol is a vitamin D analogue that is used to treat psoriasis. It is classified as an aprotic solvent and is not soluble in water, but it dissolves in organic solvents. Calcipotriol binds to the receptor for nuclear factor kappa-B (NF-κB) and inhibits its activation, which suppresses the production of cytokines that are involved in inflammation and immune responses. The calcipotriol molecule has been shown to inhibit EGFR signaling, thereby suppressing tumor growth. This drug has also been shown to be effective in combination therapy with other drugs such as dithranol or anthralin for the treatment of psoriasis. Calcipotriol can be administered topically or by oral administration. It is usually applied twice daily and the dosage depends on the severity of the disease.</p>

<p>Peptide H-FLASVSTVLTSK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>human rhinovirus (HRV) VPg uridylylation.</p>

<p>Pyroglutamyl β-Amyloid (4-14) Biotin is derived from Amyloid-β, which has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.This peptide contains a C-terminal Biotin tag that is covalently bonded via ethylenediamine and can be used for detection and purification. Additionally, there is a Pyroglutamyl molecule located at the N-terminal position.</p>

<p>Complement C5 is a fundamental factor of the complement system pathways and whose cleavage by C5 convertase produces the anaphylatoxins C5a and C5b. This cleavage occurs due to the C3b factor binding to the C3 convertases from all the complement pathways: the classical, lectin and alternative and generating the C5 convertases C4bC2aC3b and C3bBbC3b.Overall the main functions of the complement system are to mark cells for phagocytosis, the recruitment of inflammatory cells and the cell lysis of bacteria cell by the MAC. The anaphylatoxins C3a and C5a recruit neutrophils and causes the inflammatory response while the MAC produces pores in the bacterial membrane thus causing a Ca2+ influx into the cell and bacterial cell death.Complement C5 is vital for the assembly of the MAC as C5b, the product of C5, in complex with C6 can bind to target cells. C5bC6 can then form a complex with C7, C8 and C9 to create the MAC, also known as C5b-9.The complement system as a whole can be associated with the neurological diseases, bacterial meningitis, thrombotic disorders, neurological and autoimmune diseases.The arginine residue at position 13 of complement C5 (437-449) is isotopically labelled with carbon-13 (6) and nitrogen-14 (4).</p>

<p>Cell permeable peptide where the amyloid forming sequence is homologous to a nucleating sequence from the human Tau protein (306VQIVYK311). Forms long lived oligomers that are taken up by endocytosis and is cytotoxic in multiple cell lines.- Co-localizes with pathological hyperphosphorylated forms of Tau in vitro.</p>

<p>Amlodipine is a calcium channel blocker that is used to treat hypertension and angina. This drug inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle.</p>

<p>P1A was the first tumour antigen identified to be recognised by cytotoxic T cells. Tumour antigens are highly expressed on tumour cells however, they are also expressed during early embryogenesis then largely silenced in adulthood thus termed onco-fetal antigens. Targetting tumours expressing these antigens is possible due to their absence in adult tissue (apart from within the testes and placenta). The immune response to the P1A antigen is the major component of the tumour rejection response observed in normal mice. P1A antigen has been tested as a vaccine for tumours to induce P1A-specific CD8+ tumour-infiltrating lymphocytes (TILs). Therefore, the P1A antigen is a useful tool in the search in new cancer immunotherapies using targeted tumour-specific antigens.</p>

<p>Selective inhibitor of the mutated RET variant RETV804M, which is the anticipated drug-resistant RET mutant that can occur in tumours treated with kinase inhibitors. The compound has a biochemical IC50 of 0.02 µM and selectivity for purified RETV804M over purified RET and KDR of 3.7 and 110, respectively. The efficacy of the compound was shown also in cell cultures with IC50 of 4.4 µM, and cell assay selectivity for RETV804M over RET and KDR of 0.89 and 2.3, respectively.</p>

<p>Guanidine is a guanidine salt that is used in the chemical industry as a raw material for the manufacture of plastics and synthetic rubber. It is also used as a disinfectant and deodorizer in wastewater treatment. The reaction mechanism of guanidine HCl involves hydrogen bonding interactions with the metal hydroxides and receptor activity. Guanidine has been shown to have an inhibitory effect on mucin gene expression, which may be due to its ability to inhibit toll-like receptor signalling pathways.</p>

<p>LRRK2 is a leucine rich repeat kinase 2. Increase in LRRK2 kinase activity due to mutation has been linked to numerous forms of Parkinson disease (PD). Theoretically, identification of suitable inhibitors of LRRK2 could be the basis for treatments of PD. Markers of LRRK2 activity and function are available that may be clinically relevant in the future as prognostic indicators. Nictide is a substrate model peptide for LRRK2 activity in in vitro kinase assay analysis. -LRRK2 phosphorylates Rab GTPases and alters their association with effector proteins leading to changes in a vast array of cellular functions including the immune response. The use of in vitro kinase assays with small molecules substrates makes screening for LRRK2 inhibitors possible. Alongside nictide, LRRKtide is also used in the same in vitro assays as a substrate model peptide for LRRK2.- Nictide and LRRKtide are available in our catalogue.</p>

<p>C20 Ceramide (d17:1/20:0) is a sphingolipid analog, specifically synthesized for laboratory research. It is a ceramide, a type of lipid molecule found in cell membranes, derived from a synthetic source to facilitate targeted scientific inquiries. The mode of action involves its incorporation into cell membranes, mimicking endogenous ceramides to alter and study cellular signaling pathways, particularly those related to apoptosis, cell growth, and differentiation.</p>

<p>Acetylated α-synuclein (1-13) is derived from the alpha-synuclein intrinsically disordered protein which is found in the neurons and presynaptic terminals. Encoded by the SNCA1/PARK1 gene alpha-synclein is structurally composed of 140 amino acids, making up the three domains: N-terminal membrane binding domain, a hydrophobic non-amyloid-β component domain and a hydrophilic C-terminal domain. Usually alpha-synuclein plays a role in protecting neurons from apoptotic stimuli and is involved in synaptic vesical trafficking.However it has been found that the accumulation of alpha-synuclein aggregates can lead to neurodegenerative diseases such as Parkinson disease, dementia with Lewy bodies and multiple system atrophy. It is further involved in the fibrilisation of amyloid-b and tau which play a major role in Alzheimer disease. Amyloid fibrils are formed from alpha synuclein monomers within the cytosol and when bound to membranes these monomers can undergo conformational changes to form protofibrils and then ring like oligomers. This can result in the formation of transmembrane pores which disrupts the membrane, calcium homeostasis and signalling.Alpha-synuclein can be subjected to the post-translational modifications of phosphorylation and N-terminal acetylation. When acetylation occurs at the N-terminus of an alpha-synuclein monomer, the intramolecular hydrogen bonds are altered thus reducing the rate of alpha-synuclein aggregation and the strength at which it interacts with the membrane is increased.</p>

<p>Portion of EBV</p>

<p>The Bid BH3 Peptide is derived from the pro-apoptotic proteins Bid (BH3-interacting domain death agonist) and BH3, which are both members of the BCL-2 family proteins and activate the BAX and BAK proteins to promote apoptosis.The process of apoptosis can be activated by the intrinsic or extrinsic pathways, the former is activated by stress stimuli such as DNA damage and nutrient deficiency, while the latter is induced through activation of the death receptors FAS and TRAIL.The BCL-2 family's transmembrane anchor at the C-terminus allows them to locate at the mitochondrial outer membrane and play a vital role in apoptosis.Within the mitochondria BH3 molecules, containing the members BID, BIM, PUMA and NOXA, can be activated by the intrinsic pathway. These in turn can initiate the homo-oligomerisation of BAX and BAK which induce mitochondrial outer membrane permeabilisation (MOMP) and the release of cytochrome c into the cytosol. Here cytochrome c associates with APAF-1 and dATP, ultimately activating effector caspase3/7 and apoptosis.In addition to Bid's role in apoptosis, it also plays a role within a mitosis checkpoint and genomic stability maintenance. Bid's main role is in the extrinsic pathway of apoptosis. When the death receptors are activated Caspase-8 generates tBid through the cleavage of Bid. This then locates to and targets Bax to the outer mitochondrial membrane (OMM) where it induces permeabilisation and hence apoptosis.</p>