Biochemicals and Reagents

<p>Peptide 5-azido-pentanoyl-RKKRRQRRR-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>3-Indolepropionyl-coa is a potent inhibitor of cancer cell cycle and has been found to induce apoptosis in human cancer cells. This compound is an analog of the naturally occurring urinary metabolite, indole-3-acetic acid, which has been shown to have anticancer properties. 3-Indolepropionyl-coa is a promising medicinal compound for the development of novel anticancer drugs due to its ability to inhibit protein kinase activity in Chinese hamster ovary cells. It has also been reported to inhibit tumor growth and proliferation by blocking the production of cyclin-dependent kinases, which are essential for cell division. The potential use of 3-Indolepropionyl-coa as a therapeutic agent for cancer treatment warrants further investigation.</p>

<p>Retroprogesterone is a human urine-derived compound that has shown promising results in the field of cancer research. It is an analog of oseltamivir and acts as a kinase inhibitor, which makes it an effective anticancer agent. Retroprogesterone has been shown to induce apoptosis in cancer cells by inhibiting protein kinases that are essential for cell survival and proliferation. This compound has demonstrated potent tumor growth inhibition in Chinese hamster ovary cells, making it a potential candidate for cancer therapy. Retroprogesterone has also been studied as an inhibitor of various kinases involved in cancer development and progression. Its ability to target multiple pathways involved in cancer makes it a valuable tool for future research and drug development.</p>

<p>2-Benzyl-2,8-diazaspiro[4.5]decan-1-one hydrochloride is a chemical compound utilized chiefly in pharmacological research. It is synthesized through organic chemical processes designed to produce spirocyclic frameworks that can interact specifically with biological macromolecules. The compound acts as a ligand in receptor studies, allowing researchers to investigate the binding properties and activities at selective receptor subtypes.</p>

<p>PI3K-gamma inhibitor 1 is a small molecule inhibitor, which is selectively synthesized for targeting the PI3K-gamma isoform. This inhibitor is derived through precise medicinal chemistry, involving the synthesis of compounds that specifically interact with the catalytic domain of the phosphoinositide 3-kinase gamma (PI3K-γ) enzyme. Its mode of action involves the selective inhibition of the PI3K-γ pathway, a critical signaling route responsible for modulating immune cell functions and inflammatory responses.</p>

<p>FAPI-46 trifluoroacetate is a fibroblast activation protein (FAP) inhibitor, which is synthesized as part of targeted cancer research efforts. It is derived from chemical engineering processes focusing on the modification of small molecules to selectively interact with FAP, an enzyme overexpressed in cancer-associated fibroblasts (CAFs) within the tumor microenvironment. FAPI-46 binds to and inhibits FAP, reducing its enzymatic activity. By blocking FAP, FAPI-46 trifluoroacetate disrupts the tumor-promoting interactions between CAFs and tumor cells, potentially impeding tumor growth and progression.</p>

<p>Please enquire for more information about Oligopeptide-51 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Isodesmosine is an amino acid and naturally occurring cross-linking compound, which is primarily found in elastin, a key protein in connective tissues. Its source is the structural protein elastin, where it forms stable cross-links that contribute to the elasticity and resilience of various tissues, notably the skin, lungs, and blood vessels. The mode of action of isodesmosine involves its integration into the elastin matrix, providing durability and elasticity through covalent bonding within and between polypeptide chains.</p>

<p>Please enquire for more information about Ethyl N,N-bis(1-methylethyl)phosphoramidochloridite including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Vancomycin methyl ester is an analog of the antibiotic vancomycin that has been shown to have anticancer properties. It induces apoptosis in cancer cells, particularly in Chinese hamster ovary (CHO) cells and human tumor cell lines. Vancomycin methyl ester acts as a cyclin-dependent kinase inhibitor by binding to the ATP-binding site of these kinases, thereby inhibiting their activity. This protein kinase inhibition leads to the downregulation of proteins involved in cell cycle progression, such as cyclin D1 and E2F1, ultimately leading to cell death. Vancomycin methyl ester has also been found to inhibit the growth of certain types of cancer cells by blocking angiogenesis, which is the formation of new blood vessels that tumors need for their growth and survival. Additionally, this compound has been detected in human urine after administration and may have potential therapeutic applications in cancer treatment.</p>

<p>ALX-1393 is a synthetic compound that acts as an inhibitor, specifically targeting the glycine transporter 1 (GlyT1). As a small molecule inhibitor derived from chemical synthesis, it modulates neurotransmitter systems by blocking the reuptake of glycine, an important co-agonist of the NMDA receptor, in the central nervous system. The mode of action of ALX-1393 involves binding to the GlyT1 transporter, thereby increasing the synaptic concentration of glycine. This elevation in glycine levels enhances NMDA receptor function, which is crucial for synaptic plasticity, learning, and memory.</p>

<p>The hCG protein is a growth factor that plays a crucial role in various biological processes. It is involved in the regulation of cell growth, differentiation, and development. This protein has been extensively studied in the field of Life Sciences and has shown promising results in various applications. One of the key characteristics of the hCG protein is its ability to interact with arginase, an enzyme involved in the metabolism of arginine. Through molecular docking studies, it has been shown that hCG can bind to arginase and modulate its activity, leading to potential therapeutic applications. Monoclonal antibodies targeting the hCG protein have been developed for research purposes. These antibodies are highly specific and can be used in immunoassays to detect and quantify hCG levels in human serum samples. They have also been used for the immobilization of hCG on electrodes, enabling the development of biosensors for diagnostic purposes. Furthermore, studies have demonstrated that the hCG protein plays a role in the regulation of mes</p>

<p>Please enquire for more information about Opiorphin trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>TES, also known as N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid, is a buffering agent that is used in protein assays and forms complexes with DNA and copper ions. The optimal pH range of this zwitterionic buffer is 6.8-8.2 and its pKa is 7.4.</p>

<p>β-Chlornaltrexamine dihydrochloride (β-CNTA) is a non-competitive antagonist of the kappa opioid receptor. It has been shown to inhibit camp levels and whole-cell recordings in cells expressing the G protein, guanine nucleotide binding proteins, and ryanodine receptor. β-CNTA also inhibits locomotor activity in mice and reverses the effects of morphine on rotarod performance. In addition, β-CNTA has been shown to be effective against human cell line HL60.END&gt;</p>

<p>8-(3-Chlorostyryl)caffeine is a caffeine derivative that binds to the adenosine A3 receptor. It has been shown to inhibit locomotor activity and increase diastolic pressure in knockout mice lacking the adenosine A3 receptor. 8-(3-Chlorostyryl)caffeine has also been shown to have inhibitory properties on cyclase, which is necessary for the production of cAMP, the second messenger in cells. This drug also inhibits dopamine release from neurons and hydrogen bond formation with DNA, protein, and other biomolecules. Lastly, 8-(3-Chlorostyryl)caffeine can bind to both A1 and A2A receptors as well as to dna binding sites.</p>

<p>Please enquire for more information about Ethyl N,N,N',N'-Tetraisopropylphosphorodiamidite including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-Leu-Leu-Gly-OH trifluroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-Palmitoyl-rac-glycero-3-phosphocholine is a biological lipid that has been shown to be a potent growth factor for cells in culture. It binds to DNA and modulates transcriptional regulation. 1-Palmitoyl-rac-glycero-3-phosphocholine also inhibits the production of lysophosphatidylcholine, which is an inflammatory mediator that promotes the release of histamine from mast cells. This compound may be useful as an antimicrobial agent, as it has been shown to inhibit the growth of bacteria and fungi.</p>

<p>PF2562 is a potent and selective activator of the metabotropic glutamate receptor mGluR5. It is a competitive antagonist at AMPA receptors, with no activity at NMDA or kainate receptors. PF2562 is known to inhibit protein interactions between the proteins encoded by the gene for the metabotropic glutamate receptor mGluR5 and its ligands, such as l-glutamic acid and d-serine. This inhibition leads to activation of these receptors, which may be important in research on neurological disorders and other diseases involving glutamate signaling.</p>

<p>Please enquire for more information about Cerebellin trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Benzoylecgonine antibody was raised in mouse using benzoyl ecgonine-BSA as the immunogen.</p>

<p>The Methotrexate antibody is a monoclonal antibody that specifically targets and binds to Methotrexate, a commonly used cytotoxic drug in the field of Life Sciences. This antibody has been extensively tested and validated for its high affinity and specificity towards Methotrexate. It can be used in various applications such as ELISA, Western blotting, immunohistochemistry, and flow cytometry. The Methotrexate antibody works by binding to Methotrexate molecules and preventing their interaction with their target enzymes involved in DNA synthesis. This inhibits the growth of cancer cells and autoimmune responses mediated by activated T-cells. Additionally, this antibody can also be utilized as a tool for studying the intracellular localization and trafficking of Methotrexate within cells. The unique features of this Methotrexate antibody include its ability to recognize both free Methotrexate molecules as well as Methotrexate conjugated to proteins or other biomolecules. It exhibits minimal cross-reactivity with</p>

<p>Alprostadil alfadex is a medicinal drug that has been found to have anticancer properties. It works by inhibiting the growth of cancer cells and inducing apoptosis, or programmed cell death. This drug is an analog of a naturally occurring protein that acts as a tumor inhibitor in humans. Alprostadil alfadex has been shown to be effective against various types of cancer, including those found in the urinary tract and prostate. It works by blocking the action of certain enzymes and proteins involved in the cell cycle, thereby preventing cancer cells from dividing and multiplying. Chinese researchers have also found that this drug has a kinase-inhibiting effect, which may contribute to its anticancer activity.</p>

<p>FluM1 (58-66) is a short part of the matrix protein of Influenza A virus which is the most abundant component of this enveloped virus localized under the viral lipid envelope. The GILGFVFTL epitope is highly conserved in Influenza A virus strains at a rate of 93% for 69 strains tested. Human Influenza epitopes may bind MHC molecules and then may be recognized by CD8+ cytotoxic T cells. Applications of FluM1 (58-66): FluM1 (58-66) is used to stimulate CTL responses in peripheral blood mononuclear cells (PBMCs). Then, ELISPOT assay is used to quantify peptide epitope specificity and IFN-γ releasing effector cells. FluM1 (58-66) has shown CTL responses qualified of immunodominant with restriction by HLA-A*02:01. It has also been detected CTL responses when FluM1 (58-66) is restricted by all HLA-C. Therefore, FluM1 (58-66) may help to understand the reaction of immune system against Influenza virus of each populations having different HLA type. FluM1 (58-66) has indeed prompted research to develop T-cell vaccine strategies capable of inducing specific CTL responses in patients upon immunization with Influenza M1 antigenic epitope. MVA-NP+M1 vaccine use GILGFVFTL epitope and is tested in clinical trial. Potential cross-reactivity with HIV-1 p17 Gag (77-85): Moreover, FluM1 (58-66) share similarities with HIV-1 p17 Gag (77-85) which can potentially show a cross-reactivity between these epitopes. It has been demonstrated a cross-reactivity and results suggest that immunity following infection by Influenza virus causes specific immune response to HIV-1 p17 Gag (77-85).</p>

<p>Recombinant canine thyroid-stimulating hormone (TSH)</p>

<p>N-Acetylpiperazine-N-(4-phenol) ketoconazole is an analog inhibitor that has been shown to inhibit the activity of several kinases. This compound has been tested against a variety of cancer cells and has demonstrated potent anticancer activity, inducing apoptosis in Chinese hamster ovary cells. N-Acetylpiperazine-N-(4-phenol) ketoconazole also inhibits the activity of dapoxetine, a drug used to treat premature ejaculation. In addition to its anticancer properties, this compound has shown promise as an anti-inflammatory agent due to its ability to inhibit the production of prostaglandins. This inhibitor can be detected in urine and may have potential therapeutic applications in the treatment of various cancers.</p>

<p>Fluorescent derivative of cyclopamine</p>

<p>H-Glu-Gly-Arg-chloromethylketone trifluoroacetate salt is an anticoagulant drug that prevents the formation of blood clots by inhibiting the enzyme thrombin. This drug is effective in enhancing blood flow and oxygen supply to the heart and other organs. H-Glu-Gly-Arg-chloromethylketone trifluoroacetate salt has been shown to have a positive effect on patients with congestive heart failure. It has also been used as an adjuvant therapy in bypassing procedures, where clotting occurs at the site of an artificial conduit placed in the body to allow blood flow between two points. In vitro studies have demonstrated that this drug inhibits protease activity, which may be due to its ability to inhibit fibrinogen and serine protease activity.</p>

<p>Please enquire for more information about (Pyr³)-Amyloid B-protein (3-42) trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-Bromo-L-thyroxine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Z-VRPR-FMK trifluoroacetate is an apoptosis-inducing inhibitor that works by inhibiting a specific kinase in the human body. It has been shown to have anti-cancer properties and may be useful in the treatment of various types of cancer. Z-VRPR-FMK trifluoroacetate is a menthol analog that acts as an inhibitor of apoptosis, which is the process by which cells die naturally. This compound has been tested on Chinese hamster ovary cells and has been found to be effective at inducing apoptosis in these cells. Additionally, Z-VRPR-FMK trifluoroacetate has been shown to inhibit tylosin-induced apoptosis in human colon cancer cells. Overall, this compound shows promise as a potential therapeutic agent for the treatment of cancer and other diseases.</p>

<p>Imidazole-15N2 is an analog of the calcium channel blocker nifedipine that has been shown to have anticancer properties. It induces apoptosis in cancer cells by inhibiting protein kinases, which are involved in tumor growth and survival. Imidazole-15N2 has been studied in both Chinese hamster ovary cells and human cancer cell lines, where it has demonstrated potent inhibition of kinase activity. This drug is a promising candidate for the development of novel cancer therapies due to its ability to selectively target cancer cells while sparing normal cells. Imidazole-15N2 can be detected in urine and may serve as a biomarker for the presence of protein kinase inhibitors in the body.</p>

<p>UM729 is an advanced surface coating, which is a chemical formulation with the aim of enhancing surface durability and protection. Sourced from novel polymeric materials, UM729 is designed to form a robust and resilient layer when applied to various substrates. Its mode of action involves cross-linking at the molecular level, creating a cohesive barrier that offers resistance to environmental factors such as abrasion, moisture, and UV radiation.</p>

<p>GC-globulin is a protein that is found in human plasma. It can be used as an activator, inhibitor, or ligand for ion channels, receptors, and other proteins. GC-globulin has been shown to inhibit the function of receptor tyrosine kinases on B-cells with antibodies that bind to the Fc region of the protein. This inhibition prevents activation of the B-cell receptor and thus inhibits antibody production by B cells. GC-globulin also binds to peptides during cell division and functions as a cofactor for proteolytic enzymes such as plasminogen activator (PA). GC-globulin has been shown to activate PA which leads to fibrinolysis.</p>

<p>LY 117018 is a dopamine analog that binds to the toll-like receptor and blocks the production of proinflammatory cytokines. LY 117018 also inhibits epidermal growth factor (EGF) in liver cells and cyclin D2, which is involved in cell cycle regulation. This drug has been shown to be effective in a model system using fetal bovine serum with angiogenic factors, such as vascular endothelial growth factor (VEGF). The effect on blood vessels was dose-dependent for LY 117018. This drug potentiates the actions of 17β-estradiol on mcf-7 cells and serum prolactin levels are significantly decreased in vivo by this compound.</p>

<p>TFA salt</p>

<p>μ- and κ- opioid receptor antagonist; partial agonist of δ- opioid receptors</p>

<p>Endogenous heptapetide which causes vasodilation and has anti-hypertensive properties.</p>

<p>Please enquire for more information about Pheromone Cymit Quimicaesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>H-Met-Gln-OH TFA salt is a recombinant human metalloproteinase that has been shown to activate polymorphonuclear and mononuclear cells. H-Met-Gln-OH TFA salt enhances the production of reactive oxygen species and induces the release of proinflammatory cytokines such as tumor necrosis factor alpha, interleukin 1, and interleukin 6. This protein also cleaves sulfoxide bonds in proteins, which may be due to its ability to catalyze the oxidation of sulfhydryl groups in proteins. H-Met-Gln-OH TFA salt has been shown to be effective in enhancing red blood cell production, which may be due to its ability to cleave hemoglobin S bonds in erythrocytes.</p>

<p>Please enquire for more information about Fmoc-D-Asp(OtBu)-(Dmb)β-Ala-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Cyclo(L-alanyl-L-tryptophyl) trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>L-leucine with a lipid chain.</p>

<p>Dansyl-D-Ala-Gly-4-nitro-Phe-Gly-OH trifluoroacetate salt is a fluorescent marker that can be used in immunohistochemical staining. It binds to endogenous vasoactive intestinal peptide, calcitonin and other proteins in tissues and can be detected using immunostaining. Dansyl-D-Ala-Gly-4-nitro-Phe-Gly-OH trifluoroacetate salt is optimised for use as a substrate for neutral endopeptidase and metalloendopeptidase enzymes, which are responsible for the degradation of vasoactive intestinal peptide.</p>

<p>L-MobileTrex is an advanced analytical technology platform, which is a product of cutting-edge research in data science and computational modeling. This platform operates by integrating multi-dimensional datasets through sophisticated algorithms, providing enhanced data visualization and interpretability.</p>

<p>3,4-Dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]methanone is a potent and selective inhibitor of the ion channel TRPM8. It reduces pain and inflammation by inhibiting the action of TRPV1 and TRPA1. 3,4-Dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]methanone is an inhibitor of the TRPM8 ion channel with IC50 value of 0.06 μM. 3,4-Dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]methanone inhibits TRPA1 with IC50 value of</p>

<p>a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response</p>

<p>D-Hyoscyamine is a potent anticancer agent that has been shown to induce apoptosis in cancer cells. It works by inhibiting kinases, which are enzymes that play a key role in the regulation of cell growth and division. D-Hyoscyamine has been tested on both human and Chinese hamster ovary cells, and has demonstrated significant anticancer activity. It is an analog of several kinase inhibitors, including cyclin-dependent kinase (CDK) inhibitors, which are commonly used in cancer therapy. In addition to its anticancer properties, D-Hyoscyamine has also been found to have potential therapeutic applications for other diseases such as Alzheimer's disease and Parkinson's disease. It is derived from urine and acts as a potent inhibitor of protein kinases.</p>

<p>Sheep polyclonal Mescaline antibody</p>

<p>Pseudoisoeugenyl 2-methylbutyrate is an analog of astaxanthin that has shown promising results in inhibiting tumor growth and inducing apoptosis in cancer cells. It acts as a kinase inhibitor, preventing the replication of cancer cells and promoting anticancer effects. Pseudoisoeugenyl 2-methylbutyrate has been tested on human and Chinese hamster ovary cell lines, demonstrating its potential as a potent anticancer agent. This compound has also been found in urine samples, suggesting that it may have natural sources in the body. Its ability to inhibit kinases makes it a promising candidate for further research into cancer treatment.</p>

<p>Please enquire for more information about HYYYGAAPPGQKGQANATRIPAKTPPAPK{pT}PPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLP{pT}PPTREPKKVA-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cys-Gly-3M3SH is a cationic antimicrobial peptide that has been shown to be effective against Staphylococcus aureus. Cys-Gly-3M3SH binds to the bacterial enzyme urease, which is responsible for converting urea into ammonia and carbon dioxide. The binding of this peptide prevents the hydrolysis of urea, leading to cell death by disruption of the proton motive force. Cys-Gly-3M3SH is also biotransformed by bacteria in humans and can be used as a probe for transport studies in vitro. It can also be used as a molecular probe for structural biology research, such as protein crystallization and electron microscopy studies.</p>

<p>Please enquire for more information about 4-[3-[5-Amino-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl]propyl]phenol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>S 25585 is a psychostimulant that has been shown to modulate the function of animals. It can be used in the treatment of cancer and autoimmune diseases, as well as to induce overfeeding in animals. S 25585 is an endogenous molecule with a cyclic structure. The affinity for binding of S 25585 to its receptor may depend on whether it is bound or unbound at the time of binding. This drug also has anti-cancer effects, which are due to its ability to inhibit uptake and stabilize cells that are not undergoing cell division. 6-Fluoro-3-indoxyl-beta-D-galactopyranoside (Rifapentine) is an antituberculosis drug that belongs to the class of rifamycins. It is the most active of the rifamycins for the treatment of tuberculosis. Rifapentine inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing</p>

<p>Lactimidomycin is a peptide antibiotic that blocks the activity of ion channels, which are proteins that control the flow of ions across cell membranes. Lactimidomycin binds to specific ligands on the surface of cells and inhibits membrane depolarization. It has been shown to inhibit the activity of calcium-gated potassium channels, hyperpolarize nerve cells, and inhibit neuronal excitability. Lactimidomycin has also been shown to be an inhibitor of protein interactions with antibodies and other cellular factors. This drug can be used as a research tool for studying protein interactions in living cells. Lactimidomycin is available in high purity and at CAS No. 134869-15-1.</p>

<p>Mycosubtilin is a potent antifungal lipopeptide, which is a secondary metabolite produced by the bacterium Bacillus subtilis. It is characterized by its ability to disrupt fungal cell membranes, leading to cell lysis and eventual death of the fungus. This mode of action is attributed to its amphiphilic structure, which allows it to integrate into the lipid bilayers of fungal cells, compromising the integrity of the membrane and altering its permeability.Mycosubtilin finds applications in various scientific and agricultural fields due to its efficacy against a broad spectrum of fungal pathogens. It is particularly useful in plant disease management, where it plays a role in biocontrol strategies against phytopathogenic fungi. Additionally, its antifungal properties make it a subject of interest in pharmaceutical research, where it is investigated for potential therapeutic applications in combating fungal infections. Researchers also explore Mycosubtilin as a model compound to understand lipopeptide interactions with membranes, contributing to the broader knowledge of antimicrobial agents.</p>

<p>Please enquire for more information about Bantag-1 trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>A novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors</p>

<p>N-Desethyl N-methyl rivastigmine is an analog of rivastigmine and a potent inhibitor of kinases. It has been shown to induce apoptosis in cancer cells, making it a promising candidate for the treatment of various types of tumors. This medicinal compound is excreted through urine and has been found to have anticancer properties by inhibiting protein kinases. In Chinese hamster ovary cells, N-Desethyl N-methyl rivastigmine was found to inhibit the activity of several kinases involved in cell proliferation and survival. This inhibitor has potential therapeutic applications for cancer treatment due to its ability to target specific kinases that are essential for tumor growth and progression.</p>

<p>Cortisol antibody was raised in mouse using cortisol-3 BSA as the immunogen.</p>

<p>1-Demethylcolchicine is a research tool for the study of ligand-receptor interactions and cell biology. It has also been used to study ion channels in the central nervous system, as well as antibody production. 1-Demethylcolchicine is a potent inhibitor of protein synthesis and is used to study peptides and proteins. 1-Demethylcolchicine binds to the receptor site on cells, which inhibits the activity of the ion channels that are responsible for generating an action potential. This inhibition leads to decreased nerve impulses in neurons, which may contribute to its sedative effects.</p>

<p>Purified native Human CEA protein (Preservative-free)</p>

<p>CAY10727 is a potent biochemical inhibitor, which is derived from synthetic sources with specific action targeting cyclooxygenase-2 (COX-2) enzymes. It functions by selectively blocking the enzymatic activity of COX-2, which plays a critical role in the biosynthesis of prostaglandins involved in inflammatory responses. This targeted inhibition allows the study of COX-2-related pathways without interference from COX-1, which is significant for maintaining gastrointestinal integrity.The use and applications of CAY10727 are primarily in research settings where understanding the pathways involved in inflammation, pain, and cancer progression are critical. This compound is utilized in various in vitro experiments to delineate the role of COX-2 in cellular and molecular contexts, enabling scientists to dissect complex signaling networks. Given its specificity, CAY10727 is instrumental in the development of new therapeutic approaches where selective COX-2 inhibition might offer benefits over non-selective inhibitors.</p>

<p>Please enquire for more information about HYYYGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLP{pT}PPTREPKKVA-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Coibamide A including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-(5-Aminopentyl) methotrexate amide-LC-biotin is a specialized bioconjugate, derived through the conjugation of methotrexate, an established antifolate drug, with an LC-biotin moiety. This product is synthesized by covalently linking methotrexate, which is known for its role in cancer therapy through the inhibition of dihydrofolate reductase (DHFR), to a biotin moiety via a long-chain spacer. The resultant bioconjugate retains the therapeutic effects of methotrexate, particularly in its ability to interrupt nucleotide synthesis, thereby affecting cell division in rapidly proliferating cancer cells.The inclusion of biotin in the structure allows for facile attachment to avidin or streptavidin-labeled systems, facilitating targeted delivery and enhanced detection in molecular and cellular studies. The primary application of N-(5-Aminopentyl) methotrexate amide-LC-biotin lies in the realm of targeted drug delivery and advanced research into methotrexate metabolism. By leveraging the high affinity of biotin-streptavidin interactions, researchers can effectively study the biodistribution and cellular uptake of methotrexate, advancing cancer therapeutic strategies and providing insights into antifolate drug mechanisms at the molecular level.</p>

<p>The CYFRA21-1 antibody is a powerful tool in the field of Life Sciences. This antibody specifically targets fibronectin, a protein involved in cell adhesion and migration. It has cytotoxic properties, making it useful for studying cellular processes and identifying potential therapeutic targets. Additionally, the CYFRA21-1 antibody can be used to detect inhibitory factors or antiphospholipid antibodies in biological samples. It is also effective in detecting insulin antibodies, autoantibodies, and antibodies involved in glycosylation processes. With its high specificity and sensitivity, this monoclonal antibody is an invaluable tool for researchers looking to uncover new insights into various biological pathways and disease mechanisms.</p>

<p>Osmanthuside H is a natural compound, specifically a phenylethanoid glycoside, which is predominantly sourced from the plant Osmanthus fragrans, as well as other related species. This compound is characterized by a specific glycosidic linkage that contributes to its stability and bioactivity. The mode of action of Osmanthuside H primarily involves its significant antioxidant properties, attributed to the presence of its phenolic structure and glycosidic moiety. This facilitates its role in scavenging free radicals and reducing oxidative stress within biological systems.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of TPCN1 antibody, catalog no. 70R-5158</p>

<p>Faradiol 3-laurate is an analog that has been shown to induce apoptosis in cancer cells. It is a promising compound for the treatment of tumors due to its ability to inhibit proteins that are involved in cancer cell growth and survival. Faradiol 3-laurate has been found in medicinal plants and human urine, and has been used as a Chinese traditional medicine for centuries. This compound is also a potent inhibitor of kinases, which are enzymes that play a critical role in the regulation of cellular processes such as cell growth and differentiation. Its anticancer properties make it an attractive candidate for further research in the development of novel cancer therapies.</p>

<p>The POLR3A protein (His &amp; Thioredoxin tag) is a highly versatile and essential component in Life Sciences research. This medicament is a Conjugated Protein that offers numerous applications in various fields. It can be used as a valuable tool for studying protein-protein interactions, carbon quantum dynamics, chemokine signaling pathways, and influenza hemagglutinin structure and function. Additionally, the POLR3A protein (His &amp; Thioredoxin tag) has been employed in the development of novel therapeutic strategies. Its unique properties make it an ideal candidate for the production of Proteins and Antigens, collagen-based scaffolds for tissue engineering, peptide agents for drug delivery systems, and as a carrier for endogenous erythropoietin. Furthermore, this product can be utilized as a reliable reagent in monoclonal antibody production and neutralizing assays against TGF-beta. Its exceptional binding affinity ensures accurate results in these experiments. The POLR3A protein (</p>

<p>A negative allosteric modulator of Flt-3 receptor tyrosine kinase</p>

<p>N-[(1S)-1-(3-Fluorophenyl)-3-[(1R,5S)-3-[2-methyl-5-(2-methylpropanoyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridin-1-yl]-8-azabicyclo[3.2. 1]octan-8-yl]propyl]acetamide is a research tool for use in cell biology and pharmacology studies. It is an activator that binds to the receptor or ligand and stimulates the activity of the protein. It has been shown to bind to ion channels, which are proteins that regulate the flow of ions across a biological membrane. This drug also interacts with antibodies and peptides (small chains of amino acids), which are important in life sciences as they are involved in many cellular functions including enzyme regulation and energy production.</p>

<p>Secologanate is a peptide that has been used as a research tool to study the interactions between proteins and ligands. Secologanate is an inhibitor of ion channels, which are membrane-spanning proteins that control the flow of ions in and out of cells. It also inhibits protein interactions by blocking the binding site on one molecule for a second molecule. Secologanate has been shown to inhibit the ion channel TRPV1, which is involved in pain sensation. Secologanate has also been shown to be a ligand for the human angiotensin II receptor type 1 (AT1R).</p>

<p>1-Oleoyl-2-docosahexaenoyl phosphatidylcholine is a fatty acid derived from the biogenesis of phosphatidylcholine, which is an important component of all cell membranes.</p>

<p>DTR-I is an analog of ghrelin, a protein hormone that regulates appetite and energy balance. It is a potent inhibitor of kinases, which are enzymes that play a crucial role in cancer cell growth and survival. DTR-I has been shown to induce apoptosis, or programmed cell death, in various types of cancer cells. This anticancer effect is thought to be due to its ability to inhibit the activity of protein kinases that are overexpressed in human tumors. In addition, DTR-I has been found in urine samples from Chinese cancer patients, indicating its potential as a diagnostic marker for certain types of cancer. The development of DTR-I as a novel anticancer agent holds promise for the treatment of various types of cancer in the future.</p>

<p>Please enquire for more information about MS67N including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>VS1 is a novel synthetic peptide, which is engineered to function as an antimicrobial agent. This peptide originates from recombinant DNA technology, providing a customizable approach to target specific microbial strains. Its mode of action involves the selective disruption of microbial cell membranes, leading to the lysis and consequent death of the target cell. The specificity of VS1 for microbial cells over mammalian cells minimizes off-target effects, making it a highly effective agent for infection control.</p>

<p>1,2-Dipalmitoyl-3-dimethylammonium-propane is a cationic lipid, which is a type of synthetic lipid commonly used in biochemical and biophysical research. It is sourced from chemical synthesis, involving the formulation of lipid molecules with specific chemical modifications to confer particular properties. The mode of action of this compound involves its ability to integrate into lipid bilayers and form liposomes. These liposomes can encapsulate nucleic acids, facilitating their delivery into cells by merging with cell membranes, which is crucial for gene delivery applications.</p>

<p>Fentanyl p Conjugate for use in immunoassays</p>

<p>Please enquire for more information about 1,8-Dinitropyrene-d8 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Foslevodopa is a prodrug that is converted to levodopa in the body. This drug has been shown to be safe and effective for the treatment of Parkinson's disease with minimal side effects, although it does not affect the progression of the disease. Foslevodopa is a synthetic compound that has been synthesized using chemical methods. It can be manufactured in large quantities, making it a scalable pharmaceutical formulation.</p>

<p>S-Lenalidomide is a drug that is used to treat cancer and autoimmune diseases. It is an immunomodulatory agent that induces cytokine release and inhibits the production of interleukin-2 (IL-2) by T cells. This drug also has a concentration-dependent effect on the activity of oxidative enzymes, such as benzalkonium chloride and light emission. S-Lenalidomide has been shown to be clinically relevant in infectious diseases, with concentrations producing significant effects on disease activity. The water vapor stability of this drug makes it suitable for use in humid environments such as those found in developing countries. S-Lenalidomide has been shown to induce antitumor responses without causing immunosuppression or toxicity in rats.</p>

<p>Please enquire for more information about Bromantane-d5 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>A naturally isolated steroid</p>

<p>Alvameline is a muscarinic receptor agonist, which is a small molecule drug derived from synthetic chemistry processes. Its primary source is the intricate design of pharmacologically active compounds targeting the central nervous system. Alvameline exerts its effects through selective agonism of muscarinic acetylcholine receptors, playing a pivotal role in modulating neurotransmission. Specifically, by activating these receptors, it enhances cholinergic signaling, which is crucial for cognitive functions such as memory and attention.</p>

<p>Diethoxy disulfide is a cyclin-dependent kinase inhibitor that induces apoptosis in cancer cells. It is an analog of the medicinal plant compound, alliin, and has been found to have potent anticancer activity. Diethoxy disulfide inhibits the activity of Chinese hamster ovary cell cycle kinases and human tumor-associated kinases, leading to cell cycle arrest and inhibition of cancer cell growth. This compound has been shown to be effective against a variety of cancer types, including breast, lung, and prostate cancer. Additionally, it has been found to sensitize cancer cells to other anticancer drugs by enhancing their cytotoxic effects. Overall, diethoxy disulfide is a promising candidate for the development of novel anticancer therapies.</p>

<p>Crt0066101 hydrochloride is a peptide that has been shown to inhibit the activity of receptors for the neurotransmitter acetylcholine. It binds to the receptor and blocks access by acetylcholine, which prevents activation of the receptor. Crt0066101 hydrochloride is a ligand that inhibits ion channels in cells, including potassium channels, calcium channels, and sodium channels. This drug can be used as a research tool to study protein interactions in cell biology and pharmacology as well as to identify new drugs with potential therapeutic benefits. Crt0066101 hydrochloride is an inhibitor of G-protein coupled receptors (GPCRs) that has been shown to block the activation of muscarinic receptors on heart tissue. It also inhibits calcium-activated potassium channels on smooth muscle cells, leading to reduced blood pressure in animal models.</p>

<p>Aryl hydrocarbon receptor (AhR) agonist</p>

<p>The Tetracycline antibody is a highly specific monoclonal antibody that binds to tetracycline, a broad-spectrum antibiotic. This antibody has a high receptor binding affinity and can be used in various applications, such as polymerase chain reactions (PCR), immunohistochemistry, and Western blotting. It specifically targets tetracycline residues in biological samples, allowing for the detection and quantification of this antibiotic. In addition to its use in research, the Tetracycline antibody has potential applications in the field of medicine. It can be used to study the cellular localization of tetracycline within cells or tissues, providing valuable insights into its mechanism of action. Furthermore, this antibody can be utilized to investigate protein-protein interactions involving tetracycline or its derivatives. The Tetracycline antibody is produced using advanced techniques in monoclonal antibody production. It exhibits high specificity and sensitivity, ensuring reliable and accurate results. This antibody is compatible with various sample types, including</p>

<p>Cytochrome P450 2C19 (CYP2C19) is an enzyme that metabolizes retinoic acid, which is an important signaling molecule in the development and homeostasis of various tissues. CYP2C19 also metabolizes a variety of other compounds including xenobiotics such as drugs, carcinogens and environmental pollutants. CYP2C19 has been found to have a polymorphism at position 331 (I331V), which has been shown to be associated with an increase in metabolism of retinoic acid. This variant leads to increased activity for the enzyme and can result in vitamin A deficiency, hypervitaminosis A or teratogenicity.</p>

<p>Please enquire for more information about 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranose including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PF-06658607 is an investigational drug that is classified as a small molecule inhibitor. It is developed from synthetic chemical sources with a specific mode of action targeting aggrecanases, enzymes that degrade aggrecan, a critical component of cartilage. By inhibiting these enzymes, PF-06658607 aims to prevent the breakdown of cartilage in joints.</p>

<p>L 162389 is a synthetic, non-steroidal, anti-inflammatory drug (NSAID) that inhibits the enzyme cyclooxygenase. It inhibits the production of prostaglandins, which are known to cause pain and inflammation in the body. L 162389 is used for the treatment of inflammatory conditions such as rheumatoid arthritis and osteoarthritis.</p>

<p>Panulisib is a Toll-like receptor (TLR) modulator that inhibits the TLR signaling pathway. It has been shown to inhibit the replication of certain viruses and to induce significant cytotoxicity in cancer cells. Panulisib binds to the toll-like receptor 7 (TLR7) and prevents it from activating downstream signaling pathways, which may be due to its ability to inhibit endothelial cell proliferation. The drug also shows some activity against hepatitis B virus-induced hepatitis in preclinical studies. In addition, panulisib inhibits growth factor signaling pathways and suppresses tumorigenesis by inhibiting the downstream effects of angiogenesis.</p>

<p>Debio-0827 is a peptide that activates the human G protein coupled receptor (GPCR) of the serotonin type 2A (5HT2A) receptor. It has been used as a research tool for studying the activation of 5HT2A receptors and their effects on ion channels and protein interactions. Debio-0827 is a potent inhibitor to the binding of ligands to 5HT2A receptors, which may be used in pharmacological studies.</p>

<p>2A peptide-linked polycistronic vectors can be used to express multiple proteins from a single open reading frame (ORF). The small 2A peptide sequences, when cloned between genes, allows for efficient, stoichiometric production of discrete protein products within a single vector through a novel "cleavage" event within the 2A peptide sequence. 2A was discovered in the foot-and-mouth disease virus (FMDV, a picornavirus). The 2A peptide acts through ribosomal skipping to allow for the encoding of polyproteins which can dissociate into individual proteins upon translation. Anti-T2A antibody recognises 2A tagged recombinant proteins and is an excellent tool for researchers using 2A peptide based expression systems.<br>0.2mg/ml TEA (Rb L02T), 0.5mg/ml Glycine (Rb L02G). Used for ELISA (1:1000). Reacts with T2A tag.</p>