Heterocycles with Nitrogen (N)

<p>Applications 2-(1-Adamantyl)-4,5-dihydro-1H-imidazole (cas# 52725-79-8) is a useful research chemical.<br></p>

<p>Applications 1-Phenyl-3-pyrrolidinone-d5 is the isotope labelled analog of 1-Phenyl-3-pyrrolidinone (P336730); a reagent used in the synthesis of a series of non-classical antifolates which were evaluated for their in vitro cytotoxicity. Also used in the preparation of azetidine- and pyrrolidine-containing alkynes as mGluR5 regulators.<br>References Huang, Y., et al.: Bioorg. Med. Chem., 11, 145 (2003); Chen, L., et al.: PCT Int. Appl. WO 2014124560 A1 20140821. Aug 21, 2014<br></p>

<p>Applications 2-Benzoylpyrrole (cas# 7697-46-3) is a compound useful in organic synthesis.<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 1-Octyl-4-(1-octylpyridin-1-ium-4-yl)pyridin-1-ium dibromide is a viologen and chromophore used in low-energy driven electrochromic devices comprising of polymeric ionic liquids.<br>References Lu, H.; et al.: ACS Appl. Mater. Interfaces, 8, 30351 (2016).<br></p>

<p>Applications 5-Amino-4H-1,2,4-triazole-3-carboxylic Acid is a building block used in the synthesis of purine nucleotide analogs by a promiscuous hypoxanthine phosphoribosyltransferase.<br>References Scism, R.A., et. al.: Org. Lett., 9, 4179 (2007)<br></p>

<p>Applications 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide (cas# 1189858-48-7) is a compound useful in organic synthesis.<br></p>

<p>Applications A stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. Useful reagent in peptide synthesis.<br>References Baslow, M., et al.: J. Inherit. Metab. Dis., 23, 684 (2000), Lee, Y., et al.: Bioorg. Med. Chem. Lett., 10, 2771 (2000), Baslow, M., et al.: Neurochem. Res., 27, 403 (2002),<br></p>

<p>Applications Methyl 4-hydroxy-1H-pyrrole-2-carboxylate is a useful reagent for organic synthesis.<br></p>

<p>Applications Fmoc-1-pyrrolidine-3-carboxylic acid<br></p>

<p>Applications Isoxazolo[5,4-b]pyridin-3-amine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 6-Bromopiperonal is a disubstituted 1,3-benzodioxole that displayed synergistic activity with carbaryl on houseflies. 6-Bromopiperonal is used as an intermediate in the preparation of GPR30-selective agonist G-1.<br>References Wilkinson, C.F. et al.: J. Agric. Food Chem., 15, 139 (1967): Hewlett, P.S. et al.: J. Sci. Food Agric., 18, 279 (1967); Burai, R. et al.: Org. Biomol. Chem., 8, 2252 (2010);<br></p>

<p>Applications 4-Hydroxypiperidine-3,3,4,5,5-d5 (CAS# 1219799-35-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Nitropyrido[2,3-d]pyrimidin-4(3H)-one is a useful research chemical for organic synthesis and other chemical processes.<br></p>

<p>Applications 5-Aminopyrazine-2-boronic acid pinacol ester is a reagent for the synthesis of amino-pyrido-indol-carboxamides that acts as a JAK2 inhibitor used in the treatment of myeloproliferative disorder.<br>References Lim, J., et al.: J. Med. Chem., 54, 7334 (2011)<br></p>

<p>Applications 2-(3-Aminophenyl)pyridine Dihydrochloride<br></p>

<p>Applications Pyrrolidine-2,2,5,5-d4 Hydrochloride is the salt, labeled analogue of Pyrrolidine (P997950), a heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs).<br>References Li, X. et al.: Mini-Rev. Med. Chem., 10, 794 (2010); Gragutan, I. et al.: Beil. J. Org. Chem., 7, 699 (2011)<br></p>

<p>Applications 1-Ethyl-3-piperidinone Hydrochloride used in preparation of Aminoimidazoles.<br>References Sabbasani, Venkata R., et al.: Angewandte Chemie, 58, 18913-18917 (2019);<br></p>

<p>Applications tert-Butyl 4-(6-ethylthieno[3,2-d]pyrimidin-4-yl)piperazine-1-carboxylate is an intermediate for the synthesis of 6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride (E926745), which is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation.<br>References Grembecka, J. et al.: Nat. Chem. Biol., 8, 277 (2012)<br></p>

<p>Applications 6-Fluoro-4-methyl-2-pyridinamine can be synthesized from 2,6-Dichloro-4-methylpyridine (39621-00-6).<br></p>

<p>Applications 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinol, can be used for the synthesis of a novel series of [3.2.1] azabicyclic biaryl ethers as α3β4 and α6/4β4 nicotinic receptor agonists.<br>References Lowe, J. A., et al.: Bioorg. Med. Chem. Lett., 20, 4749 (2010);<br></p>

<p>Applications 4-(chloromethyl)-3,5-dimethyl-1H-pyrazole (cas# 152239-41-3) is a useful research chemical.<br></p>

<p>Applications 2,4-Diamino-6-hydroxypyrimidine-15N4 is an intermediate in the synthesis of 2’-Deoxyguanosine-5N5 which is a nucleoside.<br>References Krenitsky, T.A., et al.: Biochemistry, 20, 3615 (1981), Chapeau, M.-C., et al.: Chem. Res. Toxicol., 4, 636 (1991),<br></p>

<p>Applications 5-[4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-chloro-4-fluorobenzoic Acid is an intermediate in the synthesis of Fluazolate (F407500), the active ingredient in the preparation of agrochemicals and drugs in amorphous form.<br></p>

<p>Applications N-BOC-Piperidin-4-ylmethyleneboronic acid pinacol ester is a useful research chemical.<br></p>

<p>Applications N-Butyryl-4-(S)-phenylmethyl-2-oxazolidinone (cas# 112459-79-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Imidazo[1,2-a]pyridine-6-boronic acid is a useful intermediate for organic synthesis and other pharmaceutical processes.<br>References Gonzalez C., et al.: J. Med. Chem., 55, 11022 (2012); Cooper, A. B., et al.: Bioorg. Med. Chem. Lett., 27, 4471 (2017)<br></p>

<p>Applications 2-(1-(4-Bromophenyl)-1H-1,2,3-triazol-4-yl)propan-2-ol<br></p>

<p>Applications ethyl 4-(hydroxymethyl)piperidine-1-carboxylate (cas# 118156-56-2) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxypiperidine-d9 is labelled 4-Hydroxypiperidine (H950845) which is used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.<br>References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999)<br></p>

<p>Applications 2-Fluoro-5-bromopyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. Also used in the synthesis of benzofurano[3,2-d]pyrimidin-2-one derived inhbitors.<br>References Li, J. et al.: J. Med. Chem., 56, 6216 (2013); James, C. et al.: Bioorg. Med. Chem. Lett., 23, 2781 (2013);<br></p>

<p>Applications [3-(Trifluoromethyl)-1H-pyrazol-4-yl]boronic Acid Pinacol Ester is a chemical reagent used in the synthesis of carboxamides used in the treatment of lymphomas, psoriasis and endometriosis.<br></p>

<p>Applications 3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid<br></p>

<p>Applications 2-propylpiperidine (cas# 3238-60-6) is a useful research chemical.<br></p>

<p>Applications [3-(2-Amino-6-methoxy-4-pyrimidinyl)phenyl](3,6-dihydro-4-methyl-1(2H)-pyridinyl)-methanone is a useful chemical for cancer immunotherapy research.<br></p>

<p>Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications Ethyl 4-Methyl-1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylate is an intermediate used in the synthesis of 4-Methyl-1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylic Acid (M339120), which is an impurity of the drug Amphetamine (A634248).<br></p>

<p>Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d16-1-oxyl (CAS# 36763-53-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-(Bromomethyl)-2-fluoropyridine is a useful reagent for preparation of N-Benzylisatinsulfonamides as potent caspase-3 inhibitors.<br>References Chu, W., et al.: J. Med. Chem., 48, 7637 (2005);<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Used in the synthesis of peptides. Contains up to 10% imidazole.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pierschbacher, M., et al.: Nature, 309, 30 (1984),<br></p>

<p>Applications 2,5,6-Triamino-4(3H)-pyrimidinone Sulfate is used in the preparation of guanines and other purine derivatives with antiviral activities.<br>References Hemmati, S. et al.: Int. J. Chem. Sci., 2, 9 (2004); Chetsanga, C.J. et al.: Chem.-Biol. inter., 58, 117 (1986);<br></p>

<p>Applications 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine is an intermediate in the synthesis of Blonanserin (B595850), a 5-HT2 serotonin receptor and D2 dopamine receptor antagonist, used as an antipsychotic.<br>References Oka, T., et al.: Life Sci., 76, 225 (2004), Singh, A., et al.: Int. Med. J., 12, 175 (2005), Ochi, T., et al.: Bioorg. Med. Chem., Lett., 15, 1055 (2005),<br></p>

<p>Applications 6-Methyl-2,3'-bipyridine (cas# 78210-78-3) is a useful research chemical.<br></p>

<p>Applications N-[5-(4-Bromophenyl)-6-[2-(2-pyrimidinyloxy)ethoxy]-4-pyrimidinyl]-N'-propyl-sulfamide is a degradation product of Macitentan (M105005).<br>References Thummar, Mohit, et al.: Chromatographia, 81(3), 525-531 (2018)<br></p>

<p>Applications 3-(Pyridin-2-yl)propiolic Acid is a useful reagent in the regioselective Pd-catalyzed carbopalladation/decarboxylative allylic alkynylation of ortho-iodoallenamides.<br>References Hedouin, J., et al.: J. Org. Chem., 84, 10535 (2019)<br></p>

<p>Applications 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile (cas# 33097-13-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-amino-6-cyanopyridazine (cas# 340759-46-8) is a useful research chemical.<br></p>

<p>Applications 2,5-Diamino-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one (cas# 22288-77-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-methyl-2-oxo-4-[(5,6,7,8-tetrahydronaphthalen-2-yl)amino]-1,2-dihydropyridine-3-carboxylic acid (cas# 1239521-17-5) is a useful research chemical.<br></p>

<p>Applications N,N-Diethyl-3-pyrrolidinamine Dihydrochloride (cas# 20984-82-1) is a useful research chemical.<br></p>

<p>Applications 4-Benzyloxazolidine-2,5-dione (cas# 583-47-1) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxypyridine, is a building block used in various chemical synthesis. It is used for the synthesis of bicyclic pyridinol analogues acting as antioxidants and capable of preserving mitochondrial function.<br>References Xiaoqing, X. C., et al.: Bioorg. Med. Chem., 20 (11), 3584 (2012);<br></p>

<p>Applications (4-Chlorobenzo[b]thiophen-2-yl)(piperazin-1-yl)methanone is a useful research chemical.<br></p>

<p>Applications Shows systemic antifungal activity accompanied by high levels of phytotoxicity.<br>References Carter, G.A., et al.: Ann. Appl. Biol., 84, 333 (1976)<br></p>

<p>Applications A substituted pyrimidine used in the study for prediction of relative potency of ketone protease inhibitors using molecular orbital theory.<br>References Chan, A. W. E., et al.: Bioorg. Med. Chem., 4, 1673 (1996),<br></p>

<p>Applications 5-(Aminomethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one Hydrochloride is a useful research chemical.<br></p>