Heterocycles with Nitrogen (N)

<p>Applications 1-Ethyl-2-piperazinone is used in the synthesis of piperidine and piperazine derivatives as cognition enhancers.<br>References Bioorg, Med. Chem., 16, 1431 (2008);<br></p>

<p>Applications 2-Chloromethyl-3,5-dimethylpyridin-4-one (cas# 1114596-75-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Amino-5-iodopyridine (cas# 20511-12-0) is a compound useful in organic synthesis.<br></p>

<p>Applications An intermediate of fluorobenzoylpiperidinopropylbenzodiazepinone as anticonvulsants and antiepileptics.<br></p>

<p>Applications 1-Phenyl-2-(4-N-Cbz-phenylamino-piperidin-1-yl)-propan-1-one (cas# 936498-12-3) is a useful research chemical.<br></p>

<p>Applications tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-aminopyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate (cas# 1448436-04-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Aminothieno[3,2-d]pyrimidine is a useful research intermediate<br>References Robba, M., et al.: Tetrahedron, 27, 487 (1971); Park, J. H., et al.: Heterocycles, 91, 835 (2015)<br></p>

<p>Applications 5-(N,N-Diethylcarboxamide)-1-phenylpyridin-2(1H)-one (cas# 1076199-97-7) is a compound useful in organic synthesis.<br></p>

<p>Applications (R)-4-isobutyl-1-(((2R,3S,4S,5R)-2,3,4,5-tetrahydroxytetrahydro-2H-pyran-2-yl)methyl)pyrrolidin-2-one is a useful chemical reagent.<br></p>

<p>Applications 5-Bromohexahydro-2,6-dioxo-4-pyrimidinecarboxylic Acid-15N2 is an intermediate used in the synthesis of Orotic Acid-15N2 Monohydrate (O691504), which is a labeled analogue of Orotic Acid Monohydrate (O691500) that is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment. Also, it is the labeled form of 5-Bromohexahydro-2,6-dioxo-4-pyrimidinecarboxylic Acid (B699363), an intermediate in synthesizing Orotic Acid Monohydrate (O691500), which is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.<br></p>

<p>Applications 2-Chloro-5-(phenylsulfonyl)pyridine is a starting material and useful building block of various pharmaceuticals.<br></p>

<p>Stability Hygroscopic<br>Applications 2-(2-Fluorophenyl)pyrrolidine<br></p>

<p>Applications 5-(1-Piperazinyl)-2-Benzofurancarboxylic Acid Ethyl Ester Diydrochloride Hydrate cas# 1422956-31-7) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 3,​3',​3''-​(2,​4,​6-​boroxintriyl)​tris-Pyridine Hydrochloride is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications 2-Aminopyrimidine-5-boronic acid<br></p>

<p>Applications 2-Acetyl-3,4,5,6-tetrahydropyridine-d4 Hydrochloride, is the labeled analogue of 2-Acetyl-3,4,5,6-tetrahydropyridine Hydrochloride (A188500), the most important bread flavor component.<br>References Buttery, R.G., et al.: J. Agric. Food Chem., 43, 1878 (1995),<br></p>

<p>Applications 2-(1-Piperidino)aniline is used to prepare oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. It is also used to synthesize benzimidazole derivatives as AMP-activated protein kinase activators.<br>References Liu, G., et al.: J. Med. Chem., 46, 2093 (2003); Charton, J., et al.: Bioorg. Med. Chem., 14, 4490 (2006)<br></p>

<p>Applications 5-BROMO-1H-IMIDAZO[4,5-b]PYRAZINE (cas# 91225-41-1) is a useful research chemical.<br></p>

<p>Applications An intermediate in the preparation of Pipradrol Hydrochloride<br></p>

<p>Applications Used in the preparation of heterocyclic compounds of pharamaceutical interest.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Di Fabio, R., et al.: J. Med. Chem., 51, 7370 (2008), Vaccaro, W., et al.: Bioorg. Med. Chem. Lett., 18, 6381 (2008),<br></p>

<p>Applications Methyl 3,6-dichloropyridine-2-carboxylate<br></p>

<p>Applications 5-Amino-1-tert-butyl-3-(3-methylbenzyl)-4-cyanopyrazole (cas# 1185162-28-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Pyridine-3,5-dicarboxamide (cas# 4663-99-4) is a useful research chemical.<br></p>

<p>Applications 6-methyl-2-oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid (cas# 10176-79-1) is a useful research chemical.<br></p>

<p>Applications 3H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine (cas# 706757-05-3) is a useful research chemical.<br></p>

<p>Applications Imidazo[1,2-a]pyridine-6-carboxylic acid<br></p>

<p>Applications tert-Butyl 4-(3-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate (cas# 1211876-26-4) is a useful reagent for the preparation of heterocyclic compounds as CaMKII inhibitors.<br>References Matsunaga, N., et al.: PCT Int. Appl. (2018) WO 2018183112 A1<br></p>

<p>Applications 4-Amino-1,5-dimethylpyrazole is used in the preparation of pyridine compounds as focal adhesion kinase inhibitors.<br></p>

<p>Applications 5-[2-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxylic acid (cas# 1003561-80-5) is a useful research chemical.<br></p>

<p>Applications Isotope labelled B-[1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]boronic Acid is used in the preparation of ALK receptor mediators.<br></p>

<p>Applications 7-(3-Bromophenyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (cas# 933054-30-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Nitro-2-(propylthio)pyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 4'-(Imidazol-1-yl)acetophenone (cas# 10041-06-2) is a useful research chemical.<br></p>

<p>Applications 5-(BROMOMETHYL)-2-NITROPYRIDINE (cas# 448968-52-3) is a useful research chemical.<br></p>

<p>Applications 3-phenyl-1H-pyrrole-2-carboxylic acid (cas# 802052-63-7) is a useful research chemical.<br></p>

<p>Applications 4-Bromo-2-(methoxymethyl)pyridine (cas# 864412-04-4) is a useful research chemical.<br></p>

<p>Applications Ethyl 2,5-Dibromo-1,3-oxazole-4-carboxylate is useful for the synthesis of substituted oxazoles.<br>References Hodgetts, K. J., et al.: Org. Lett., 4, 2905-2907 (2002)<br></p>

<p>Applications 4-Pyridineacetic Acid Hydrochloride is used in the preparation of a highly tumor-selective organometallic ruthenium(II)-Arene complex.<br>References Clavel, C.M., et. al.: J. Med. Chem., 57, 3546 (2014)<br></p>

<p>Applications Used for preparation of substituted phenyl-containing imidazolium ionic liquid.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Peris, E., et al.: Coord. Chem. Rev., 248, 2239 (2004),<br></p>

<p>Applications 4-Cyclohexyl-2-piperidinecarboxylic Acid is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Oxo-2-(1-phenyl-1H-pyrazol-4-yl)acetic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.<br>References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)<br></p>

<p>Applications 1-(4-Hydroxyphenyl)piperazine<br></p>

<p>Applications 2-​(Methoxy-​d3)​-​3-​(1-​methylethyl)​pyrazine is a useful compound in the study of isotope effect in gas liquid chromatography separation of deuterated and nondeuterated compounds using ionic liquid stationary phases.<br>References Schmarr, H., et al.: J. Chromatogr. A., 1270, 310 (2012);<br></p>

<p>Applications 5-Bromo-4-chloro-2,6-dimethoxypyrimidine (cas# 42362-16-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Hydroxypyrimidine Hydrochloride, is used as a reagent in the synthesis of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for potential treatment of chronic hepatitis C virus infection.<br>References Beaulieu, P.L., et al.: J. Med. Chem., 57, 10130 (2014)<br></p>

<p>Applications 5-(trifluoromethyl)dihydropyrimidine-2,4(1H,3H)-dione (cas# 2145-56-4) is a useful research chemical.<br></p>

<p>Applications (2,3-Dimethylpyridin-4-yl)boronic Acid is used to prepare substituted azaanthracene derivatives as GLP-1 receptor modulators useful in the treatment of GLP-1 receptor-mediated diseases<br>References Mjalli, A., et al.: PCT Int. Appl. (2010), WO 2010114824 A1 20101007<br></p>

<p>Applications 2-Hydroxy-N-(pyridin-4-yl)butanamide is a useful synthetic intermediate.<br></p>