Heterocycles with Nitrogen (N)

<p>Applications 6-chloro[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas# 33050-32-7) is a useful research chemical.<br></p>

<p>Applications 5-(2-Pyridyl)-1,2-dihydropyridin-2-one is used in the synthesis of AMPA receptor antagonists in the treatment of neurological diseases causing dysfunction of glutamatergic neurotransmission.<br>References Hibi, S. et al.: J. Med. Chem., 55, 10584 (2012); McElhinny, C. et al.: Synthesis, 44, 57 (2012);<br></p>

<p>Applications 2,3,5,6-Tetramethylpyrazolo[1,2-a]pyrazole-1,7-dione (cas# 68654-22-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,6-Dimethyl-3,5-dicarboxy-4-(2-nitrophenyl)-1,4-dihydropyridine is used as a reactant in the preparation of hydroxyindolecarboxylate and hydroxycarbolinecarboxylate from nifedipine analogous cyanoethyl ester.<br>References Gorlitzer, K., et al.: Pharmazie, 55, 35 (2000)<br></p>

<p>Applications 4,5-Dicyanoimidazole is commonly used in activation of nucleoside phosphoramidites during solid-phase oligonucleotide synthesis, and synthesis of nucleoside phosphoramidites, synthesis of novel nucleosides. IT is often used as an alternative to Tetrazole (T307500).<br>References Vargeese, C., et al.: Nucleic Acid Res.,  26 1046 (1998); Jin, Y., et al.: Tetrahedron Lett., 37, 973 (1996); Lackey, J., et al.: J. Am. Chem. Soc., 131, 8496 (2009)<br></p>

<p>Applications 6-(Dimethylamino)pyridine-3-boronic acid<br></p>

<p>Applications tert-Butyl 6-(Hydroxymethyl)pyridin-3-ylcarbamate, is a reagent in the monitoring of dynamic glycosylation in vivo using supersensitive click chemistry in mammalian cells and in early zebra fish embryogenesis.<br>References Jiang, H., et al.: Bioconjugate Chem., 25, 698 (2014)<br></p>

<p>Applications Used in the preparation of Eszopiclone (E889150) impurity.<br>References Sha, Y. et al.: Molecules 13, 1817(2008).<br></p>

<p>Applications 1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride (cas# 89501-93-9) is a useful research chemical.<br></p>

<p>Applications 2-Nitro-3-pyridinol may be used in the synthesis of novel sulfonates that are potent inhibitors of cell proliferation and tubulin polymerization. It may also be used to prepare (aminoaryl)(benzyloxy)pyridines as potential antitumor agents.<br>References Gwaltney, S., et al.: Bioorg. Med. Chem. Lett., 11, 1671 (2001); Cui, J., et al.: J. Med. Chem., 54, 6342 (2011)<br></p>

<p>Applications H-D-Phe-Homopro-Arg-pNA.2 Acetate is a useful organic reagent.<br></p>

<p>Applications 2-Amino-3-pyridinecarbonitrile is used as a reagent in the synthesis of novel imidazo[1,2-a]pyridine derivatives as potent c-Met inhibitors and antimycobacterials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, C., et al.: ACS Med. Chem. Lett., 6, 507 (2015); Ramachandran, S., et al.: Bioorg. Med. Chem. Lett., 23, 4996 (2013)<br></p>

<p>Applications Contains up to 5 % Sodium Acetate by weight.<br></p>

<p>Applications 2-Piperidin-4-yl-1H-benzimidazole is used as a reagent in the synthesis of 3-amino-1-(5-indanyloxy)-2-propanol derivatives as potent sodium channel blockers for the treatment of ischemic stroke. Also used as a reagent in the synthesis of 2,3,5-trisubstituted pyridine derivatives as potent Akt1/Akt2 dual inhibitors.<br>References Seki, M., et al.: Chem. Pharm. Bull., 60, 488 (2012); Zhao, Z., et al.: Bioorg. Med. Chem. Lett., 15, 905 (2005)<br></p>

<p>Applications Boronic acid derivatives and their binding affinities with diols.<br>References Yang, W., et al.: Bioorg. Med. Chem. Lett., 12, 2175 (2002), Yang, W., et al.: Med. Res. Rev., 23, 346 (2003),<br></p>

<p>Applications 3-Isopropenyl-2-oxo-1-benzimidazolinebutyric Acid Ethyl Ester (cas# 116199-87-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-{3H-Imidazo[4,5-c]pyridin-2-yl}aniline is derived from 3,4-Diaminopyridine (D415950), which is used as a reagent in the preparation of 9-deazaxanthine derivatives which had activity as dual antagonists/MAO-B inhibitors with potential as anti-Parkinson’s agent.<br>References Rivara, S., et al.: J. Med. Chem., 56, 1247 (2013)<br></p>

<p>Applications 4-​(4-​Amino-​3-​fluorophenoxy)​pyridine-​2-​carboxamide is a reagent used in the synthesis of heterocyclic urea derivatives as kinase inhibitors in the treatment of myeloproliferative and other diseases.<br>References Flynn, D. et al.: PCT Int. Appl. (2013), WO 2013036232 A2 20130314;<br></p>

<p>Applications B-[2-(Methylamino)-4-pyridinyl]boronic Acid Hydrochlroide, is used to prepare novel selective thiazoleacetic acids as CRTH2 antagonists.<br>References Grimstrup, M., et al.: Bioorg. Med. Chem. Lett., 20, 1181 (2010)<br></p>

<p>Applications 3-Bromo-1-(triisopropylsilyl)pyrrole<br></p>

<p>Applications N-Acetylpiperazine-d4 is labelled N-Acetylpiperazine-d4 which was used to prepare (aryl)sulfanyltriazoles with HIV-1 non-nucleoside reverse transcriptase inhibiting activities. It was also used to synthesize diphenylpyrazolecarboxamides as heat shock protein chaperone inhibitors and anticancer agents.<br>References Wang, Z., et al.: Bioorg. Med. Chem. Lett., 16, 4174 (2006); Brough, P., et al.: J. Med. Chem, 51, 196 (2008)<br></p>

<p>Applications 5-Formyl-2-methylpyrimidine (cas# 90905-33-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(2-Pyridinyl)benzotriazole (cas# 13174-93-1) is a compound useful in organic synthesis.<br></p>

<p>Applications (4S)​- 5,​5-​Dimethyl-​2-​[[[(5-​methyl-​3-​phenyl-​4-​isoxazolyl)​carbonyl]​amino]​methyl]​-4-​thiazolidinecarboxyl​ic acid is a useful reactant.<br></p>

<p>Applications 1-Pyridin-2-yl-propan-2-one is an antimicrobial bioactive compound extracted from Lactarius vellereus fermenting liquor.<br>References Ji, H., et al.: Beijing Linye Daxue Xuebao, 30, 92 (2008); Song, R., et al.: From Faming Zhuanli Shenqing (2008), CN 101230368 A 20080730;<br></p>

<p>Applications 2,3-Diaminopyridine is used as a reagent in the synthesis of novel imidazopyridine derivatives which can exhibit cytotoxic activity against MCF-7 human breast adenocarcinoma cell line. 2,3-Diaminopyridine is also used in the preparation of non-camptothecin topoisomerase I inhibitors which exhibit antitumor activity.<br>References Puskullu, M.O., et al.: Chem. Heterocyc. Compd., 51, 723 (2015); Zhang, C., et al.: Bioorg. Med. Chem. Lett., 25, 4693 (2015)<br></p>

<p>Applications methyl 2-amino-5-benzyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-3-carboxylate (cas# 1428234-04-1) is a useful research chemical.<br></p>

<p>Applications 4-PIPERAZIN-1-YL-QUINOLINE DIHYDROCHLORIDE (cas# 1350361-89-5) is a useful research chemical.<br></p>

<p>Applications 1-(2-bromophenyl)piperazine (cas# 1011-13-8) is a useful research chemical.<br></p>

<p>Applications 1H-1,2,4-Triazole-3-carboxylic acid, 1-ethyl-, methyl ester (cas# 1034197-43-7) is a useful research chemical.<br></p>

<p>Applications (R)-Benzyl 2-((5-bromo-1H-indol-3-yl)methyl)pyrrolidine-1-carboxylate is used in the preparation of indole-derivative serotoninergic receptor agonists.<br></p>

<p>Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol-d3 is the isotope labelled analog of α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol (D473780); a reagent in the synthesis of Medetomidine (M203250) which is an α2-adrenergic agonist. Also a sedative and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010<br></p>

<p>Applications A useful synthetic intermediate<br></p>

<p>Applications N-1H-Imidazol-2-yl-formamide is used as a reagent in the synthesis of N-pyridinyl-2-[(thienylcarbonyl)amino]benzamides and its analogs as anticoagulants.<br>References Arnaiz, D.O., et al.: U.S. US 6140351 A 20001031. Oct 31, 2000<br></p>

<p>Applications (±)-N-(2,6-Dimethylphenyl)-1-iso-propyl-d7-2-piperidinecarboxamide (CAS# 1276197-11-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications methyl 1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyrazole-5-carboxylate (cas# 929899-20-7) is a useful research chemical.<br></p>

<p>Applications 1-PHENYL-3-(PIPERIDIN-1-YL)PROPAN-1-ONE HCL (cas# 886-06-6) is a useful research chemical.<br></p>

<p>Stability Air Sensitive<br>Applications [1,2,4]Triazolo[4,3-a]pyridine-3-thiol (cas# 6952-68-7) is a useful research chemical.<br></p>

<p>Applications 5-Methyl-pyrazine-2-carboxylic Acid (cas# 5521-55-1) is a compound useful in organic synthesis.<br></p>

<p>Applications (αR)-α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxy-benzeneacetic Acid is an intermediate used to prepare Cephalosporin derivatives with activities against both Gram-positive and Gram-negative bacteria.<br>References Albrecht, H., et al.: J. Med. Chem., 37, 400 (1994)<br></p>

<p>Applications 2-Amino-3-bromopyrazine-5-carboxylic Acid (cas# 887352-34-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Dichloro-5-trifluoromethylpyrimidine is a reactant in the preparation of pyrimidine derivatives as inhibitors of gene ALK protein Kinase phosphorylating kinase and as cell proliferation inhibitors.<br>References Yang, E.H., et. al.: Bull. Korean Chem. Soc., 34, 3129 (2013)<br></p>

<p>Applications 2-Benzotriazol-1-yl-propionic acid is used in the synthesis of N-substituted benzotriazole/morpholine derivatives which has antiinflammatory anthelmintics properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Upadhyay, R. K., et al.: J. In. Coun. Chem., 9, 36 (1993);<br></p>

<p>Applications 4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride (cas# 62002-31-7) is a useful research chemical.<br></p>

<p>Applications (1-Ethyl-piperidin-3-yl)-carbamic Acid tert-Butyl Ester is an intermediate in the synthesis of 4-Amino-N-(1-ethyl-3-piperidinyl)-5-(ethylsulfonyl)-2-methoxybenzamide (A609495), which is an impurity of Amisulpride (A633250). Amisulpride EP Impurity G.<br>References Elslager, E.F., et al.: J. Med. Chem., 24, 127 (1981)<br></p>

<p>Applications 3,5-Diphenylpyrazole (cas# 1145-01-3) is a useful research chemical.<br></p>

<p>Applications 2,2,2-trifluoro-1-(3-hydroxypiperidin-1-yl)ethan-1-one (cas# 73193-62-1) is a useful research chemical.<br></p>

<p>Applications N-2-Pyridinyl-1,2-ethanediamine is a reactant used in the synthesis of dual histamine H1 and H2 receptor antagonists based on cyanoguanidine. Also used in the synthesis of 2-thiohydantoins as somatostatin receptor ligands,<br>References Sadek, B. et al.: Molecules, 18, 14186 (2013); Wang, X. et al.: Lett. Drug Design. DIsc., 9, 655 (2012);<br></p>

<p>Applications 2-[4-(3-Trifluoromethylphenyl)-1-piperazinyl]propanol is an intermediate in the synthesis of Antrafenine (A697800), a phenylpiperazine derivative drug used as an analgesic and anti-inflammatory.<br>References Meguro, K., et al.: Chem. Pharma. Bull., 33, 3787 (1985);<br></p>

<p>Applications N,N-Diethyl-3-pyrrolidinamine Dihydrochloride (cas# 20984-82-1) is a useful research chemical.<br></p>

<p>Applications 2,4,6-Trimethylpyridine-d11 (CAS# 1219805-54-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-α-D-Arabinofuranosyl-2-nitro-1H-imidazole is a synthon for a number of potential markers of tissue hypoxia.<br>References Naimi, E., et al.: Nucleosides. Nucleotides. Nuc. Acid., 24, 173 (2005); Schneider, R.F., et al.: J. Label. Comp. Radiopharma., 39, 541 (1997); Sakaguchi, M., et al.: J. Med. Chem., 26, 20 (1983);<br></p>

<p>Applications 3,5-Diethyl 1H-pyrazole-3,5-dicarboxylate<br></p>

<p>Applications 5,6-Diamino-2-hydroxybenzimidazole (cas# 55621-49-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-cyclopropyl-3-phenylpiperazine (cas# 1248907-49-4) is a useful research chemical.<br></p>

<p>Applications 4,6-Dichloroimidazo[4,5-c]pyridine (cas# 2589-12-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one is used as a reactant in the preparation of pyrido[2,3-d]pyrimidin-7-one derivatives as selective inhibitors of cyclin-dependent kinases 4 and 6.<br>References VanderWel, S., et al.: J. Med. Chem., 48, 2371 (2005); Toogood, P., et al.: J. Med. Chem., 48, 2388 (2005);<br></p>

<p>Applications 1,1'-Ethylenedipiperazine Hydrochloride Salt is the salt form of 1,1'-Ethylenedipiperazine, which is used in the synthetic preparation of novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazoles as anticancer agents.<br>References Zhang, R.; et al.: Bioorganic Med. Chem., 19, 7023 (2011)<br></p>

<p>Applications 6-Chloro-2-methoxypyridine-3-boronic acid<br></p>