Building Blocks

Stability Light Sensitive
Applications Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor & anti-cancer activity.

Applications 1-Phenyl-2,4-pyrrolidinedione is a synthetic intermediate and is obtained from N-Phenylglycine Ethyl Ester and Diethyl Malonate (D444420) which is used in the preparation of barbiturates, artificial flavourings, vitamin B1, and vitamin B6 as well as in perfumes.
References Svhreier, P. et al.: J. Agric. Food. Chem., 27, 365 (1979); Opdyke, D.L.J.: Food Cosm. Toxicol., 14, 745 (1976);

Applications NS 3623 selectively activates the human ether-a-go-go related gene (hERG) potassium channel which mediates the repolarizing cardiac current IKr. NS 3623 an IKr agonist, cause QT interval prolongation, increasing the risk of dangerous ventricular fibrillations, eventually leading to sudden cardiac death.
References Hansen, R. et al.: J. Cardiovas. Pharmacol., 52, 35 (2008)

Applications 1-Pyrrolidinebutyric Acid Hydrochloride is used in biological studies in the preparation of betaine analogs of mildronate as inhibitors of γ-butyrobetaine hydroxylase, and crystal structures of BBOX-inhibitor complexes.
References Tars, K., et al.: J. Med. Chem., 57, 2213 (2014);

Applications 17alpha-Ethynylestradiol-16,16-d2 3-Methyl Ether is a useful isotopically labeled compound of Mestranol (M258755)

Applications 3,4-(Methylenedioxy)phenylacetic Acid (cas# 2861-28-1) is a compound useful in organic synthesis.
References Perez-Medrano, A., et al.: J. Med. Chem., 52, 3366 (2009), Moon, J., et al.: Bioorg. Med. Chem. Lett., 20, 734 (2010),

Applications 3-Pyrrolin-2-one is an oxo analogue and oxidation product of pyrrole.
References Bocchi, V. et al.: Chim. Indust., 49, 1346 (1967);

Applications N-ethyl-3,4-dimethoxyaniline (cas# 32953-13-2) is a useful research chemical.

Applications Benzouracil is a building block used in many fragment-based drug design. Benzouracil is an alkaloid from marine bryozoan.
References Krimm, I.: MedChemComm, 3, 605 (2012); Tian, X.R., et. al.: Biochem. Syst. Ecol., 38, 1250 (2010)

Applications Reagent used in the preparation of pharmaceutically active Dibenzocyclohenptenes.

Applications Intermediate in the production of Isosafrole and Ethylone.
References Katoch-Rouse, R., et al.: J. Med. Chem., 46, 642 (2003), Andrade, E., et al.: Chem. Biodivers., 5, 197 (2008),

Applications n-Heptyl-d15 Alcohol (CAS# 194793-95-8) is a useful isotopically labeled research compound.

Applications 2-Methoxycarbonylphenylboronic acid

Applications Sodium Hexanoate-6,6,6-d3 (CAS# 1219794-91-8) is a useful isotopically labeled research compound.

Applications The Dihydrochloride salt of Methanediamine (M260225) in used in synthesizing FK-506 3’-Methyl Ether (F370010).
References Matsumura, H., et al.: J. Colloid. Interface. Sci., 139, 331-336 (1990)

Applications Pyrrole-2-carboxylic Acid is a reagent used in the synthesis of potent small molecule inhibitors of severe acute respiratory syndrome (SARS) coronavirus. Also used in the synthesis of [2,3-c]pyridine-7-one scaffolds.
References Jacobs, J. et al.: 56, 534 (2013); Nechayev, M. et al.: Mol. Div., 16, 749 (2012);

Applications Used as a building block for the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.
References Herschhorn, A., et al.: J. Med. Chem., 50, 3402 (2007),

Applications (±)-Tetrahydro-2-furoic-d7 Acid (CAS# 1219798-42-1) is a useful isotopically labeled research compound.

Applications Pyrrole-2,3,4,5-d4 (CAS# 17767-94-1) is a useful isotopically labeled research compound.

Applications 2,2,2-Trifluoroacetamide (cas# 354-38-1) is a useful research chemical.

Applications 4-(Methyl-d3-amino)butyric-2,2,3,3,4,4-d6 Acid HCl (CAS# 1219805-36-3) is a useful isotopically labeled research compound.

Applications 1,1'-(1,4-phenylene)bis-Ethanone can undergo oxidative C-C Bond Cleavage to synthesize an aryl carboxylic acid with an iodine catalyst . 1,1'-(1,4-phenylene)bis-Ethanone is also capable of Suzuki-Miyaura coupling.
References Xu, L.; et al.: Synlett, 29, 1505 (2018). Xia, Y.; et al.: J. Am. Chem. Soc., 140, 5347 (2018).

Applications Ethyl 5-(thiophen-2-yl)isoxazole-3-carboxylate is a useful reagent for organic synthesis.

Applications (Hydroxymethyl)pentafluorobenzene is a good analogue of Benzyl Alcohol (T536635). Benzyl Alcohol is a good substrate that has been used extensively for kinetic studies and evaluation of quantum mechanical tunneling.
References Plapp, B., et al.: 51,Biochemistry, 4035 (2012);

Applications Dehydroacetic Acid Sodium is used as a food additive, preservative, and antimicrobial agent.
References Sakaguchi, Y., et. al.: J. Appl. Toxicol., 28, 524 (2008); Sipes, N.S., et. al.: Chem. Res. Toxicol., 26, 878 (2013);

Applications NS 9283 is a positive allosteric modulator of α4β2 receptor affecting the potency of acetylcholine (Ach) related events. This has been linked to affect on everyday brain function including cognitive function and pain alleviation.
References Olsen, J. et al.: J. Biol. Chem., 288, 35997 (2013); Marotta, C. et al.: ACS Chem. Biol., 9, 1153 (2014);

Applications A nucleoside analog as potent inhibitor of purine nucleoside phosphorylase.
References Erion, M.D., et al.: J. Med. Chem., 36, 3771 (1993), Seela, F., et al.: Org. Biomol. Chem., 4, 3993 (2006), Hikishima S., et al.: Bioorg. Med. Chem. Lett., 17, 4173 (2007),

Applications 1,1,2-Trimethyl-1H-benzo[e]indole (cas# 41532-84-7) is a useful research chemical.

Applications N-Methylurea is used as a reagent in the synthesis of bis(aryl)(hydroxyalkyl)(methyl)glycoluril derivatives and is a potential byproduct of caffeine.
References Antonova, M.M., et al.: Chem. Heterocycl. Comp., 50, 503 (2014); Zarrelli, A., et al.: Sci. Total Environ., 470, 453 (2014)

Applications 1,2,4,5-Benzenetetracarboxylic Dianhydride-d2 (CAS# 106426-63-5) is a useful isotopically labeled research compound.

Applications (S)-4-Benzyl-3-[(S)-3-(2-bromo-4-methoxyphenyl)-2-(4-methoxyphenyl)_x000D_propanoyl]-2-oxazolidinone (cas# 917379-10-3) is a compound useful in organic synthesis.

Applications Pyromeconic acid is an important intermediate of synthesizing maltoland its homologous.
References Timmermann, B., et al.: J. Nat. Prod., 46, 365 (1983), Baruah, N., et al.: Phytochemistry, 36, 29 (1994),

Applications 4-Pyrrolidinopyridine is a catalyst employed in polymerization reactions.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ahmed, A., et al.: Polymer, 34, 1297 (1993); Gu, J., et al.: J. Appl. Polym. Sci. Symp., 50, 149 (1993); Zambrano, C., et al.: Polyhedron 12, 689 (1993)

Applications 3-(2,5-Dioxo-2,5-Dihydro-1h-Pyrrol-1-yl)benzoic Acid (cas# 17057-07-7) is a useful research chemical.

Applications 4,5,6,7-tetrahydro-1H-indazole-6-carboxylic acid (cas# 1354950-72-3) is a useful research chemical.

Applications 6-methyl-2-oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid (cas# 10176-79-1) is a useful research chemical.

Applications 1-Phenyldodecane-d30 (CAS# 352431-29-9) is a useful isotopically labeled research compound.

Applications 2-Bromo-3'-nitroacetophenone is a reagent used the preparation of arylthiazolidinone derivatives which have BRD4 bromodomain inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhao, L., et al.: J. Med. Chem., 56, 3833 (2013);

Applications 4-Hydroxy-5-methyl-3-furanone causes dephosphorylation of endothelial nitric oxide synthase (eNOS) at Thr-495 possibly via protein phosphatase 1 (PP1) and enhances eNOS activity in human vascular endothelial cells
References Schmitt, C., et al.: Cardiovasc. Res., 81, 750 (2009)

Applications m-Xylene-d4 (ring-d4) (CAS# 425420-97-9) is a useful isotopically labeled research compound.

Applications 2,6-Dimethylphenylboronic acid

Applications 3,3'-Dithiobis[6-nitrobenzoic Acid is an membrane-impermeant thiol/disulfide exchange blocker. 3,3'-Dithiobis[6-nitrobenzoic Acid is also used to quantify the number or concentration of thiol groups in a sample.
References Calderon, M.N., et al.: Intervirol., 55, 451 (2012); Li, J.M., et al.: J. Material. Chem., 22, 12100 (2012);

Applications 4-(3,5-Dimethylpyrazol-1-yl)phenylboronic acid, pinacol ester

Applications Chromone-3-carboxylic Acid (cas# 39079-62-4) is a useful research chemical.

Applications 1-(pyridin-4-yl)-1H-pyrazole-3-carboxylic acid (cas# 911463-81-5) is a useful research chemical.

Applications N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid-d15 (CAS# 1219794-63-4) is a useful isotopically labeled research compound.

Applications Benzyl-alpha,alpha-d2 Bromide (CAS# 51271-29-5) is a useful isotopically labeled research compound.

Applications Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.
References Sun, L. et al.: Cell, 148, 213 (2012);

Applications o-Nitrofluorobenzene is an intermediate in the synthetic preparations of various pharmaceutical goods.
References Ma. W., et al.: QSAR. Combin. Sci., 25, 895 (2006); Sutton, P.G., et al.: Analyst., 124, 877 (1999); Yi, W.B., et al.: J. Fluorine. Chem., 129, 524 (2008);

Applications 3-Bromothioanisole (cas# 33733-73-2) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications N,N-Dimethyl-d3-glycine HCl (N-methyl-d3) (CAS# 1219795-14-8) is a useful isotopically labeled research compound.

Applications 2-Bromothiophene (cas# 1003-09-4) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Chloro-3-hydroxybenzoic acid (cas# 51786-10-8) is a useful research chemical.

Applications 1-Pentane-d11-thiol is a useful isotopically labeled compound of 1-Pentanethiol (P274053)
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Methylpropyl-d9-amine HCl (CAS# 1219799-03-7) is a useful isotopically labeled research compound.

Applications 1-(2-Hydroxyethyl)lepidinium Bromide (cas# 26468-13-3) is a compound useful in organic synthesis.

Applications Phenyl-d5-acetylene (CAS# 25837-46-1) is a useful isotopically labeled research compound.

Applications 4,4-Dimethyl-1,3-cyclohexanedione (cas# 562-46-9) is a useful research chemical.

Applications 4,4-dimethyldihydrofuran-2,3-dione (cas# 13031-04-4) is a useful research chemical.

Applications 3,​3-​Dimethyl-​2,​4-​pentanedione is used in asymmetric hydrosilation of ketones.
References Kuwano, R., et al.: Bull. Chem. Soc. Jpn., 73, 485 (2000).

Applications Phenylacetylene-d6 (CAS# 25837-47-2) is a useful isotopically labeled research compound.

Applications 5,5-Dimethylhydantoin is part of a group of hydantoin compounds that are being evaluated for their anticonvulsant and central nervous system antitumour properties.
References Rishipathak, D., et al.: Asian J. Chem., 19, 5450 (2007); Peng, G., et al.: J. Med. Chem., 18, 846 (1975)

Applications 1,10-Phenanthrolin-5-amine is a potential fluorescent label for DNA detection. 1,10-Phenanthrolin-5-amine is used as a mediator for glucose oxidase for development of biosensors and biofuel cells
References Qin, P.-Z. et al.: Analyst, 135, 2144 (2010); Oztekin, Y. et al.: Biosens. Bioelectron., 26, 267 (2010);