Building Blocks

<p>Applications Hydrocinnamic-alpha,alpha-d2 Acid (CAS# 19136-97-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,3,4-Trihydroxybenzoic Acid is used in preparation of Polyester Polyol for solar backboard coating adhesive.<br>References Hu, Y., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications 1,1,1,3,3,3-Hexafluoro-2-methyl-2-propanol is used as an activator for the chemical fixation of carbon dioxide onto epoxides. Also used as a reagent in the synthesis of highly substituted furfuryl alcohols and amines.<br>References Gennen, S. et al.: ChemSusChem., 8, 1845 (2015); Clark, J. S. et al.: Angew. Chem. Int. Ed., 51, 12128 (2012);<br></p>

<p>Applications 2-Nitropropane-1,1,1,3,3,3-d6 (CAS# 52809-86-6) is a useful isotopically labeled research compound.<br></p>

<p>Stability Store at -20°C under Argon. Air Sensitive.<br>Applications 5,5-Diethoxypentanal (cas# 79893-96-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Pentamidine-d4 2HCl (pentane-1,1,5,5-d4) (CAS# 1276197-32-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexanoic Anhydride, is used as a reactant in the total synthesis of acremomannolipin A via steroselective β-mannosylation of 4,6,-O-benzylidene-protected mannosyl sulfoxide with a D-mannitol derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsutsui, N., et al.: Tetrahedron Lett. 54, 451(2013)<br></p>

<p>Stability Hygroscopic<br>Applications 3-Oxo-2,3-dihydro-1H-indazole-5-carboxylic acid (cas# 787580-93-2) is a useful research chemical.<br></p>

<p>Applications 2-Phenylethyl Acetate-d3 (CAS# 1219805-43-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications A degradation product of herbicide Molinate in pot soil and rice plants.<br>References Kriek, E., et al.: Biochemistry, 6, 177 (1967), Farmer, P., et al.: Toxicol. Lett., 149, 3 (2004), Gyorffy, E., et al.: Carcinogenesis, 25, 1201 (2004),<br></p>

<p>Applications 3-Pyridyl Trifluoromethanesulfonate (cas# 107658-27-5) is a compound useful in organic synthesis.<br></p>

<p>Applications n-Hexadecyltrimethylammonium-d42 Chloride (CAS# 2095863-88-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,10-Phenanthrolin-5-amine is a potential fluorescent label for DNA detection. 1,10-Phenanthrolin-5-amine is used as a mediator for glucose oxidase for development of biosensors and biofuel cells<br>References Qin, P.-Z. et al.: Analyst, 135, 2144 (2010); Oztekin, Y. et al.: Biosens. Bioelectron., 26, 267 (2010);<br></p>

<p>Applications 2-(1-Methylpiperidin-3-yl)ethan-1-ol (cas# 101257-32-3) is a useful reagent for preparing 3-(ω-hydroxyalkyl)-substituted N-methylpiperdines and N-methyl-2-piperidones.<br>References Schneider, W., et al.: Archiv der Pharmazie., 300, 540 (1967)<br></p>

<p>Applications 1-Bromo-2,3-dimethyl-benzene is a useful synthetic intermediate. It is used as a reagent to synthesize vaniprevir. It can also be used to synthesize various piperidine derivatives, e.g., 4-arylpiperidines and cinnamoylpiperidine, which are 5-HT2C agonist and PAR1 antagonist, respectively.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Song, Z., et a;.: J. Org. Chem., 76, 9553 (2011); Conway, R., et al.: Bioorg. Med. Chem. Lett., 22, 2560 (2012); Planty, B., et al.: Bioorg. Med. Chem. Lett., 20, 1735 (2010)<br></p>

<p>Applications (9H-Purin-6-ylamino)-acetic acid (cas# 10082-93-6) is a useful research chemical.<br></p>

<p>Stability Volatile<br>Applications 2,5-Norbornadiene shows anti-ethylene effects on plants and inhibits polyphenol oxidase, peroxidase and phenylalanine ammonia lyase activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hu, W., et al.: J Food Sci, 3, 123-130 (2013)<br></p>

<p>Applications 4-Methoxy-3-methylphenol (cas# 14786-82-4) is a useful research chemical.<br></p>

<p>Applications Phenoxy-2-propanone is a general chemical reagent used in the preparation of α-arylthio ketones via DL-proline.<br>References Vaquer, A. et al.: RSC Adv. 5, 96695 (2015);<br></p>

<p>Applications 2-(2-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 106128-44-3) is a useful research chemical.<br></p>

<p>Applications H-Glu(OBzl)-OH<br></p>

<p>Applications Pentanedioic-d6 Anhydride (CAS# 1219794-53-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzyl-d7-amine HCl (CAS# 352431-27-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromo-3,5-dichlorobenzene-d3 (CAS# 1219803-83-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,6-Difluorobenzonitrile is a halogenated benzonitrile with fungacidal activity. 2,6-Difluorobenzonitrile is the difluoro analogue of the herbicide Dichlobenil.<br>References Turner, N.J.: Curr. Top. Plant Sci., 50 (1969); Vosahlova, J. et al.: Pest Sci., 49, 303 (1997);<br></p>

<p>Applications 3,5-Dihydroxybenzaldehyde, is a benzaldehyde derivative, that can be used as a building block in the synthesis of more complex structures. It is used in the synthesis of Terbutaline (T109750), which is an important bronchodilator.<br>References Effenberger, F. et al.: J. Org. Chem., 62, 3867 (1997);<br></p>

<p>Applications A reagent for the synthesis of optically pure α-amino-acids.<br></p>

<p>Applications 1-(Phenylmethyl)-1H-pyrrole-2,5-dione is used in the synthesis of anthracenedicarboximides as semiconductors for transistors. Also used in the discovery of a new synthetic route towards Paroxetine<br>References Wang, Z. et al.: J. Am. Chem. Soc., 129, 13362 (2007);<br></p>

<p>Applications 1,10-Dibromodecane-d20 (CAS# 150017-88-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Oxa-7-azaspiro[3.5]nonane is an intermediate used to prepare benzothienoazepine derivatives as potent respiratory syncytial virus RNA polymerase inhibitors. It is also used to prepare 1,7-Diazacarbazole derivatives as inhibitors of checkpoint kinase 1.<br>References Xiong, H., et al.: Bioorg. Med. Chem. Lett., 23, 6789 (2013); Gazzard, L., et al.: J. Med. Chem., 58, 5053 (2015)<br></p>

<p>Applications tert-butyl 2-(4-(bromomethyl)phenyl)acetate (cas# 77292-91-2) is a useful research chemical.<br></p>

<p>Applications Benzyl-alpha,alpha-d2 Bromide (CAS# 51271-29-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications (S)-4-Benzyl-3-[(S)-3-(2-bromo-4-methoxyphenyl)-2-(4-methoxyphenyl)_x000D_propanoyl]-2-oxazolidinone (cas# 917379-10-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,3-disubstituted benzaldehyde.<br></p>

<p>Applications 2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one is an intermediate used to prepare aminothiazoles as therapeutic leads for prion diseases. It is also used in the synthesis of pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.<br>References Gallardo-Godoy, A., et al.: J. Med. Chem., 54, 1010 (2011); Keith, J., et al.: Bioorg. Med. Chem. Lett., 17, 2603 (2007)<br></p>

<p>Applications exo-Norborneol (cas# 497-37-0) is a useful research chemical.<br></p>

<p>Applications 4-Phenoxyphenol is a porous organic material with dumbbell channels that appear throughout its structure. These channels can also host solvent molecules during crystal growth. 4-Phenoxyphenol is also part of a group of phenolic compounds that have potential apoptotic activity, which can be used in the development of new treatments for cancer therapy.<br>References Hansch, C., et al.: Bioorg. Med. Chem., 11, 617 (2003); Thomas, L., et al.: Cryst. Growth. Des., 12, 1746 (2012)<br></p>

<p>Applications Gaboxadol is a sleep aid drug used for the treatment of chronic pain and insomnia. Gaboxadol is also known to exhibit antidepressant like properties through its agonistic activities towards GABA sites.<br>References Vashchinkina, E., et al.: J. Neurosci., 32, 5310 (2012); Christensen, T., et al.: Eur. Neuropsychopharmacol., 22, 751 (2012);<br></p>

<p>Applications 3,5-Difluorobenzoic-d3 Acid (CAS# 934397-71-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications The preparation of 1,7-Dihydroxynaphthalene and its prompt characterization from its NMR data and peculiarities. Removal of dihydroxynaphthalenes from aqueous solution with the aid of an oxidoreductase polyphenol oxidase and biopolymer chitosan.<br>References Peterson, I. V., et al.: Magn. Reson. Chem., 51, 762-766 (2013); Kimura, Y., et al.: Environ. Technol., 35, 2910-2919 (2014)<br></p>

<p>Applications Fumaryl Chloride is a reagent used in the synthesis of thermosetting resins which are widely used in industrial fields.<br>References Kudo, K. et al.: J. App. Polym. Sci., 133 (2016);<br></p>

<p>Applications 1,2,4,5-Benzenetetracarboxylic Acid-d6 (CAS# 344298-79-9) is a useful isotopically labeled research compound.<br></p>

<p>Stability Light Sensitive<br>Applications (E)-3-(Furan-2-yl)acrylaldehyde is a useful reagent in the synthesis of highly substituted tetrahydrofurans and tetrahydropyrans using double Michael addition strategy. A synthesis intermediate.<br>References Mondal, B., et al.: Asian J. Org. Chem., 7, 1788 (2018); Mukherjee, S., et al.: Org. Lett., 20, 2952 (2018)<br></p>

<p>Applications 1-Bromo-2-methylpropane-3,3,3-d3 (CAS# 344299-42-9) is a useful isotopically labeled research compound.<br></p>

<p>Stability Volatile<br>Applications 1-Bromo-2-methylpropane is a halogenated alkane used in various synthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Noller, C.R., et al.: Org. Syntheses., 13, (1933); Wang, Z.M., et al.: Lett. Org. Chem., 4, 72 (2007);<br></p>

<p>Applications 6-Bromo-2-picoline is a halogenated pyridine derivative used is a building block in the preparation of nitrogen containing heterocyclic compounds.<br>References Long, G.V. et al.: J. Chem. Soc. Dalt. Trans. Inorg. Chem., 21, 3175 (1993); Uenishi, J. et al.: J. Org. Chem., 58, 4382 (1993);<br></p>

<p>Applications 6-Bromo-2-naphthol is a flavonoid molecule that shows steroid hormone activity and may be useful on anticancer therapy.<br>References Zand, R. et al.: Breast. Can. Res. Treat., 62, 35 (2000);<br></p>

<p>Applications 4-(ethenesulfonyl)benzonitrile (cas# 1154397-48-4) is a useful research chemical.<br></p>

<p>Applications 1-Bromo-3-chloro-5-fluorobenzene-d3 (CAS# 1219805-00-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Bromo-1-butyne is used in the regioselective preparation and CDC25 phosphatase inhibition activity SAR of triazolobenzylidene-thiazolopyrimidines via parallel click chemistry between azidobenzylidene-thiazolopyrimidines and alkynes<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Duval, R., et al.: J. Comb. Chem., 11, 947 (2009)<br></p>

<p>Applications 2-Benzoylpyrrole (cas# 7697-46-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Bromodecane-1,1,2,2-d4 (CAS# 1219805-58-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Propyl-3,3,3-d3-amine HCl (CAS# 478702-86-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Fmoc-Leu-OH-5,5,5-d3 is an isotope labelled compound of Fmoc-L-Leu-OH (F625015). Fmoc-L-Leu-OH is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.<br>References Haochen, W., et al.: J. Cell. Biochem., 114, 1969 (2013)<br></p>

<p>Applications 1-Bromodecane-9,9,10,10,10-d5 (CAS# 1219802-02-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromodecane-10,10,10-d3 (CAS# 284474-47-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromodecane-d21 (CAS# 98195-39-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl phenyl sulfone (cas# 3112-85-4) is a useful research chemical.<br></p>

<p>Applications L-Methionine-d3-N-FMOC (S-methyl-d3) (CAS# 502692-58-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Bromo-1-butanol is a useful reactant for the synthesis of tetrasubstituted alkenes from cross-​electrophile coupling and tandem metallacycle formation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shimkin, K.W., et al.: J. Am. Chem. Soc., 140, 7074-78 (2018);<br></p>

<p>Applications 1,10-Phenanthroline-d8 (CAS# 90412-47-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications BPTES is a potent and selective Glutaminase inhibitor. Used in the treatment of renal cell carcinomas resulting from overexpression of the MYC oncogene.<br>References Shroff, E. et al.: PNAS. U.S.A., 112, 6539 (2015); Thomas, A. et al.: Biochem. Biophys. Res. Comm., 443, 32 (2014);<br></p>

<p>Applications N-Fmoc-L-cysteine is the N-Fmoc-protected form of L-Cysteine (C995000), a non-essential α-amino acid that is biosynthesized in humans. L-Cysteine is also a bicarbonate-sensitive endogenous excitotoxin in rats and possibly humans.<br>References Li, Q. et al.: Mat. Lett., 64, 614 (2010); Olney, J., et al.: Science, 4, 596 (1990)<br></p>

<p>Applications L-Valine-d8-N-t-BOC (CAS# 153568-33-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Alanine-2-d1-N-t-BOC (CAS# 88181-11-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Fmoc-L-cyclopropylalanine is used to develop low molecular weight HIV-1 protease dimerization inhibitors. It is also used to prepare piperazinone derivatives as a novel class of potent HCV NS4B inhibitors.<br>References Hwang, Y., et al.: J. Med. Chem., 48, 2239 (2005); Kakaria, R., et al.: J. Med. Chem., 57, 2136 (2014)<br></p>

<p>Applications Fmoc-Cop is used in the synthesis of disubstituted pyrimidines as Lck inhibitors.<br>References Hunt, J., et al.: Bioorg. Med. Chem. Lett., 19, 5440 (2009)<br></p>