Building Blocks

<p>Glyoxal is a chemical compound that has shown to have bactericidal activity against human pathogens such as Mycobacterium tuberculosis, Helicobacter pylori, and Staphylococcus aureus. It is used in the synthesis of heterocyclic amines and can be found as an impurity in imidazole derivatives. Glyoxal is a broad-spectrum antimicrobial that has been shown to inhibit the growth of fungi and bacteria by reacting with functional groups on the microorganisms' cell walls. It reacts with bacterial cell walls by forming an intermediate molecule, which reacts with other molecules present in the microorganism's environment to form carbon dioxide, water, and glyoxal. The reaction time for glyoxal depends on temperature; higher temperatures will result in faster reactions. Techniques used to synthesize glyoxal include dehydration of oximes or by reaction with phosphorus oxychloride.</p>

<p>Applications Reagent used for asymmetric syntheses.<br>References Schlessinger, R., et al.: J. Org. Chem., 28, 3070 (1986)<br></p>

<p>Applications 2-Chloroethanol is used in the preparation of TTFTT (tetrathiafulvalene-2,3,6,7-tetrathiolate) and important building block in TTF syntheis. In addition, it is used in the synthesis of vinyltriazoles. This is the labeled analog.<br>Dangerous Goods Info This compound is forbidden to ship by air under IATA regulations.<br>References Svenstrup, N. et al.: Synthesis, 8, 809 (1994); Thibault, R. et al.: J. Am. Chem. Soc., 128, 12084 (2006);<br></p>

<p>Applications A labelled isotope of a toxic volatile hydrazine found in rocket fuel systems.<br>References Oanasyuk, A.G. et al.: Vis. Nat. Tekh. Univ. KhPI, 13, 59 (2010);<br></p>

<p>Applications Glyceryl Trihexadecanoate-13C1 (2-Hexadecanoate-1-13C) is a useful isotopically labeled compound of Tripalmitin (T808130)<br></p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Pyrazolo[1,5-a]pyridin-4-ol is a heteroaromatic compound that acts as an inhibitor of phosphodiesterase (PDE). It prevents the breakdown of cyclic nucleotides and thus leads to increased levels of cAMP and cGMP. Pyrazolo[1,5-a]pyridin-4-ol has been shown to have bronchodilatory activity in animal models. The drug also inhibits the production of inflammatory mediators such as prostaglandins by inhibiting cyclooxygenases. In addition, pyrazolo[1,5-a]pyridin-4-ol has been shown to be a potential PDE inhibitor replacement for the more commonly used PDE inhibitors such as sildenafil and tadalafil. However, due to its lack of stereochemistry and its bicyclic chemical structure, pyrazolo[1,5-a]</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Bromo-1-hydroxynaphthalene-2-carboxylic acid (4BHN) is a spectroscopic compound that has been used as a radioligand to study the binding of dopamine and dopamine D3 receptors. This compound binds to the d3 receptor with high affinity and specificity, but it does not interact with the d1 or d2 receptors. 4BHN has been shown to act as an agonist at the dopamine D3 receptor. It also acts as an antagonist at the piperidine site of the dopamine D2 receptor. The effects of 4BHN are reversible, which means that it can be displaced by unlabeled 4BHN or other compounds that bind to the same site on the receptor. This technique is useful for studying drug interactions and for determining whether drugs have a subtype selectivity profile.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>