Acids and Synthetic Reagents

<p>Stability Moisture Sensitive<br>Applications 1-(Trimethylsiloxy)cyclohexene is used as a reagent in the synthesis of 6-Methyl Chrysene (M265140); an aryl hydrocarbon receptor (AhR) agonist that has been listed as possibly carcinogenic to humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amin, S. et al.: Cancer Res., 45, 6406 (1985); Blaha, L. et al.: Toxicol. Sci., 65, 43 (2002); Brack, W. et al.: Environ. Sci. Technol., 37, 3062 (2003); Andrysik, Z. et al.: Mutat. Res., 615, 87 (2007)<br></p>

<p>Applications 1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. A potential candidate in the treatment of patients with renal parenchymal hypertension.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ohya, Y. et al.: Int. J. Clin. Pharmacol. Therap., 38, 304 (2000); Huh, W. S. et al.: Curr. Therap. Res., 61, 395 (2000); Katoh, M. et al.: Eur. J. Clin. Pharmacol., 55, 843 (2000);<br></p>

<p>Applications PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Slee, E., et al.: J. Biol. Chem., 276, 7320 (2001), Pop, C., et al.: Biochemistry, 42, 12311 (2003), Li, L., et al.: Science, 305, 1471 (2004), Green, D., et al.: J. Clin. Invest., 115, 2610 (2005), Satoh, T., et al.: Clin. Cancer Res., 15, 3872 (2009),<br></p>

<p>Applications AHR 11652 is a metabolite of Bromfenac sodium (B678550).<br>References Walsh, D.A., et al.: J. Med. Chem., 25, 446 (1982),<br></p>

<p>Applications Phosphomolybdic Acid Hydrate functions as catalyst, and also use in the preparation of other catalyst, e.g. the preparation of highly active deep HDS catalysts prepared using Mo and W heteropolyacids supported on SBA-15. It is also a reagent for the preparation of molybdophosphate complexes of rare earth elememts. Dyes and metabolites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lizama, L., et al.: Appl. Catal., B: Env., 82, 139 (2008); Xiao, Z., et al.: Fujian Shifan Daxue Xuebao, Ziran Kexueban, 2, 77 (1986)<br></p>

<p>Stability Moisture Sensitive<br>Applications Ethyl Malonyl Chloride is used as a reagent in the synthesis of novel thiadiazoloacrylamide analogs as inhibitors of dengue-2 virus NS2B/NS3 protease. Ethyl Malonyl Chloride is also used as a reagent in the synthesis of quinolone-benzylpiperidine derivatives as acetylcholinesterase inhibitors and antioxidant hybrids for Alzheimer disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, H., et al.: Bioorg. Med. Chem., 22, 6344 (2014); Pudlo, M., et al.: Bioorg. Med. Chem., 22, 2496 (2014)<br></p>

<p>Applications Dabrafenib is an inhibitor of mutated BRAF kinase and has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.<br>References Hauschild, A., et al.: Lancet, 380, 358 (2012); Falchook, G.S., et al.: Lancet, 379, 1893 (2012); Ascierto, P.A., et al.: J. Clin. Oncol., 31, 3205 (2013);<br></p>

<p>Applications Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.<br>References Curtis, et al.: Nature, 226, 1222 (1970), Avoli, M., et al.: J. Physiol. Pharmacol., 75, 526 (1997), Chebib, M., et al.: Clin. Exp. Pharmacol. Physiol., 26, 927 (1999),<br></p>

<p>Applications Ammonium Iron(II) Sulfate Hexahydrate (Mohr’s Salt) is used in analytical chemistry allowing products to resist oxidation. In addition it is used in the measurement of high doses of gamma rays.<br>References Hickman, C. et al.: Rad. Prot. Dent., 17, 255 (1986);<br></p>

<p>Applications Serotonin antagonist structurally related to Cyproheptadine. Antimigraine; appetite stimulant.<br>References Geraud, G., et al.: Clin. Ther., 26, 1305 (2004), Bolay, H., et al.: Nat. Med., 8, 136 (2002), Scher, A., et al.: Pain, 106, 81 (2003), Richter, F., et al.: J. Cereb. Blood Flow Metab., 25, 1225 (2005),<br></p>

<p>Applications A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase.<br>References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999), Davies, S., et al.: Biochem. J., 351, 95 (2000), Regan, J., et al.: J. Med. Chem., 45, 2994 (2002), Bain, J., et al.: Biochem. J., 371, 199 (2003), Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (2005),<br></p>

<p>Applications Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.<br>References Liagre B. et al.: Int. J. Mol. Med., 20, 451 (2007);<br></p>

<p>Applications Hydrogen Tetrafluoroborate(1-) is a useful building block for organic synthesis.<br>References Ohkuma, T., et al.: Journal of the American Chemical Society., 218, 8724 (2006)<br></p>

<p>Applications Tris(dibenzylideneacetone)dipalladium is used in the preparation of semiconducting polymers processed from nonchlorinated solvents into high performance thin film transistors. Also used in the synthesis of polymer bulk-heterojunction solar sells as a semiconductor.<br>References Matthews, J. et al.: Chem. Mat., 25, 782 (2013); Hwang, Y. et al.: Macromol., 45, 9056 (2012);<br></p>

<p>Applications Nickel(II) chloride anhydrous (cas# 7718-54-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,5-Diazabicyclo[4.3.0]non-5-ene is used as a nucleophilic catalyst for the Freidel-Crafts C-acylation of pyrroles and indoles. 1,5-Diazabicyclo[4.3.0]non-5-ene is also an inhibitor of indoleamine-N-methyltransferase (II) of rabbit lung in vitro.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mandel, L.: Biochem. Pharmacol., 25, 2251 (1976); Taylor, J., et al.: Org. Lett., 12, 5740 (2010)<br></p>

<p>Applications Brolitene was studied as one of palmitoylethanolamide derivatives as anticonvulsants and antidepressants.<br>References Guan, L., et al.: Med. Chem. Res., 20, 601 (2011);<br></p>

<p>Applications A biphosphonate bone resorption inhibitor.<br>References Green, J.R., et al.: J. Bone Min. Res., 9, 745 (1994), Risser, F., et al.: J. Pharm. Biomed. Anal., 15, 1877 (1997), Body, J.J., Cancer, 80, 1699 (1997),<br></p>

<p>Applications Triptolide is a diterpenoid triepoxide with immunosuppressant and antitumor properties.<br>References Hikim, S., et al.: J. Androl., 21, 431 (2000), Chang, W.-T., et al.: J. Biol. Chem., 276, 222 (2001), Kiviharju, T.M., et al.: Clin. Cancer Res., 8, 2666 (2002), Leuenroth, S.J., et al.: Chem. Biol., 12, 1259 (2005),<br></p>

<p>Applications EGTA is a calcium chelator. EGTA protects mature oligodendrocytes from NO generated by S-nitroso-N-acetyl-penicillamine.<br>References Nielsen, A.D., et. al.: Anal. Biochem., 314, 227 (2003); Boullerne, A., et. al.: J. Neurosci. Res., 63, 124 (2001)<br></p>

<p>Stability Air Sensitive<br>Applications Thioglycolic Acid is an organic compound containing both a thiol and a carboxylic acid. Thioglycolic Acid is a precursor to ammonium thioglycolate, a chemical used for permanents. Thioglycolic Acid is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, T.R. et al.: Bull. Kor. Chem. Soc., 3, 162 (1982); Badr, M.Z.A. et al.: Bull. Chem. Soc. Jap., 56, 326 (1983); Langler, R.F. et al.: Can. J. Chem., 57, 3193 (1979);<br></p>

<p>Applications Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).<br>References Baker, W. &amp; White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)<br></p>

<p>Applications (1R)-(+)-α-Pinene is used in hydroboration reactions and the reduction of ketones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, H. et al.: J. Org. Chem., 50, 1384 (1985);<br></p>

<p>Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)<br></p>

<p>Applications Etidronic acid is used as a calcium regulator. Etidronic acid is a bisphosphonate antiresorptive agent.<br>References Francis, M.D., et al.: Science, 165, 1264 (1969), Jowsey, J., et al.: J. Lab. Clin. Med. , 76, 126 (1970), Altman, R.D.: N. Engl. J. Med., 79, 583 (1985)<br></p>

<p>Applications A nucleotide analog, useful as an oral reverse transcriptase inhibitor (ntRTI).<br>References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010), Ming, X., et al.: Biochem. Pharmacol., 79, 455 (2010),<br></p>

<p>Applications 3-Carboxyphenylboronic Acid is used in phenylboronic acid-decorated gelatin nanoparticles for enhanced tumor targeting and penetration.<br>References Wang, X., et al.: Nanotechnology, 27, 385101 (2016); Wang, X., et al.: Eur. J. Pharm. Biopharm., 113, 168 (2017)<br></p>

<p>Applications Labelled selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; in treatment of chronic obstructive pulmonary disease.<br>References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001), Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001), Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002), Rabe, K.F., et al.: Lancet, 366, 563 (2005),<br></p>

<p>Applications Antipsychotic used in the treatment of schizophrenia.<br>References Nourian, Z., et al.: Eur. J. Pharmacol., 596, 32 (2008), Karczewski, J., et al.: Biochem. Pharmacol., 77, 1602 (2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009), Goetghebeur, P., et al.: Psychopharmacol., 202, 287 (2009),<br></p>

<p>Applications N-Methyl-2-(4-nitrophenyl)ethanamine Hydrochloride is used as a reactant in the preparation of small molecule CDC25 phosphatases inhibitors.<br>References Contour-Galcera, Marie-Odile, et al.: Bioorg. &amp; Med. Chem. Let., 14(23), 5809-5812 (2004)<br></p>

<p>Applications (R)-(-)-2-Amino-1-butanol (cas# 5856-63-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Sodium Iodide is used in the synthesis of dye-sensitized solar cells. Also used in the preparation of propargylamines as inhibitors of lysine specific. demethylase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zalas, M. et al.: Electrochem. Acta., 108, 736 (2013); Schmitt, M. et al.: J. Med. Chem., 56, 7334 (2013);<br></p>

<p>Applications 5-Carboxyfluorescein is a useful reagent for the preparation of hydrolytically stable fluorescent conjugates and is a useful starting material for the synthesis of other fluorescein-derives reagent. Dyes and metabolites.<br>References Theisen, P., et al.: Tetrahedron Lett., 33, 5033 (1992); Mattingly, P.: Bioconjgate Chem., 3, 430 (1992); Bertrand, R., et al.: Biochemistry, 34, 9500 (1995);<br></p>

<p>Applications 2-Bromo-1,4-naphthoquinone is a structural analog of Vitamin K3 (V676130) and has been used in cancer research studies to increase H2O2 production in tumor cell lines.<br>References Graciani, F.S., et al.: Braz. J. Med. Biol. Res., 45, 701 (2012)<br></p>

<p>Stability Light Sensitive<br>Applications 2-Methyl-2-propen-1-ol has been used in the synthesis of C2-methyl-1,2-di-O-hexadecylglycerophosphocholine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bittman, R., Witzke N.M.: Chem. Physics Lipid, 50, 99 (1989)<br></p>

<p>Applications Xenon Difluoride is a fluorination agent used in gas chromatography.<br>References Zhu, M. et al.: J. Micromech. Microeng., 27, 125007 (2017);<br></p>

<p>Applications The Shvo catalyst is an organoruthenium compound that is used for transfer hydrogenation<br>References Shvo, Y.; Czarkie, D.; Rahamim, Y. (1986). "A new group of ruthenium complexes: structure and catalysis". J. Am. Chem. Soc. 108 (23): 7400–2.<br></p>

<p>Applications OCTADECYLTRIMETHOXYSILANE (cas# 3069-42-9) is a useful research chemical.<br></p>

<p>Applications Copper(II) carbonate dihydroxide is commonly used as an impregnant in activated carbons for respiratory filters. Copper(II) carbonate dihydroxide is also used to form a protective layer around the corrosion sites of electrodes to prevent them from further corrosion.<br>References Mattsson, E. &amp; Fredriksson, A.: Brit. Corr. J., 3, 246 (1968); Smith, J., et al.: J. Coll. Inter. Sci., 337, 313 (2009)<br></p>

<p>Applications D-(-)-Tartaric Acid the synthetic enantiomer of L-(+)-Tartaric Acid (T007630), used in the preparation of synthetic analgesics.<br>References Van Bever, W. et al.: J. Med. Chem., 17, 1047 (1974);<br></p>

<p>Stability Very Hygroscopic<br>Applications Potassium trifluoroacetate (cas# 2923-16-2) is a useful research chemical.<br></p>

<p>Applications Used for preparation of hydrophilic polymers for biomedical devices.<br>References Delbressine, L., et al.: Xenobiotica, 11, 241 (1981), Gerberick, G., et al.: Toxicol. Sci., 97, 417 (2007),<br></p>

<p>Applications Mercury(II) Chloride is used to produce amalgamated aluminium which is used as reducing agent. Mercury(II) Chloride is also used as a catalyst for the conversion of acetylene to vinyl chloride.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Diuguid, L., et al.: J. Am. Chem. Soc., 12,3527 (1941);<br></p>

<p>Applications A serotonin 5-HT2A receptor antagonist. Used as potential controls in various biological studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wong, D.F., et al.: Science, 226, 1393 (1984), Blin, J., et al.: Eur. J. Pharmacol., 147, 73 (1988), Kehne, J.H., et al.: J. Pharmacol. Exp. Ther., 277, 968 (1996),<br></p>

<p>Applications A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro.<br>References Kontoghiorghes, G.J.: Lancet I, 817 (1985), Kontoghiorghes, G.J., et al.: Br. J. Haematol., 62, 607 (1986), Kontoghiorghes, G.J., et al.: Biochem. Biophys. Acta, 869, 141 (1986), Kontoghiorghes, G.J., et al.: Arzneim.-Forsch., 37, 1099 (1987),<br></p>

<p>Applications N-Isopropylbenzylamine, can be used as an intermediate in the synthesis of pharmaceutical compounds,and as a precursor to the manufacture of some drugs. Due to it’s similarity in appearance and physical properties to methamphetamine, it has been recently come under consideration of DEA.<br></p>

<p>Applications 2-Chloroethyl isocyanate is used as a reagent and building block in chemical synthesis. In particular, it is used in the preparation of functionalized aminobenzoboroxoles which are potential anti-cancer agents and also the synthesis of 3-(2-chloroethyl)-5-methyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4-(3H)-one which also exhibit antiproliferative activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Suman, P., et al.: J. Organomet. Chem., Ahead of Print (2015); Maggio, B., et al.: Eur. J. Med. Chem., 96, 98 (2015)<br></p>

<p>Applications An anti-ulcer drug. Potent PDE4 inhibitor<br>References Kishimoto, A., et al.: J. Periodont. Res., 43, 508 (2008), Masuyama, H., et al.: Ther. Res., 29, 415 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),<br></p>

<p>Applications MTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.<br>References Hao, J. et al.: Bioorg. Med. Chem. Lett., 23, 1249 (2013);<br></p>

<p>Applications DMTMM, a conjugating agent that efficiently conjugat PnPS to Luminex microspheres without affecting the antigenicity of a broad set of PnPS.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wrzesien, J. &amp; Graham, D.: Tetrahedron, 68, 1230 (2012); Schlottmann, S. et al.: J. Im. Meth., 309, 75 (2006)<br></p>

<p>Applications Benzyltrimethylammonium Hydroxide is a reagent used in the preparation of dithiocabamates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zaidi, S. et al.: Chem. Biol. Interface., 7, 166 (2017);<br></p>

<p>Applications DL-Dapoxetine HCl (cas# 1071929-03-7) is a useful research chemical.<br></p>

<p>Applications An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.<br>References Dolan, M.E., et al.: Proc. Natl. Acad. Sci. USA, 87, 5356 (1990), Goodtzova, K., et al.: Biochemistry, 33, 385 (1994), Elder, R.H., et al.: Biochem. J., 298, 231 (1994)<br></p>

<p>Applications Saxagliptin Hydrate is a selective and reversible dipeptidyl peptidase-4 (DPP4) inhibitor that may be used to develop treatment for type 2 diabetes.<br>References Gu, S., et al.: PLoS One. 11, e0167190 (2016); Dave, D. J.: J Pharmacol Pharmacother 2, 230 (2011)<br></p>

<p>Applications 2-(4-Methoxyphenyl)ethylamine is used in the synthesis of 1,3-disubstituted β-carboline alkaloids. It is also used in the preparation of antibacterial lysine-peptoid hybrids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ryge, T. et al.: Bioorg. Med. Chem. Lett., 14, 4444 (2006); Tagawa, S. et al.: Heterocycles, 87, 357 (2013);<br></p>

<p>Applications R-enantiomer of Epichlorohydrin, an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. It is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Romano, K.P. et al.: Chem. Res. Toxicol., 20, 832 (2007); Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 30, 63 (1948);<br></p>

<p>Stability Hygroscopic<br>Applications Calcium Dobesilate (cas# 117552-78-0) is a useful research chemical. A vasoprotective.<br>References Caproiu, R., et al.: Revistade Chimie, 39, 528 (1988); Huang, Z., et al.: From Faming Zhuanli Shenqing (2007), CN 101081823 A 20071205<br></p>

<p>Applications Diammonium salt of Phosphoric Acid, used in various chemical processes as a phosphorylating compound. Also used in the preparation of prosthetics and collagen nanocomposites due to the bone-like properties.<br>References Ezhova, Z. et al.: Russ. J. Inorg. Chem., 58, 1177 (2013); Wu, Y. et al.: Asian J. Chem., 25, 5881 (2013);<br></p>

<p>Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)<br></p>

<p>Applications L-threo-Phenylserine is a valuable chiral synthon.<br></p>

<p>Stability Hygroscopic<br>Applications (R)-Phenylephrine Hydrochloride is an α-Adrenergic agonist. Mydriatic; decongestant.<br>References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 86, 284 (1946); Gaglia, C.A., et al.: Anal. Profiles Drug Subs., 3, 483 (1974);<br></p>

<p>Applications β-Methylphenethylamine is a positional isomer of Amphetamine (HCl: A634240), and as a result, has been classified as a doping agent by the World-Anti Doping Agency.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cho?bi?ski, P., et al.: Anal. Bioanal. Chem., No vol. given, 1 (2014); Cohen, P., et al.: New Engl. J. Med., 370, 1277 (2014); Pawar, R., et al.: J. Pharm. Biomed. Anal., 88, 457 (2014); Vaclavik, L., et al.: Anal. Chim. Acta, 810, 45 (2014)<br></p>

<p>Stability Freezer at -20°C<br>Applications A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.<br>References HonorÈ, T., et al.: Science, 241, 701 (1988), Gill, et al.: Brain Res., 580, 35 (1992), Pook, et al.: Br. J. Pharmacol., 108, 179 (1993)<br></p>

<p>Applications Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100µM.(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneSelective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.<br>References Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)<br></p>

<p>Applications Gabexate mesylate is used in combination with somatostatin and octreotide in the treatment of severe acute pancreatitis in elderly patients.<br>References Li, X., et al.: Xiandai Zhenduan Yu Zhiliao, 25, 3719 (2014); Wei, Q., et al.: Xiandai Zhenduan Yu Zhiliao, 25, 5346 (2014)<br></p>

<p>Applications A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial.<br>References English, A.R., et al.: Antimicrob. Agents Chemother., 14, 414 (1978), Stromberg, B.V., Surg. Gynecol. Obstet., 162, 575 (1986), Mehtar, S., et al.: J. Antimicrob. Chemother., 17, 389 (1986), Campoli-Richards, D.M., et al.: Drugs, 33, 577 (1987),<br></p>

<p>Stability Hygroscopic and Moisture Sensitive<br>Applications Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009);<br></p>

<p>Applications MEK 162 is a MEK1/2 inhibitor allowing it to be a effective anti-cancer medication.<br>References Kopetz,S., et al.: N. Engl., 381, 1632-1643<br></p>

<p>Applications Protected 1,2-Phenyldiamine, an intermediate in the synthesis of histone deacetylase agents and antitumor agents.<br>References Andrews, D., et al.: Bioorg. Med. Chem. Lett., 18, 2580 (2008), Mahboobi, S., et al.: J. Med. Chem., 52, 2265 (2009),<br></p>

<p>Applications Bromochloroacetic acid is a halogenated disinfection byproduct commonly found in drinking water, fruit juice, and cheese. Bromochloroacetic acid has been shown to cause mesothelioma, fibroadenomas, and adenomas in rats<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hang, C., et al.: Sci Total Environ. 543, 425 (2016); Cardador, M. J. and Gallego, M.: Food Chem. 173, 685 (2015); Natl Toxicol Program Tech Rep Ser. 549, 1 (2009)<br></p>

<p>Stability -200C<br>Applications A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase.<br>References Kawasaki, H., et al.: J. Biol. Chem., 272, 18518 (1997), Ward, S.G., et al.: Biochem. Soc. Trans., 245, 304S (1997), Clerk, A., et al.: FEBS Lett., 426, 93 (1998),<br></p>